Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study.

abstract：:Initial molecular events leading to natural killer lymphocyte (NK) and dendritic cell (DC) interactions are largely unknown. Here, the role of CX3CL1 (fractalkine), a chemokine expressed on mature dendritic cells (mDCs) has been investigated. We show that CX3CL1 promotes NK activation by mDCs. After blocking of CX3CL1...

journal_title：Blood

authors： Pallandre JR,Krzewski K,Bedel R,Ryffel B,Caignard A,Rohrlich PS,Pivot X,Tiberghien P,Zitvogel L,Strominger JL,Borg C

更新日期：2008-12-01 00:00:00

abstract：:The use of recombinant adeno-associated virus (rAAV) vectors provides a new strategy to investigate the role of specific regulatory elements and trans-acting factors in globin gene expression. We linked hypersensitivity site 2 (HS2) from the locus control region (LCR) to a A gamma-globin gene (A gamma*) mutationally m...

journal_title：Blood

authors： Miller JL,Walsh CE,Ney PA,Samulski RJ,Nienhuis AW

更新日期：1993-09-15 00:00:00

abstract：:The human pluripotent UT-7 cell line is growth factor-dependent for proliferation and differentiation. We have previously shown that (1) granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Epo) induce a myeloid and erythroid pattern of differentiation, respectively; (2) GM-CSF acts predominan...

journal_title：Blood

authors： Hermine O,Dubart A,Porteux F,Mayeux P,Titeux M,Dumenil D,Vainchenker W

更新日期：1996-03-01 00:00:00

abstract：:Using age-fractionated erythrocytes, warm autoantibodies can be classified into two distinct categories, depending on their reactivity with reticulocyte-enriched (younger) or reticulocyte-poor (older) red cell fractions. The strength of the direct antiglobulin test (DAT) on the age-fractionated red cells of 24 patient...

journal_title：Blood

authors： Branch DR,Shulman IA,Sy Siok Hian AL,Petz LD

更新日期：1984-01-01 00:00:00

abstract：:Parasitic worms of the genus Schistosoma excrete relatively large amounts of immunogenic glycoproteins (circulating cathodic antigen [CCA]) that contain polysaccharide side chains with the trisaccharide Lewis-x (L(ex)) as a repeating unit. These carbohydrates evoke high titers of specific IgM antibodies that cross-rea...

journal_title：Blood

authors： van Dam GJ,Claas FH,Yazdanbakhsh M,Kruize YC,van Keulen AC,Ferreira ST,Rotmans JP,Deelder AM

更新日期：1996-12-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV)-related multicentric Castleman disease (MCD) is potentially lethal. Growing evidence indicates that, as in Epstein-Barr virus-driven lymphoproliferative disorders after transplantation, KSHV DNA burden in peripheral blood mononuclear cells (PBMCs) may represent the most acc...

journal_title：Blood

authors： Corbellino M,Bestetti G,Scalamogna C,Calattini S,Galazzi M,Meroni L,Manganaro D,Fasan M,Moroni M,Galli M,Parravicini C

更新日期：2001-12-01 00:00:00

abstract：:Previous studies on patients with storage pool deficiency (SPD) who are specifically deficient in platelet dense granules (delta-SPD) have suggested a role for dense granule substances, in all likelihood adenosine diphosphate (ADP), in mediating thrombus formation on subendothelium at high shear rates. The role of den...

journal_title：Blood

authors： Weiss HJ,Lages B,Hoffmann T,Turitto VT

更新日期：1996-05-15 00:00:00

abstract：:The prognostic significance of c-kit receptor expression on leukemic blast cells was determined in 122 children with acute myeloid leukemia (AML) entered onto Childrens Cancer Group protocol 213. Clinical and laboratory characteristics as well as outcome were analyzed according to the percentage of blast cells express...

journal_title：Blood

authors： Smith FO,Broudy VC,Zsebo KM,Lampkin BC,Buckley CV,Buckley JD,Opie T,Woods WG,Hammond GD,Bernstein ID

更新日期：1994-08-01 00:00:00

abstract：:The ability to determine the functional capacity of putative human hematopoietic stem cell (HSC) populations requires in vivo assays in which long-term multilineage differentiation can be assessed. We hypothesized that if human fetal bone was transplanted adjacent to a fetal thymus fragment in severe combined immunode...

journal_title：Blood

authors： Fraser CC,Kaneshima H,Hansteen G,Kilpatrick M,Hoffman R,Chen BP

更新日期：1995-09-01 00:00:00

abstract：:Peripheral blood stem cells (PBSCs) are widely used in autologous transplantation because of ease of collection and rapid hematopoietic reconstitution. However, PBSCs have rarely been used for allogeneic transplantation because of concerns about donor toxicities from cytokine administration and the theoretical increas...

journal_title：Blood

authors： Bensinger WI,Weaver CH,Appelbaum FR,Rowley S,Demirer T,Sanders J,Storb R,Buckner CD

更新日期：1995-03-15 00:00:00

abstract：:Human K562 erythroleukemia cells were transfected with human band 3 (anion exchanger 1 [AE1]) cDNA, using the pBabe retroviral vector. Stable K562 clones expressing band 3 were isolated by flow cytometry, and surface expression was quantified by immunoblotting. The function of band 3 expressed at the cell surface was ...

