Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.

abstract：:Human fibrinogen 1 is homodimeric with respect to its gamma chains (gammaA-gammaA'), whereas fibrinogen 2 molecules each contain one gammaA (gammaA1-411V) and one gamma' chain, which differ by containing a unique C-terminal sequence from gamma'408 to 427L that binds thrombin and factor XIII. We investigated the struct...

journal_title：Blood

authors： Siebenlist KR,Mosesson MW,Hernandez I,Bush LA,Di Cera E,Shainoff JR,Di Orio JP,Stojanovic L

更新日期：2005-10-15 00:00:00

abstract：:Acquisition of mature T cell function and the T cell antigen receptor repertoire occur in the thymus. In an effort to delineate the cascade of events leading to T cell maturation, we analyzed a series of clonal human precursor T cell neoplasms representing early, middle, and late stages of intrathymic differentiation....

journal_title：Blood

authors： Pittaluga S,Uppenkamp M,Cossman J

更新日期：1987-04-01 00:00:00

abstract：:Precursor B-cell acute lymphoblastic leukemias (B-ALLs) have been shown to be oligoclonal at the Ig heavy-chain (IgH) gene level in up to 40% of cases by Southern blot hybridization. In contrast, oligoclonality as deduced from diversity of T-cell receptor (TcR)-delta gene rearrangements of the immature types (ie, V de...

journal_title：Blood

authors： Ghali DW,Panzer S,Fischer S,Argyriou-Tirita A,Haas OA,Kovar H,Gadner H,Panzer-Grümayer ER

更新日期：1995-05-15 00:00:00

abstract：:In diffuse large B-cell lymphoma (DLBCL), previous studies have suggested that, while concordant bone marrow (BM) involvement confers a poor prognosis, discordant BM involvement does not. Whether this correlation is independent of the non-Hodgkin lymphoma International Prognostic Index (IPI) was previously unknown. We...

journal_title：Blood

authors： Chung R,Lai R,Wei P,Lee J,Hanson J,Belch AR,Turner AR,Reiman T

更新日期：2007-08-15 00:00:00

abstract：:Platelets stored as concentrates (PC) for 72 h at 22 degrees C develop a functional defect. Alterations in adenine nucleotides of platelets have been shown to affect platelet function. Adenine nucleotide content of platelets was measured before and after storage and a decrease of 27.1 /+- 1.7% (mean /+- SE) in ATP and...

journal_title：Blood

authors： Rao AK,Niewiarowski S,Murphy S

更新日期：1981-02-01 00:00:00

abstract：:We conducted a prospective randomized trial to evaluate the ability of the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein, PIXY321, to ameliorate cumulative thrombocytopenia after multiple cycles of 5-fluorouracil, leucovorin, doxorubicin, cyclophosphamide (FLAC) chemotherapy co...

journal_title：Blood

authors： O'Shaughnessy JA,Tolcher A,Riseberg D,Venzon D,Zujewski J,Noone M,Gossard M,Danforth D,Jacobson J,Chang V,Goldspiel B,Keegan P,Giusti R,Cowan KH

更新日期：1996-03-15 00:00:00

abstract：:Containers constructed of polyvinylchloride (PVC) are used for the storage of platelet concentrates (PC) for transfusion, At 22 degrees C, pH often falls to such low levels (pH is less that 6.0) that viability is lost. Far lesser degrees of pH fall are observed in bags constructed of polyethylene (PE). In this study, ...

journal_title：Blood

authors： Murphy S,Gardner FH

更新日期：1975-08-01 00:00:00

abstract：:Ubiquitin is suggested to play a key role in essential intracellular functions, such as heat shock response, protein breakdown, and regulation of immune responses. Ubiquitin has also been detected in the extracellular space, but the function and biologic significance is unclear. We describe a new function of extracell...

journal_title：Blood

authors： Majetschak M,Krehmeier U,Bardenheuer M,Denz C,Quintel M,Voggenreiter G,Obertacke U

更新日期：2003-03-01 00:00:00

abstract：:Custom-made monoclonal anti-idiotype antibodies (anti-Id MoAbs) have been tested as a treatment modality in 34 non-Hodgkin's lymphoma (NHL) patients. Partial or complete tumor remissions have been induced with this treatment in 68% of these patients. One mechanism by which anti-idiotype antibodies may have induced the...

journal_title：Blood

authors： Vuist WM,Levy R,Maloney DG

更新日期：1994-02-15 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a polyphenol extracted from green tea, is an antioxidant with chemopreventive and chemotherapeutic actions. Based on its ability to modulate growth factor-mediated cell proliferation, we evaluated its efficacy in multiple myeloma (MM). EGCG induced both dose- and time-dependent growt...

journal_title：Blood

authors： Shammas MA,Neri P,Koley H,Batchu RB,Bertheau RC,Munshi V,Prabhala R,Fulciniti M,Tai YT,Treon SP,Goyal RK,Anderson KC,Munshi NC

