A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax.

abstract：:Deregulation of signal transduction pathways (STPs) may promote leukemogenesis by conferring cell proliferation and survival advantages in acute myelogenous leukemia (AML). Several agents targeting STPs are under development; however, redundancy and cross-talk between STPs could activate multiple downstream effectors ...

journal_title：Blood

authors： Kornblau SM,Womble M,Qiu YH,Jackson CE,Chen W,Konopleva M,Estey EH,Andreeff M

更新日期：2006-10-01 00:00:00

abstract：:Children with constitutional trisomy 21 (Down syndrome) have an approximately 500-fold increased risk of developing acute megakaryoblastic leukemia (AMKL), a form of acute myeloid leukemia. Unique to newborn infants with Down syndrome is a transient leukemia (TL), also referred to as transient myeloproliferative syndr...

journal_title：Blood

authors： Hitzler JK,Cheung J,Li Y,Scherer SW,Zipursky A

更新日期：2003-06-01 00:00:00

abstract：:We have conducted a pilot study to investigate the role of high-dose therapy and autologous bone marrow/stem cell transplantation (ASCT) during first complete or partial remission in 52 patients with poor-risk aggressive lymphoma. There were 42 patients with intermediate-grade or immunoblastic lymphoma who were consid...

journal_title：Blood

authors： Nademanee A,Molina A,O'Donnell MR,Dagis A,Snyder DS,Parker P,Stein A,Smith E,Planás I,Kashyap A,Spielberger R,Fung H,Wong KK,Somlo G,Margolin K,Chow W,Sniecinski I,Vora N,Blume KG,Niland J,Forman SJ

更新日期：1997-11-15 00:00:00

abstract：:We previously reported the characterization of human osteoclast-associated receptor (hOSCAR), a novel Fc receptor gamma-chain (FcRgamma)-associated receptor expressed by myeloid cells. Here we show that ligation of hOSCAR by specific antibodies promotes dendritic cell (DC) survival by an extracellular signal-regulated...

journal_title：Blood

authors： Merck E,de Saint-Vis B,Scuiller M,Gaillard C,Caux C,Trinchieri G,Bates EE

更新日期：2005-05-01 00:00:00

abstract：:A noninferiority study was performed comparing low-dose and standard-dose prophylactic platelet transfusions. A double-blind randomized controlled trial (RCT) was performed in 6 sites in 3 countries. Thrombocytopenic adults requiring prophylactic platelet transfusion were randomly allocated to standard-dose (300-600 x...

journal_title：Blood

authors： Heddle NM,Cook RJ,Tinmouth A,Kouroukis CT,Hervig T,Klapper E,Brandwein JM,Szczepiorkowski ZM,AuBuchon JP,Barty RL,Lee KA,SToP Study Investigators of the BEST Collaborative.

更新日期：2009-02-12 00:00:00

abstract：:Recently, messenger RNAs in eukaryotes have shown to associate with antisense (AS) transcript partners that are often referred to as long noncoding RNAs (lncRNAs) whose function is largely unknown. Here, we have identified a natural AS transcript for tyrosine kinase containing immunoglobulin and epidermal growth facto...

journal_title：Blood

authors： Li K,Blum Y,Verma A,Liu Z,Pramanik K,Leigh NR,Chun CZ,Samant GV,Zhao B,Garnaas MK,Horswill MA,Stanhope SA,North PE,Miao RQ,Wilkinson GA,Affolter M,Ramchandran R

更新日期：2010-01-07 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) have previously been reported to mediate phagocytosis of anti-CD20-opsonized B cells from patients with chronic lymphocytic leukemia (CLL). However, recent data have suggested that PMNs, like macrophages, can also mediate trogocytosis. We have performed experiments to more precisel...

journal_title：Blood

authors： Valgardsdottir R,Cattaneo I,Klein C,Introna M,Figliuzzi M,Golay J

更新日期：2017-05-11 00:00:00

abstract：:Human neutrophils possess a very short half-life because they constitutively undergo apoptosis. Cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), and other agents can rescue neutrophils from apoptosis but the molecular mechanisms involved in this rescue are undefined. Here, we show by Weste...

journal_title：Blood

authors： Moulding DA,Quayle JA,Hart CA,Edwards SW

更新日期：1998-10-01 00:00:00

abstract：:In vitro models of granulopoiesis involving the inducible expression of either CCAAT enhancer binding protein alpha (C/EBP alpha) or C/EBP epsilon in myeloid cells have been shown to lead to the induction of a granulocytic maturation program accompanied by the expression of myeloid-specific genes. Since members of the...

journal_title：Blood

authors： Khanna-Gupta A,Zibello T,Sun H,Gaines P,Berliner N

更新日期：2003-05-01 00:00:00

abstract：:We have amplified and sequenced the 5' flanking and the second intervening sequence (IVS-II) regions of both the G gamma- and A gamma-globin genes of the beta S chromosomes from sickle cell anemia (SS) patients with homozygosities for five different haplotypes. The sequencing data, compared with previously published s...

