In vivo production of interleukin-5, granulocyte-macrophage colony-stimulating factor, macrophages colony-stimulating factor, and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients.

abstract：:People with hemophilia were formerly at very high risk of infection with hepatitis C virus (HCV). Approximately 20% of HCV-infected patients spontaneously clear the virus. To identify correlates of spontaneous clearance of HCV, we studied a cohort of HCV-infected hemophilic subjects without human immunodeficiency viru...

journal_title：Blood

authors： Zhang M,Rosenberg PS,Brown DL,Preiss L,Konkle BA,Eyster ME,Goedert JJ,Second Multicenter Hemophilia Cohort Study.

更新日期：2006-02-01 00:00:00

abstract：:To develop a sensitive and specific assay for minimal residual disease in acute lymphoblastic leukemia (ALL), we exploited the enormous diversity of genomic sequences created by immune receptor gene rearrangements. To isolate clone-specific sequences, we first synthesized oligonucleotides that match conserved variable...

journal_title：Blood

authors： Jonsson OG,Kitchens RL,Scott FC,Smith RG

更新日期：1990-11-15 00:00:00

abstract：:We previously reported the characterization of human osteoclast-associated receptor (hOSCAR), a novel Fc receptor gamma-chain (FcRgamma)-associated receptor expressed by myeloid cells. Here we show that ligation of hOSCAR by specific antibodies promotes dendritic cell (DC) survival by an extracellular signal-regulated...

journal_title：Blood

authors： Merck E,de Saint-Vis B,Scuiller M,Gaillard C,Caux C,Trinchieri G,Bates EE

更新日期：2005-05-01 00:00:00

abstract：:Time-lapse videotape recordings of polymorphonuclear leukocytes (PMNs) from clot preparations were used to quantify the locomotive behavior of individual PMNs from normal subjects. Tracings derived from the videotapes allow one to quantify multiple parameters of the locomotive behavior of PMNs--direction, distance, ra...

journal_title：Blood

authors： Howard TH

更新日期：1982-05-01 00:00:00

abstract：:The malaria parasite Plasmodium falciparum releases the ring-infected erythrocyte surface antigen (RESA) inside the red cell on entry. The protein migrates to the host cell membrane, where it binds to spectrin, but neither the nature of the interaction nor its functional consequences have previously been defined. Here...

journal_title：Blood

authors： Pei X,Guo X,Coppel R,Bhattacharjee S,Haldar K,Gratzer W,Mohandas N,An X

更新日期：2007-08-01 00:00:00

abstract：:T-cell receptor (TCR) beta-chain proteins appear early (approximately 15th week of gestation) during human thymic ontogenesis. These beta-chain proteins, which appear before terminal deoxynucleotidyl transferase (TdT), could be an expression of a fully rearranged (V-D-J), incompletely rearranged (D-J), or germline TCR...

journal_title：Blood

authors： Bonati A,Zanelli P,Ferrari S,Plebani A,Starcich B,Savi M,Neri TM

更新日期：1992-03-15 00:00:00

abstract：:GVHD and tumor relapse are fundamental problems in allogeneic HSCT. Recent research has linked neovascularization to GVHD, tumor growth, and graft-versus-tumor (GVT) activity. Damage of the endothelium by the conditioning regimen provides the initiation stimulus for recruitment of donor-derived endothelial cells and t...

journal_title：Blood

authors： Penack O,Socié G,van den Brink MR

更新日期：2011-04-21 00:00:00

abstract：:Monoclonal antibodies were raised after injecting mice with isolated human dense granules. Several of these monoclonals were found to recognize a 40-Kd dense granule membrane protein. Western blot and immunofluorescent analysis confirmed the dense-granule specificity. After thrombin activation, the protein was found i...

journal_title：Blood

authors： Gerrard JM,Lint D,Sims PJ,Wiedmer T,Fugate RD,McMillan E,Robertson C,Israels SJ

更新日期：1991-01-01 00:00:00

abstract：:Anacardic acid (6-pentadecylsalicylic acid) is derived from traditional medicinal plants, such as cashew nuts, and has been linked to anticancer, anti-inflammatory, and radiosensitization activities through a mechanism that is not yet fully understood. Because of the role of nuclear factor-kappaB (NF-kappaB) activatio...

journal_title：Blood

authors： Sung B,Pandey MK,Ahn KS,Yi T,Chaturvedi MM,Liu M,Aggarwal BB

更新日期：2008-05-15 00:00:00

abstract：:Recent studies of retroviral-mediated gene transfer have shown that retroviral integrations themselves may trigger nonmalignant clonal expansion of hematopoietic stem cells (HSCs) in transplant recipients. These observations suggested that previous conclusions of HSC dynamics based on gamma-retroviral gene marking sho...

