Neutrophil migration is defective during recombinant human granulocyte-macrophage colony-stimulating factor infusion after autologous bone marrow transplantation in humans.

Abstract:

:We have previously reported that continuous intravenous (IV) administration of recombinant granulocyte-macrophage colony-stimulating factor (rHuGM-CSF) to humans following high-dose alkylating agent chemotherapy and autologous bone marrow support (ABMS) results in myeloid bone marrow maturation, accelerated granulocyte recovery, and reduced treatment-related toxicity. However, we found that leukocyte counts declined rapidly after discontinuation of rHuGM-CSF therapy, which suggests possible growth factor effects on leukocyte margination and migration. For these reasons we studied granulocyte margination by using 111In-labeled autologous granulocytes and found similar granulocyte margination before (21.5% +/- 13.4%) and during continuous IV rHuGM-CSF infusion (23.3% +/- 9.6%). Phagocytosis of Cryptococcus neoformans and granulocyte hydrogen peroxide production was similar before and during rHuGM-CSF infusion and similar to patients treated with the same high-dose chemotherapy and ABMS but not receiving growth factor. However, migration of granulocytes to a sterile inflammatory site was markedly reduced during continuous rHuGM-CSF infusion (1.2 +/- 0.9 WBCs/cm2, 24 hr) as compared with baseline (39.6 +/- 17.7 WBCs/cm2/24 hr; P less than .0008). These findings may be of relevance when extravascular granulocytes are required for host defense.

journal_name

Blood

journal_title

Blood

authors

Peters WP,Stuart A,Affronti ML,Kim CS,Coleman RE

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

1310-5

issue

4

eissn

0006-4971

issn

1528-0020

journal_volume

72

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Regulatory T-cell compartmentalization and trafficking.

    abstract::CD4(+)CD25(+)FOXP3(+) regulatory T cells (CD4(+) Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2006-01-0177

    authors: Wei S,Kryczek I,Zou W

    更新日期:2006-07-15 00:00:00

  • Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers.

    abstract::Hematide is an investigational pegylated synthetic peptide that stimulates erythropoiesis in animal models and is being developed for the treatment of anemia associated with chronic renal failure and cancer. This study evaluated the safety and pharmacodynamics of single, intravenous doses (0.025, 0.05, and 0.1 mg/kg) ...

    journal_title:Blood

    pub_type: 杂志文章,随机对照试验

    doi:10.1182/blood-2006-04-015818

    authors: Stead RB,Lambert J,Wessels D,Iwashita JS,Leuther KK,Woodburn KW,Schatz PJ,Okamoto DM,Naso R,Duliege AM

    更新日期:2006-09-15 00:00:00

  • Purification and functional characterization of homodimeric gamma B-gamma B fibrinogen from rat plasma.

    abstract::Heterogeneity in the human and rat plasma fibrinogen (FBG) gamma chains is due to differential splicing of the primary gamma chain mRNA transcript. The subunit composition of FBG containing the predominant form of the gamma chain is homodimeric (human: A alpha 2, B beta 2, gamma 50-gamma 50; rat: A alpha 2, B beta 2, ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Lawrence SO,Wright TW,Francis CW,Fay PJ,Haidaris PJ

    更新日期:1993-10-15 00:00:00

  • Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia.

    abstract::Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct subgroup of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) that has a dismal outcome when treated with standard therapy. For improved diagnosis and risk stratification, the initiating genetic events need to be elucidated. To...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-01-329961

    authors: Rand V,Parker H,Russell LJ,Schwab C,Ensor H,Irving J,Jones L,Masic D,Minto L,Morrison H,Ryan S,Robinson H,Sinclair P,Moorman AV,Strefford JC,Harrison CJ

    更新日期:2011-06-23 00:00:00

  • Separation of blast cell and T-lymphocyte progenitors in the blood of patients with acute myeloblastic leukemia.

    abstract::The peripheral blood of acute myeloblastic leukemia (AML) patients often contains large numbers of two distinct cell populations, both capable of forming colonies in culture under similar conditions. The first population consists of the precursors of blast cells and has specificity for AML; the second population consi...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Minden MD,Buick RN,McCulloch EA

    更新日期:1979-07-01 00:00:00

  • alpha-thalassemia resulting from a negative chromosomal position effect.

