CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway.

abstract：:Although hereditary spherocytosis (HS) is a common disorder of the red cell membrane, its clinical and biologic expression at birth and in early infancy has received little attention. In order to obtain insights into the natural history of HS during infancy, we studied 46 neonates, 39 from families in which 1 of the p...

journal_title：Blood

authors： Delhommeau F,Cynober T,Schischmanoff PO,Rohrlich P,Delaunay J,Mohandas N,Tchernia G

更新日期：2000-01-15 00:00:00

abstract：:The absence of expanded numbers of hepatitis C virus (HCV)-reactive CD8(+) T lymphocytes (CTLs) in patients chronically infected with HCV has led to the investigation of dendritic cell (DC) function in this population as a potential cause for this defect. Several studies have shown evidence for impaired monocyte-deriv...

journal_title：Blood

authors： Longman RS,Talal AH,Jacobson IM,Albert ML,Rice CM

更新日期：2004-02-01 00:00:00

abstract：:More than 90% of both unfractionated and blast-enriched T cell-depleted mononuclear cells (MNC) from a patient with a morphologically and phenotypically unclassified acute leukemia expressed interleukin 2 receptors (IL2-R), whereas 50% unfractionated MNC displayed monocyte/myeloid- (My7, My9, and OKM1) and B cell-rest...

journal_title：Blood

authors： Bentaboulet M,Allouche M,Tsapis A,Jasmin C,Georgoulias V

更新日期：1987-10-01 00:00:00

abstract：:Although mycosis fungoides (MF) is typically an indolent disease, patients with advanced-stage disease (stages IIB-IVB), including Sézary syndrome (SS), often have a poor outcome. A 31-year, retrospective analysis of our cutaneous lymphoma database, of 297 patients with MF and SS, was undertaken to study long-term out...

journal_title：Blood

authors： Arulogun SO,Prince HM,Ng J,Lade S,Ryan GF,Blewitt O,McCormack C

更新日期：2008-10-15 00:00:00

abstract：:The anti-CD20 monoclonal antibody (mAb) rituximab has revolutionized the treatment of B-cell malignancies. This unprecedented success has not only substantially changed the mindset of the clinical community about the ability of mAb to improve outcomes but has catalyzed the interest in the pharmaceutical industry to de...

journal_title：Blood

authors： Alduaij W,Illidge TM

更新日期：2011-03-17 00:00:00

abstract：:Activated protein C is a potent anticoagulant and profibrinolytic enzyme that can be derived from the vitamin-K-dependent serine protease zymogen, protein C, by the action of thrombin. Protein C antigen concentration was determined in plasmas from normals (n = 40) and from 38 patients with intravascular coagulation as...

journal_title：Blood

authors： Griffin JH,Mosher DF,Zimmerman TS,Kleiss AJ

更新日期：1982-07-01 00:00:00

abstract：:The development of alloantibodies against von Willebrand factor (VWF) represents a rare but serious complication of treatment of von Willebrand disease (VWD), occurring in ~5% to 10% of type 3 VWD patients. Affected patients can present with a range of symptoms, including lack or loss of hemostatic response to infused...

journal_title：Blood

authors： James PD,Lillicrap D,Mannucci PM

更新日期：2013-08-01 00:00:00

abstract：:In this report, we describe a modification of the assay for long-term culture-initiating cells (LTC-IC) that allows a subset of murine LTC-IC (designated as LTC-ICML) to express both their myeloid (M) and lymphoid (L) differentiative potentials in vitro. The modified assay involves culturing test cells at limiting dil...

journal_title：Blood

authors： Lemieux ME,Rebel VI,Lansdorp PM,Eaves CJ

更新日期：1995-08-15 00:00:00

abstract：:Neutrophils exposed to fluoride ion (F-) respond with a delayed and sustained burst of superoxide anion release that is both preceded by and dependent on the influx of Ca2+ from the extracellular medium. The results of this study demonstrate a similarly delayed and sustained generation of 1,2-diglyceride in F(-)-treat...

journal_title：Blood

authors： English D,Taylor G,Garcia JG

更新日期：1991-06-15 00:00:00

abstract：:The serine/threonine Pim kinases are up-regulated in specific hematologic neoplasms, and play an important role in key signal transduction pathways, including those regulated by MYC, MYCN, FLT3-ITD, BCR-ABL, HOXA9, and EWS fusions. We demonstrate that SMI-4a, a novel benzylidene-thiazolidine-2, 4-dione small molecule ...

journal_title：Blood

authors： Lin YW,Beharry ZM,Hill EG,Song JH,Wang W,Xia Z,Zhang Z,Aplan PD,Aster JC,Smith CD,Kraft AS

更新日期：2010-01-28 00:00:00

abstract：:A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect, anemic cancer patients, both adults and children, have been treated with recombinant human EPO (rHuEPO). To furth...

