A role for transforming growth factor-beta1 in the increased pneumonitis in murine allogeneic bone marrow transplant recipients with graft-versus-host disease after pulmonary herpes simplex virus type 1 infection.

abstract：:Chronic lymphocytic leukemia (CLL) is an incurable adult disease of unknown etiology. Understanding the biology of CLL cells, particularly cell maturation and growth in vivo, has been impeded by lack of a reproducible adoptive transfer model. We report a simple, reproducible system in which primary CLL cells prolifera...

journal_title：Blood

authors： Bagnara D,Kaufman MS,Calissano C,Marsilio S,Patten PE,Simone R,Chum P,Yan XJ,Allen SL,Kolitz JE,Baskar S,Rader C,Mellstedt H,Rabbani H,Lee A,Gregersen PK,Rai KR,Chiorazzi N

更新日期：2011-05-19 00:00:00

abstract：:Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells within the leukemic population that possess extensive proliferation and self-renewal capacity not found in the...

journal_title：Blood

authors： Fang B,Zheng C,Liao L,Han Q,Sun Z,Jiang X,Zhao RC

更新日期：2005-04-01 00:00:00

abstract：:Inhibitors of cyclin-dependent kinases (Cdks) have been reported to have activities in chronic lymphocytic leukemia cells by inhibiting Cdk7 and Cdk9, which control transcription. Here we studied the novel Cdk inhibitor SNS-032, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. We h...

journal_title：Blood

authors： Chen R,Wierda WG,Chubb S,Hawtin RE,Fox JA,Keating MJ,Gandhi V,Plunkett W

更新日期：2009-05-07 00:00:00

abstract：:Platelet factor 4 (PF4) serves as a lineage-specific marker of megakaryocyte development. We previously identified two positively acting sequences in the human platelet factor 4 (hPF4) gene promoter that synergized to drive high-level luciferase reporter gene expression in vitro. Using portions of the hPF4 5'-flanking...

journal_title：Blood

authors： Cui Z,Reilly MP,Surrey S,Schwartz E,McKenzie SE

更新日期：1998-04-01 00:00:00

abstract：:Endothelial sialomucin CD34 functions as an L-selectin ligand mediating lymphocyte extravasation only when properly glycosylated to express a sulfated carbohydrate epitope, 6-sulfo sialyl Lewis x (6-sulfo SLe(x)). It is thought that multivalent 6-sulfo SLe(x) expression promotes high-affinity binding to L-selectin by ...

journal_title：Blood

authors： Hernandez Mir G,Helin J,Skarp KP,Cummings RD,Mäkitie A,Renkonen R,Leppänen A

更新日期：2009-07-16 00:00:00

abstract：:If bone marrow transplantation is to become widely applicable in the treatment of patients with leukemia and aplastic anemia, the necessity to have a perfectly histocompatible donor must be overcome. In an effort to define the roles of HL-A type and mixed lymphocyte culture (MLC) reactivity in the determination of suc...

journal_title：Blood

authors： Feig SA,Opelz G,Winter HS,Falk PM,Neerhout RC,Sparkes R,Gale RP

更新日期：1976-09-01 00:00:00

abstract：:Acute bleeding after bone marrow transplantation (BMT) was investigated in 1,402 patients receiving transplants at Johns Hopkins Hospital between January 1, 1986 and June 30, 1995. Bleeding categorization was based on daily scores of intensity used by the blood transfusion service. Moderate and severe episodes were an...

journal_title：Blood

authors： Nevo S,Swan V,Enger C,Wojno KJ,Bitton R,Shabooti M,Fuller AK,Jones RJ,Braine HG,Vogelsang GB

更新日期：1998-02-15 00:00:00

abstract：:Pregnancy can precipitate thrombotic thrombocytopenic purpura (TTP). We present a prospective study of TTP cases from the United Kingdom Thrombotic Thrombocytopenic Purpura (UK TTP) Registry with clinical and laboratory data from the largest cohort of pregnancy-associated TTP and describe management through pregnancy,...