journal_title：Blood

authors： Lanclos KD,Oner C,Dimovski AJ,Gu YC,Huisman TH

更新日期：1991-06-01 00:00:00

abstract：:The associations between immune-related conditions and multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) have previously been investigated with inconsistent results. In a large population-based study, we identified 19 112 patients with MM, 5403 patients with MGUS, 96 617 matched contr...

journal_title：Blood

authors： Lindqvist EK,Goldin LR,Landgren O,Blimark C,Mellqvist UH,Turesson I,Wahlin A,Björkholm M,Kristinsson SY

更新日期：2011-12-08 00:00:00

abstract：:Homing of blood-borne lymphocytes to peripheral lymph nodes (PLNs) is a multistep process dependent on the sequential engagement of L-selectin, which mediates lymphocyte rolling along the luminal surface of high endothelial venules (HEVs), followed by activation of lymphocyte integrins and transmigration through HEVs....

journal_title：Blood

authors： Stein JV,Soriano SF,M'rini C,Nombela-Arrieta C,de Buitrago GG,Rodríguez-Frade JM,Mellado M,Girard JP,Martínez-A C

更新日期：2003-01-01 00:00:00

abstract：:The extracellular presence of endotoxin-free heat shock protein 70 (HSP70) enhances the rate and capacity of macrophage-mediated phagocytosis at 6 times the basal rate. It is protein-specific, dose- and time-dependent and involves the internalization of inert microspheres, Gram-positive and -negative bacteria and fung...

journal_title：Blood

authors： Wang R,Kovalchin JT,Muhlenkamp P,Chandawarkar RY

更新日期：2006-02-15 00:00:00

abstract：:Perforin (pfp) and interferon-gamma (IFN-gamma) together in C57BL/6 (B6) and BALB/c mouse strains provided optimal protection in 3 separate tumor models controlled by innate immunity. Using experimental (B6, RM-1 prostate carcinoma) and spontaneous (BALB/c, DA3 mammary carcinoma) models of metastatic cancer, mice defi...

journal_title：Blood

authors： Street SE,Cretney E,Smyth MJ

更新日期：2001-01-01 00:00:00

abstract：:Blood platelets are anuclear cell fragments that are essential for blood clotting. Platelets are produced by bone marrow megakaryocytes (MKs), which extend protrusions, or so-called proplatelets, into bone marrow sinusoids. Proplatelet formation requires a profound reorganization of the MK actin and tubulin cytoskelet...

journal_title：Blood

authors： Pleines I,Dütting S,Cherpokova D,Eckly A,Meyer I,Morowski M,Krohne G,Schulze H,Gachet C,Debili N,Brakebusch C,Nieswandt B

更新日期：2013-10-31 00:00:00

abstract：:Although the expression of Pitx2, a bicoid family homeodomain transcription factor, is highly regulated during hematopoiesis, its function during this process was not documented; we thus studied hematopoiesis in Pitx2-null mice. We found that Pitx2(-/-) embryos display hypoplastic livers with reduced numbers of hemato...

journal_title：Blood

authors： Kieusseian A,Chagraoui J,Kerdudo C,Mangeot PE,Gage PJ,Navarro N,Izac B,Uzan G,Forget BG,Dubart-Kupperschmitt A

更新日期：2006-01-15 00:00:00

abstract：:The rapid transformation of human blood platelets from inert discoid cells to spheroechinocytes that is induced by adenosine diphosphate (ADP) has been followed by right-angle light scattering intensity measurements using a laser light source and a sensitive photomultiplier. Two steps have been observed, and their rat...

journal_title：Blood

authors： Hantgan RR

更新日期：1984-10-01 00:00:00

abstract：:The activities of four purified human growth factors: biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor (GM-CSF); recombinant erythroid-potentiating activity (EPA); natural and recombinant pluripoietin (Ppo); and natural pluripoietin alpha (Ppo alpha), were compared on the growth of hematopoi...

journal_title：Blood

authors： Strife A,Lambek C,Wisniewski D,Gulati S,Gasson JC,Golde DW,Welte K,Gabrilove JL,Clarkson B

更新日期：1987-05-01 00:00:00

abstract：:Natural killer (NK) cells play critical roles in protection against hematological malignancies but can acquire a dysfunctional state, which limits antitumor immunity. However, the underlying reasons for this impaired NK cell function remain to be uncovered. We found that NK cells in aggressive B-cell lymphoma underwen...

journal_title：Blood

authors： Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR

更新日期：2020-12-24 00:00:00

abstract：:Liver injury is a frequent, serious complication of allogeneic hematopoietic cell transplantation (HCT) following myeloablative preparative regimens. We sought to determine the frequency and severity of hepatic injury after nonmyeloablative conditioning and its relationship to outcomes. One hundred ninety-three consec...

journal_title：Blood

authors： Hogan WJ,Maris M,Storer B,Sandmaier BM,Maloney DG,Schoch HG,Woolfrey AE,Shulman HM,Storb R,McDonald GB