journal_title：Blood

authors： Gonzalez-Murillo A,Lozano ML,Montini E,Bueren JA,Guenechea G

更新日期：2008-10-15 00:00:00

abstract：:The response of human myeloid leukemia cells to treatment with 1-beta-arabinofuranosylcytosine (ara-C) includes the induction of apoptosis. Ara-C induced apoptosis is associated with proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and protein kinase C (PKC) delta. However, the signals involved in this respo...

journal_title：Blood

authors： Datta R,Banach D,Kojima H,Talanian RV,Alnemri ES,Wong WW,Kufe DW

更新日期：1996-09-15 00:00:00

abstract：:We used a sensitive, quantitative bisulfite PCR assay, methylation sensitive single nucleotide primer extension (Ms-SNuPE), to measure methylation of the 5' CpG islands of c-abl and p15 in chronic myelogenous leukemia (CML) patients during progression. We found that the Pa promoter of c-abl was methylated in 81% (17/2...

journal_title：Blood

authors： Nguyen TT,Mohrbacher AF,Tsai YC,Groffen J,Heisterkamp N,Nichols PW,Yu MC,Lübbert M,Jones PA

更新日期：2000-05-01 00:00:00

abstract：:Under evolutionary pressure to counter the toxicity of iron and to maintain adequate iron supply for hemoglobin synthesis and essential metabolic functions, humans and other vertebrates have effective mechanisms to conserve iron and to regulate its concentration, storage, and distribution in tissues. The iron-regulato...

journal_title：Blood

authors： Ganz T

更新日期：2011-04-28 00:00:00

abstract：:Interleukin (IL)-32 was originally identified in natural killer cells and IL-2-activated human T lymphocytes. As T cells are activated in allogeneic transplantation, we determined the role of IL-32 in human mixed lymphocyte cultures (MLCs) and GVHD. In allogeneic MLCs, IL-32 increased two-fold in responding T cells, a...

journal_title：Blood

authors： Marcondes AM,Li X,Tabellini L,Bartenstein M,Kabacka J,Sale GE,Hansen JA,Dinarello CA,Deeg HJ

更新日期：2011-11-03 00:00:00

abstract：:Shiga-like toxin-1 (SLT-1) is a bacterial toxin that kills cells by inhibiting protein synthesis. SLT-1 is composed of one cytotoxic A-subunit and five B-subunits that bind to CD77, a cell-surface glycolipid. In the human hematopoietic system, CD77 expression is restricted to a subset of activated B cells and derived ...

journal_title：Blood

authors： LaCasse EC,Saleh MT,Patterson B,Minden MD,Gariépy J

更新日期：1996-09-01 00:00:00

abstract：:A new combination of total lymphoid irradiation and cyclophosphamide was used prior to bone marrow transplantation in an attempt to achieve decreased rejection rates and graft-versus-host disease. Nine previously transfused patients with severe aplastic anemia received marrow from an HLA-identical, MLC-compatible sibl...

journal_title：Blood

authors： Ramsay NK,Kim T,Nesbit ME,Krivit W,Coccia PF,Levitt SH,Woods WG,Kersey JH

更新日期：1980-02-01 00:00:00

abstract：:Tissue factor-induced blood coagulation was studied in 20 individuals, for varying periods of time during 54 months, in contact pathway-inhibited whole blood at 37 degrees C and evaluated in terms of the activation of various substrates. After quenching over time with inhibitors, the soluble phases were analyzed for t...

journal_title：Blood

authors： Brummel KE,Paradis SG,Butenas S,Mann KG

更新日期：2002-07-01 00:00:00

abstract：:We confirmed that murine hematopoietic stem cells express the c-kit molecule but not lymphohematopoietic lineage markers. These lineage marker-negative c-kit-positive (Lin- c-kit+) cells were further divided according to the uptake of rhodamine-123 (Rh-123). Approximately 1,000 Lin- c-kit+ rhodamine-123dull cells, whi...

journal_title：Blood

authors： Okada S,Nagayoshi K,Nakauchi H,Nishikawa S,Miura Y,Suda T

更新日期：1993-04-01 00:00:00

abstract：:Notch and its ligands have been implicated in the regulation and differentiation of various CD4(+) T-helper cells. Regulatory T cells (T(regs)), which express the transcription factor Foxp3, suppress aberrant immune responses that are typically associated with autoimmunity or excessive inflammation. Previous studies h...

journal_title：Blood

authors： Samon JB,Champhekar A,Minter LM,Telfer JC,Miele L,Fauq A,Das P,Golde TE,Osborne BA

更新日期：2008-09-01 00:00:00

abstract：:Pain is the leading cause of emergency department visits, hospitalizations, and daily suffering in individuals with sickle cell disease (SCD). The pathologic mechanisms leading to the perception of pain during acute RBC sickling episodes and development of chronic pain remain poorly understood and ineffectively treate...

journal_title：Blood

authors： Hillery CA,Kerstein PC,Vilceanu D,Barabas ME,Retherford D,Brandow AM,Wandersee NJ,Stucky CL