journal_title：Blood

authors： Beckmann R,Smythe JS,Anstee DJ,Tanner MJ

更新日期：1998-12-01 00:00:00

abstract：:Strategies that augment a GVL effect without increasing the risk of GVHD are required to improve the outcome after allogeneic stem cell transplantation (SCT). Azacitidine (AZA) up-regulates the expression of tumor Ags on leukemic blasts in vitro and expands the numbers of immunomodulatory T regulatory cells (Tregs) in...

journal_title：Blood

authors： Goodyear OC,Dennis M,Jilani NY,Loke J,Siddique S,Ryan G,Nunnick J,Khanum R,Raghavan M,Cook M,Snowden JA,Griffiths M,Russell N,Yin J,Crawley C,Cook G,Vyas P,Moss P,Malladi R,Craddock CF

更新日期：2012-04-05 00:00:00

abstract：:Homing of blood-borne lymphocytes to peripheral lymph nodes (PLNs) is a multistep process dependent on the sequential engagement of L-selectin, which mediates lymphocyte rolling along the luminal surface of high endothelial venules (HEVs), followed by activation of lymphocyte integrins and transmigration through HEVs....

journal_title：Blood

authors： Stein JV,Soriano SF,M'rini C,Nombela-Arrieta C,de Buitrago GG,Rodríguez-Frade JM,Mellado M,Girard JP,Martínez-A C

更新日期：2003-01-01 00:00:00

abstract：:Notch and its ligands have been implicated in the regulation and differentiation of various CD4(+) T-helper cells. Regulatory T cells (T(regs)), which express the transcription factor Foxp3, suppress aberrant immune responses that are typically associated with autoimmunity or excessive inflammation. Previous studies h...

journal_title：Blood

authors： Samon JB,Champhekar A,Minter LM,Telfer JC,Miele L,Fauq A,Das P,Golde TE,Osborne BA

更新日期：2008-09-01 00:00:00

abstract：:Memory stem T cells (TSCM) have been proposed as key determinants of immunologic memory. However, their exact contribution to a mounting immune response, as well as the mechanisms and timing of their in vivo generation, are poorly understood. We longitudinally tracked TSCM dynamics in patients undergoing haploidentica...

journal_title：Blood

authors： Cieri N,Oliveira G,Greco R,Forcato M,Taccioli C,Cianciotti B,Valtolina V,Noviello M,Vago L,Bondanza A,Lunghi F,Marktel S,Bellio L,Bordignon C,Bicciato S,Peccatori J,Ciceri F,Bonini C

更新日期：2015-04-30 00:00:00

abstract：:Inhibition of complement-mediated granulocyte aggregation has recently been proposed as a mechanism of action of high-dose corticosteroids in shock states. Such inhibition may be effected through alteration of receptor function. Methylprednisolone inhibits binding of the synthetic chemotaxin f-methionine-leucine-pheny...

journal_title：Blood

authors： Skubitz KM,Hammerschmidt DE

更新日期：1986-10-01 00:00:00

abstract：:Perforin (pfp) and interferon-gamma (IFN-gamma) together in C57BL/6 (B6) and BALB/c mouse strains provided optimal protection in 3 separate tumor models controlled by innate immunity. Using experimental (B6, RM-1 prostate carcinoma) and spontaneous (BALB/c, DA3 mammary carcinoma) models of metastatic cancer, mice defi...

journal_title：Blood

authors： Street SE,Cretney E,Smyth MJ

更新日期：2001-01-01 00:00:00

abstract：:A microperfusion system containing a glass capillary, the inner surface of which is coated with a phospholipid bilayer containing tissue factor, was used to explore the requirement for factors VIIa and Xa in the complex formed with the lipoprotein-associated coagulation inhibitor (LACI). Various combinations of factor...

journal_title：Blood

authors： Gemmell CH,Broze GJ Jr,Turitto VT,Nemerson Y

更新日期：1990-12-01 00:00:00

abstract：:Primary infection with the human herpesvirus, Epstein-Barr virus (EBV), may result in subclinical seroconversion or may appear as infectious mononucleosis (IM), a lymphoproliferative disease of variable severity. Why primary infection manifests differently between patients is unknown, and, given the difficulties in id...

journal_title：Blood

authors： Silins SL,Sherritt MA,Silleri JM,Cross SM,Elliott SL,Bharadwaj M,Le TT,Morrison LE,Khanna R,Moss DJ,Suhrbier A,Misko IS

更新日期：2001-12-15 00:00:00

abstract：:The proteolytic cleavage and subsequent inactivation of recombinant human factor VIII (rhFVIII) and human factor VIIIa (rhFVIIIa) by recombinant human activated protein C (rAPC) was analyzed in the presence and absence of human protein S and human factor V (FV). Membrane-bound rhFVIIIa spontaneously looses most of its...