更新日期：2006-10-15 00:00:00

abstract：:Keeping track of individual cell identifications is imperative to the study of dynamic single-cell behavior over time. Highly motile hematopoietic stem and progenitor cells (HSPCs) migrate quickly and do not adhere, and thus must be imaged very frequently to keep cell identifications. Even worse, they are also flushed...

journal_title：Blood

authors： Loeffler D,Wang W,Hopf A,Hilsenbeck O,Bourgine PE,Rudolf F,Martin I,Schroeder T

更新日期：2018-03-29 00:00:00

abstract：:Fetal hemoglobin (HbF) and adult hemoglobin (HbA) synthesis was studied in fetal baboons, Papio cynocephalus, to determine the normal pattern of hemoglobin production during fetal development. Fetuses ranging from 53 to 180 days gestation (term gestation 184 days) were used. Erythroid cells were incubated with 3H-L-le...

journal_title：Blood

authors： De Simone J,Mueller AL

更新日期：1979-01-01 00:00:00

abstract：:Several studies demonstrate that hemolysis and free heme in circulation cause endothelial barrier dysfunction and are associated with severe pathological conditions such as acute respiratory distress syndrome, acute chest syndrome, and sepsis. However, the precise molecular mechanisms involved in the pathology of heme...

journal_title：Blood

authors： James J,Srivastava A,Varghese MV,Eccles CA,Zemskova M,Rafikova O,Rafikov R

更新日期：2020-08-06 00:00:00

abstract：:Chronic myeloid leukemia (CML) patients with the BCR-ABL T315I mutation do not benefit from therapy with currently approved tyrosine kinase inhibitors. Omacetaxine mepesuccinate is a protein synthesis inhibitor that has demonstrated activity in cells harboring the T315I mutation. This phase 2 trial assessed the effica...

journal_title：Blood

authors： Cortes J,Lipton JH,Rea D,Digumarti R,Chuah C,Nanda N,Benichou AC,Craig AR,Michallet M,Nicolini FE,Kantarjian H,Omacetaxine 202 Study Group.

更新日期：2012-09-27 00:00:00

abstract：:The principal aim of our study was to investigate whether patients transplanted more than 20 years ago for β-thalassemia major had a different health-related quality of life (HRQoL) compared with the general population. The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the Functional Assessment o...

journal_title：Blood

authors： La Nasa G,Caocci G,Efficace F,Dessì C,Vacca A,Piras E,Sanna M,Marcias M,Littera R,Carcassi C,Lucarelli G

更新日期：2013-09-26 00:00:00

abstract：:An understanding of the number and contribution of individual pluripotent hematopoietic stem cells (HSCs) to the formation of blood lineages has important clinical implications for gene therapy and stem cell transplantation. We have been able to efficiently mark rhesus macaque long-term repopulating stem and progenito...

journal_title：Blood

authors： Kuramoto K,Follman D,Hematti P,Sellers S,Laukkanen MO,Seggewiss R,Metzger ME,Krouse A,Donahue RE,von Kalle C,Dunbar CE

更新日期：2004-09-01 00:00:00

abstract：:We have previously described the development of oncoretrovirus vectors for human gamma-globin using a truncated beta-globin promoter, modified gamma-globin cassette, and alpha-globin enhancer. However, one of these vectors is genetically unstable, and both vectors exhibit variable expression patterns in cultured cells...

journal_title：Blood

authors： Emery DW,Yannaki E,Tubb J,Nishino T,Li Q,Stamatoyannopoulos G

更新日期：2002-09-15 00:00:00

abstract：:T-cell prolymphocytic leukemia (T-PLL), a rare form of mature T-cell leukemias, and ataxia telangiectasia clonal proliferation, a related condition occurring in patients suffering from ataxia telangiectasia, have been associated to translocations involving the 14q32.1 or Xq28 regions, where are located the TCL1 and MT...

journal_title：Blood

authors： Madani A,Choukroun V,Soulier J,Cacheux V,Claisse JF,Valensi F,Daliphard S,Cazin B,Levy V,Leblond V,Daniel MT,Sigaux F,Stern MH

更新日期：1996-03-01 00:00:00

abstract：:One hundred twenty-five cases of Hodgkin's disease from the United States (79), Mexico City (31), and Costa Rica (15) were analyzed for the presence of Epstein-Barr virus (EBV) by in situ hybridization to EBER1 transcripts. EBV was more frequently detected in the Reed-Sternberg (RS) cells of mixed cellularity Hodgkin'...

journal_title：Blood

authors： Gulley ML,Eagan PA,Quintanilla-Martinez L,Picado AL,Smir BN,Childs C,Dunn CD,Craig FE,Williams JW Jr,Banks PM

更新日期：1994-03-15 00:00:00

abstract：:Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have alre...

