Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro.

abstract：:We tested the ability of CD34+lin- precursor cells isolated from marrow after treatment with 4-hydroperoxycyclophosphamide (4HC) to generate colony-forming cells (CFC). In liquid cultures, recombinant human stem cell factor (SCF), in combination with interleukin-1 (IL-1), IL-3, IL-6, granulocyte-macrophage colony-stim...

journal_title：Blood

authors： Rowley SD,Brashem-Stein C,Andrews R,Bernstein ID

更新日期：1993-07-01 00:00:00

abstract：:Hypodiploidy <40 chromosomes is an uncommon genetic feature of acute lymphoblastic leukemia (ALL) in both children and adults. It has long been clear by cytogenetic analyses, and recently confirmed by mutational profiling, that these cases may be further subdivided into 2 subtypes: near-haploid ALL with 24 to 30 chrom...

journal_title：Blood

authors： Safavi S,Paulsson K

更新日期：2017-01-26 00:00:00

abstract：:Erythropoietin (Ep), insulin, and prostaglandins E1 and A1 (PGE1, PGA1) enhanced heme synthesis by mitochondria isolated from embryonic and adult mouse liver cells. The combination of Ep with PGE1 had an antagonistic effect, while that of Ep with PGA1 gave an additive result. The capability of isolated human platelet ...

journal_title：Blood

authors： Agam G,Djaldetti M

更新日期：1978-06-01 00:00:00

abstract：:This prospective multicenter study examined whether simultaneous administration of granulocyte colony-stimulating factor (G-CSF; Filgrastim) and induction chemotherapy for adult acute lymphoblastic leukemia (ALL) could prevent treatment-related neutropenia, infections, and resulting treatment delays. Seventy-six patie...

journal_title：Blood

authors： Ottmann OG,Hoelzer D,Gracien E,Ganser A,Kelly K,Reutzel R,Lipp T,Busch FW,Schwonzen M,Heil G

更新日期：1995-07-15 00:00:00

abstract：:A cytotoxic common ALL antiserum (CALLA) specific for leukemic cells of most patients with non-T-cel- acute lymphoblastic leukemia (ALL) and of some patients with chronic myelogenous leukemia (CML) in blast crisis has been reproducibly prepared using cell lines for absorption. CALLA reacts with leukemic cells of 110 o...

journal_title：Blood

authors： Pesando JM,Ritz J,Lazarus H,Costello SB,Sallan S,Schlossman SF

更新日期：1979-12-01 00:00:00

abstract：:Myelofibrosis in myeloproliferative neoplasms (MPNs) with mutations such as JAK2V617F is an unfavorable sign for uncontrollable disease progression in the clinic and is complicated with osteosclerosis whose pathogenesis is largely unknown. Because several studies have revealed that macrophages are an indispensable sup...

journal_title：Blood

authors： Wakahashi K,Minagawa K,Kawano Y,Kawano H,Suzuki T,Ishii S,Sada A,Asada N,Sato M,Kato S,Shide K,Shimoda K,Matsui T,Katayama Y

更新日期：2019-04-11 00:00:00

abstract：:Dendritic cells (DCs) process and present bacterial and endogenous lipid antigens in complex with CD1 molecules to T cells and invariant natural killer T (NKT) cells. However, different types of DCs, such as blood myeloid DCs and skin Langerhans cells, exhibit distinct patterns of CD1a, CD1b, CD1c, and CD1d expression...

journal_title：Blood

authors： Smed-Sörensen A,Moll M,Cheng TY,Loré K,Norlin AC,Perbeck L,Moody DB,Spetz AL,Sandberg JK

更新日期：2008-05-15 00:00:00

abstract：:Angiotensin II (Ang-II) exerts inflammatory activity and is involved in different cardiovascular disorders. This study has evaluated the involvement of tumor necrosis factor alpha (TNFalpha) in the leukocyte accumulation elicited by Ang-II. Ang-II (1 nM intraperitoneally in rats) induced TNFalpha release at 1 hour fol...

journal_title：Blood

authors： Mateo T,Naim Abu Nabah Y,Losada M,Estellés R,Company C,Bedrina B,Cerdá-Nicolás JM,Poole S,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ

更新日期：2007-09-15 00:00:00

abstract：:Containers constructed of polyvinylchloride (PVC) are used for the storage of platelet concentrates (PC) for transfusion, At 22 degrees C, pH often falls to such low levels (pH is less that 6.0) that viability is lost. Far lesser degrees of pH fall are observed in bags constructed of polyethylene (PE). In this study, ...

journal_title：Blood

authors： Murphy S,Gardner FH

更新日期：1975-08-01 00:00:00

abstract：:Thrombopoietin (TPO) is a recently cloned cytokine that binds to its receptor, Mpl, and promotes hematopoietic expansion and maturation, primarily of the megakaryocyte lineage. The signaling pathways responsible for these events are thought to involve the Janus family of nonreceptor tyrosine kinases (JAKs) and the sig...

