Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications.

abstract：:The efficacy and safety of zanolimumab in patients with refractory cutaneous T-cell lymphoma (CTCL) have been assessed in two phase 2, multicenter, prospective, open-label, uncontrolled clinical studies. Patients with treatment refractory CD4(+) CTCL (mycosis fungoides [MF], n = 38; Sézary syndrome [SS], n = 9) receiv...

journal_title：Blood

authors： Kim YH,Duvic M,Obitz E,Gniadecki R,Iversen L,Osterborg A,Whittaker S,Illidge TM,Schwarz T,Kaufmann R,Cooper K,Knudsen KM,Lisby S,Baadsgaard O,Knox SJ

更新日期：2007-06-01 00:00:00

abstract：:We performed a randomized trial to compare the safety and efficacy of itraconazole with fluconazole in preventing fungal infections in patients undergoing allogeneic stem cell transplantation (SCT). Itraconazole (intravenous 200 mg daily, or oral solution 2.5 mg/kg 3 times daily) and fluconazole (intravenous or oral, ...

journal_title：Blood

authors： Marr KA,Leisenring W,Crippa F,Slattery JT,Corey L,Boeckh M,McDonald GB

更新日期：2004-02-15 00:00:00

abstract：:Posttransplantation lymphoproliferative disorder (PTLD) is a devastating post-transplantation complication often associated with Epstein-Barr virus (EBV). Although the type and length of immunosuppression are risk factors, a patient's inherent immune capacity also likely contributes to this disorder. This report uses ...

journal_title：Blood

authors： Dierksheide JE,Baiocchi RA,Ferketich AK,Roychowdhury S,Pelletier RP,Eisenbeis CF,Caligiuri MA,VanBuskirk AM

更新日期：2005-02-15 00:00:00

abstract：:In systemic light-chain amyloidosis, λ light chains produced by clonal plasma cells cause organ damage and early death. In pursuit of novel therapy, we developed 1 pool of short interfering RNA (siRNA) targeting the constant region of λ light chains that substantially and promptly reduces λ-light-chain production and ...

journal_title：Blood

authors： Zhou P,Ma X,Iyer L,Chaulagain C,Comenzo RL

更新日期：2014-05-29 00:00:00

abstract：:Human hematopoietic stem cells are pluripotent, ie, capable of producing both lymphoid and myeloid progeny, and are therefore used for transplantation and gene therapy. An in vitro culture system was developed to study the multi-lineage developmental potential of a candidate human hematopoietic stem cell population, C...

journal_title：Blood

authors： Hao QL,Smogorzewska EM,Barsky LW,Crooks GM

更新日期：1998-06-01 00:00:00

abstract：:The extent and rapidity with which T cells are regenerated from graft-derived precursor cells directly influences the incidence of infection and the T-cell-based graft-versus-tumor effect. Measurement of T-cell receptor excision circles (TRECs) in peripheral blood is a means of quantifying recent thymic T-cell product...

journal_title：Blood

authors： Chen X,Barfield R,Benaim E,Leung W,Knowles J,Lawrence D,Otto M,Shurtleff SA,Neale GA,Behm FG,Turner V,Handgretinger R

更新日期：2005-01-15 00:00:00

abstract：:The endogenous presentation of the majority of viral epitopes through MHC class I pathway is strictly dependent on the transporter associated with antigen processing (TAP) complex, which transfers the peptide products of proteasomal degradation into the endoplasmic reticulum. A small number of epitopes can be presente...

journal_title：Blood

authors： Tey SK,Khanna R

更新日期：2012-08-02 00:00:00

abstract：:Recently, messenger RNAs in eukaryotes have shown to associate with antisense (AS) transcript partners that are often referred to as long noncoding RNAs (lncRNAs) whose function is largely unknown. Here, we have identified a natural AS transcript for tyrosine kinase containing immunoglobulin and epidermal growth facto...

