Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells.

abstract：:Characterization of hematopoietic cells and measurement of their proliferative potential is critical in many research and clinical applications. Because in vivo assay of human cells is not possible and xenogeneic assays are not yet routine, in vitro assays such as the long-term culture-initiating cell (LTC-IC) assay h...

journal_title：Blood

authors： Koller MR,Manchel I,Smith AK

更新日期：1998-06-01 00:00:00

abstract：:Targeted irradiation of the bone marrow with radiolabeled monoclonal antibodies (radioimmunotherapy) represents a novel therapeutic approach with both myeloablative and antileukemic potential. In an open-label, single-center pilot study, 30 pediatric and adolescent patients undergoing hematopoietic cell transplantatio...

journal_title：Blood

authors： Schulz AS,Glatting G,Hoenig M,Schuetz C,Gatz SA,Grewendorf S,Sparber-Sauer M,Muche R,Blumstein N,Kropshofer G,Suttorp M,Bunjes D,Debatin KM,Reske SN,Friedrich W

更新日期：2011-04-28 00:00:00

abstract：:Plasmacytoid dendritic cells (PDCs) are crucial effectors in innate immunity. In this study, we show that imatinib, a potent inhibitor of BCR/ABL tyrosine kinase activity, in the presence of Flt3-Ligand, could induce CD34+ progenitors from chronic myeloid leukemia (CML) to give rise in vitro to typical BDCA-2+ type I ...

journal_title：Blood

authors： Mohty M,Jourdan E,Mami NB,Vey N,Damaj G,Blaise D,Isnardon D,Olive D,Gaugler B

更新日期：2004-06-15 00:00:00

abstract：:Genetic risk factors contribute to adverse outcome of hematopoietic stem cell transplantation (HSCT). Mismatching of the HLA complex most strongly determines outcomes, whereas non-HLA genetic polymorphisms are also having an impact. Although the majority of HSCTs are mismatched, only few studies have investigated the ...

journal_title：Blood

authors： Harkensee C,Oka A,Onizuka M,Middleton PG,Inoko H,Hirayasu K,Kashiwase K,Yabe T,Nakaoka H,Gennery AR,Ando K,Morishima Y,Japan Marrow Donor Program.

更新日期：2012-06-28 00:00:00

abstract：:Survivin and XIAP, members of the protein family known as the inhibitors of apoptosis, interfere with the activation of caspases, called the "cell death executioners." We examined Survivin (n = 116) and XIAP (n = 172) expression in primary acute myeloid leukemia (AML) blasts and assessed the impact of their expression...

journal_title：Blood

authors： Carter BZ,Kornblau SM,Tsao T,Wang RY,Schober WD,Milella M,Sung HG,Reed JC,Andreeff M

更新日期：2003-12-01 00:00:00

abstract：:Bryostatin 1, a macrocyclic lactone isolated from the marine bryozoan Bugula neritina, has demonstrated both antineoplastic activity against the murine P388 leukemia line in vivo and stimulatory activity against mouse and human hematopoietic progenitors. We studied the effects of bryostatin 1 on the growth of human le...

journal_title：Blood

authors： Jones RJ,Sharkis SJ,Miller CB,Rowinsky EK,Burke PJ,May WS

更新日期：1990-03-15 00:00:00

abstract：:The cellular isoform of the prion protein (PrPC) is a small glycoprotein attached to the outer leaflet of the plasma membrane by a glycosylphosphatidylinositol anchor. This molecule is involved in the pathogenesis of prion diseases in both humans and animals. We have characterized the expression patterns of PrPC durin...

journal_title：Blood

authors： Dodelet VC,Cashman NR

更新日期：1998-03-01 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic stem cell transplant (alloHSCT), underscoring the need to further elucidate its mechanisms and develop novel treatments. Based on recent observations that microRNA-155 (miR-155) is up-regulated during T-cell activation, we...

journal_title：Blood

authors： Ranganathan P,Heaphy CE,Costinean S,Stauffer N,Na C,Hamadani M,Santhanam R,Mao C,Taylor PA,Sandhu S,He G,Shana'ah A,Nuovo GJ,Lagana A,Cascione L,Obad S,Broom O,Kauppinen S,Byrd JC,Caligiuri M,Perrotti D,Hadley G

更新日期：2012-05-17 00:00:00

abstract：:Mast cells accumulate at sites of neovascularization, solid tumors, and many immune reactions. Such accumulation requires directed migration of mature mast cells or their precursors. The nature of the chemoattractants that regulate mast cell motility and the identity of the receptors that mediate the chemotactic respo...

