Transfected leukocyte integrin CD11b/CD18 (Mac-1) mediates phorbol ester-activated, homotypic cell:cell adherence in the K562 cell line.

abstract：:Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma in children. It has minimal bone marrow toxicity. Its major side effects are anaphylaxis, pancreatitis, diabetes, coagulation abnormalities, and thrombosis, especially intracranial. It is derived from 2 different...

journal_title：Blood

authors： Duval M,Suciu S,Ferster A,Rialland X,Nelken B,Lutz P,Benoit Y,Robert A,Manel AM,Vilmer E,Otten J,Philippe N

更新日期：2002-04-15 00:00:00

abstract：:We report the nonrandom occurrence, frequency, and degree of immunophenotype association of the t(1;14)(p34;q11) in children with acute lymphoblastic leukemia (ALL). This chromosomal abnormality occurred in leukemia cells from 5 of 1,630 (0.3%) consecutive children with newly diagnosed ALL who were entered on a single...

journal_title：Blood

authors： Carroll AJ,Crist WM,Link MP,Amylon MD,Pullen DJ,Ragab AH,Buchanan GR,Wimmer RS,Vietti TJ

更新日期：1990-09-15 00:00:00

abstract：:Although bispecific antibodies directed against malignant lymphoma have been shown to be effective in vitro and in vivo, extended clinical trials so far have been hampered by the fact that conventional approaches to produce these antibodies suffer from low yields, ill-defined byproducts, or laborious purification proc...

journal_title：Blood

authors： Löffler A,Kufer P,Lutterbüse R,Zettl F,Daniel PT,Schwenkenbecher JM,Riethmüller G,Dörken B,Bargou RC

更新日期：2000-03-15 00:00:00

abstract：:In diffuse large B-cell lymphoma (DLBCL), the number of circulating monocytes and neutrophils represents an independent prognostic factor. These cell subsets include monocytic and granulocytic myeloid-derived suppressor cells (M- and G-MDSCs) defined by their ability to suppress T-cell responses. MDSCs are a heterogen...

journal_title：Blood

authors： Azzaoui I,Uhel F,Rossille D,Pangault C,Dulong J,Le Priol J,Lamy T,Houot R,Le Gouill S,Cartron G,Godmer P,Bouabdallah K,Milpied N,Damaj G,Tarte K,Fest T,Roussel M

更新日期：2016-08-25 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is a rare X-linked immunodeficiency with microthrombocytopenia, eczema, recurrent infections, autoimmune disorders, and malignancies that are life-threatening in the majority of patients. In this long-term, retrospective, multicenter study, we analyzed events that occurred in 96 WAS pati...

journal_title：Blood

authors： Ozsahin H,Cavazzana-Calvo M,Notarangelo LD,Schulz A,Thrasher AJ,Mazzolari E,Slatter MA,Le Deist F,Blanche S,Veys P,Fasth A,Bredius R,Sedlacek P,Wulffraat N,Ortega J,Heilmann C,O'Meara A,Wachowiak J,Kalwak K,Matthes-

更新日期：2008-01-01 00:00:00

abstract：:The Y chromosome encodes male-specific minor histocompatibility (H-Y) antigens that stimulate T- and B-lymphocyte responses after sex-mismatched allogeneic hematopoietic cell transplantation (HCT). A CD8(+) cytotoxic T lymphocyte (CTL) clone that recognizes a novel HLA-B*2705-restricted H-Y antigen encoded by the DDX3...

journal_title：Blood

authors： Rosinski KV,Fujii N,Mito JK,Koo KK,Xuereb SM,Sala-Torra O,Gibbs JS,Radich JP,Akatsuka Y,Van den Eynde BJ,Riddell SR,Warren EH

更新日期：2008-05-01 00:00:00

abstract：:Alternatively activated macrophages (AAMϕ) are a major component of the response to helminth infection; however, their functions remain poorly defined. To better understand the helminth-induced AAMϕ phenotype, we performed a systems-level analysis of in vivo derived AAMϕ using an established mouse model. With next-gen...

journal_title：Blood

authors： Thomas GD,Rückerl D,Maskrey BH,Whitfield PD,Blaxter ML,Allen JE

更新日期：2012-12-13 00:00:00

abstract：:Migration to lymph nodes and secretion of cytokines are critical functions of mature dendritic cells (DCs); however, these 2 functions are not necessarily linked. This is the first report showing that quantitative differences in identical signaling pathways determine DC migration and cytokine secretion. Using differen...

journal_title：Blood

authors： Luft T,Maraskovsky E,Schnurr M,Knebel K,Kirsch M,Görner M,Skoda R,Ho AD,Nawroth P,Bierhaus A

