Clinical efficacy of zanolimumab (HuMax-CD4): two phase 2 studies in refractory cutaneous T-cell lymphoma.

abstract：:p38 MAP kinase in human platelets is activated by platelet agonists including thrombin, thromboxane A2 (TxA2), ADP, and others. However, both upstream mechanisms of p38 MAP kinase activation, and their downstream sequelae, are presently controversial and essentially unclear. Certain studies report sequential activatio...

journal_title：Blood

authors： Begonja AJ,Geiger J,Rukoyatkina N,Rauchfuss S,Gambaryan S,Walter U

更新日期：2007-01-15 00:00:00

abstract：:Phosphatidylserine (PS) is normally confined to the cytoplasmic leaflet of the red blood cell (RBC) membrane, but some sickle RBCs expose PS in the outer leaflet (PS+ cells). This study examined the relationships among PS externalization, fetal hemoglobin content, hydration state, and cell age. Sickle RBCs exhibit a w...

journal_title：Blood

authors： Yasin Z,Witting S,Palascak MB,Joiner CH,Rucknagel DL,Franco RS

更新日期：2003-07-01 00:00:00

abstract：:Extensive in vitro self-renewal of proerythroblasts from the earliest period of definitive erythropoiesis, as reported by England and co-investigators in this issue of Blood, expands the potential role of self-renewal in mammalian hematopoiesis and suggests a possible source of blood cells for clinical treatments. ...

journal_title：Blood

authors： Koury MJ

更新日期：2011-03-03 00:00:00

abstract：:Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE) induces osteoclast formation from monocyte/macrophage lineage cells via various transcription factors, including the Mi transcription factor (Mitf). Here, we show that inhibitors of differentiation/DNA binding (Ids), helix-loop-helix (HLH) transc...

journal_title：Blood

authors： Lee J,Kim K,Kim JH,Jin HM,Choi HK,Lee SH,Kook H,Kim KK,Yokota Y,Lee SY,Choi Y,Kim N

更新日期：2006-04-01 00:00:00

abstract：:To define conditions for improved efficiency of retroviral-mediated gene transfer and expression in primate progenitor cells, four rhesus monkeys were treated with a 200 mg/kg intravenous bolus of 5-fluorouracil (5-FU). The kinetics of hematopoietic suppression and recovery were assessed in peripheral blood, bone marr...

journal_title：Blood

authors： Wieder R,Cornetta K,Kessler SW,Anderson WF

更新日期：1991-02-01 00:00:00

abstract：:The CD11b/CD18 leukocyte integrin molecule mediates diverse neutrophil adherence-related functions, including cell:cell and cell:extracellular matrix attachments. To study the individual role of this leukocyte integrin in cell adherence in hematopoietic cells, we expressed the CD11b/CD18 complex on the surface of K562...

journal_title：Blood

authors： Hickstein DD,Grunvald E,Shumaker G,Baker DM,Back AL,Embree LJ,Yee E,Gollahon KA

更新日期：1993-10-15 00:00:00

abstract：:Congenital afibrinogenemia is a rare inherited coagulopathy, characterized by very low or unmeasurable plasma levels of immunoreactive fibrinogen. So far, 25 mutations have been identified in afibrinogenemia, 17 in the Aalpha, 6 in the gamma, and only 2 in the Bbeta fibrinogen-chain genes. Here, 2 afibrinogenemic prob...

journal_title：Blood

authors： Spena S,Duga S,Asselta R,Malcovati M,Peyvandi F,Tenchini ML

更新日期：2002-12-15 00:00:00

abstract：:Platelet membrane GPIIb is comprised of a disulfide-linked heavy chain (GPIIb(H)) and light chain (GPIIb(L)). We have examined the role of the two chains of GPIIb in the maintenance of the GPIIb-IIIa heterodimer and Arg-Gly-Asp (RGD) peptide-binding function. Lysates of surface radioiodinated platelets were treated wi...

journal_title：Blood

authors： Lam SC,Plow EF,Ginsberg MH

更新日期：1989-05-01 00:00:00

abstract：:CD34 is expressed on human hematopoietic stem and progenitor cells, and its clinical usefulness for the purification of stem cells has been well established. However, a similar pattern of expression for murine CD34 (mCD34) has not yet been determined. Two polyclonal anti-mCD34 antibodies that specifically recognize bo...

journal_title：Blood

authors： Krause DS,Ito T,Fackler MJ,Smith OM,Collector MI,Sharkis SJ,May WS

更新日期：1994-08-01 00:00:00

abstract：:Drug-dependent antibodies (DDAbs) can cause the precipitous destruction of platelets if a patient is exposed to the drug for which the antibodies are specific. The molecular character of the epitopes recognized is poorly understood, and the mechanism by which drugs promote tight binding of these antibodies to platelet...

journal_title：Blood

authors： Peterson JA,Nyree CE,Newman PJ,Aster RH

更新日期：2003-02-01 00:00:00

abstract：:CD34+ cells devoid of detectable mature and immature T and B lymphocytes, expressing the CD2, CD10, and CD20 antigens, were isolated from marrows of three pairs of sex-mismatched, mixed lymphocyte culture (MLC) nonreactive, sibling baboons. Reciprocal transplants were performed between members of each pair, using the ...

