当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Allogeneic peripheral blood progenitor cell transplantation in a murine model: evidence for an improved graft-versus-leukemia effect.

Allogeneic peripheral blood progenitor cell transplantation in a murine model: evidence for an improved graft-versus-leukemia effect.

Abstract：

:Peripheral blood progenitor cells (PBPCs) are increasingly being used to replace bone marrow cells (BMCs) as a source of hematopoietic stem cells also in the field of allogeneic transplantation. Whereas it is well known that PBPC grafts and BM differ significantly in progenitor cell content and lymphocyte dose, the clinical consequences of these differences with respect to engraftment, graft-versus-host disease (GVHD), and the graft-versus-leukemia (GVL) effect are more difficult to assess. We present a murine model that allows us to evaluate engraftment, GVHD, and GVL effect of allogeneic PBPC transplantation (PBPCT). Balb/c mice (H-2d) served as recipients. Donors were major histocompatibility complex-matched DBA/2 mice or syngeneic Balb/c mice, respectively. Experiments with increasing numbers of BMCs or Filgastrim-mobilized PBPCs showed that the number of progenitor cells in the graft was correlated with the probability to engraft, irrespective of the graft type. With identically high cell numbers transferred (1 x 10(9) nucleated cells/kg body weight [BW]), the mortality rates due to GVHD (25%) were about the same after allogeneic BM transplantation (BMT) and allogeneic PBPCT, although PBPC grafts contained four times more CD3+ T cells as compared with BM grafts (6.2 x 10(8) v 1.4 x 10(8)/kg BW). For investigation of GVL activity, Balb/c recipients were injected with syngeneic cells of the B-lymphocytic leukemia cell line A20 2 days before transplantation. After total body irradiation to a dose of 7.5 Gy, 1 x 10(9)/kg BW Balb/c PBPCs, DBA BMCs, or DBA PBPCs were infused. The relapse rates observed were 80% after syngeneic PBPCT (n = 22), 60% after allogeneic BMT (n = 23), and 34% after allogeneic PBPCT (n = 26) (allogeneic BMT v PBPCT, P = .032). We conclude that transplantation of allogeneic PBPCs instead of BM may enhance the GVL effect without an increase of GVHD.

journal_name

Blood

journal_title

Blood

authors

Glass B,Uharek L,Zeis M,Dreger P,Löffler H,Steinmann J,Schmitz N

subject

Has Abstract

pub_date

1997-08-15 00:00:00

pages

1694-700

issue

4

eissn

0006-4971

issn

1528-0020

journal_volume

90

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Heterogeneity in filamentous actin content among individual human blood platelets.

    abstract：:The content of filamentous actin in individual platelets was measured by flow cytometry, using a fluorescent probe specific for filamentous actin (F-actin), 7-nitrobenz-2-oxa-1,3-phallacidin (NBD-phallacidin). NBD-phallacidin binding to fixed platelets was specific in that either pretreatment of platelets with unlabel...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Oda A,Daley JF,Cabral C,Kang JH,Smith M,Salzman EW

    更新日期：1992-02-15 00:00:00

  • Complete allogeneic hematopoietic chimerism achieved by a combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion.

    abstract：:In utero hematopoietic stem cell transplantation (IUHSCTx) can achieve mixed hematopoietic chimerism and donor-specific tolerance without cytoreductive conditioning or immunosuppression. The primary limitation to the clinical application of IUHSCTx has been minimal donor cell engraftment, well below therapeutic levels...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2002-01-0016

    authors： Hayashi S,Peranteau WH,Shaaban AF,Flake AW

    更新日期：2002-08-01 00:00:00

  • Quantification of the preexisting CD4 T-cell repertoire specific for human erythropoietin reveals its immunogenicity potential.

    abstract：:Antibody-mediated pure red cell aplasia is a rare but serious event resulting from the induction of neutralizing erythropoietin (Epo)-specific antibodies provoked by treatment with recombinant Epo. Because of the crucial role of CD4 T cells in humoral response, we have quantified the number of Epo-specific CD4 T cells...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-04-280875

    authors： Delluc S,Ravot G,Maillere B

    更新日期：2010-11-25 00:00:00

  • Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer.

    abstract：:A 64-yr-old female developed acute myeloblastic leukemia following radiation and drug therapy for colon carcinoma. The patient was heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD) and displayed types A and B isoenzymes in nonhematopoietic tissue. In contrast, only type B G-6-PD was observed in peripheral bl...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Wiggans RG,Jacobson RJ,Fialkow PJ,Woolley PV 3rd,Macdonald JS,Schein PS

    更新日期：1978-10-01 00:00:00

  • In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance.