journal_title：Blood

authors： Lu D,Kalafatis M,Mann KG,Long GL

更新日期：1996-06-01 00:00:00

abstract：:Complement plays a key role in host defense, but its dysregulation can cause autologous tissue injury. Complement activation is normally controlled by regulatory proteins, including factor H (FH) in plasma and membrane cofactor protein (MCP) on the cell surface. Mutations in FH and MCP are linked to atypical hemolytic...

journal_title：Blood

authors： Ueda Y,Mohammed I,Song D,Gullipalli D,Zhou L,Sato S,Wang Y,Gupta S,Cheng Z,Wang H,Bao J,Mao Y,Brass L,Zheng XL,Miwa T,Palmer M,Dunaief J,Song WC

更新日期：2017-03-02 00:00:00

abstract：:Thrombopoietin (TPO), the major growth factor for cells of the megakaryocytic lineage, is removed from circulation by binding to c-mpl receptors present on platelets and megakaryocytes. We studied patients with acute lymphoblastic leukemia (ALL) or acute myeloblastic leukemia (AML) and used TPO-induced c-fos protein u...

journal_title：Blood

authors： Corazza F,Hermans C,D'Hondt S,Ferster A,Kentos A,Benoît Y,Sariban E

更新日期：2006-03-15 00:00:00

abstract：:Low linear energy transfer (LET) ionizing radiation (IR) is an important form of therapy for acute leukemias administered externally or as radioimmunotherapy. IR is also a potential source of DNA damage. High LET IR produces structurally different forms of DNA damage and has emerged as potential treatment of metastati...

journal_title：Blood

authors： Haro KJ,Scott AC,Scheinberg DA

更新日期：2012-09-06 00:00:00

abstract：:Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). We investigated the feasibility of intensified preemptive immunotherapy in children receiving allo-SCT for AML. Eighty-four...

journal_title：Blood

authors： Rettinger E,Willasch AM,Kreyenberg H,Borkhardt A,Holter W,Kremens B,Strahm B,Woessmann W,Mauz-Koerholz C,Gruhn B,Burdach S,Albert MH,Schlegel PG,Klingebiel T,Bader P

更新日期：2011-11-17 00:00:00

abstract：:Platelet activation is normally induced by primary agonists such as adenosine diphosphate (ADP), thrombin, and collagen, whereas other agonists, such as epinephrine, can play important accessory roles. It is now reported that the macrophage-derived chemokine (MDC), thymus activation-regulated chemokine (TARC), and str...

journal_title：Blood

authors： Gear AR,Suttitanamongkol S,Viisoreanu D,Polanowska-Grabowska RK,Raha S,Camerini D

更新日期：2001-02-15 00:00:00

abstract：:Tissue factor (TF), the cellular receptor for factor VIIa (FVIIa), besides initiating blood coagulation, is believed to play an important role in tissue repair, inflammation, angiogenesis, and tumor metastasis. Like TF, the chemokine interleukin-8 (IL-8) is shown to play a critical role in these processes. To elucidat...

journal_title：Blood

authors： Hjortoe GM,Petersen LC,Albrektsen T,Sorensen BB,Norby PL,Mandal SK,Pendurthi UR,Rao LV

更新日期：2004-04-15 00:00:00

abstract：:We previously showed that incorporating target sequences for the hematopoietic-specific microRNA miR-142 into an antigen-encoding transgene prevents antigen expression in antigen-presenting cells (APCs). To determine whether this approach induces immunologic tolerance, we treated mice with a miR-142-regulated lentivir...

journal_title：Blood

authors： Annoni A,Brown BD,Cantore A,Sergi LS,Naldini L,Roncarolo MG

更新日期：2009-12-10 00:00:00

abstract：:Biochemical and morphological evidence is presented to support the characterization of a rat bone-marrow-derived cell line (RPM) as an analog of the promegakaryoblast. The conditions for in vitro growth and maturation of the RPM line are described. Rapid proliferation of the RPM line is readily achieved when cultures ...

journal_title：Blood

authors： Weinstein R,Stemerman MB,MacIntyre DE,Steinberg HN,Maciag T

更新日期：1981-07-01 00:00:00

abstract：:Human immunodeficiency virus-1 subtypes A and C differ in the highly conserved Gag-TL9 epitope at a single amino acid position. Similarly, the TL9 presenting human leukocyte antigen (HLA) class I molecules B42 and B81 differ only at 6 amino acid positions. Here, we addressed the influence of such minor viral and host ...

journal_title：Blood

authors： Geldmacher C,Metzler IS,Tovanabutra S,Asher TE,Gostick E,Ambrozak DR,Petrovas C,Schuetz A,Ngwenyama N,Kijak G,Maboko L,Hoelscher M,McCutchan F,Price DA,Douek DC,Koup RA

更新日期：2009-08-20 00:00:00

abstract：:The translocation t(15;17)(q22;q21) is seen exclusively in patients with acute promyelocytic leukemia (APL) and in the promyelocytic blast crisis of chronic myeloid leukemia (CML). This translocation juxta-poses the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor-alpha (RARA) gene on ...

journal_title：Blood

authors： Hiorns LR,Min T,Swansbury GJ,Zelent A,Dyer MJ,Catovsky D

更新日期：1994-05-15 00:00:00