Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages.

abstract：:Stable gene replacement by in vivo administration of lentiviral vectors (LVs) has therapeutic potential for metabolic disorders and other systemic diseases. We studied the expression of intracellular and secreted proteins by LVs in immunocompetent mice. Liver, spleen, and bone marrow cells were efficiently transduced....

journal_title：Blood

authors： Follenzi A,Battaglia M,Lombardo A,Annoni A,Roncarolo MG,Naldini L

更新日期：2004-05-15 00:00:00

abstract：:Hematopoietic stem cells (HSCs) show pronounced heterogeneity in self-renewal and differentiation behavior, which is reflected in their repopulation kinetics. Here, a single-cell-based mathematical model of HSC organization is used to examine the basis of HSC heterogeneity. Our modeling results, which are based on the...

journal_title：Blood

authors： Roeder I,Horn K,Sieburg HB,Cho R,Muller-Sieburg C,Loeffler M

更新日期：2008-12-15 00:00:00

abstract：:Personalized immunotherapy of lymphoma based on tumor idiotype (Id) has shown anti-idiotype humoral immune responses in 40%-50% and cellular immune responses in 50%-75% of follicular lymphoma patients, indicating that this therapy can be clinically successful. We have developed a novel vaccine against lymphoma consist...

journal_title：Blood

authors： Carlring J,Szabo MJ,Dickinson R,De Leenheer E,Heath AW

更新日期：2012-03-01 00:00:00

abstract：:Inversion of chromosome 16 is a consistent finding in patients with acute myeloid leukemia subtype M4 with eosinophilia, which generates a CBFB-MYH11 fusion gene. Previous studies showed that the interaction between CBFβ-smooth muscle myosin heavy chain (SMMHC; encoded by CBFB-MYH11) and RUNX1 plays a critical role in...

journal_title：Blood

authors： Zhen T,Kwon EM,Zhao L,Hsu J,Hyde RK,Lu Y,Alemu L,Speck NA,Liu PP

更新日期：2017-11-30 00:00:00

abstract：:We evaluated the impact of recipient and cord blood unit (CBU) genetic polymorphisms related to immune response on outcomes after unrelated cord blood transplantations (CBTs). Pretransplant DNA samples from 696 CBUs with malignant diseases were genotyped for NLRP1, NLRP2, NLRP3, TIRAP/Mal, IL10, REL, TNFRSF1B, and CTL...

journal_title：Blood

authors： Cunha R,Zago MA,Querol S,Volt F,Ruggeri A,Sanz G,Pouthier F,Kogler G,Vicario JL,Bergamaschi P,Saccardi R,Lamas CH,Díaz-de-Heredia C,Michel G,Bittencourt H,Tavella M,Panepucci RA,Fernandes F,Pavan J,Gluckman E,Roch

更新日期：2017-01-26 00:00:00

abstract：:Antiphospholipid antibodies including anticardiolipin antibodies, lupus anticoagulants, and anti-beta(2) glycoprotein-1-specific antibodies may identify patients at elevated risk of first or recurrent venous or arterial thromboembolism. Traditionally, published case series supplemented by anecdotal experience have for...

journal_title：Blood

authors： Garcia DA,Khamashta MA,Crowther MA

更新日期：2007-11-01 00:00:00

abstract：:The pathophysiology of microthrombocytopenia in the Wiskott-Aldrich syndrome (WAS) and its milder form, X-linked thrombocytopenia (XLT), is unclear. Although quantitative defects are correctable by splenectomy, residual platelet abnormalities are suggestive of intrinsic disturbances of production. In contrast to human...

journal_title：Blood

authors： Sabri S,Foudi A,Boukour S,Franc B,Charrier S,Jandrot-Perrus M,Farndale RW,Jalil A,Blundell MP,Cramer EM,Louache F,Debili N,Thrasher AJ,Vainchenker W