journal_title：Blood

authors： Holtan SG,Pasquini M,Weisdorf DJ

更新日期：2014-07-17 00:00:00

abstract：:We conducted a multicenter trial of treatment with all-trans retinoic acid (ATRA) for newly diagnosed acute promyelocytic leukemia (APL) in the AML-92 study and compared it with our previous study with standard intensive chemotherapy, the AML-89 study, in the view of complete remission (CR) rate, incidence of early de...

journal_title：Blood

authors： Kanamaru A,Takemoto Y,Tanimoto M,Murakami H,Asou N,Kobayashi T,Kuriyama K,Ohmoto E,Sakamaki H,Tsubaki K

更新日期：1995-03-01 00:00:00

abstract：:Erythropoietin (Epo) and dimethyl sulfoxide (DMSO) are believed to induce the differentiation of transformed erythroid cells by different signal transduction pathways. We have now obtained evidence for the interaction of these pathways. We used a Rauscher murine erythroleukemia cell line with a relatively low (8% to 1...

journal_title：Blood

authors： Chern Y,Yonekura S,Sytkowski AJ

更新日期：1990-12-01 00:00:00

abstract：:Infections during granulocytopenia are major complications of autologous bone marrow transplantation (ABMT). Since recombinant human granulocyte-macrophage colony-stimulating factor (rhuGM-CSF) has proved to accelerate bone marrow recovery after cytostatic chemotherapy, we studied its effects on hematopoietic regenera...

journal_title：Blood

authors： Link H,Boogaerts MA,Carella AM,Ferrant A,Gadner H,Gorin NC,Harabacz I,Harousseau JL,Hervé P,Holldack J

更新日期：1992-11-01 00:00:00

abstract：:Complete interleukin-12/interleukin-23 receptor beta1 (IL-12Rbeta1) deficiency is the most frequent known genetic etiology of the syndrome of Mendelian susceptibility to mycobacterial disease. The patients described to date lack IL-12Rbeta1 at the surface of their natural killer (NK) and T cells due to IL12RB1 mutatio...

journal_title：Blood

authors： Fieschi C,Bosticardo M,de Beaucoudrey L,Boisson-Dupuis S,Feinberg J,Santos OF,Bustamante J,Levy J,Candotti F,Casanova JL

更新日期：2004-10-01 00:00:00

abstract：:This study examined the prognostic value of circulating peripheral blood plasma cells (PBPCs) in patients with primary systemic amyloidosis (AL). A sensitive slide-based immunofluorescence technique was used to assess 147 patients for circulating PBPCs. Circulating monoclonal plasma cells were quantified as a percenta...

journal_title：Blood

authors： Pardanani A,Witzig TE,Schroeder G,McElroy EA,Fonseca R,Dispenzieri A,Lacy MQ,Lust JA,Kyle RA,Greipp PR,Gertz MA,Rajkumar SV

更新日期：2003-02-01 00:00:00

abstract：:In this issue of Blood, Navarrete et al report that upfront immunization of follicular B-cell lymphoma patients with bacterially produced Fab fragments induces immune responses; however, the influence on patient outcome is not yet known. ...

journal_title：Blood

authors： Bogen B

更新日期：2011-02-03 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) can bind to two distinct transmembrane receptors, the p55 and p75 TNF receptors. We compared the capability of two mutant TNF proteins with exclusive affinity for the p55 or p75 TNF receptor with that of wild type TNF, to activate the hemostatic mechanism in baboons. Both activa...

journal_title：Blood

authors： van der Poll T,Jansen PM,Van Zee KJ,Welborn MB 3rd,de Jong I,Hack CE,Loetscher H,Lesslauer W,Lowry SF,Moldawer LL

更新日期：1996-08-01 00:00:00

abstract：:To determine whether the erythropoietin receptor (Epo-R) plays a role in the course of malignant erythropoietic disorders, this gene was studied in murine and human erythroleukemia cells. An altered Epo-R gene was found in a murine Friend erythroleukemia cell line, FCL1, due to a spleen focus-forming virus (SFFV) long...

journal_title：Blood

authors： Chretien S,Moreau-Gachelin F,Apiou F,Courtois G,Mayeux P,Dutrillaux B,Cartron JP,Gisselbrecht S,Lacombe C

更新日期：1994-04-01 00:00:00

abstract：:Adult T-cell leukemia (ATL) is neoplasm of the mature helper T lymphocytes and human T-cell lymphotropic virus type-I (HTLV-I) has been shown to be causative virus of ATL. Because HTLV-I integrates its provirus randomly into host chromosomal DNA, monoclonal integration of HTLV-I provirus indicates the clonal prolifera...

journal_title：Blood

authors： Takemoto S,Matsuoka M,Yamaguchi K,Takatsuki K

更新日期：1994-11-01 00:00:00

abstract：:In this issue of Blood, the findings of Chakraborty et al and Emile et al support a model in which the mitogen-activated protein kinase (MAPK) and PI3K/AKT pathways are critical in the pathogenesis of 2 of the most common histiocytoses—Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD)—whereas their...

journal_title：Blood

authors： Prince HM

更新日期：2014-11-06 00:00:00