FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation.

abstract：:Mig, the monokine induced by interferon-gamma, is a CXC chemokine active as a chemoattractant for activated T cells. Mig is related functionally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3. Previously, IP-10 was found to have antitumor activity in vivo. In the present study, muri...

journal_title：Blood

authors： Sgadari C,Farber JM,Angiolillo AL,Liao F,Teruya-Feldstein J,Burd PR,Yao L,Gupta G,Kanegane C,Tosato G

更新日期：1997-04-15 00:00:00

abstract：:The granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin (IL)-3/IL-5 receptor family regulates the production and function of myeloid cells. These cytokines signal through receptor complexes that consist of unique ligand-binding alpha-chains and common signaling beta-chains. IL-5 is distinct from IL-3...

journal_title：Blood

authors： Beekman JM,Verhagen LP,Geijsen N,Coffer PJ

更新日期：2009-10-29 00:00:00

abstract：:The t(8;21) and inv(16)/t(16;16) rearrangements affecting the core-binding factors RUNX1 and CBFB, respectively, are found in 15% to 20% of adult de novo acute myeloid leukemia (AML) cases and are associated with a favorable prognosis. Since the expression of the fusion genes CBFB/MYH11 or RUNX1/RUNX1T1 alone is not s...

journal_title：Blood

authors： Opatz S,Polzer H,Herold T,Konstandin NP,Ksienzyk B,Zellmeier E,Vosberg S,Graf A,Krebs S,Blum H,Hopfner KP,Kakadia PM,Schneider S,Dufour A,Braess J,Sauerland MC,Berdel WE,Büchner T,Woermann BJ,Hiddemann W,Spiekerma

更新日期：2013-09-05 00:00:00

abstract：:We genotyped 370 subjects with primary myelofibrosis (PMF) and 148 with postpolycythemia vera/postessential thrombocythemia (PPV/PET) MF for mutations of EZH2. Mutational status at diagnosis was correlated with hematologic parameters, clinical manifestations, and outcome. A total of 25 different EZH2 mutations were de...

journal_title：Blood

authors： Guglielmelli P,Biamonte F,Score J,Hidalgo-Curtis C,Cervantes F,Maffioli M,Fanelli T,Ernst T,Winkelman N,Jones AV,Zoi K,Reiter A,Duncombe A,Villani L,Bosi A,Barosi G,Cross NC,Vannucchi AM

更新日期：2011-11-10 00:00:00

abstract：:Pure red cell aplasia (PRCA) is a rare complication in patients with chronic lymphocytic leukemia (CLL). It is characterized by reticulocytopenia and by an absence of red cell precursors in the bone marrow. Unlike autoimmune hemolytic anemia, which is characterized by an increased number of reticulocytes, positive Coo...

journal_title：Blood

authors： Ghazal H

更新日期：2002-02-01 00:00:00

abstract：:Microarray gene expression profiling studies have demonstrated immune response gene signatures that appear predictive of outcome in follicular lymphoma (FL). However, measurement of these marker genes in routine practice remains difficult. We have therefore investigated the immune response in FL using real-time polyme...

journal_title：Blood

authors： Byers RJ,Sakhinia E,Joseph P,Glennie C,Hoyland JA,Menasce LP,Radford JA,Illidge T

更新日期：2008-05-01 00:00:00

abstract：:Antisense oligodeoxynucleotide (ODN) drugs might be more effective if their delivery was optimized and they were targeted to short-lived proteins encoded by messenger RNA (mRNA) species with equally short half-lives. To test this hypothesis, an ODN targeted to the c-myb proto-oncogene was developed and used to purge m...

journal_title：Blood

authors： Luger SM,O'Brien SG,Ratajczak J,Ratajczak MZ,Mick R,Stadtmauer EA,Nowell PC,Goldman JM,Gewirtz AM

更新日期：2002-02-15 00:00:00

abstract：:Recombinant human interleukin-2 (IL-2), administered to cancer patients by continuous intravenous (IV) infusion (3 x 10(6) U/m2/d), was found to induce the in vivo production of colony-stimulating factors (CSF). Plasma obtained from patients during IL-2 treatment stimulated in vitro colony formation of normal human bo...

journal_title：Blood

authors： Schaafsma MR,Falkenburg JH,Landegent JE,Duinkerken N,Osanto S,Ralph P,Kaushansky K,Wagemaker G,Van Damme J,Willemze R

更新日期：1991-10-15 00:00:00

abstract：:Acute myeloid leukemia (AML) is an aggressive malignancy with a relapse rate approaching 50%, despite aggressive chemotherapy. New therapies for AML are targeted at signal transduction pathways known to support blast survival, such as the Stat3 pathway. Aberrant activation of Stat3 has been demonstrated in many differ...

journal_title：Blood

authors： Redell MS,Ruiz MJ,Alonzo TA,Gerbing RB,Tweardy DJ

更新日期：2011-05-26 00:00:00

abstract：:The prognostic implications of t(9;22)(q34;q11) were assessed at a median follow-up of 3.5 years in 434 children receiving intensive treatment for acute lymphoblastic leukemia (ALL). Four-year event-free and overall survivals were 81% and 88%, respectively, in 419 children lacking t(9;22), but were 0% and 20%, respect...