更新日期：2006-07-01 00:00:00

abstract：:The molecular mechanisms by which mesenchymal stem cells (MSCs) suppress T-cell proliferation are poorly understood, and whether a soluble factor plays a major role remains controversial. Here we demonstrate that the T-cell-receptor complex is not a target for the suppression, suggesting that downstream signals mediat...

journal_title：Blood

authors： Sato K,Ozaki K,Oh I,Meguro A,Hatanaka K,Nagai T,Muroi K,Ozawa K

更新日期：2007-01-01 00:00:00

abstract：:Warm autoimmune hemolytic anemia (WAIHA) is characterized by an accelerated clearance of red blood cells (RBCs) associated with the presence of anti-RBC immunoglobulin (Ig)G autoantibodies. In the present study, we analyzed the self-reactive IgG and IgM antibody repertoires of patients with WAIHA using a technique of ...

journal_title：Blood

authors： Stahl D,Lacroix-Desmazes S,Heudes D,Mouthon L,Kaveri SV,Kazatchkine MD

更新日期：2000-01-01 00:00:00

abstract：:Even if neoplastic cells express tumor associated antigens they still may fail to function as antigen presenting cells (APC) if they lack expression of one or more molecules critical for the induction of productive immunity. These cellular defects can be repaired by physiologic activation, transfection, or fusion of t...

journal_title：Blood

authors： Cardoso AA,Schultze JL,Boussiotis VA,Freeman GJ,Seamon MJ,Laszlo S,Billet A,Sallan SE,Gribben JG,Nadler LM

更新日期：1996-07-01 00:00:00

abstract：:In this issue of Blood, Buchlis and colleagues describe the long-term persistence (up to 10 years) of factor IX (FIX) expression in adeno-associated virus serotype 2 (AAV-2)–injected muscles of a patient with hemophilia B. ...

journal_title：Blood

authors： Benveniste O

更新日期：2012-03-29 00:00:00

abstract：:A simple and reliable cytogenetic test for Fanconi's anemia (FA) that is based on the hypersensitivity of FA cells to mitomycin C (MC) is described. Equal volumes of whole blood from a patient in whom the diagnosis of FA is suspected and from a normal person of the opposite sex are co-cultured in phytohemagglutinin-co...

journal_title：Blood

authors： German J,Schonberg S,Caskie S,Warburton D,Falk C,Ray JH

更新日期：1987-06-01 00:00:00

abstract：:STI571 induces sustained hematologic remission in patients with chronic myeloid leukemia (CML) in chronic phase. However, in advanced phases, especially blast crisis, the leukemia usually becomes resistant within months. It has been investigated whether resistance to STI571 is stable and immutable or whether it can be...

journal_title：Blood

authors： Tipping AJ,Mahon FX,Lagarde V,Goldman JM,Melo JV

更新日期：2001-12-15 00:00:00

abstract：:The CD11b/CD18 leukocyte integrin molecule mediates diverse neutrophil adherence-related functions, including cell:cell and cell:extracellular matrix attachments. To study the individual role of this leukocyte integrin in cell adherence in hematopoietic cells, we expressed the CD11b/CD18 complex on the surface of K562...

journal_title：Blood

authors： Hickstein DD,Grunvald E,Shumaker G,Baker DM,Back AL,Embree LJ,Yee E,Gollahon KA

更新日期：1993-10-15 00:00:00

abstract：:Blood platelets are anuclear cell fragments that are essential for blood clotting. Platelets are produced by bone marrow megakaryocytes (MKs), which extend protrusions, or so-called proplatelets, into bone marrow sinusoids. Proplatelet formation requires a profound reorganization of the MK actin and tubulin cytoskelet...

journal_title：Blood

authors： Pleines I,Dütting S,Cherpokova D,Eckly A,Meyer I,Morowski M,Krohne G,Schulze H,Gachet C,Debili N,Brakebusch C,Nieswandt B

