Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A.

abstract：:Despite matching for serologically defined HLA-A, B, DR antigens, acute graft-versus-host disease (GVHD) is a major complication contributing to increased morbidity and mortality in patients who undergo marrow transplantation from unrelated donors. The extent to which unrecognized mismatching for alleles that encode D...

journal_title：Blood

authors： Petersdorf EW,Longton GM,Anasetti C,Martin PJ,Mickelson EM,Smith AG,Hansen JA

更新日期：1995-08-15 00:00:00

abstract：:Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains, followed by 7 additional T domains and 2 CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains. ADAMTS13 inhibits the ...

journal_title：Blood

authors： Zhu J,Muia J,Gupta G,Westfield LA,Vanhoorelbeke K,Tolia NH,Sadler JE

更新日期：2019-04-25 00:00:00

abstract：:Glutathione-S-transferase (GST)-Grb2 fusion proteins have been used to identify the potential role of Grb2-binding proteins in platelet activation by the platelet low-affinity IgG receptor, Fc gamma RIIA. Two tyrosine phosphoproteins of 38 and 63 kD bind to the SH2 domain of Grb2 following Fc gamma RIIA stimulation of...

journal_title：Blood

authors： Robinson A,Gibbins J,Rodríguez-Liñares B,Finan PM,Wilson L,Kellie S,Findell P,Watson SP

更新日期：1996-07-15 00:00:00

abstract：:To further investigate the erythroid nature of the two human erythroleukemia cell lines, K562 and HEL-60, and to define the ontogeny of pyruvate kinase (PK) isozymes (R, M2) in developing human erythroid cells, we have studied the isozymic alterations, if any, during differentiation of these cell lines in vitro and no...

journal_title：Blood

authors： Max-Audit I,Testa U,Kechemir D,Titeux M,Vainchenker W,Rosa R

更新日期：1984-10-01 00:00:00

abstract：:The introduction of immunosuppressive therapy for treatment of aplastic anemia has led to a considerable improvement in the prognosis of this disease. However, long-term follow-up of these patients showed a high incidence of "late" hematologic complications such as myelodysplasia and paroxysmal nocturnal hemoglobinuri...

journal_title：Blood

authors： Schubert J,Vogt HG,Zielinska-Skowronek M,Freund M,Kaltwasser JP,Hoelzer D,Schmidt RE

更新日期：1994-04-15 00:00:00

abstract：:We previously found that the myeloid cell surface glycoprotein CD13 (gp150) is identical to aminopeptidase N (EC 3.4.11.2), a widely distributed membrane-bound, zinc-dependent metalloprotease with an extracellular enzymatic domain that cleaves N-terminal amino acid residues from oligopeptides (J Clin Invest 83:1299, 1...

journal_title：Blood

authors： Ashmun RA,Look AT

更新日期：1990-01-15 00:00:00

abstract：:Self-renewal is a feature of cancer and can be assessed by cell transplantation into immune-compromised or immune-matched animals. However, studies in zebrafish have been severely limited by lack of these reagents. Here, Myc-induced T-cell acute lymphoblastic leukemias (T-ALLs) have been made in syngeneic, clonal zebr...

journal_title：Blood

authors： Smith AC,Raimondi AR,Salthouse CD,Ignatius MS,Blackburn JS,Mizgirev IV,Storer NY,de Jong JL,Chen AT,Zhou Y,Revskoy S,Zon LI,Langenau DM

更新日期：2010-04-22 00:00:00

abstract：:The clinical course of chronic lymphocytic leukemia (CLL) differs significantly between patients with mutated (M-CLL) and unmutated (U-CLL) immunoglobulin (Ig) variable heavy-chain (V(H)) genes, implying a role for B-cell receptor (BCR) signaling in the pathogenesis of this disease. We have now investigated activation...

journal_title：Blood

authors： Petlickovski A,Laurenti L,Li X,Marietti S,Chiusolo P,Sica S,Leone G,Efremov DG

更新日期：2005-06-15 00:00:00

abstract：:Mast cells are inflammatory and immunoregulatory cells resident in tissues. They develop from bone marrow-derived progenitor cells that enter the tissue through the blood circulation. The specific localization and migration of mast cells in tissues is dependent on their interaction with extracellular matrix (ECM) prot...

journal_title：Blood

authors： Lorentz A,Schuppan D,Gebert A,Manns MP,Bischoff SC

更新日期：2002-02-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widely used in healthy donors for collection of peripheral blood progenitor cells (PBPCs) for allogeneic transplantation and granulocytes for transfusion. The spectrum of its biologic and molecular activities in healthy individuals is coming into sha...

journal_title：Blood

authors： Anderlini P,Champlin RE

更新日期：2008-02-15 00:00:00

abstract：:The incidence of chronic lymphocytic leukemia (CLL) in Taiwan is markedly lower than that in Western countries, but we have seen a drastically increasing trend. We explored this distinct incidence trend of CLL for Taiwanese. The epidemiologic data of CLL for Taiwanese and Caucasian Americans during 1986 to 2005 were o...