更新日期：2004-01-01 00:00:00

abstract：:Chronic active EBV disease (CAEBV) is a lymphoproliferative disorder characterized by markedly elevated levels of antibody to EBV or EBV DNA in the blood and EBV RNA or protein in lymphocytes in tissues. We present our experience with CAEBV during the last 28 years, including the first 8 cases treated with hematopoiet...

journal_title：Blood

authors： Cohen JI,Jaffe ES,Dale JK,Pittaluga S,Heslop HE,Rooney CM,Gottschalk S,Bollard CM,Rao VK,Marques A,Burbelo PD,Turk SP,Fulton R,Wayne AS,Little RF,Cairo MS,El-Mallawany NK,Fowler D,Sportes C,Bishop MR,Wilson W,St

更新日期：2011-06-02 00:00:00

abstract：:The binding of neutrophil beta2 integrin to intercellular adhesion molecule-1 (ICAM-1) expressed on the inflamed endothelium is critical for neutrophil arrest at sites of tissue inflammation. To quantify the strength and kinetics of this interaction, we measured the adhesion between chemotactically stimulated neutroph...

journal_title：Blood

authors： Neelamegham S,Taylor AD,Burns AR,Smith CW,Simon SI

更新日期：1998-09-01 00:00:00

abstract：:During the early period following bone marrow transplantation before the immune system has reached full functional maturity, unprimed, nonspecific lytic systems may play a critical role as antiviral or antitumor effectors. The reconstitution of cells with this potential is of particular importance in recipients of bon...

journal_title：Blood

authors： Keever CA,Welte K,Small T,Levick J,Sullivan M,Hauch M,Evans RL,O'Reilly RJ

更新日期：1987-12-01 00:00:00

abstract：:The majority of mouse Vα14 invariant natural killer T (Vα14i NKT) cells produce several cytokines, including IFNγ and IL-4, very rapidly after activation. A subset of these cells, known as NKT17 cells, however, differentiates in the thymus to preferentially produce IL-17. Here, we show that the transcription factor-kn...

journal_title：Blood

authors： Engel I,Zhao M,Kappes D,Taniuchi I,Kronenberg M

更新日期：2012-11-29 00:00:00

abstract：:What are the rules that govern a naive T cell's prospects for survival or division after export from the thymus into the periphery? To help address these questions, we combine data from existing studies with robust mathematical models to estimate the absolute contributions of thymopoiesis, peripheral division, and los...

journal_title：Blood

authors： Bains I,Antia R,Callard R,Yates AJ

更新日期：2009-05-28 00:00:00

abstract：:Recent studies on the immunoglobulin variable heavy chain (IgV(H)) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated V(H) genes. We have analyzed the V(H) gene mutation status and V(H) gene usage in 119 B-CLL cases...

journal_title：Blood

authors： Tobin G,Thunberg U,Johnson A,Thörn I,Söderberg O,Hultdin M,Botling J,Enblad G,Sällström J,Sundström C,Roos G,Rosenquist R

更新日期：2002-03-15 00:00:00

abstract：:Increasing evidence indicates that the gut microbiota is closely associated with acute graft-versus-host disease (aGVHD) in stem cell transplantation (SCT). Fecal microbiota transplantation (FMT) could represent an alternative treatment option for aGVHD. However, FMT for SCT patients carries a potential risk of infect...

journal_title：Blood

authors： Kakihana K,Fujioka Y,Suda W,Najima Y,Kuwata G,Sasajima S,Mimura I,Morita H,Sugiyama D,Nishikawa H,Hattori M,Hino Y,Ikegawa S,Yamamoto K,Toya T,Doki N,Koizumi K,Honda K,Ohashi K

更新日期：2016-10-20 00:00:00

abstract：:We have used a combination of hematopoietic growth factors to induce in vitro granulocytic maturation. A fraction of marrow cells enriched for hematopoietic progenitor cells (CD34+, HLA-DR+) was isolated from normal human bone marrow by monoclonal antibody staining and fluorescence-activated cell sorting. Cells were c...

journal_title：Blood

authors： Berliner N,Hsing A,Graubert T,Sigurdsson F,Zain M,Bruno E,Hoffman R

更新日期：1995-02-01 00:00:00

abstract：:It has recently been shown that the Naka antigen, which is absent in 3% to 11% of Japanese blood donors, is expressed on platelet glycoprotein IV (GPIV; CD36) (Tomiyama et al, BLOOD, 75:684, 1990). In the present studies, flow cytometry was used to distinguish differences in the reactivity of Naka+ and Naka- platelets...

journal_title：Blood

authors： Yamamoto N,Ikeda H,Tandon NN,Herman J,Tomiyama Y,Mitani T,Sekiguchi S,Lipsky R,Kralisz U,Jamieson GA

更新日期：1990-11-01 00:00:00

abstract：:The mevalonate pathway produces many critical substances in cells, including sterols essential for membrane structure and isoprenoids vital to the function of many membrane proteins. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a rate-limiting enzyme in the mevalonate pathway. Because cholesterol is a ...

journal_title：Blood

authors： Li HY,Appelbaum FR,Willman CL,Zager RA,Banker DE

更新日期：2003-05-01 00:00:00