journal_title：Blood

authors： Li K,Blum Y,Verma A,Liu Z,Pramanik K,Leigh NR,Chun CZ,Samant GV,Zhao B,Garnaas MK,Horswill MA,Stanhope SA,North PE,Miao RQ,Wilkinson GA,Affolter M,Ramchandran R

更新日期：2010-01-07 00:00:00

abstract：:Rituximab therapy is associated with a long in vivo persistence, yet little is known about the effect of circulating rituximab on B-cell non-Hodgkin lymphoma (B-NHL) targeting by the other available anti-CD20 monoclonal antibodies (MoAbs) (131)iodine-tositumomab and (90)yttrium-ibritumomab tiuxetan. Therefore we asses...

journal_title：Blood

authors： Gopal AK,Press OW,Wilbur SM,Maloney DG,Pagel JM

更新日期：2008-08-01 00:00:00

abstract：:Adherent cell layers and their associated extracellular matrices form when human marrow is incubated in cultures containing hydrocortisone and horse serum. These stromal layers contain cells positive for alkaline phosphatase; secrete collagens types I and III and fibronectin, bind the anti-actin monoclonal antibodies ...

journal_title：Blood

authors： Liesveld JL,Abboud CN,Duerst RE,Ryan DH,Brennan JK,Lichtman MA

更新日期：1989-05-15 00:00:00

abstract：:Recently (J Pharmacol Exp Ther 261:580, 1992), we have shown that K562 leukemia cells express a calcium-signaling purinoceptor with characteristics of the P2T receptor subtype for adenosine diphosphate (ADP) previously found only in platelets. Because these results suggested that the P2T receptor may be an early marke...

journal_title：Blood

authors： Murgo AJ,Contrera JG,Sistare FD

更新日期：1994-03-01 00:00:00

abstract：:Expression of the arterial marker molecule ephrinB2 in endothelial cells is a prerequisite for adequate remodeling processes of the developing or angiogenic vasculature. Although its role in these processes has been extensively studied, the impact of ephrinB2 on the remodeling of adult arteries is largely unknown. To ...

journal_title：Blood

authors： Korff T,Braun J,Pfaff D,Augustin HG,Hecker M

更新日期：2008-07-01 00:00:00

abstract：:The bone marrow (BM) microenvironment consists of extracellular-matrix and the cellular compartment including immune cells. Multiple myeloma (MM) cell and BM accessory cell interaction promotes MM survival via both cell-cell contact and cytokines. Immunomodulatory agents (IMiDs) target not only MM cells, but also MM c...

journal_title：Blood

authors： Görgün G,Calabrese E,Soydan E,Hideshima T,Perrone G,Bandi M,Cirstea D,Santo L,Hu Y,Tai YT,Nahar S,Mimura N,Fabre C,Raje N,Munshi N,Richardson P,Anderson KC

更新日期：2010-10-28 00:00:00

abstract：:Anticoagulation with vitamin K antagonists (VKAs) is problematic because of difficulties in safely managing dosing. Polymorphisms in cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase genes (VKORC1) have been shown to affect VKA dosing in adults. The association of these polymorphisms on VKA dosing in childr...

journal_title：Blood

authors： Nowak-Göttl U,Dietrich K,Schaffranek D,Eldin NS,Yasui Y,Geisen C,Mitchell LG

更新日期：2010-12-23 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an autoimmune disease with a complex pathogenesis. As in many B cell-related autoimmune diseases, rituximab (RTX) has been shown to increase platelet counts in some ITP patients. From an immunologic standpoint, the mode of action of RTX and the reasons underlying its limited efficacy h...

journal_title：Blood

authors： Audia S,Samson M,Guy J,Janikashvili N,Fraszczak J,Trad M,Ciudad M,Leguy V,Berthier S,Petrella T,Aho-Glélé S,Martin L,Maynadié M,Lorcerie B,Rat P,Cheynel N,Katsanis E,Larmonier N,Bonnotte B