journal_title：Blood

authors： Wu SJ,Huang SY,Lin CT,Lin YJ,Chang CJ,Tien HF

更新日期：2010-11-25 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate natural killer (NK) cells in a human leukocyte antigen (HLA)-dependent manner. KIR/HLA mismatched hematopoietic stem cell transplants induce alloreactive NK cells, which prevent leukemia relapse. Certain KIR/HLA combinations protect against HIV-1 infection, but the ...

journal_title：Blood

authors： Jennes W,Verheyden S,Mertens JW,Camara M,Seydi M,Dieye TN,Mboup S,Demanet C,Kestens L

更新日期：2013-02-14 00:00:00

abstract：:Transforming mutations in NRAS and KRAS are thought to play a causative role in the development of numerous cancers, including myeloid malignancies. Although mutations at amino acids 12, 13, or 61 account for the majority of oncogenic Ras variants, we hypothesized that less frequent mutations at alternate residues may...

journal_title：Blood

authors： Tyner JW,Erickson H,Deininger MW,Willis SG,Eide CA,Levine RL,Heinrich MC,Gattermann N,Gilliland DG,Druker BJ,Loriaux MM

更新日期：2009-02-19 00:00:00

abstract：:We report here 7 new mutations in the ADAMTS13 gene responsible for Upshaw-Schulman syndrome (USS), a catastrophic phenotype of congenital thrombotic thrombocytopenic purpura, by analyzing 5 Japanese families. There were 3 mutations that occurred at exon-intron boundaries: 414+1G>A at intron 4, 686+1G>A at intron 6, a...

journal_title：Blood

authors： Matsumoto M,Kokame K,Soejima K,Miura M,Hayashi S,Fujii Y,Iwai A,Ito E,Tsuji Y,Takeda-Shitaka M,Iwadate M,Umeyama H,Yagi H,Ishizashi H,Banno F,Nakagaki T,Miyata T,Fujimura Y

更新日期：2004-02-15 00:00:00

abstract：:Fetal and neonatal immune thrombocytopenia (FNIT) is a severe bleeding disorder in which maternal antibodies cross the placenta and destroy fetal/neonatal platelets. It has been demonstrated that the neonatal Fc receptor (FcRn) regulates immunoglobulin G (IgG) homeostasis and plays an important role in transplacental ...

journal_title：Blood

authors： Chen P,Li C,Lang S,Zhu G,Reheman A,Spring CM,Freedman J,Ni H

更新日期：2010-11-04 00:00:00

abstract：:The role of platelets in hemostasis and thrombosis is clearly established; however, the mechanisms by which platelets mediate inflammatory and immune pathways are less well understood. Platelets interact and modulate the function of blood and vascular cells by releasing bioactive molecules. Although the platelet is an...

journal_title：Blood

authors： Risitano A,Beaulieu LM,Vitseva O,Freedman JE

更新日期：2012-06-28 00:00:00

abstract：:CXC ligand 12 (CXCL12; also known as stromal cell-derived factor 1alpha/SDF-1alpha) chemoattracts hematopoietic stem and progenitor cells (HSCs/HPCs) and is thought to play a crucial role in the mobilization of HSCs/HPCs from the bone marrow. CD26 (dipeptidylpeptidase IV [DPPIV]) is a membrane-bound extracellular pept...

journal_title：Blood

authors： Christopherson KW 2nd,Cooper S,Broxmeyer HE

更新日期：2003-06-15 00:00:00

abstract：:Hematopoietic stem and progenitor cells were previously found to express Toll-like receptors (TLRs), suggesting that bacterial/viral products may influence blood cell formation. We now show that common lymphoid progenitors (CLPs) from mice with active HSV-1 infection are biased to dendritic cell (DC) differentiation, ...

journal_title：Blood

authors： Welner RS,Pelayo R,Nagai Y,Garrett KP,Wuest TR,Carr DJ,Borghesi LA,Farrar MA,Kincade PW

更新日期：2008-11-01 00:00:00

abstract：:Hypereosinophilic syndromes (HESs) are a heterogeneous group of uncommon disorders characterized by marked peripheral eosinophilia and end organ manifestations attributable to the eosinophilia or unexplained in the clinical setting. Whereas corticosteroids remain the mainstay of treatment for most patients, recent dia...

journal_title：Blood

authors： Klion AD

更新日期：2009-10-29 00:00:00

abstract：:Fetal hemoglobin (HbF) is a potent genetic modifier of the severity of beta-thalassemia and sickle cell anemia. We used an in vitro culture model of human erythropoiesis in which late-stage erythroblasts are derived directly from human CD34(+) hematopoietic cells to evaluate HbF production. This system recapitulates e...

journal_title：Blood

authors： Wilber A,Tschulena U,Hargrove PW,Kim YS,Persons DA,Barbas CF 3rd,Nienhuis AW

更新日期：2010-04-15 00:00:00

abstract：:Mammalian TOR (mTOR) regulates cell growth, proliferation, and migration. Because mTOR knock-outs are embryonic lethal, we generated a viable hypomorphic mouse by neo-insertion that partially disrupts mTOR transcription and creates a potential physiologic model of mTORC1/TORC2 inhibition. Homozygous knock-in mice exhi...