更新日期：2013-10-31 00:00:00

abstract：:Investigators in the United Kingdom have shown that hereditary amyloidosis can be misdiagnosed as Ig light-chain (AL) amyloidosis because family history is an ineffective screen, and tissue staining used to type amyloid is unreliable. Misdiagnosis of AL can lead to inappropriate use of chemotherapy and failure to diag...

journal_title：Blood

authors： Comenzo RL,Zhou P,Fleisher M,Clark B,Teruya-Feldstein J

更新日期：2006-05-01 00:00:00

abstract：:Ischemia of the heart, brain, and limbs is a leading cause of morbidity and mortality worldwide. Treatment with tissue type plasminogen activator (tPA) can dissolve blood clots and can ameliorate the clinical outcome in ischemic diseases. But the underlying mechanism by which tPA improves ischemic tissue regeneration ...

journal_title：Blood

authors： Ohki M,Ohki Y,Ishihara M,Nishida C,Tashiro Y,Akiyama H,Komiyama H,Lund LR,Nitta A,Yamada K,Zhu Z,Ogawa H,Yagita H,Okumura K,Nakauchi H,Werb Z,Heissig B,Hattori K

更新日期：2010-05-27 00:00:00

abstract：:The efficacy and safety of zanolimumab in patients with refractory cutaneous T-cell lymphoma (CTCL) have been assessed in two phase 2, multicenter, prospective, open-label, uncontrolled clinical studies. Patients with treatment refractory CD4(+) CTCL (mycosis fungoides [MF], n = 38; Sézary syndrome [SS], n = 9) receiv...

journal_title：Blood

authors： Kim YH,Duvic M,Obitz E,Gniadecki R,Iversen L,Osterborg A,Whittaker S,Illidge TM,Schwarz T,Kaufmann R,Cooper K,Knudsen KM,Lisby S,Baadsgaard O,Knox SJ

更新日期：2007-06-01 00:00:00

abstract：:The high frequency of allogeneic reactive CD8(+) T cells in human and their resistance to immunosuppression might be one of the reasons why successful tolerance-inducing strategies in rodents have failed in primates. Studies on the requirement for T-helper cells in priming CD8(+) T-cell responses have led to disparate...

journal_title：Blood

authors： Lemoine R,Velge-Roussel F,Herr F,Felix R,Nivet H,Lebranchu Y,Baron C

更新日期：2010-10-21 00:00:00

abstract：:High levels of coagulation factor VIII (FVIII) have been associated with cardiovascular disease. Low-density lipoprotein receptor (LDLR) has been recently demonstrated to contribute to FVIII clearance from plasma. The aim of this study was to evaluate 3 single nucleotide polymorphisms in SMARCA4-LDLR gene locus (rs112...

journal_title：Blood

authors： Martinelli N,Girelli D,Lunghi B,Pinotti M,Marchetti G,Malerba G,Pignatti PF,Corrocher R,Olivieri O,Bernardi F

更新日期：2010-12-16 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMC) from 17 patients receiving HLA-identical sibling bone marrow grafts were stimulated with host pretransplant PBMC. Cytotoxic T-cell lines (TCL) with specificity for host pretransplant PBMC were obtained from 9 of these patients, all presenting with severe graft-versus-host dise...

journal_title：Blood

authors： Niederwieser D,Grassegger A,Auböck J,Herold M,Nachbaur D,Rosenmayr A,Gächter A,Nussbaumer W,Gaggl S,Ritter M

更新日期：1993-04-15 00:00:00

abstract：:Human herpesvirus 6 activity (HHV-6) was studied in 15 allogeneic and 11 autologous marrow transplantation patients. After transplantation, HHV-6 was isolated from the peripheral blood mononuclear cells of 12 of 26 patients (6 allogeneic and 6 autologous). All isolates were variant B. Eleven of 26 and 12 of 19 patient...

journal_title：Blood

authors： Kadakia MP,Rybka WB,Stewart JA,Patton JL,Stamey FR,Elsawy M,Pellett PE,Armstrong JA