    abstract：:We previously showed that incorporating target sequences for the hematopoietic-specific microRNA miR-142 into an antigen-encoding transgene prevents antigen expression in antigen-presenting cells (APCs). To determine whether this approach induces immunologic tolerance, we treated mice with a miR-142-regulated lentivir...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2009-04-214569

    authors： Annoni A,Brown BD,Cantore A,Sergi LS,Naldini L,Roncarolo MG

    更新日期：2009-12-10 00:00:00

  • A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation.

    abstract：:A1, a bcl-2 family member, has been identified as a hematopoietic-specific, early inducible gene. In this study it is shown that stable transfection of A1 into an interleukin-3 (IL-3)-dependent myeloid precursor cell line, 32D c13, leads to a retardation of IL-3 withdrawal-induced cell death similar to that observed w...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Lin EY,Orlofsky A,Wang HG,Reed JC,Prystowsky MB

    更新日期：1996-02-01 00:00:00

  • Acute cholesterol depletion impairs functional expression of tissue factor in fibroblasts: modulation of tissue factor activity by membrane cholesterol.

    abstract：:Cholesterol, in addition to providing rigidity to the fluid membrane, plays a critical role in receptor function, endocytosis, recycling, and signal transduction. In the present study, we examined the effect of membrane cholesterol on functional expression of tissue factor (TF), a cellular receptor for clotting factor...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-03-0990

    authors： Mandal SK,Iakhiaev A,Pendurthi UR,Rao LV

    更新日期：2005-01-01 00:00:00

  • Megakaryocyte maturation indicated by methanol inhibition of an acid phosphatase shared by magakaryocytes and platelets.

    abstract：:Optimal conditions necessary for the cytochemical demonstration of megakaryocyte (Mk) and platelet acid phosphatase (AP) were determined. Methanol, a constituent of fixatives commonly used in AP cytochemistry, was found to inhibit MkAP, and the degree of inhibition varied with Mk maturity. Immature Mk contained predom...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Markovic OS,Shulman NR

    更新日期：1977-11-01 00:00:00

  • Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group.

    abstract：:Trial ALL-BFM 90 was designed to improve outcome in patients with childhood acute lymphoblastic leukemia (ALL) by using a reduced treatment regimen. Patients were stratified into a standard-risk group (SRG), a medium-risk group (MRG), both defined by adequate early treatment response; and a high-risk group (HRG), defi...

    journal_title：Blood

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Schrappe M,Reiter A,Ludwig WD,Harbott J,Zimmermann M,Hiddemann W,Niemeyer C,Henze G,Feldges A,Zintl F,Kornhuber B,Ritter J,Welte K,Gadner H,Riehm H

    更新日期：2000-06-01 00:00:00

  • Beyond hairy cell: the activity of cladribine in other hematologic malignancies.

    abstract：:Before the contemporary development of rationally designed antineoplastic therapies, cladribine was identified as a lymphocyte-specific agent. Its profound impact on the natural history of hairy cell leukemia, with responses approaching 100% and a median duration of response of nearly a decade after only a single 7-da...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2010-02-246140

    authors： Sigal DS,Miller HJ,Schram ED,Saven A

    更新日期：2010-10-21 00:00:00

  • Basic fibroblast growth factor mediates its effects on committed myeloid progenitors by direct action and has no effect on hematopoietic stem cells.

    abstract：:Basic fibroblast growth factor or fibroblast growth factor-2 (FGF) has been shown to affect myeloid cell proliferation and hypothesized to stimulate primitive hematopoietic cells. We sought to evaluate the effect of FGF on hematopoietic stem cells and to determine if FGF mediated its effects on progenitor cells direct...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Berardi AC,Wang A,Abraham J,Scadden DT

    更新日期：1995-09-15 00:00:00

  • Phase 1 study of weekly dosing with the investigational oral proteasome inhibitor ixazomib in relapsed/refractory multiple myeloma.

    abstract：:Proteasome inhibition is an effective treatment strategy for multiple myeloma. With improving survival, attention is increasingly focusing on ease of administration and toxicity profile. Ixazomib is an investigational, orally bioavailable 20S proteasome inhibitor. Sixty patients with relapsed and/or refractory multipl...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-01-548941

    authors： Kumar SK,Bensinger WI,Zimmerman TM,Reeder CB,Berenson JR,Berg D,Hui AM,Gupta N,Di Bacco A,Yu J,Shou Y,Niesvizky R

    更新日期：2014-08-14 00:00:00

  • Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: clinical and biologic activities in the phase 1 setting.