journal_title：Blood

authors： Corazza F,Beguin Y,Bergmann P,André M,Ferster A,Devalck C,Fondu P,Buyse M,Sariban E

更新日期：1998-09-01 00:00:00

abstract：:Autologous T cells engineered to express a CD19-specific chimeric antigen receptor (CAR) have produced impressive minimal residual disease-negative (MRD-negative) complete remission (CR) rates in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the factors associated with durable...

journal_title：Blood

authors： Hay KA,Gauthier J,Hirayama AV,Voutsinas JM,Wu Q,Li D,Gooley TA,Cherian S,Chen X,Pender BS,Hawkins RM,Vakil A,Steinmetz RN,Schoch G,Chapuis AG,Till BG,Kiem HP,Ramos JD,Shadman M,Cassaday RD,Acharya UH,Riddell SR

更新日期：2019-04-11 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation system, synthesized in endothelial cells, which has recently been shown to play an important role in the regulation of activated coagulation factors at the endothelial cell surface. In the present study we investigated t...

journal_title：Blood

authors： Hansen JB,Olsen R,Webster P

更新日期：1997-11-01 00:00:00

abstract：:From 1990 to 1996, a total of 386 adult patients with early/intermediate Hodgkin disease (HD) were randomly assigned to receive 3 cycles of adriamycin, bleomycin, vinblastine, dacarbazine (an alkylating agent), and methylprednisolone (ABVDm, arm A) or epirubicin, bleomycin, vinblastine, methotrexate, and methylprednis...

journal_title：Blood

authors： le Maignan C,Desablens B,Delwail V,Dib M,Berthou C,Vigier M,Ghandour C,Atmani S,Casassus P,Maisonneuve H,Le Mevel A,Traulle C,Bernard M,Briere J,Colonna P,Andrieu JM

更新日期：2004-01-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) causes impairment of the immune system in part by targeting CD4(+) T cells for infection and dysfunction. HIV envelope (Env) present on free virions and infected cells causes dysfunction of uninfected bystander CD4(+) T cells via interaction with both CD4 and coreceptors. Env is ...

journal_title：Blood

authors： Fernando K,Hu H,Ni H,Hoxie JA,Weissman D

更新日期：2007-03-15 00:00:00

abstract：:The functions of the alphaC domains of fibrinogen in clotting and fibrinolysis, which have long been enigmatic, were determined using recombinant fibrinogen truncated at Aalpha chain residue 251. Scanning electron microscopy and confocal microscopy revealed that the fibers of alpha251 clots were thinner and denser, wi...

journal_title：Blood

authors： Collet JP,Moen JL,Veklich YI,Gorkun OV,Lord ST,Montalescot G,Weisel JW

更新日期：2005-12-01 00:00:00

abstract：:There is evidence from clinical studies and animal experiments that aspirin has a greater antithrombotic activity in males compared to females. We investigated platelet function in vitro and in vivo in rabbits before and after the administration of a dose of aspirin (5 mg/kg) which inhibited collagen stimulated thromb...

journal_title：Blood

authors： Kelton JG,Carter CJ,Santos A,Hirsh J

更新日期：1982-03-01 00:00:00

abstract：:Despite many studies on the pathophysiology of antiphospholipid antibodies (aPL), the mechanism by which aPL causes thrombosis has not been established. We have tried to elucidate the paradox between the prolongation of the clotting time of phospholipid-dependent coagulation tests in vitro and the occurrence of thromb...

journal_title：Blood

authors： Oosting JD,Derksen RH,Bobbink IW,Hackeng TM,Bouma BN,de Groot PG

更新日期：1993-05-15 00:00:00

abstract：:Mammalian beta-globin loci are composed of multiple orthologous genes whose expression is erythroid specific and developmentally regulated. The expression of these genes both from the endogenous locus and from transgenes is strongly influenced by a linked 15-kilobase region of clustered DNaseI hypersensitive sites (HS...

journal_title：Blood

authors： Bender MA,Mehaffey MG,Telling A,Hug B,Ley TJ,Groudine M,Fiering S

更新日期：2000-06-01 00:00:00

abstract：:Lymphocytes bound at endothelial cell junctions extravasate within minutes. Lymphocyte-endothelial cell binding is mediated by receptors such as vascular cell adhesion molecule 1 (VCAM-1). VCAM-1 activates endothelial cell nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in minutes, and this activity is req...

journal_title：Blood

authors： Deem TL,Cook-Mills JM

更新日期：2004-10-15 00:00:00

abstract：:Approximately 50% of multi-transfused individuals become refractory to random donor platelets. Recent clinical data suggest that those patients receiving leukocyte-depleted blood products are less likely to become refractory to random donor platelets than recipients of non-leukocyte-depleted products. Leukocyte deplet...