更新日期：1996-06-15 00:00:00

abstract：:Coagulation factor XIII (FXIII) is the main stabilizer of the fibrin clot. It circulates in plasma as a tetramer of two A-subunits and two B-subunits. Under physiological conditions, FXIII-A exists as a dimer (FXIII-A2). The interactions between the FXIII-A-subunits that stabilize the FXIII-A2 dimer are not fully unde...

journal_title：Blood

authors： Li B,Kohler HP,Schroeder V

更新日期：2020-01-09 00:00:00

abstract：:The interaction of von Willebrand factor (vWF) with the alpha v beta 3 integrin of human umbilical vein endothelial cells is dependent on the RGD sequence present at residues 1744-1746 of the mature vWF subunit. We compared vWF and its two dimeric fragments, SpIII (residues 1-1365) and SpII (residues 1366-2050), as ad...

journal_title：Blood

authors： Denis C,Williams JA,Lu X,Meyer D,Baruch D

更新日期：1993-12-15 00:00:00

abstract：:It has previously been shown that monolayer cultures derived adherent cells (MDAC), apparently consisting of fibroblasts, macrophages, epithelioid cells, and fat cells, can support long-term stem cell proliferation in vitro. In the present study, the hematopoietic support capability of murine MDAC monolayers was confi...

journal_title：Blood

authors： Bentley SA,Foidart JM

更新日期：1980-12-01 00:00:00

abstract：:The Children's Cancer Group (CCG) and the Pediatric Oncology Group (POG) joined to form the Children's Oncology Group (COG) in 2000. This merger allowed analysis of clinical, biologic, and early response data predictive of event-free survival (EFS) in acute lymphoblastic leukemia (ALL) to develop a new classification ...

journal_title：Blood

authors： Schultz KR,Pullen DJ,Sather HN,Shuster JJ,Devidas M,Borowitz MJ,Carroll AJ,Heerema NA,Rubnitz JE,Loh ML,Raetz EA,Winick NJ,Hunger SP,Carroll WL,Gaynon PS,Camitta BM

更新日期：2007-02-01 00:00:00

abstract：:2-Methoxyestradiol (2-ME), a new anticancer agent currently in clinical trials, has been demonstrated to inhibit superoxide dismutase (SOD) and to induce apoptosis in leukemia cells through a free radical-mediated mechanism. Because the accumulation of superoxide (O(2)-) by inhibition of SOD depends on the cellular ge...

journal_title：Blood

authors： Zhou Y,Hileman EO,Plunkett W,Keating MJ,Huang P

更新日期：2003-05-15 00:00:00

abstract：:Cerebral malaria is a severe multifactorial condition associated with the interaction of high numbers of infected erythrocytes to human brain endothelium without invasion into the brain. The result is coma and seizures with death in more than 20% of cases. Because the brain endothelium is at the interface of these pro...

journal_title：Blood

authors： Tripathi AK,Sha W,Shulaev V,Stins MF,Sullivan DJ Jr

更新日期：2009-11-05 00:00:00

abstract：:The coagulation factors V (FV) and VIII (FVIII) are important at sites of vascular injury for the amplification of the clotting cascade. Natural variants of these factors frequently lead to severe bleeding disorders. To understand the mechanisms of activation of FVIII by thrombin, we used a bank of mutant thrombins to...

journal_title：Blood

authors： Myles T,Yun TH,Leung LL

更新日期：2002-10-15 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) in children is sometimes characterized by a severe course, requiring prolonged administration of immunosuppressive therapy. Rituximab is able to cause selective in vivo destruction of B lymphocytes, with abrogation of antibody production. In a prospective study, we have evaluated the...

journal_title：Blood

authors： Zecca M,Nobili B,Ramenghi U,Perrotta S,Amendola G,Rosito P,Jankovic M,Pierani P,De Stefano P,Bonora MR,Locatelli F

更新日期：2003-05-15 00:00:00