journal_title：Blood

authors： Scully M,Thomas M,Underwood M,Watson H,Langley K,Camilleri RS,Clark A,Creagh D,Rayment R,Mcdonald V,Roy A,Evans G,McGuckin S,Ni Ainle F,Maclean R,Lester W,Nash M,Scott R,O Brien P,collaborators of the UK TTP Registr

更新日期：2014-07-10 00:00:00

abstract：:Improved supportive care, more precise risk stratification, and personalized chemotherapy based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and pharmacogenetics) have pushed the cure rate of childhood acute lymphoblastic leukemia to near 90%. Further increase in cure rate can be expected f...

journal_title：Blood

authors： Pui CH,Mullighan CG,Evans WE,Relling MV

更新日期：2012-08-09 00:00:00

abstract：:In lymphatic tissues, chronic lymphocytic leukemia (CLL) cells are interspersed with CD68(+) nurselike cells (NLCs), T cells, and other stromal cells that constitute the leukemia microenvironment. However, the mechanism regulating colocalization of CLL and these accessory cells are largely unknown. To dissect the mole...

journal_title：Blood

authors： Burger JA,Quiroga MP,Hartmann E,Bürkle A,Wierda WG,Keating MJ,Rosenwald A

更新日期：2009-03-26 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which are allosteric mTOR complex 1 (mTORC1) inhibitors, are active in mantle cell lymphoma and other lymphoid neoplasms, but responses are usually partial and short-li...

journal_title：Blood

authors： Gupta M,Hendrickson AE,Yun SS,Han JJ,Schneider PA,Koh BD,Stenson MJ,Wellik LE,Shing JC,Peterson KL,Flatten KS,Hess AD,Smith BD,Karp JE,Barr S,Witzig TE,Kaufmann SH

更新日期：2012-01-12 00:00:00

abstract：:Humans and grey collie dogs with cyclic neutropenia are known to suffer from an increased rate of bacterial infection. Because of the previously described microanatomic abnormalities of lysosome formation found in the polymorphonuclear leukocytes (PMNs) of dogs with canine cyclic neutropenia, studies of these cells we...

journal_title：Blood

authors： Chusid MJ,Bujak JS,Dale DC

更新日期：1975-12-01 00:00:00

abstract：:Understanding the repopulating characteristics of human hematopoietic stem/progenitor cells is crucial for predicting their performance after transplant into patients receiving high-dose radiochemotherapy. We have previously reported that CD34(+) cord blood (CB) cells can be expanded in vitro for several months in ser...

journal_title：Blood

authors： Piacibello W,Sanavio F,Severino A,Danè A,Gammaitoni L,Fagioli F,Perissinotto E,Cavalloni G,Kollet O,Lapidot T,Aglietta M

更新日期：1999-06-01 00:00:00

abstract：:Receptors for the Fc portion of IgG (FcγRs) are mandatory for the induction of various IgG-dependent models of autoimmunity, inflammation, anaphylaxis, and cancer immunotherapy. A few FcγRs have the ability to bind monomeric IgG: high-affinity mouse mFcγRI, mFcγRIV, and human hFcγRI. All others bind IgG only when aggr...

journal_title：Blood

authors： Mancardi DA,Albanesi M,Jönsson F,Iannascoli B,Van Rooijen N,Kang X,England P,Daëron M,Bruhns P

更新日期：2013-02-28 00:00:00

abstract：:Hypomethylating agents (HMAs) improve survival in patients with higher-risk myelodysplastic syndromes (MDS) but are less well-studied in lower-risk disease. We compared the safety and efficacy of low-dose decitabine vs low-dose azacitidine in this group of patients. Adults with low- or intermediate 1-risk MDS or MDS/m...

journal_title：Blood

authors： Jabbour E,Short NJ,Montalban-Bravo G,Huang X,Bueso-Ramos C,Qiao W,Yang H,Zhao C,Kadia T,Borthakur G,Pemmaraju N,Sasaki K,Estrov Z,Cortes J,Ravandi F,Alvarado Y,Komrokji R,Sekeres MA,Steensma DP,DeZern A,Roboz G,