更新日期：2011-10-20 00:00:00

abstract：:Peripheral blood (PB) CD34+ cells from four commonly used mobilization protocols were studied to compare their phenotype and proliferative capacity with steady-state PB or bone marrow (BM) CD34+ cells. Mobilized PB CD34+ cells were collected during hematopoietic recovery after myelosuppressive chemotherapy with or wit...

journal_title：Blood

authors： To LB,Haylock DN,Dowse T,Simmons PJ,Trimboli S,Ashman LK,Juttner CA

更新日期：1994-11-01 00:00:00

abstract：:Primary effusion lymphoma (PEL) is a rare B-cell malignancy that most often occurs in immunocompromised patients, such as HIV-infected individuals and patients receiving organ transplantation. The main characteristic of PEL is neoplastic effusions in body cavities without detectable tumor masses. The onset of the dise...

journal_title：Blood

authors： Shimada K,Hayakawa F,Kiyoi H

更新日期：2018-11-01 00:00:00

abstract：:The TEL/PDGFbetaR fusion protein is expressed as the consequence of a recurring t(5;12) translocation associated with chronic myelomonocytic leukemia (CMML). Unlike other activated protein tyrosine kinases associated with hematopoietic malignancies, TEL/PDGFbetaR is invariably associated with a myeloid leukemia phenot...

journal_title：Blood

authors： Tomasson MH,Williams IR,Hasserjian R,Udomsakdi C,McGrath SM,Schwaller J,Druker B,Gilliland DG

更新日期：1999-03-01 00:00:00

abstract：:In this issue of Blood, the findings of Chakraborty et al and Emile et al support a model in which the mitogen-activated protein kinase (MAPK) and PI3K/AKT pathways are critical in the pathogenesis of 2 of the most common histiocytoses—Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD)—whereas their...

journal_title：Blood

authors： Prince HM

更新日期：2014-11-06 00:00:00

abstract：:In this cooperative study, we explored the role of the carbohydrate moiety (CHO) of von Willebrand factor (vWF) in supporting platelet adhesion. Because of previous discrepant results, all purification steps and CHO modifications by various enzymes were critically evaluated. Under our conditions, CHO-modified vWF prep...

journal_title：Blood

authors： Federici AB,De Romeuf C,De Groot PG,Samor B,Lombardi R,D'Alessio P,Mazurier C,Mannucci PM,Sixma JJ

更新日期：1988-04-01 00:00:00

abstract：:Natural killer (NK) cell activity is severely impaired in untreated patients with hairy cell leukemia (HCL). In an attempt to investigate whether this impairment is related to a defect at the target cell binding and/or at the post target cell binding level, we evaluated the peripheral blood mononuclear cells (PBMC) of...

journal_title：Blood

authors： Trentin L,Zambello R,Agostini C,Ambrosetti A,Chisesi T,Raimondi R,Bulian P,Pizzolo G,Semenzato G

更新日期：1990-04-01 00:00:00

abstract：:Currently, there are no reliable RBC invasion assays to guide the discovery of vaccines against Plasmodium vivax, the most prevalent malaria parasite in Asia and South America. Here we describe a protocol for an ex vivo P vivax invasion assay that can be easily deployed in laboratories located in endemic countries. Th...

journal_title：Blood

authors： Russell B,Suwanarusk R,Borlon C,Costa FT,Chu CS,Rijken MJ,Sriprawat K,Warter L,Koh EG,Malleret B,Colin Y,Bertrand O,Adams JH,D'Alessandro U,Snounou G,Nosten F,Rénia L

更新日期：2011-09-29 00:00:00

abstract：:Clonality studies of hematopoietic reconstitution after remission were performed in 24 female patients (pts) with leukemias characterized by specific molecular markers. At diagnosis, 13 pts had promyelocytic leukemia (PML) retinoic acid receptor-alpha (RAR-alpha)-rearranged acute promyelocytic leukemia (APL), 8 Philad...