    abstract::To date, all of the chromosomal deletions that cause alpha-thalassemia remove the structural alpha genes and/or their regulatory element (HS -40). A unique deletion occurs in a single family that juxtaposes a region that normally lies approximately 18-kilobase downstream of the human alpha cluster, next to a structura...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Barbour VM,Tufarelli C,Sharpe JA,Smith ZE,Ayyub H,Heinlein CA,Sloane-Stanley J,Indrak K,Wood WG,Higgs DR

    更新日期:2000-08-01 00:00:00

  • Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.

    abstract::Inhibitors of cyclin-dependent kinases (Cdks) have been reported to have activities in chronic lymphocytic leukemia cells by inhibiting Cdk7 and Cdk9, which control transcription. Here we studied the novel Cdk inhibitor SNS-032, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. We h...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-12-190256

    authors: Chen R,Wierda WG,Chubb S,Hawtin RE,Fox JA,Keating MJ,Gandhi V,Plunkett W

    更新日期:2009-05-07 00:00:00

  • Are all mutant SNARES equal?

    abstract::In this issue of Blood, Pagel et al carefully deliniate some fascinating phenotype/genotype correlations in a larger cohort than in their earlier reports of familial hemophagocytic lymphohistiocytosis (HLH). ...

    journal_title:Blood

    pub_type: 评论,杂志文章

    doi:10.1182/blood-2012-04-422485

    authors: McClain KL

    更新日期:2012-06-21 00:00:00

  • When a little aspirin may be enough.

    abstract::In this issue of Blood, Larocca et al in a large prospective study show that thromboprophylaxis with low-dose aspirin is very effective in previously untreated myeloma patients with a low thromboembolic risk receiving lenalidomide with low-dose dexamethasone. ...

    journal_title:Blood

    pub_type: 评论,杂志文章

    doi:10.1182/blood-2011-08-375089

    authors: Kastritis E,Dimopoulos MA

    更新日期:2012-01-26 00:00:00

  • Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration.

    abstract::Tissue factor (TF), the cellular receptor for factor VIIa (FVIIa), besides initiating blood coagulation, is believed to play an important role in tissue repair, inflammation, angiogenesis, and tumor metastasis. Like TF, the chemokine interleukin-8 (IL-8) is shown to play a critical role in these processes. To elucidat...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-10-3417

    authors: Hjortoe GM,Petersen LC,Albrektsen T,Sorensen BB,Norby PL,Mandal SK,Pendurthi UR,Rao LV

    更新日期:2004-04-15 00:00:00

  • Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma.

    abstract::Anaplastic large cell lymphoma (ALCL) is an aggressive lymphoma that is frequently associated with the t(2;5)(p23;q35), resulting in expression of a fusion protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), which can be detected by either monoclonal or polyclonal antibodies to the ALK protein. The clinical f...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Gascoyne RD,Aoun P,Wu D,Chhanabhai M,Skinnider BF,Greiner TC,Morris SW,Connors JM,Vose JM,Viswanatha DS,Coldman A,Weisenburger DD

    更新日期:1999-06-01 00:00:00

  • The hypercoagulable state in thalassemia.

    abstract::Thalassemia is a congenital hemolytic disorder caused by a partial or complete deficiency of alpha- or beta-globin chain synthesis. Homozygous carriers of beta-globin gene defects suffer from severe anemia and other serious complications from early childhood. The disease is treated by chronic blood transfusion. Howeve...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood.v99.1.36

    authors: Eldor A,Rachmilewitz EA

    更新日期:2002-01-01 00:00:00

  • Clinical quantitation of immune signature in follicular lymphoma by RT-PCR-based gene expression profiling.

    abstract::Microarray gene expression profiling studies have demonstrated immune response gene signatures that appear predictive of outcome in follicular lymphoma (FL). However, measurement of these marker genes in routine practice remains difficult. We have therefore investigated the immune response in FL using real-time polyme...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2007-10-115915

    authors: Byers RJ,Sakhinia E,Joseph P,Glennie C,Hoyland JA,Menasce LP,Radford JA,Illidge T

    更新日期:2008-05-01 00:00:00

  • Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment.

    abstract::Natural killer (NK) cells play critical roles in protection against hematological malignancies but can acquire a dysfunctional state, which limits antitumor immunity. However, the underlying reasons for this impaired NK cell function remain to be uncovered. We found that NK cells in aggressive B-cell lymphoma underwen...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.2020005602

    authors: Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR

    更新日期:2020-12-24 00:00:00

  • Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity.