journal_title：Blood

authors： Meininger CJ,Yano H,Rottapel R,Bernstein A,Zsebo KM,Zetter BR

更新日期：1992-02-15 00:00:00

abstract：:An inhibitor of procoagulant and fibrinolytic enzymes was derived from cabbage seeds by a procedure using acetone precipitation, ion-exchange chromatography, and gel filtration. The cabbage seed inhibitor was a 10-Kd monomeric protein with intrachain disulfide bonds. This preparation prevented clot formation in whole ...

journal_title：Blood

authors： Carter TH,Everson BA,Ratnoff OD

更新日期：1990-01-01 00:00:00

abstract：:Immunosuppression with antithymocyte globulin, (methyl)prednisolone, and cyclosporin A is considered the treatment of choice for the patient with aplastic anemia without a donor for standard-risk stem cell transplantation. This consensus is supported by the results of several series, including a randomized German tria...

journal_title：Blood

authors： Frickhofen N,Heimpel H,Kaltwasser JP,Schrezenmeier H,German Aplastic Anemia Study Group.

更新日期：2003-02-15 00:00:00

abstract：:The microsomal fraction of M1 cells (an established cell line of myeloid leukemia) was capable of catalyzing acylation of sn-glycerol 3-phosphate by long-chain fatty acyl-CoA thioesters. The principal lipid product formed was identified as phosphatidic acid. Palmityl-CoA, stearyl-CoA, and oleyl-CoA were more effective...

journal_title：Blood

authors： Okuma M,Ichikawa Y,Yamashita S,Kitajima K,Numa S

更新日期：1976-03-01 00:00:00

abstract：:Intravital microscopy was used to monitor leukocyte traffic across rat mesenteric postcapillary venules induced by the inactive terminal complement (C) complex (iTCC) topically applied to ileal mesentery. Leukocytes started rolling within 15 minutes from the administration of iTCC, and by 1 hour they adhered almost co...

journal_title：Blood

authors： Dobrina A,Pausa M,Fischetti F,Bulla R,Vecile E,Ferrero E,Mantovani A,Tedesco F

更新日期：2002-01-01 00:00:00

abstract：:Antibodies play a fundamental role in diagnostic immunophenotyping of leukemias and in cell-targeting therapy. However, this versatility is not reflected in imaging diagnostics. In the present study, we labeled anti–human mAbs monochromatically against selected human myeloid markers expressed on acute myeloid leukemia...

journal_title：Blood

authors： McCormack E,Mujić M,Osdal T,Bruserud Ø,Gjertsen BT

更新日期：2013-02-14 00:00:00

abstract：:We used both radiolabeled and fluorescein-labeled antiglobulins in assays to detect antibodies against platelets in multiply transfused patients to determine the value of these tests in predicting the outcome of platelet transfusion in such patients. In 15 allosensitized patients, we studied 68 single-donor platelet t...

journal_title：Blood

authors： Ware R,Reisner EG,Rosse WF

更新日期：1984-05-01 00:00:00

abstract：:Clonal chromosomal abnormalities in Philadelphia chromosome-negative (CCA/Ph-) metaphases emerge as patients with chronic phase chronic myeloid leukemia (CP-CML) are treated with tyrosine kinase inhibitors (TKIs). We assessed the characteristics and prognostic impact of 598 patients with CP-CML treated on clinical tri...

journal_title：Blood

authors： Issa GC,Kantarjian HM,Gonzalez GN,Borthakur G,Tang G,Wierda W,Sasaki K,Short NJ,Ravandi F,Kadia T,Patel K,Luthra R,Ferrajoli A,Garcia-Manero G,Rios MB,Dellasala S,Jabbour E,Cortes JE

更新日期：2017-11-09 00:00:00

abstract：:The Kindlin family of intracellular proteins has recently emerged as key regulators of cellular functions and cell-matrix interactions. The 3 members of this family, Kindlin-1, -2, and -3, perform an essential role in activation of integrin adhesion receptors, and expression of at least 1 Kindlin paralog is required t...

journal_title：Blood

authors： Malinin NL,Plow EF,Byzova TV

更新日期：2010-05-20 00:00:00

abstract：:Subsets of natural killer (NK) cells are characterized by the expression of inhibitory and/or stimulatory receptors specific for major histocompatibility complex (MHC) class I determinants. In mice, these include the Ly49 family of molecules. One mechanism by which tumor cells may evade NK cell killing is by expressin...

journal_title：Blood

authors： Koh CY,Blazar BR,George T,Welniak LA,Capitini CM,Raziuddin A,Murphy WJ,Bennett M

更新日期：2001-05-15 00:00:00

abstract：:Ikaros plays an important role in the control of differentiation and proliferation of all lymphoid lineages. The expression of short isoforms lacking DNA-binding motifs alters the differentiation capacities of hematopoietic progenitors, arresting lineage commitment. We sought to determine whether molecular abnormaliti...