journal_title：Blood

authors： Drachman JG,Sabath DF,Fox NE,Kaushansky K

更新日期：1997-01-15 00:00:00

abstract：:Blood cells of an adult vertebrate are continuously generated by hematopoietic stem cells (HSCs) that originate during embryonic life within the aorta-gonad-mesonephros region. There is now compelling in vivo evidence that HSCs are generated from aortic endothelial cells and that this process is critically regulated b...

journal_title：Blood

authors： Lam EY,Hall CJ,Crosier PS,Crosier KE,Flores MV

更新日期：2010-08-12 00:00:00

abstract：:Granzyme H (GzmH) belongs to a family of 5 human serine proteases that are expressed by cytotoxic immune effector cells. Although GzmH is most closely related to the caspase-activating granzyme B (GzmB), neither a natural substrate nor a role in immune defense reactions has been demonstrated for this orphan granzyme. ...

journal_title：Blood

authors： Fellows E,Gil-Parrado S,Jenne DE,Kurschus FC

更新日期：2007-07-15 00:00:00

abstract：:Numerous studies have suggested that iron (Fe) chelators such as desferrioxamine (DFO) may be useful antitumor agents (Blatt and Stitely, Cancer Res 47:1749, 1987; Becton and Bryles, Cancer Res 48:7189, 1988). Recent work with several analogues of the lipophilic Fe chelator, pyridoxal isonicotinoyl hydrazone (PIH), in...

journal_title：Blood

authors： Richardson DR,Tran EH,Ponka P

更新日期：1995-12-01 00:00:00

abstract：:Molecular mechanisms preserving hematopoietic stem cell (HSC) self-renewal by maintaining a balance between proliferation, differentiation, and other processes are not fully understood. Hyperactivation of the mammalian target of rapamycin (mTOR) pathway, causing sustained proliferative signals, can lead to exhaustion ...

journal_title：Blood

authors： Campbell TB,Basu S,Hangoc G,Tao W,Broxmeyer HE

更新日期：2009-10-15 00:00:00

abstract：:We investigated whether atorvastatin (AT) was capable of protecting animals from acute graft-versus-host disease (aGVHD) across major histocompatibility complex (MHC) mismatch barriers. AT treatment of the donor induced a Th-2 cytokine profile in the adoptively transferred T cells and reduced their in vivo expansion, ...

journal_title：Blood

authors： Zeiser R,Youssef S,Baker J,Kambham N,Steinman L,Negrin RS

更新日期：2007-12-15 00:00:00

abstract：:We demonstrate here that EL4-6.1 cells, a mouse thymoma that expresses high levels of membrane interleukin (IL)-1 receptors, produce IL-1 beta as an autocrine regulatory factor. Endogenous IL-1 beta sustains both proliferation and apoptosis: during the exponential phase, it mainly promotes proliferation, while during ...

journal_title：Blood

authors： Fratelli M,Gagliardini V,Galli G,Gnocchi P,Ghiara P,Ghezzi P

更新日期：1995-06-15 00:00:00

abstract：:High-dose cyclophosphamide, without stem cell rescue, has been used successfully to treat aplastic anemia and other autoimmune disorders. To determine the safety and efficacy of high-dose cyclophosphamide among patients with severe refractory autoimmune hemolytic anemia, we treated 9 patients with cyclophosphamide (50...

journal_title：Blood

authors： Moyo VM,Smith D,Brodsky I,Crilley P,Jones RJ,Brodsky RA

更新日期：2002-07-15 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which are allosteric mTOR complex 1 (mTORC1) inhibitors, are active in mantle cell lymphoma and other lymphoid neoplasms, but responses are usually partial and short-li...

journal_title：Blood

authors： Gupta M,Hendrickson AE,Yun SS,Han JJ,Schneider PA,Koh BD,Stenson MJ,Wellik LE,Shing JC,Peterson KL,Flatten KS,Hess AD,Smith BD,Karp JE,Barr S,Witzig TE,Kaufmann SH

更新日期：2012-01-12 00:00:00

abstract：:In a previous study, we described a form of nondeletion alpha-thalassemia (alpha T Saudi alpha) found in subjects of Saudi Arabian origin. In the current study, using synthetic oligoprobe hybridization and restriction enzyme analysis, we have demonstrated that the molecular basis of alpha T Saudi alpha is due solely t...

journal_title：Blood

authors： Thein SL,Wallace RB,Pressley L,Clegg JB,Weatherall DJ,Higgs DR

更新日期：1988-02-01 00:00:00

abstract：:Hypotransferrinemic (Trf(hpx/hpx)) mice have a severe deficiency in serum transferrin (Trf) as the result of a spontaneous mutation linked to the murine Trf locus. They are born alive, but before weaning, die from severe anemia if they are not treated with exogenous Trf or red blood cell transfusions. We have determin...

journal_title：Blood

authors： Trenor CC 3rd,Campagna DR,Sellers VM,Andrews NC,Fleming MD

更新日期：2000-08-01 00:00:00

abstract：:Evidence is presented showing that a protein tyrosine phosphatase different from CD45 is present on the membrane of human hematopoietic cells. The molecule recognized by the monoclonal antibody 143-41, which has been classified as CD148 in the VI International Workshop on Leukocyte Differentiation Antigens, was immuno...