    abstract::The process of dendritic cell (DC) maturation, critical for effective DC-based immunotherapy, also alters the proteasome such that peptides presented in the context of HLA class I are generated not by the constitutive proteasome, but by the immunoproteasome. Cytotoxic T lymphocytes (CTLs) induced by such DCs might not...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2007-04-083188

    authors: Dannull J,Lesher DT,Holzknecht R,Qi W,Hanna G,Seigler H,Tyler DS,Pruitt SK

    更新日期:2007-12-15 00:00:00

  • Identification of risk groups for development of central nervous system leukemia in adults with acute lymphocytic leukemia.

    abstract::The risk of development of CNS leukemia was investigated in 153 adults with acute lymphocytic leukemia (ALL) who received systemic combination chemotherapy without CNS prophylaxis. Overall, 31 patients (20%) developed CNS leukemia after a median of 6 months of therapy; the estimated 1-year incidence of CNS leukemia wa...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Kantarjian HM,Walters RS,Smith TL,Keating MJ,Barlogie B,McCredie KB,Freireich EJ

    更新日期:1988-11-01 00:00:00

  • Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status.

    abstract::B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin V(H) genes have better outcome than unmutated cases. V(H)-mutated CLLs display longer telomeres compared with unmutated cases and telomere length has been indicated to predict outcome, although the progn...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-11-4394

    authors: Grabowski P,Hultdin M,Karlsson K,Tobin G,Aleskog A,Thunberg U,Laurell A,Sundström C,Rosenquist R,Roos G

    更新日期:2005-06-15 00:00:00

  • Proliferation and apoptosis-related gene expression in experimental acquired immunodeficiency syndrome-related simian lymphoma.

    abstract::Lymphomas in 10 cynomolgus monkeys infected with a simian immunodeficiency virus (SIVsm) were studied with regard to proliferative activity and apoptosis-related gene expression. All were diffuse large-cell lymphomas, showed mono or oligoclonality and a 9/10 diploid cellular DNA content. Expression of a simian homolog...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Castaños-Vélez E,Heiden T,Ekman M,Lawrence J,Biberfeld G,Biberfeld P

    更新日期:1999-02-15 00:00:00

  • Role and initiation mechanism of the interaction of glycoprotein Ib with surface-immobilized von Willebrand factor in a solid-phase platelet cohesion process.

    abstract::To know the role and initiation mechanism of the interaction of glycoprotein (GP) Ib with surface-immobilized von Willebrand factor (vWF), we examined the effect of shear stress levels on platelet binding to vWF-coated plates using a cone-and-plate type viscometer capable of loading various levels of shear stress. The...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Tsuji S,Sugimoto M,Kuwahara M,Nishio K,Takahashi Y,Fujimura Y,Ikeda Y,Yoshioka A

    更新日期:1996-11-15 00:00:00

  • Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses.

    abstract::The mevalonate pathway produces many critical substances in cells, including sterols essential for membrane structure and isoprenoids vital to the function of many membrane proteins. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a rate-limiting enzyme in the mevalonate pathway. Because cholesterol is a ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-07-2283

    authors: Li HY,Appelbaum FR,Willman CL,Zager RA,Banker DE

    更新日期:2003-05-01 00:00:00

  • Effects of erythropoietin on erythroid colony formation in uremic rabbit bone marrow cultures.

    abstract::Erythropoietin-responsive stem cell (ERC) kinetics in anephric uremic rabbits were studied in vitro using the growth of erythroid colonies in a methyl cellulose system in cultures with and without the addition of erythropoietin (ESF). Approximately 68 hr after bilateral nephrectomy, an increase in BUN and decreases in...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Moriyama Y,Fisher JW

    更新日期:1975-05-01 00:00:00

  • Myeloid and monocytic dyspoiesis as determined by flow cytometric scoring in myelodysplastic syndrome correlates with the IPSS and with outcome after hematopoietic stem cell transplantation.

    abstract::Marrow cells of myeloid lineage from 115 patients with myelodysplastic syndrome (MDS) were characterized by multidimensional flow cytometry and compared with findings in 104 patients with various disorders and 25 healthy donors. Based on phenotypic and scatter characteristics, a flow cytometric scoring system (FCSS) w...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-09-2768

    authors: Wells DA,Benesch M,Loken MR,Vallejo C,Myerson D,Leisenring WM,Deeg HJ

    更新日期:2003-07-01 00:00:00

  • Control of cell cycle progression in human natural killer cells through redox regulation of expression and phosphorylation of retinoblastoma gene product protein.

    abstract::Using thiol deprivation, we have previously shown that the response of natural killer (NK) cells to interleukin-2 (IL-2) is subject to redox regulation downstream of IL-2 binding and internalization. We have now used the IL-2-dependent cell line, NK3.3 to study redox regulation of NK cells further, and found that NK3....