journal_title：Blood

authors： Andrews RG,Bryant EM,Bartelmez SH,Muirhead DY,Knitter GH,Bensinger W,Strong DM,Bernstein ID

更新日期：1992-10-01 00:00:00

abstract：:Primary mediastinal B-cell lymphoma (PMBL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that is putatively derived from a thymic B cell. Accounting for up to 10% of cases of DLBCL, this subtype predominantly affects women in the third and fourth decades of life. Its clinical and molecular characteristics are ...

journal_title：Blood

authors： Dunleavy K,Wilson WH

更新日期：2015-01-01 00:00:00

abstract：:Fetal and neonatal immune thrombocytopenia (FNIT) is a severe bleeding disorder in which maternal antibodies cross the placenta and destroy fetal/neonatal platelets. It has been demonstrated that the neonatal Fc receptor (FcRn) regulates immunoglobulin G (IgG) homeostasis and plays an important role in transplacental ...

journal_title：Blood

authors： Chen P,Li C,Lang S,Zhu G,Reheman A,Spring CM,Freedman J,Ni H

更新日期：2010-11-04 00:00:00

abstract：:Th17 cells play an essential role in the pathogenesis of autoimmune and inflammatory diseases. Most of our current understanding on Th17 cell differentiation relies on studies carried out in mice, whereas the molecular mechanisms controlling human Th17 cell differentiation are less well defined. In this study, we iden...

journal_title：Blood

authors： Tuomela S,Salo V,Tripathi SK,Chen Z,Laurila K,Gupta B,Äijö T,Oikari L,Stockinger B,Lähdesmäki H,Lahesmaa R

更新日期：2012-06-07 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a malignant disorder of the hematopoietic stem cell. It has been shown that normal stem cells coexist with malignant stem cells in the bone marrow of patients with chronic-phase CML. To characterize the primitive hematopoietic progenitor cells within CML marrow, CD34+DR- and CD34+DR+ ...

journal_title：Blood

authors： Leemhuis T,Leibowitz D,Cox G,Silver R,Srour EF,Tricot G,Hoffman R

更新日期：1993-02-01 00:00:00

abstract：:Drug-induced immune thrombocytopenia (DITP) is an adverse drug effect mediated by drug-dependent antibodies. Intravenous immunoglobulin (IVIG) is frequently used to treat DITP and primary immune thrombocytopenia (ITP). Despite IVIG's proven beneficial effects in ITP, its efficacy in DITP is unclear. We have establishe...

journal_title：Blood

authors： Liang SX,Pinkevych M,Khachigian LM,Parish CR,Davenport MP,Chong BH

更新日期：2010-09-16 00:00:00

abstract：:CD27, a transmembrane disulfide-linked 55-kD homodimer, belongs to the nerve growth factor-receptor family, a group of homologous molecules involved in lymphocyte differentiation and selection. It is expressed on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells. We investigated the expressio...

journal_title：Blood

authors： van Oers MH,Pals ST,Evers LM,van der Schoot CE,Koopman G,Bonfrer JM,Hintzen RQ,von dem Borne AE,van Lier RA

更新日期：1993-12-01 00:00:00

abstract：:Many surface receptors and signaling molecules are thought to associate with unique membrane microdomains termed lipid rafts. We examined the involvement of lipid rafts in the activation of leukocyte function-associated antigen-1 (LFA-1). Depletion or sequestration of cholesterol with methyl-beta-cyclodextrin (MCD) or...

journal_title：Blood

authors： Marwali MR,Rey-Ladino J,Dreolini L,Shaw D,Takei F

更新日期：2003-07-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal recessive syndrome characterized by progressive bone marrow failure and cancer predisposition. Eight FA complementation groups have been identified. The FANCA, FANCC, FANCE, FANCF, and FANCG proteins form a nuclear complex required for the monoubiquination of the FANCD2 protein. To ...

journal_title：Blood

authors： Gordon SM,Buchwald M

更新日期：2003-07-01 00:00:00

abstract：:Scott syndrome, a bleeding disorder caused by defective phospholipid scrambling, has been associated with mutations in the TMEM16F gene. The role of TMEM16F in apoptosis- or agonist-induced phosphatidylserine (PS) exposure was studied in platelets from a Scott syndrome patient and control subjects. Whereas stimulation...

journal_title：Blood

authors： van Kruchten R,Mattheij NJ,Saunders C,Feijge MA,Swieringa F,Wolfs JL,Collins PW,Heemskerk JW,Bevers EM

更新日期：2013-03-07 00:00:00

abstract：:B7-H2, which is expressed constitutively on B cells and binds the inducible costimulator (ICOS) on antigen-activated T cells, is a member of the B7 family of costimulatory ligands. We have inactivated B7-H2 in the mouse. B7-H2-/- mice generate normal populations of B and T cells in their various lymphoid organs but ha...