更新日期：2017-09-28 00:00:00

abstract：:Recombinant human interleukin-2 (IL-2), administered to cancer patients by continuous intravenous (IV) infusion (3 x 10(6) U/m2/d), was found to induce the in vivo production of colony-stimulating factors (CSF). Plasma obtained from patients during IL-2 treatment stimulated in vitro colony formation of normal human bo...

journal_title：Blood

authors： Schaafsma MR,Falkenburg JH,Landegent JE,Duinkerken N,Osanto S,Ralph P,Kaushansky K,Wagemaker G,Van Damme J,Willemze R

更新日期：1991-10-15 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS) is a severe immunodeficiency and platelet deficiency disease arising from mutation(s) in the WASP gene, which in normal cells encodes an intracellular protein able to interact with other proteins relevant to the control of cytoskeleton organization. Immunodeficiency is mainly due to ...

journal_title：Blood

authors： Gallego MD,Santamaría M,Peña J,Molina IJ

更新日期：1997-10-15 00:00:00

abstract：:Platelets are pivotal to the process of arterial thrombosis resulting in ischemic stroke. Occlusive thrombosis is initiated by the interaction of von Willebrand factor (vWf) and platelet glycoprotein (GP) Ibalpha. Three polymorphisms have been described in GP Ibalpha (Kozak T/C polymorphism, variable number of tandem ...

journal_title：Blood

authors： Baker RI,Eikelboom J,Lofthouse E,Staples N,Afshar-Kharghan V,López JA,Shen Y,Berndt MC,Hankey G

更新日期：2001-07-01 00:00:00

abstract：:A recent clinical trial for adrenoleukodystrophy (ALD) showed the efficacy and safety of lentiviral vector (LV) gene transfer in hematopoietic stem progenitor cells. However, several common insertion sites (CIS) were found in patients' cells, suggesting that LV integrations conferred a selective advantage. We performe...

journal_title：Blood

authors： Biffi A,Bartolomae CC,Cesana D,Cartier N,Aubourg P,Ranzani M,Cesani M,Benedicenti F,Plati T,Rubagotti E,Merella S,Capotondo A,Sgualdino J,Zanetti G,von Kalle C,Schmidt M,Naldini L,Montini E

更新日期：2011-05-19 00:00:00

abstract：:Although proinflammatory cytokines are key mediators of tissue damage during graft-versus-host disease (GVHD), IFNgamma has previously been attributed with both protective and pathogenic effects. We have resolved this paradox by using wild-type (wt), IFNgamma(-/-), and IFNgammaR(-/-) mice as donors or recipients in we...

journal_title：Blood

authors： Burman AC,Banovic T,Kuns RD,Clouston AD,Stanley AC,Morris ES,Rowe V,Bofinger H,Skoczylas R,Raffelt N,Fahy O,McColl SR,Engwerda CR,McDonald KP,Hill GR

更新日期：2007-08-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) with thrombosis is a serious complication of heparin use. HIT sera can generate platelet-derived microparticles, which are produced in a heparin-dependent manner and are hypothesized to be important initial pathological participants because they promote vascular occlusion. To dat...

journal_title：Blood

authors： Hughes M,Hayward CP,Warkentin TE,Horsewood P,Chorneyko KA,Kelton JG

更新日期：2000-07-01 00:00:00

abstract：:Patients with severe aplastic anemia were conditioned with cyclophosphamide (200 mg/kg) and given marrow grafts from HLA-identical family members. Among 233 patients transplanted, 225 survived greater than or equal to 14 days and could be evaluated for engraftment. Forty-four of the 225 rejected their graft; 33 of the...

journal_title：Blood

authors： Deeg HJ,Self S,Storb R,Doney K,Appelbaum FR,Witherspoon RP,Sullivan KM,Sheehan K,Sanders J,Mickelson E