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Yamauchi A,Bloom ET

    更新日期:1997-06-01 00:00:00

  • HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients.

    abstract::Human herpesvirus 6 (HHV-6) is detected in the plasma of approximately 40% of patients undergoing hematopoietic cell transplantation (HCT) and sporadically causes encephalitis in this population. The effect of HHV-6 reactivation on central nervous system function has not been fully characterized. This prospective stud...

    journal_title:Blood

    pub_type: 临床试验,杂志文章

    doi:10.1182/blood-2010-10-316083

    authors: Zerr DM,Fann JR,Breiger D,Boeckh M,Adler AL,Xie H,Delaney C,Huang ML,Corey L,Leisenring WM

    更新日期:2011-05-12 00:00:00

  • Hematopoietic precursors resistant to treatment with 4-hydroperoxycyclophosphamide: requirement for an interaction with marrow stroma in addition to hematopoietic growth factors for maximal generation of colony-forming activity.

    abstract::We tested the ability of CD34+lin- precursor cells isolated from marrow after treatment with 4-hydroperoxycyclophosphamide (4HC) to generate colony-forming cells (CFC). In liquid cultures, recombinant human stem cell factor (SCF), in combination with interleukin-1 (IL-1), IL-3, IL-6, granulocyte-macrophage colony-stim...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Rowley SD,Brashem-Stein C,Andrews R,Bernstein ID

    更新日期:1993-07-01 00:00:00

  • The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia.

    abstract::In patients with chronic lymphocytic leukemia (CLL), lenalidomide can promote humoral immune responses but also induces a distinct disease-specific toxicity of tumor flare and cytokine release. These CLL-specific events result from increased expression of costimulatory molecules on B cells. Here we demonstrate that le...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-11-315705

    authors: Herman SE,Lapalombella R,Gordon AL,Ramanunni A,Blum KA,Jones J,Zhang X,Lannutti BJ,Puri KD,Muthusamy N,Byrd JC,Johnson AJ

    更新日期:2011-04-21 00:00:00

  • 5-Azacytidine increases HbF production and reduces anemia in sickle cell disease: dose-response analysis of subcutaneous and oral dosage regimens.

    abstract::Varying doses of 5-azacytidine (5-aza) were given to four sickle cell individuals for 500, 200, 100, and 30 days. The percentage of fetal hemoglobin (HbF) containing reticulocytes (F reticulocytes) increased two- to five-fold within five days of 5-aza therapy in all patients, with a two- to three-fold rapid response (...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Dover GJ,Charache S,Boyer SH,Vogelsang G,Moyer M

    更新日期:1985-09-01 00:00:00

  • Identification of normal human peripheral blood monocytes and liver as sites of synthesis of coagulation factor XIII a-chain.

    abstract::Factor XIII is the fibrin-stabilizing factor that covalently cross-links fibrin monomers to form a highly organized, stable fibrin clot. The plasma form of factor XIII is a heterodimer, a2b2, consisting of two a-chains and two b-chains; the intracellular form, such as in platelets and placenta, is a dimer, a2, consist...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Weisberg LJ,Shiu DT,Conkling PR,Shuman MA

    更新日期:1987-08-01 00:00:00

  • High risk of severe bleeding in aged patients with chronic idiopathic thrombocytopenic purpura.

    abstract::The purpose of this study was to estimate the incidence and to establish which factors were associated with an increased risk of hemorrhagic complications in an historic cohort of 117 consecutive and unselected patients with chronic idiopathic thrombocytopenic purpura (ITP). Sixty-eight patients (58%) underwent medica...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Cortelazzo S,Finazzi G,Buelli M,Molteni A,Viero P,Barbui T

    更新日期:1991-01-01 00:00:00

  • A monoclonal antibody (LYP18) directed against the blood platelet glycoprotein IIb/IIIa complex inhibits human melanoma growth in vivo.

    abstract::A monoclonal antibody (MoAb) (LYP18), generated against human platelet glycoprotein IIb/IIIa (GPIIb/IIIa), immuno-precipitated a IIb/IIIa-like GP complex from a highly tumorigenic human melanoma cell line (M3Dau). The M3Dau melanoma cells specifically bound 125I-labeled LYP18. To study the biologic role of these IIb/I...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Boukerche H,Berthier-Vergnes O,Bailly M,Doré JF,Leung LL,McGregor JL

    更新日期:1989-08-15 00:00:00