journal_title：Blood

authors： Lo Coco F,Pelicci PG,D'Adamo F,Diverio D,Alimena G,Montefusco E,Arcese W,Avvisati G,De Felice L,Meloni G

更新日期：1993-07-15 00:00:00

abstract：:Hematopoietic transplantation is the preferred treatment for many patients with hematologic malignancies. Some patients may develop invasive fungal diseases (IFDs) during initial chemotherapy, which need to be considered when assessing patients for transplantation and treatment posttransplantation. Given the associate...

journal_title：Blood

authors： Puerta-Alcalde P,Champlin RE,Kontoyiannis DP

更新日期：2020-12-10 00:00:00

abstract：:Scott syndrome is an hereditary bleeding disorder characterized by a deficiency in platelet procoagulant activity. Unlike normal blood cells, Scott platelets, as well as erythrocytes and lymphocytes, are strongly impaired in their ability to scramble their membrane phospholipids when challenged with Ca2+. In normal ce...

journal_title：Blood

authors： Dekkers DW,Comfurius P,Vuist WM,Billheimer JT,Dicker I,Weiss HJ,Zwaal RF,Bevers EM

更新日期：1998-03-15 00:00:00

abstract：:Eighty patients with chronic myeloid leukemia (CML) underwent T cell-depleted stem cell transplantation from an HLA-identical sibling, with add-back of donor T cells on days 30 to 45 and days 60 to 100 in patients in whom grade 2 or greater acute graft-versus-host disease (GVHD) developed. The outcomes for 54 patients...

journal_title：Blood

authors： Savani BN,Rezvani K,Mielke S,Montero A,Kurlander R,Carter CS,Leitman S,Read EJ,Childs R,Barrett AJ

更新日期：2006-02-15 00:00:00

abstract：:An abnormal von Willebrand factor (vWF) gene restriction pattern has been found in a patient with von Willebrand disease. Because this gene alteration is not present in his parents or in 50 normal and 25 affected subjects, and the restriction fragment length polymorphism haplotypes are inherited normally in the patien...

journal_title：Blood

authors： Bernardi F,Marchetti G,Guerra S,Casonato A,Gemmati D,Patracchini P,Ballerini G,Conconi F

更新日期：1990-02-01 00:00:00

abstract：:Depletion of guanine nucleotide pools after inhibition of inosine monophosphate dehydrogenase (IMPDH) potently inhibits DNA synthesis by arresting cells in G1 and has been shown to induce the differentiation of cultured myeloid and erythroid cell lines, as well as chronic granulocytic leukemic cells after blast transf...

journal_title：Blood

authors： Laliberté J,Yee A,Xiong Y,Mitchell BS

更新日期：1998-04-15 00:00:00

abstract：:Artemisinin resistance threatens worldwide malaria control and elimination. Elevation of phosphatidylinositol-3-phosphate (PI3P) can induce resistance in blood stages of Plasmodium falciparum The parasite unfolded protein response (UPR) has also been implicated as a proteostatic mechanism that may diminish artemisinin...

journal_title：Blood

authors： Bhattacharjee S,Coppens I,Mbengue A,Suresh N,Ghorbal M,Slouka Z,Safeukui I,Tang HY,Speicher DW,Stahelin RV,Mohandas N,Haldar K

更新日期：2018-03-15 00:00:00

abstract：:Anemia is a common clinical problem, and there is much interest in its role in promoting left ventricular hypertrophy through increasing cardiac workload. Normally, red blood cell production is adjusted through the regulation of erythropoietin (Epo) production by the kidney. One important cause of anemia is relative d...

journal_title：Blood

authors： Binley K,Askham Z,Iqball S,Spearman H,Martin L,de Alwis M,Thrasher AJ,Ali RR,Maxwell PH,Kingsman S,Naylor S

更新日期：2002-10-01 00:00:00