journal_title：Blood

authors： de la Fuente-García MA,Nicolás JM,Freed JH,Palou E,Thomas AP,Vilella R,Vives J,Gayá A

更新日期：1998-04-15 00:00:00

abstract：:Viral infections have been associated with reduced platelet counts, the biological significance of which has remained elusive. Here, we show that infection with encephalomyocarditis virus (EMCV) rapidly reduces platelet count, and this response is attributed to platelet Toll-like receptor 7 (TLR7). Platelet-TLR7 stimu...

journal_title：Blood

authors： Koupenova M,Vitseva O,MacKay CR,Beaulieu LM,Benjamin EJ,Mick E,Kurt-Jones EA,Ravid K,Freedman JE

更新日期：2014-07-31 00:00:00

abstract：:Cumulative evidence indicates that MYC, one of the major downstream effectors of NOTCH1, is a critical component of T-cell acute lymphoblastic leukemia (T-ALL) oncogenesis and a potential candidate for targeted therapy. However, MYC is a complex oncogene, involving both fine protein dosage and cell-context dependency,...

journal_title：Blood

authors： Bonnet M,Loosveld M,Montpellier B,Navarro JM,Quilichini B,Picard C,Di Cristofaro J,Bagnis C,Fossat C,Hernandez L,Mamessier E,Roulland S,Morgado E,Formisano-Tréziny C,Dik WA,Langerak AW,Prebet T,Vey N,Michel G,Gabert

更新日期：2011-06-16 00:00:00

abstract：:The extravasation of leukocytes from the lumen of the vessel to a site of inflammation requires specific binding events. The interaction of leukocytes with endothelium, via specific receptors, may provide intracellular signals that activate extravasating cells. In the present study, we have investigated the production...

journal_title：Blood

authors： Lukacs NW,Strieter RM,Elner V,Evanoff HL,Burdick MD,Kunkel SL

更新日期：1995-10-01 00:00:00

abstract：:Regulated by histone acetyltransferases and deacetylases (HDACs), histone acetylation is a key epigenetic mechanism controlling chromatin structure, DNA accessibility, and gene expression. HDAC inhibitors induce growth arrest, differentiation, and apoptosis of tumor cells and are used as anticancer agents. Here we des...

journal_title：Blood

authors： Roger T,Lugrin J,Le Roy D,Goy G,Mombelli M,Koessler T,Ding XC,Chanson AL,Reymond MK,Miconnet I,Schrenzel J,François P,Calandra T

更新日期：2011-01-27 00:00:00

abstract：:The antibody-mediated delivery of therapeutic agents to sites of angiogenesis is an attractive strategy for anticancer therapy, but is largely unexplored in hematologic malignancies. In the present study, we show that the extra domain B (EDB) of fibronectin, a marker of angiogenesis, is expressed in B-cell non-Hodgkin...

journal_title：Blood

authors： Schliemann C,Palumbo A,Zuberbühler K,Villa A,Kaspar M,Trachsel E,Klapper W,Menssen HD,Neri D

更新日期：2009-03-05 00:00:00

abstract：:To program pluripotent cells into blood, a knowledge of the locations of precursors during their journey through the embryo and the signals they experience would be informative. The anterior (a) and posterior (p) ventral blood islands (VBIs) in Xenopus are derived from opposite sides of the pregastrula embryo. The aVB...

journal_title：Blood

authors： Walmsley M,Cleaver D,Patient R

更新日期：2008-02-01 00:00:00

abstract：:Platelet membrane GPIIb is comprised of a disulfide-linked heavy chain (GPIIb(H)) and light chain (GPIIb(L)). We have examined the role of the two chains of GPIIb in the maintenance of the GPIIb-IIIa heterodimer and Arg-Gly-Asp (RGD) peptide-binding function. Lysates of surface radioiodinated platelets were treated wi...

journal_title：Blood

authors： Lam SC,Plow EF,Ginsberg MH

更新日期：1989-05-01 00:00:00

abstract：:Epstein-Barr virus (EBV) infections may induce a diverse clinical picture, ranging from the well characterized infectious mononucleosis (IM) syndrome to the rare X-linked lymphoproliferative syndrome. We describe two unrelated children, a 21-mo-old white boy and a 15-mo-old black girl, who presented with the clinical ...

journal_title：Blood

authors： Herrod HG,Dow LW,Sullivan JL

更新日期：1983-06-01 00:00:00

abstract：:Mice deficient in intercellular adhesion molecule-1 (ICAM-1), lacking membranous ICAM-1, show a normal development but abnormalities of inflammatory and immune functions. Although the membrane-bound form of ICAM-1 is not detectable in the mutant strain, circulating ICAM-1 (cICAM) is present in serum from ICAM-1-defici...

journal_title：Blood

authors： van Den Engel NK,Heidenthal E,Vinke A,Kolb H,Martin S

更新日期：2000-02-15 00:00:00