journal_title：Blood

authors： Blajchman MA,Bardossy L,Carmen RA,Goldman M,Heddle NM,Singal DP

更新日期：1992-03-01 00:00:00

abstract：:Recent advances in molecular biology have led to the identification of hematopoietic growth factors that support and influence the proliferation of hematopoietic progenitor cells in vitro and in vivo. Although these factors have been extensively studied, little is known of their role in the regulation of cell-cycling ...

journal_title：Blood

authors： Tanaka R,Katayama N,Ohishi K,Mahmud N,Itoh R,Tanaka Y,Komada Y,Minami N,Sakurai M,Shirakawa S

更新日期：1995-07-01 00:00:00

abstract：:In this issue of Blood, Hong et al advocate for use of additional US Food and Drug Administration (FDA)–approved safety measures for transfusion. Most patients transfused with contaminated platelets do not show immediate clinical signs. Active surveillance suggests patient risk 10- to 40-fold higher than passive hemov...

journal_title：Blood

authors： Benjamin RJ

更新日期：2016-01-28 00:00:00

abstract：:Severe congenital neutropenia (CN) is a preleukemic bone marrow failure syndrome with a 20% risk of evolving into leukemia or myelodysplastic syndrome (MDS). Patterns of acquisition of leukemia-associated mutations were investigated using next-generation deep-sequencing in 31 CN patients who developed leukemia or MDS....

journal_title：Blood

authors： Skokowa J,Steinemann D,Katsman-Kuipers JE,Zeidler C,Klimenkova O,Klimiankou M,Unalan M,Kandabarau S,Makaryan V,Beekman R,Behrens K,Stocking C,Obenauer J,Schnittger S,Kohlmann A,Valkhof MG,Hoogenboezem R,Göhring G,Rein

更新日期：2014-04-03 00:00:00

abstract：:Interleukin-15 (IL-15) induces proliferation and promotes cell survival of human T and B lymphocytes, natural killer cells, and neutrophils. Here we report the constitutive expression of a functional IL-15 receptor (IL-15R) in 6 of 6 myeloma cell lines and in CD38(high)/CD45(low )plasma cells belonging to 14 of 14 pat...

journal_title：Blood

authors： Tinhofer I,Marschitz I,Henn T,Egle A,Greil R

更新日期：2000-01-15 00:00:00

abstract：:Cancer is a leading cause of thrombosis. We identify a new procoagulant mechanism that contributes to thromboembolism in prostate cancer and allows for safe anticoagulation therapy development. Prostate cancer-mediated procoagulant activity was reduced in plasma in the absence of factor XII or its substrate of the int...

journal_title：Blood

authors： Nickel KF,Ronquist G,Langer F,Labberton L,Fuchs TA,Bokemeyer C,Sauter G,Graefen M,Mackman N,Stavrou EX,Ronquist G,Renné T

更新日期：2015-09-10 00:00:00

abstract：:To define conditions for improved efficiency of retroviral-mediated gene transfer and expression in primate progenitor cells, four rhesus monkeys were treated with a 200 mg/kg intravenous bolus of 5-fluorouracil (5-FU). The kinetics of hematopoietic suppression and recovery were assessed in peripheral blood, bone marr...

journal_title：Blood

authors： Wieder R,Cornetta K,Kessler SW,Anderson WF

更新日期：1991-02-01 00:00:00

abstract：:Immunohistochemistry (IHC) was performed on archived bone marrow (BM) with a phosphospecific anti-AKT antibody. IHC on 26 BM biopsies from patients with multiple myeloma (MM) demonstrated phospho-AKT staining of malignant plasma cells in a cell membrane-specific pattern, whereas nonmalignant hematopoietic cells did no...

journal_title：Blood

authors： Hsu J,Shi Y,Krajewski S,Renner S,Fisher M,Reed JC,Franke TF,Lichtenstein A

更新日期：2001-11-01 00:00:00

abstract：:To migrate efficiently through the interstitium, dendritic cells (DCs) constantly adapt their shape to the given structure of the extracellular matrix and follow the path of least resistance. It is known that this amoeboid migration of DCs requires Cdc42, yet the upstream regulators critical for localization and activ...

journal_title：Blood

authors： Harada Y,Tanaka Y,Terasawa M,Pieczyk M,Habiro K,Katakai T,Hanawa-Suetsugu K,Kukimoto-Niino M,Nishizaki T,Shirouzu M,Duan X,Uruno T,Nishikimi A,Sanematsu F,Yokoyama S,Stein JV,Kinashi T,Fukui Y

更新日期：2012-05-10 00:00:00

abstract：:Gene transfer in human hematopoietic stem cells (HSCs) has great potential for both gene therapy and the understanding of hematopoiesis. As HSCs have extensive proliferative capacities, stable gene transfer should include genomic integration of the transgene. Lentiviral vectors are now preferred to oncoretroviral vect...

journal_title：Blood

authors： Sirven A,Pflumio F,Zennou V,Titeux M,Vainchenker W,Coulombel L,Dubart-Kupperschmitt A,Charneau P

更新日期：2000-12-15 00:00:00