journal_title：Blood

authors： Fletcher JA,Lynch EA,Kimball VM,Donnelly M,Tantravahi R,Sallan SE

更新日期：1991-02-01 00:00:00

abstract：:Treatment outcome of acute myeloid leukemia (AML) in elderly patients remains unsatisfactory. It has been shown that the infusion of granulocyte colony-stimulating factor-mobilized donor peripheral blood stem cells (G-PBSCs) can enhance graft-versus-leukemia effects and speed hematopoietic recovery. Fifty-eight AML pa...

journal_title：Blood

authors： Guo M,Hu KX,Yu CL,Sun QY,Qiao JH,Wang DH,Liu GX,Sun WJ,Wei L,Sun XD,Huang YJ,Qiao JX,Dong Z,Ai HS

更新日期：2011-01-20 00:00:00

abstract：:Prothrombin activation can proceed through the intermediates meizothrombin or prethrombin-2. To assess the contributions that these 2 intermediates make to prothrombin activation in tissue factor (Tf)-activated blood, immunoassays were developed that measure the meizothrombin antithrombin (mTAT) and α-thrombin antithr...

journal_title：Blood

authors： Whelihan MF,Zachary V,Orfeo T,Mann KG

更新日期：2012-11-01 00:00:00

abstract：:Sickle cell disease (SCD) is characterized by recurring episodes of vascular occlusion in which neutrophil activation plays a major role. The disease is associated with chronic hemolysis with elevated cell-free hemoglobin and heme. The ensuing depletion of heme scavenger proteins leads to nonspecific heme uptake and h...

journal_title：Blood

authors： Chen G,Zhang D,Fuchs TA,Manwani D,Wagner DD,Frenette PS

更新日期：2014-06-12 00:00:00

abstract：:The tal-1 gene encodes a basic helix-loop-helix (bHLH) transcription factor required for primitive and definitive hematopoiesis. Additionally, ectopic activation of the tal-1 gene during T lymphopoiesis occurs in numerous cases of human T-cell acute lymphoblastic leukemia. With the use of transgenic mice, we show that...

journal_title：Blood

authors： Goardon N,Schuh A,Hajar I,Ma X,Jouault H,Dzierzak E,Roméo PH,Maouche-Chrétien L

更新日期：2002-07-15 00:00:00

abstract：:Spectrin Jendouba (alpha II/31) was found in a Tunisian family. In the heterozygous state, it is associated with asymptomatic elliptocytosis and a minimal defect in spectrin dimer self-association. On partial digestion of spectrin with trypsin, an abnormal cleavage appeared following Lys 788. Peptide and DNA sequencin...

journal_title：Blood

authors： Alloisio N,Wilmotte R,Morlé L,Baklouti F,Maréchal J,Ducluzeau MT,Denoroy L,Féo C,Forget BG,Kastally R

更新日期：1992-08-01 00:00:00

abstract：:In this study human mononuclear phagocytes from the bone marrow (promonocytes and monocytes), peripheral blood monocytes, and tissue macrophages from the skin and the peritoneal cavity were studied with respect to their morphological, cytochemical, and functional characteristics, cell surface receptors, and 3H-thymidi...

journal_title：Blood

authors： van Furth R,Raeburn JA,van Zwet TL

更新日期：1979-08-01 00:00:00

abstract：:Chromosome 7 translocations, deletions, or monosomy are associated with myelodysplasia (MDS) and acute myeloid leukemia both in children and adults. These chromosomal anomalies represent one of the most common cytogenetic abnormalities associated with these diseases and usually herald a poor prognosis. In this study t...

journal_title：Blood

authors： Johnson EJ,Scherer SW,Osborne L,Tsui LC,Oscier D,Mould S,Cotter FE

更新日期：1996-05-01 00:00:00

abstract：:Leukocyte transendothelial migration (TEM) is a critical event during inflammation. CD47 has been implicated in myeloid cell migration across endothelium and epithelium. CD47 binds to signal regulatory protein (SIRP), SIRPalpha and SIRPgamma. So far, little is known about the role of endothelial CD47 in T-cell TEM in ...

journal_title：Blood

authors： Stefanidakis M,Newton G,Lee WY,Parkos CA,Luscinskas FW

更新日期：2008-08-15 00:00:00

abstract：:Global gene expression profiling of highly purified 5q-deleted CD34+CD38(-)Thy1+ cells in 5q- myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34+CD38(-)Thy1+ hematopoietic stem cells. Few but distinct differences in gene expression distinguished MDS and normal stem cel...

journal_title：Blood

authors： Nilsson L,Edén P,Olsson E,Månsson R,Astrand-Grundström I,Strömbeck B,Theilgaard-Mönch K,Anderson K,Hast R,Hellström-Lindberg E,Samuelsson J,Bergh G,Nerlov C,Johansson B,Sigvardsson M,Borg A,Jacobsen SE