更新日期：1986-12-01 00:00:00

abstract：:Globally suppressed T-cell function has been described in many patients with cancer to be a major hurdle for the development of clinically efficient cancer immunotherapy. Inhibition of antitumor immune responses has been mainly linked to inhibitory factors present in cancer patients. More recently, increased frequenci...

journal_title：Blood

authors： Beyer M,Kochanek M,Darabi K,Popov A,Jensen M,Endl E,Knolle PA,Thomas RK,von Bergwelt-Baildon M,Debey S,Hallek M,Schultze JL

更新日期：2005-09-15 00:00:00

abstract：:The technique described in the preceding paper was applied to 12 abnormal sera selected for their increase in one or more B12-binding proteins. Even in the presence of large amounts of R-type binder, the ammonium sulfate technique gave a reliable separation of R binding proteins from TC II. Measurement of the TC II in...

journal_title：Blood

authors： Begley JA,Hall CA

更新日期：1975-02-01 00:00:00

abstract：:Ectopic expression of c-Myc (Myc) in most primary cell types results in programmed cell death, and malignant transformation cannot occur without additional mutations that block apoptosis. The development of Myc-induced lymphoid tumors has been well studied and supports this model. Myc can be upregulated in acute myelo...

journal_title：Blood

authors： Luo H,Li Q,O'Neal J,Kreisel F,Le Beau MM,Tomasson MH

更新日期：2005-10-01 00:00:00

abstract：:We demonstrate a methodology for tracing the clonal history of hematopoietic stem and progenitor cells (HSPCs) behavior in live tissues in 4 dimensions (4D). This integrates genetic combinatorial marking using lentiviral vectors encoding various fluorescent proteins (FPs) with advanced imaging methods. Five FPs: Cerul...

journal_title：Blood

authors： Malide D,Métais JY,Dunbar CE

更新日期：2012-12-20 00:00:00

abstract：:Nitric oxide is a short-lived reactive mediator that inhibits bone marrow (BM) cell proliferation induced by granulocyte-macrophage colony-stimulating factor (GM-CSF). The present studies show that nitric oxide also inhibits macrophage colony-stimulating factor (M-CSF)-induced growth of mouse BM cells, an effect that ...

journal_title：Blood

authors： Punjabi CJ,Laskin JD,Hwang SM,MacEachern L,Laskin DL

更新日期：1994-06-01 00:00:00

abstract：:In a previous study, we reported that a single injection of cyclophosphamide (CTX) in tumor-bearing mice resulted in tumor eradication when the animals were subsequently injected with tumor-sensitized lymphocytes. Notably, CTX acted by inducing bystander effects on T cells, and the response to the combined CTX/adoptiv...

journal_title：Blood

authors： Schiavoni G,Mattei F,Di Pucchio T,Santini SM,Bracci L,Belardelli F,Proietti E

更新日期：2000-03-15 00:00:00

abstract：:The three-dimensional tertiary structure of human von Willebrand Factor (vWF) on a hydrophobic surface under aqueous conditions and different shear stress regimes was studied by atomic force microscopy (AFM). vWF was imaged by AFM at molecular level resolution under negligible shear stress, under a local applied shear...

journal_title：Blood

authors： Siedlecki CA,Lestini BJ,Kottke-Marchant KK,Eppell SJ,Wilson DL,Marchant RE

更新日期：1996-10-15 00:00:00

abstract：:Cytokine-induced expansion of hematopoietic stem and progenitor cells (HSPCs) is not fully understood. In the present study, we show that whereas steady-state hematopoiesis is normal in basic fibroblast growth factor (FGF-2)-knockout mice, parathyroid hormone stimulation and myeloablative treatments failed to induce n...

journal_title：Blood

authors： Itkin T,Ludin A,Gradus B,Gur-Cohen S,Kalinkovich A,Schajnovitz A,Ovadya Y,Kollet O,Canaani J,Shezen E,Coffin DJ,Enikolopov GN,Berg T,Piacibello W,Hornstein E,Lapidot T

更新日期：2012-08-30 00:00:00