journal_title：Blood

authors： Iacobucci I,Lonetti A,Messa F,Cilloni D,Arruga F,Ottaviani E,Paolini S,Papayannidis C,Piccaluga PP,Giannoulia P,Soverini S,Amabile M,Poerio A,Saglio G,Pane F,Berton G,Baruzzi A,Vitale A,Chiaretti S,Perini G,Foà R

更新日期：2008-11-01 00:00:00

abstract：:In this issue of Blood, Kassebaum et al estimate that the global anemia prevalence in 2010 was 32.9%, resulting in 68.4 million years lived with disability (YLD). The results emphasize the important contribution made by anemia to the overall global burden of disease and should help focus attention and resources toward...

journal_title：Blood

authors： Pasricha SR

更新日期：2014-01-30 00:00:00

abstract：:CXCL4 and CXCL4L1 are 2 closely related CXC chemokines that exhibit potent antiangiogenic activity. Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B. We further demo...

journal_title：Blood

authors： Dubrac A,Quemener C,Lacazette E,Lopez F,Zanibellato C,Wu WG,Bikfalvi A,Prats H

更新日期：2010-11-25 00:00:00

abstract：:We examined the synthesis of lactoferrin, an iron binding protein that, among hematopoietic cells, is restricted to secondary granules of polymorphonuclear leukocytes. Lactoferrin biosynthesis was absent from leukemic myeloblasts and promyelocytes but abundant in normal bone marrow and both the bone marrow and periphe...

journal_title：Blood

authors： Rado TA,Bollekens J,St Laurent G,Parker L,Benz EJ Jr

更新日期：1984-11-01 00:00:00

abstract：:Pim kinases are involved in B-cell development and are overexpressed in B-cell chronic lymphocytic leukemia (CLL). We hypothesized that Pim kinase inhibition would affect B-cell survival. Identified from a screen of imidazo[1,2-b]pyridazine compounds, SGI-1776 inhibits Pim-1, Pim-2, and Pim-3. Treatment of CLL cells w...

journal_title：Blood

authors： Chen LS,Redkar S,Bearss D,Wierda WG,Gandhi V

更新日期：2009-11-05 00:00:00

abstract：:There have been several new developments in the field of autoimmune neutropenia over the past decade. Neutropenia caused by antibodies directed against granulocyte precursor cells, the oligoclonal nature of antineutrophil antibodies, and the expanding knowledge of neutrophil antigens, particularly in relationship to a...

journal_title：Blood

authors： Shastri KA,Logue GL

更新日期：1993-04-15 00:00:00

abstract：:Radioiodinated L-cell-derived colony-stimulating factor (CSF) was used to characterize the binding reaction to murine bone marrow cells. The major increment in cell-associated radioactivity occurred over 24 hr incubation at 37 degrees C, but virtually no binding was observed at 4 degrees C. The reaction was saturable ...

journal_title：Blood

authors： Pigoli G,Waheed A,Shadduck RK

更新日期：1982-02-01 00:00:00

abstract：:Although most investigators are well aware of the incredible success of brentuximab vedotin in the treatment of patients with Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL), the study by Jacobsen and colleagues in this issue of Blood demonstrates surprising activity of this agent in patients with B-ce...

journal_title：Blood

authors： Blum KA

更新日期：2015-02-26 00:00:00

abstract：:Graft-versus-host disease (GVHD) is driven by extensive activation and proliferation of alloreactive donor T cells causing significant morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are a potent immunoregulatory T-cell subset in both human...

journal_title：Blood

authors： Schneidawind D,Baker J,Pierini A,Buechele C,Luong RH,Meyer EH,Negrin RS

更新日期：2015-05-28 00:00:00

abstract：:The treatment of multiple myeloma has evolved significantly over the last decades from primarily alkylator-based chemotherapeutic agents with minimal efficacy to the introduction of more effective agents including immune modulators and proteasome inhibitors, which have changed the landscape of therapy for this disease...

journal_title：Blood

authors： Hoyos V,Borrello I

更新日期：2016-09-29 00:00:00

abstract：:Erythroid cell iron and transferrin uptake and release was studied in the anemia of the Belgrade laboratory rat (gene symbol, b), an autosomal recessive trait characterized by hypochromia and hyperferrinemia. When reticulocyte-rich red cells were incubated in vitro with doubly (59Fe, 125I) labeled transferrin, b/b cel...

journal_title：Blood

authors： Edwards JA,Sullivan AL,Hoke JE

更新日期：1980-04-01 00:00:00

abstract：:The expression of Lewis fucosyltransferase (FT) mRNA was examined in gastric mucosa from two Lewis-positive [Le(+)] and two Lewis-negative [Le(-)] individuals. Northern blot analysis demonstrated that levels of mRNA were similar in both Le(+) and Le(-) gastric mucosa. We isolated the protein-coding region of the Lewis...

journal_title：Blood

authors： Koda Y,Kimura H,Mekada E

更新日期：1993-11-01 00:00:00