更新日期：2007-10-15 00:00:00

abstract：:Heparin-induced thrombocytopenia/thrombosis (HIT/T) is a common complication of heparin therapy that is caused by antibodies to platelet factor 4 (PF4) complexed with heparin. The immune response is polyclonal and polyspecific, ie, more than one neoepitope on PF4 is recognized by HIT/T antibodies. One such epitope has...

journal_title：Blood

authors： Li ZQ,Liu W,Park KS,Sachais BS,Arepally GM,Cines DB,Poncz M

更新日期：2002-02-15 00:00:00

abstract：:Active immunization with the idiotype of follicular lymphoma induces tumor-specific immunity. T cells induced in vivo by idiotype vaccination recognize human leukocyte antigen (HLA)--restricted hypervariable but not conserved idiotype peptides. We hypothesized that idiotype-directed T-cell immunity occurs naturally an...

journal_title：Blood

authors： Strothmeyer AM,Papaioannou D,Dühren-von Minden M,Navarrete M,Zirlik K,Heining-Mikesch K,Veelken H

更新日期：2010-09-09 00:00:00

abstract：:The purpose of this study was to characterize the stimulus that activates the 5-lipoxygenase pathway in human peripheral monocytes (PM) during the process of contact activation. Incubation of PM, but not of polymorphonuclear leukocytes (PMN), in contact-activated, recalcified plasma induced a time-dependent release of...

journal_title：Blood

authors： Weide I,Römisch J,Simmet T

更新日期：1994-04-01 00:00:00

abstract：:Platelet endothelial cell adhesion molecule 1 (PECAM-1) is involved in leukocyte migration and angiogenesis, which are key components of venous thrombus resolution. This study investigated the effect of PECAM-1 deficiency on thrombus resolution in FVB/n mice and the extent to which levels of soluble PECAM-1 (sPECAM-1)...

journal_title：Blood

authors： Kellermair J,Redwan B,Alias S,Jabkowski J,Panzenboeck A,Kellermair L,Winter MP,Weltermann A,Lang IM

更新日期：2013-11-07 00:00:00

abstract：:Tissue inhibitor of metalloproteinases-1 (TIMP-1), the major physiological matrix metalloproteinase inhibitor and a potent antimetastatic factor, also stimulates the growth of erythroid progenitors (erythroid-potentiating activity). We analyzed the relationship between the growth factor activity and protease inhibitio...

journal_title：Blood

authors： Chesler L,Golde DW,Bersch N,Johnson MD

更新日期：1995-12-15 00:00:00

abstract：:Pluripotent hematopoietic stem cells have been studied extensively, but the events that occur during their differentiation remain largely uncharted. To develop a system that allows the differentiation of cultured multipotent progenitors by time-lapse fluorescence microscopy, myelomonocytic cells were labeled with gree...

journal_title：Blood

authors： Faust N,Varas F,Kelly LM,Heck S,Graf T

更新日期：2000-07-15 00:00:00

abstract：:Screening for hereditary hemochromatosis (HHC) by means of transferrin saturation (TS) levels has been advocated and will identify many patients who are asymptomatic. The purposes of this study were (1) to determine HFE genotypes among asymptomatic HHC patients and correlate this profile with the degree of iron overlo...

journal_title：Blood

authors： Sham RL,Raubertas RF,Braggins C,Cappuccio J,Gallagher M,Phatak PD

更新日期：2000-12-01 00:00:00

abstract：:Two fractions of human prothrombin can be isolated from single donor plasma by the technique of heparin-agarose chromatography in (sodium) citrate buffer, pH 7.5, as previously reported for pooled plasma. The two fractions, designated H-II1 and H-II2, are found in a ratio of approximately 4:1. Both forms comigrate in ...

journal_title：Blood

authors： Bajaj SP,Rapaport SI,Prodonos C,Russell WA

更新日期：1981-11-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are specialized DCs that produce high levels of type I IFN upon viral infection. Despite their key immunoregulatory role, little is known about pDC ontogeny or how developmental events regulate their function. We show that mice expressing low levels of the transcription factor Ikaro...

journal_title：Blood

authors： Allman D,Dalod M,Asselin-Paturel C,Delale T,Robbins SH,Trinchieri G,Biron CA,Kastner P,Chan S

更新日期：2006-12-15 00:00:00

abstract：:Hematopoietic function of some aplastic anemia (AA) patients is dependent on the administration of cyclosporine (CyA). To investigate whether certain HLA class II genes are associated with susceptibility to such CyA-dependent AA, we determined the HLA class II alleles of 59 AA patients treated with CyA. Among 26 patie...

journal_title：Blood

authors： Nakao S,Takamatsu H,Chuhjo T,Ueda M,Shiobara S,Matsuda T,Kaneshige T,Mizoguchi H

更新日期：1994-12-15 00:00:00

abstract：:All-trans retinoic acid (ATRA) is an essential component of the treatment of acute promyelocytic leukemia (APL), but the optimal timing and duration remain to be determined. Molecular characterization of this disease can refine the diagnosis and could be potentially useful in monitoring response to treatment. Patients...

journal_title：Blood

authors： Burnett AK,Grimwade D,Solomon E,Wheatley K,Goldstone AH

更新日期：1999-06-15 00:00:00