更新日期：2011-09-22 00:00:00

abstract：:The first hematopoietic and endothelial progenitors are derived from a common embryonic precursor termed the hemangioblast. The genetic cascades that regulate the differentiation of the hemangioblast to hematopoietic and endothelial cells are largely unknown. In general, much of embryonic development is coordinately r...

journal_title：Blood

authors： Guo Y,Chan R,Ramsey H,Li W,Xie X,Shelley WC,Martinez-Barbera JP,Bort B,Zaret K,Yoder M,Hromas R

更新日期：2003-10-01 00:00:00

abstract：:To obtain information relevant to the question of bone marrow transplantation, we examined the prognostic significance of disease features recorded at the time of diagnosis among 625 patients, aged 5 to 45, with Philadelphia chromosome-positive, nonblastic chronic granulocytic leukemia. The actuarial death rate for th...

journal_title：Blood

authors： Sokal JE,Baccarani M,Tura S,Fiacchini M,Cervantes F,Rozman C,Gomez GA,Galton DA,Canellos GP,Braun TJ

更新日期：1985-12-01 00:00:00

abstract：:Previous studies on patients with storage pool deficiency (SPD) who are specifically deficient in platelet dense granules (delta-SPD) have suggested a role for dense granule substances, in all likelihood adenosine diphosphate (ADP), in mediating thrombus formation on subendothelium at high shear rates. The role of den...

journal_title：Blood

authors： Weiss HJ,Lages B,Hoffmann T,Turitto VT

更新日期：1996-05-15 00:00:00

abstract：:Val34Leu polymorphism of the A subunit of coagulation factor XIII (FXIII-A) is located in the activation peptide (AP) just 3 amino acids away from the thrombin cleavage site. This mutation has been associated with a protective effect against occlusive arterial diseases and venous thrombosis; however, its biochemical c...

journal_title：Blood

authors： Balogh I,Szôke G,Kárpáti L,Wartiovaara U,Katona E,Komáromi I,Haramura G,Pfliegler G,Mikkola H,Muszbek L

更新日期：2000-10-01 00:00:00

abstract：:The translocation between chromosomes 8 and 21, t(8;21) (q22;q22), is the most frequent abnormality in acute myeloid leukemia (AML) with French-American-British type M2 (FAB-M2) morphology. The breakpoints in this translocation have been characterized at the molecular level, and the genes involved are AML1 on chromoso...

journal_title：Blood

authors： Nucifora G,Larson RA,Rowley JD

更新日期：1993-08-01 00:00:00

abstract：:It has been shown previously that multilineage human hematopoiesis is maintained within human fetal bone marrow (BM) fragments implanted into severe combined immunodeficient (SCID) mice. We describe here an application of this animal model, the SCID-hu mouse, to the study of human myeloid leukemias. BM cells from 8 pa...

journal_title：Blood

authors： Namikawa R,Ueda R,Kyoizumi S

更新日期：1993-10-15 00:00:00

abstract：:Soluble thrombomodulin plasma concentrations are elevated in steroid-resistant graft-versus-host disease (GVHD), implying endothelial hypofunctioning for thrombomodulin-dependent generation of activated protein C's (APC) anticoagulant, anti-inflammatory, and antiapoptotic functions. Recombinant thrombomodulin or APC a...

journal_title：Blood

authors： Sinha RK,Flynn R,Zaiken M,Paz K,Gavin AL,Nemazee D,Fernández JA,Xu X,Griffin JH,Blazar BR

更新日期：2019-08-29 00:00:00

abstract：:In severe human beta-thalassemia, the pathophysiology relates to accumulation of excess alpha-globin chains at the membrane. One hypothesis is that membrane-associated alpha-globin by virtue of it's iron or hemichromes produces oxidation of adjacent membrane proteins. The availability of a mouse model of severe beta-t...

journal_title：Blood

authors： Advani R,Rubin E,Mohandas N,Schrier SL

更新日期：1992-02-15 00:00:00

abstract：:NF-IL6 was originally identified as a DNA binding protein regulating interleukin-1 (IL-1)-stimulated IL-6 expression. Direct cloning of NF-IL6 showed its homology with C/EBP, a hepatocyte- and adipocyte-specific transcription factor. This study showed that the expression of NF-IL6 messenger RNA (mRNA) increased marked...

journal_title：Blood

authors： Natsuka S,Akira S,Nishio Y,Hashimoto S,Sugita T,Isshiki H,Kishimoto T

更新日期：1992-01-15 00:00:00

abstract：:Cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) are synthetic ODNs with unmethylated DNA sequences that mimic viral and bacterial DNA and protect against infectious agents and tumor challenge. We show that CpG ODNs markedly accelerated graft-versus-host disease (GVHD) lethality by Toll-like receptor...

journal_title：Blood

authors： Taylor PA,Ehrhardt MJ,Lees CJ,Panoskaltsis-Mortari A,Krieg AM,Sharpe AH,Murphy WJ,Serody JS,Hemmi H,Akira S,Levy RB,Blazar BR

更新日期：2008-10-15 00:00:00