    abstract：:R115777 is a potent farnesyltransferase (FTase) inhibitor with substantial antitumor activity in preclinical models. We conducted a phase 1 study (3 + 3 design) of R115777 in patients with myelodysplastic syndrome (MDS). R115777 was administered twice daily (3-weeks-on/1-week-off schedule for 8 weeks) (starting dosage...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：10.1182/blood-2002-11-3359

    authors： Kurzrock R,Kantarjian HM,Cortes JE,Singhania N,Thomas DA,Wilson EF,Wright JJ,Freireich EJ,Talpaz M,Sebti SM

    更新日期：2003-12-15 00:00:00

  • How I treat disseminated intravascular coagulation.

    abstract：:Disseminated intravascular coagulation (DIC) is a condition characterized by systemic activation of coagulation, potentially leading to thrombotic obstruction of small and midsize vessels, thereby contributing to organ dysfunction. At the same time, ongoing consumption of platelets and coagulation proteins results in ...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2017-10-804096

    authors： Levi M,Scully M

    更新日期：2018-02-22 00:00:00

  • Rabbit reticulocyte coated vesicles carrying the transferrin-transferrin receptor complex: I. Purification and partial characterization.

    abstract：:Coated vesicles bearing the transferrin-transferrin receptor complex were isolated from rabbit reticulocytes by freeze-thaw cell lysis, followed by differential centrifugation with pelleting of vesicles at 100,000 g. Electronmicroscopy demonstrated the vesicles to have the characteristic morphology of coated vesicles,...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Choe HR,Moseley ST,Glass J,Nunez MT

    更新日期：1987-10-01 00:00:00

  • A special report: bone marrow transplants using volunteer donors--recommendations and requirements for a standardized practice throughout the world--1994 update. The WMDA Executive Committee.

    abstract：:A primary function of the World Marrow Donor Association is to establish general guidelines covering collaboration between international donor registries and practice in regard to bone marrow transplants (BMTs) in which the donor and recipient reside in different countries. To this end, a special report proposing spec...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Goldman JM

    更新日期：1994-11-01 00:00:00

  • The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium.

    abstract：:The CC chemokine receptor 8 (CCR8) is expressed on monocytes and type 2 T lymphocytes. CCR8 is the sole receptor for the human CC chemokine I-309, as well as for viral monocyte inflammatory protein-I (vMIP-I), a human chemokine homologue induced in human cells by the Kaposi sarcoma-related human herpesvirus-8. Recentl...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v97.1.39

    authors： Haque NS,Fallon JT,Taubman MB,Harpel PC

    更新日期：2001-01-01 00:00:00

  • Expression of human inducible nitric oxide synthase gene in T-cell lines infected with human T-cell leukemia virus type-I and primary adult T-cell leukemia cells.

    abstract：:We examined the expression of messenger RNA (mRNA) of the human inducible nitric oxide synthase (hiNOS) gene in a panel of human T-cell lines. Reverse transcriptase-polymerase chain reaction showed that human T-cell leukemia virus type-I (HTLV-I)-infected T-cell lines (MT-1, SLB-1, and C5/MJ) expressed mRNA for the hi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Mori N,Nunokawa Y,Yamada Y,Ikeda S,Tomonaga M,Yamamoto N

    更新日期：1999-10-15 00:00:00

  • RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection.

    abstract：:While the interferon (IFN)-inducible double-stranded RNA (dsRNA)-dependent protein kinase PKR is reported to initiate apoptosis in some instances, the mechanism by which diverse stress stimuli activate PKR remains unknown. Now we report that RAX, the only known cellular activator for PKR, initiates PKR activation in r...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-11-006817

    authors： Bennett RL,Blalock WL,Abtahi DM,Pan Y,Moyer SA,May WS

    更新日期：2006-08-01 00:00:00

  • HLA associations with leukemia.

    abstract：:Frequencies of 35 HLA A, B, C, and DR antigens were determined in 1,834 leukemic Caucasoids to evaluate possible associations between HLA and leukemia. In comparison with the frequencies of HLA antigens in published controls, the frequency of Cw3 was significantly higher in patients with acute lymphoblastic leukemia (...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bortin MM,D'Amaro J,Bach FH,Rimm AA,van Rood JJ

    更新日期：1987-07-01 00:00:00

  • Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax.

    abstract：:CD40 is present on both normal and neoplastic B-lineage cells. CD40 stimulation of normal B cells has been shown to promote normal growth and differentiation, whereas aggressive histology B lymphomas are growth inhibited. The inhibition of neoplastic B-cell growth is believed to occur via activation-induced cell death...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v100.1.217

    authors： Szocinski JL,Khaled AR,Hixon J,Halverson D,Funakoshi S,Fanslow WC,Boyd A,Taub DD,Durum SK,Siegall CB,Longo DL,Murphy WJ