journal_title：Blood

authors： Wong SC,Oh E,Ng CH,Lam KP

更新日期：2003-08-15 00:00:00

abstract：:The replating capability of human multipotential (colony-forming unit-granulocyte-erythrocyte-macrophage-megakaryocyte [CFU-GEMM]) and erythroid (burst-forming unit-erythroid [BFU-E]) progenitors was assessed in vitro as a potential measure of self-renewal using purified, recombinant (r) human (hu) or murine (mu) mast...

journal_title：Blood

authors： Carow CE,Hangoc G,Cooper SH,Williams DE,Broxmeyer HE

更新日期：1991-11-01 00:00:00

abstract：:We have previously reported that continuous intravenous (IV) administration of recombinant granulocyte-macrophage colony-stimulating factor (rHuGM-CSF) to humans following high-dose alkylating agent chemotherapy and autologous bone marrow support (ABMS) results in myeloid bone marrow maturation, accelerated granulocyt...

journal_title：Blood

authors： Peters WP,Stuart A,Affronti ML,Kim CS,Coleman RE

更新日期：1988-10-01 00:00:00

abstract：:The recent success of chimeric antigen receptor (CAR)-T cell therapy for treatment of hematologic malignancies supports further development of treatments for both liquid and solid tumors. However, expansion of CAR-T cell therapy is limited by the availability of surface antigens specific for the tumor while sparing no...

journal_title：Blood

authors： Akahori Y,Wang L,Yoneyama M,Seo N,Okumura S,Miyahara Y,Amaishi Y,Okamoto S,Mineno J,Ikeda H,Maki T,Fujiwara H,Akatsuka Y,Kato T,Shiku H

更新日期：2018-09-13 00:00:00

abstract：:Identification of prognostic factors for patients with relapsed/refractory Hodgkin lymphoma (HL) is essential for optimizing therapy with risk-adapted approaches. In our phase 2 study of positron emission tomography (PET)-adapted salvage therapy with brentuximab vedotin (BV) and augmented ifosfamide, carboplatin, and ...

journal_title：Blood

authors： Moskowitz AJ,Schöder H,Gavane S,Thoren KL,Fleisher M,Yahalom J,McCall SJ,Cadzin BR,Fox SY,Gerecitano J,Grewal R,Hamlin PA,Horwitz SM,Kumar A,Matasar M,Ni A,Noy A,Palomba ML,Perales MA,Portlock CS,Sauter C,Straus

更新日期：2017-11-16 00:00:00

abstract：:Purified human lactoferrin was assessed for its influence in vivo in untreated mice and in mice undergoing rebound myelopoiesis after sublethal dosages of Cytoxan. Fully iron-saturated lactoferrin suppressed the numbers of granulocytes and monocytes per femur, the numbers of granulocyte-macrophage progenitor cells (CF...

journal_title：Blood

authors： Gentile P,Broxmeyer HE

更新日期：1983-05-01 00:00:00

abstract：:By using a cDNA clone of the myeloperoxidase (MPO) gene, we have studied, by Northern blot analysis, the level of MPO mRNA in eight cases of acute lymphoblastic leukemia (ALL). The blast cell populations studied were characterized by morphologic, cytochemical, immunochemical, and molecular criteria. With all the metho...

journal_title：Blood

authors： Ferrari S,Mariano MT,Tagliafico E,Sarti M,Ceccherelli G,Selleri L,Merli F,Narni F,Donelli A,Torelli G

更新日期：1988-09-01 00:00:00

abstract：:The primitive hematopoietic stem/progenitor cells (HSPCs) during embryonic hematopoiesis are thought to be short-lived (SL) with limited self-renewal potential. The fate and consequence of these short-lived HSPCs, once reprogrammed into "long-lived" in a living animal body, remain unknown. Here we show that targeted e...

journal_title：Blood

authors： Zhou T,Wang L,Zhu KY,Dong M,Xu PF,Chen Y,Chen SJ,Chen Z,Deng M,Liu TX

更新日期：2011-10-06 00:00:00

abstract：:Heterogeneity in the human and rat plasma fibrinogen (FBG) gamma chains is due to differential splicing of the primary gamma chain mRNA transcript. The subunit composition of FBG containing the predominant form of the gamma chain is homodimeric (human: A alpha 2, B beta 2, gamma 50-gamma 50; rat: A alpha 2, B beta 2, ...

journal_title：Blood

authors： Lawrence SO,Wright TW,Francis CW,Fay PJ,Haidaris PJ

更新日期：1993-10-15 00:00:00

abstract：:We previously reported that RO(+) expression correlated with increased mutation, activation, and selection among human germinal center (GC) B cells. Here, we subdivided human tonsillar B cells, including IgD(-)CD38(+) GC B cells, into different fractions based on RB expression. Although each subset contained RB(+) cel...

journal_title：Blood

authors： Jackson SM,Harp N,Patel D,Wulf J,Spaeth ED,Dike UK,James JA,Capra JD

更新日期：2009-04-23 00:00:00