journal_title：Blood

authors： Zhang S,Readinger JA,DuBois W,Janka-Junttila M,Robinson R,Pruitt M,Bliskovsky V,Wu JZ,Sakakibara K,Patel J,Parent CA,Tessarollo L,Schwartzberg PL,Mock BA

更新日期：2011-01-27 00:00:00

abstract：:Nomifensine (Merital, Alival; Hoechst, Frankfurt, FRG), an antidepressant drug, may cause immune hemolytic anemia (IHA) of the so-called immune complex type that is believed to occur by means of an innocent-bystander mechanism. In this report we describe findings that are not consistent with this mechanism in a patien...

journal_title：Blood

authors： Salama A,Mueller-Eckhardt C

更新日期：1986-12-01 00:00:00

abstract：:Increasingly, allogeneic and even more often autologous bone marrow transplants are being done to correct a wide variety of diseases. In addition, autologous marrow transplants potentially provide an opportune means of delivering genes in transfected, engrafting stem cells. However, despite its widespread clinical use...

journal_title：Blood

authors： Nilsson SK,Dooner MS,Tiarks CY,Weier HU,Quesenberry PJ

更新日期：1997-06-01 00:00:00

abstract：:Circulating IgG autoantibodies that produce cytoplasmic immunofluorescence staining of ethanol-fixed normal neutrophils have recently been found in a large percentage of patients with active Wegener's granulomatosis. Such autoantibodies are rarely found in other diseases and are therefore virtually diagnostic of Wegen...

journal_title：Blood

authors： Niles JL,McCluskey RT,Ahmad MF,Arnaout MA

更新日期：1989-11-01 00:00:00

abstract：:In attempting to identify antigens that are differentially expressed on tumor cells following transformation from follicular small cleaved cell lymphoma (FSC) to immunoblastic lymphoma (IL), we identified a unique epitope of the transferrin receptor (TfR). The epitope is available for binding in aggressive lymphomas b...

journal_title：Blood

authors： Esserman L,Takahashi S,Rojas V,Warnke R,Levy R

更新日期：1989-12-01 00:00:00

abstract：:Essential thrombocythemia (ET) and polycythemia vera (PV) are characterized by persistent platelet activation. The mechanisms involved in their clearance are poorly characterized. In the present study, we report that leukocytes were actively involved in platelet disposal in 51 patients with ET and 30 with PV, but not ...

journal_title：Blood

authors： Maugeri N,Malato S,Femia EA,Pugliano M,Campana L,Lunghi F,Rovere-Querini P,Lussana F,Podda G,Cattaneo M,Ciceri F,Manfredi AA

更新日期：2011-09-22 00:00:00

abstract：:Acute myeloid leukemia (AML) is driven by niche-derived and cell-autonomous stimuli. Although many cell-autonomous disease drivers are known, niche-dependent signaling in the context of the genetic disease heterogeneity has been difficult to investigate. Here, we analyzed the role of Bruton tyrosine kinase (BTK) in AM...

journal_title：Blood

authors： Oellerich T,Mohr S,Corso J,Beck J,Döbele C,Braun H,Cremer A,Münch S,Wicht J,Oellerich MF,Bug G,Bohnenberger H,Perske C,Schütz E,Urlaub H,Serve H

更新日期：2015-03-19 00:00:00

abstract：:The past 40 years have witnessed major advances in defining the cytogenetic aberrations, mutational landscape, epigenetic profiles, and expression changes underlying hematological malignancies. Although it has become apparent that acute myeloid leukemia (AML) is highly heterogeneous at the molecular level, the standar...

journal_title：Blood

authors： Grimwade D,Freeman SD

更新日期：2014-11-27 00:00:00

abstract：:Residual vein thrombosis (RVT) indicates a prothrombotic state and is useful for evaluating the optimal duration of oral anticoagulant treatment (OAT). Patients with a first episode of deep vein thrombosis, treated with OAT for 3 months, were managed according to RVT findings. Those with RVT were randomized to either ...

journal_title：Blood

authors： Siragusa S,Malato A,Anastasio R,Cigna V,Milio G,Amato C,Bellisi M,Attanzio MT,Cormaci O,Pellegrino M,Dolce A,Casuccio A,Bajardi G,Mariani G

更新日期：2008-08-01 00:00:00

abstract：:Thalidomide has been reported to be an effective agent for treatment of chronic graft-versus-host disease (CGVHD). To determine the efficacy of this agent in patients with refractory CGVHD a total of 80 patients who failed to respond to prednisone (PSE) or PSE and cyclosporine (CSA) were treated with thalidomide. Sixt...

journal_title：Blood

authors： Parker PM,Chao N,Nademanee A,O'Donnell MR,Schmidt GM,Snyder DS,Stein AS,Smith EP,Molina A,Stepan DE,Kashyap A,Planas I,Spielberger R,Somlo G,Margolin K,Zwingenberger K,Wilsman K,Negrin RS,Long GD,Niland JC,Blume K

更新日期：1995-11-01 00:00:00