    更新日期：2002-07-01 00:00:00

  • Enhancement of neutrophil function by granulocyte-macrophage colony-stimulating factor involves recruitment of a less responsive subpopulation.

    abstract：:Human granulocyte-macrophage colony-stimulating factor (GM-CSF) enhances numerous functions of mature neutrophils (PMN) including phagocytosis, superoxide responses to chemotaxins, antibody-dependent cellular cytotoxicity, and expression of complement receptors. A central question concerns whether the mechanism of enh...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Fletcher MP,Gasson JC

    更新日期：1988-03-01 00:00:00

  • Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.

    abstract：:The transcription factor runt-related transcription factor 1 (Runx1) is essential for the establishment of definitive hematopoiesis during embryonic development. In adult blood homeostasis, Runx1 plays a pivotal role in the maturation of lymphocytes and megakaryocytes. Furthermore, Runx1 is required for the regulation...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2011-09-382390

    authors： Ross K,Sedello AK,Todd GP,Paszkowski-Rogacz M,Bird AW,Ding L,Grinenko T,Behrens K,Hubner N,Mann M,Waskow C,Stocking C,Buchholz F

    更新日期：2012-05-03 00:00:00

  • Clinical and biologic characterization of T-cell neoplasias with rearrangements of chromosome 7 band q34.

    abstract：:In T cell malignancy, rearrangements of chromosome 14 have been observed with a break in the band that contains the alpha chain gene for the T cell receptor (TCR). Because the beta chain TCR gene is in chromosome band 7q34, we searched for and report finding specific rearrangements of 7q34 exclusively in T cell malign...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Smith SD,Morgan R,Gemmell R,Amylon MD,Link MP,Linker C,Hecht BK,Warnke R,Glader BE,Hecht F

    更新日期：1988-02-01 00:00:00

  • Chromatin modifying gene mutations in follicular lymphoma.

    abstract：:Follicular lymphoma (FL) is an indolent malignancy of germinal center B cells. Although the overall survival of FL patients has recently improved with the introduction of novel therapies, there is significant heterogeneity in patient outcome and a need for rationally designed therapeutic strategies that target disease...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2017-08-737361

    authors： Green MR

    更新日期：2018-02-08 00:00:00

  • Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis.

    abstract：:During the past decade it was recognized that homeobox gene families such as the clustered Hox genes play pivotal roles both in normal and malignant hematopoiesis. More recently, similar roles have also become apparent for members of the ParaHox gene cluster, evolutionarily closely related to the Hox gene cluster. Thi...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2012-02-385898

    authors： Rawat VP,Humphries RK,Buske C

    更新日期：2012-07-19 00:00:00

  • High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation.

    abstract：:In lymphatic tissues, chronic lymphocytic leukemia (CLL) cells are interspersed with CD68(+) nurselike cells (NLCs), T cells, and other stromal cells that constitute the leukemia microenvironment. However, the mechanism regulating colocalization of CLL and these accessory cells are largely unknown. To dissect the mole...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-07-170415

    authors： Burger JA,Quiroga MP,Hartmann E,Bürkle A,Wierda WG,Keating MJ,Rosenwald A

    更新日期：2009-03-26 00:00:00

  • Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders.

    abstract：:An acquired gain-of-function mutation in the Janus kinase 2 (JAK2-V617F) is frequently found in patients with myeloproliferative disorders (MPDs). To test the hypothesis that JAK2-V617F is the disease-initiating mutation, we examined whether all cells of clonal origin carry the JAK2-V617F mutation. Using allele-specif...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：10.1182/blood-2005-11-009605

    authors： Kralovics R,Teo SS,Li S,Theocharides A,Buser AS,Tichelli A,Skoda RC

    更新日期：2006-08-15 00:00:00

  • Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia.

    abstract：:Regulatory T (Tr) cells have the potential to treat immune-mediated disease, but cloning such cells for study from patients with autoimmune disease has proven difficult. Here, we describe autoantigen-specific, interleukin-10 (IL-10)-secreting Tr cell clones recovered ex vivo from a patient with autoimmune hemolytic an...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2007-07-101345

    authors： Ward FJ,Hall AM,Cairns LS,Leggat AS,Urbaniak SJ,Vickers MA,Barker RN

    更新日期：2008-01-15 00:00:00

  • Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.

    abstract：:The aim of this study was to investigate whether interleukin (IL)-6 induces the production of IL-1 and tumor necrosis factor (TNF) antagonists. Serial plasma samples were obtained from cancer patients participating in phase I and II trials of recombinant IL-6 administered as a 120-hour continuous intravenous (IV) infu...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：

    authors： Tilg H,Trehu E,Atkins MB,Dinarello CA,Mier JW

    更新日期：1994-01-01 00:00:00