更新日期：2004-08-15 00:00:00

abstract：:Exposed subendothelial collagen acts as a substrate for platelet adhesion and thrombus formation after vascular injury. Synthetic collagen-derived triple-helical peptides, designated collagen-related peptide (CRP), GFOGER, and VWF-III, can specifically engage the platelet collagen receptors, glycoprotein VI and integr...

journal_title：Blood

authors： Pugh N,Simpson AM,Smethurst PA,de Groot PG,Raynal N,Farndale RW

更新日期：2010-06-17 00:00:00

abstract：:The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chronic oxidative DNA damage resulting in double-strand breaks (DSBs) in S and G(2)/M cell cycle phases. These lesions are rep...

journal_title：Blood

authors： Nowicki MO,Falinski R,Koptyra M,Slupianek A,Stoklosa T,Gloc E,Nieborowska-Skorska M,Blasiak J,Skorski T

更新日期：2004-12-01 00:00:00

abstract：:The presence of circulating tumor idiotype interferes with the in vivo effectiveness of anti-idiotype antibodies. We developed two assays that permit identification of patients with high levels of serum idiotype without the need for first producing an anti-idiotype antibody. A cell suspension made from the tumor was c...

journal_title：Blood

authors： Miller RA,Lowder JN,Gralow J,Meeker T,Levy R

更新日期：1987-04-01 00:00:00

abstract：:Anemia and neutropenia often develop in cats that are infected with the feline immunodeficiency virus (FIV), a lentivirus biologically similar to the human immunodeficiency virus (HIV). To assess the role of FIV in the pathogenesis of these abnormalities, marrow culture studies were performed on nine asymptomatic, hem...

journal_title：Blood

authors： Linenberger ML,Shelton GH,Persik MT,Abkowitz JL

更新日期：1991-10-15 00:00:00

abstract：:This study examines the role of neutrophils (PMN) in the pathogenesis of endotoxin-induced microclot formation. It is intended to clarify whether granulocytes are involved in endotoxin-induced activation of intravascular coagulation (generation of soluble fibrin) and/or in endotoxin-induced precipitation of soluble fi...

journal_title：Blood

authors： Müller-Berghaus G,Eckhardt T

更新日期：1975-05-01 00:00:00

abstract：:p15(INK4b) gene is an inhibitor of cyclin-dependent kinase (CDK) 4 and CDK6 whose expression is induced by transforming growth factor (TGF)beta. Recent reports suggest frequent methylation of the p15(INK4b) gene promoter in leukemias, and it has been proposed that this methylation could be necessary for leukemic cells...

journal_title：Blood

authors： Quesnel B,Guillerm G,Vereecque R,Wattel E,Preudhomme C,Bauters F,Vanrumbeke M,Fenaux P

更新日期：1998-04-15 00:00:00

abstract：:Nonresponse to remission-induction chemotherapy, which remains a major problem in acute myeloblastic leukemia (AML), has been linked to cellular resistance to apoptosis. Because the apoptosis induced by chemotherapeutic drugs is mediated by loss of mitochondrial transmembrane potential (MTP), it was postulated that se...

journal_title：Blood

authors： Pallis M,Grundy M,Turzanski J,Kofler R,Russell N

更新日期：2001-07-15 00:00:00

abstract：:Approximately 30% to 40% of patients with acute leukemia receiving repeated pooled random-donor platelet transfusions develop anti-HLA alloantibodies. Over time, however, serum anti-HLA concentrations decrease in approximately 50% of these patients, despite continued exposure to platelet and/or red blood cell transfus...

journal_title：Blood

authors： Atlas E,Freedman J,Blanchette V,Kazatchkine MD,Semple JW

更新日期：1993-01-15 00:00:00

abstract：:A 64-yr-old female developed acute myeloblastic leukemia following radiation and drug therapy for colon carcinoma. The patient was heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD) and displayed types A and B isoenzymes in nonhematopoietic tissue. In contrast, only type B G-6-PD was observed in peripheral bl...

journal_title：Blood

authors： Wiggans RG,Jacobson RJ,Fialkow PJ,Woolley PV 3rd,Macdonald JS,Schein PS

更新日期：1978-10-01 00:00:00

abstract：:Arsenic trioxide, as a single agent, has proven efficacy in inducing molecular remission in patients with acute promyelocytic leukemia (APL). There is limited long-term outcome data with single-agent As2O3 in the management of newly diagnosed cases of APL. Between January 1998 to December 2004, 72 newly diagnosed case...

journal_title：Blood

authors： Mathews V,George B,Lakshmi KM,Viswabandya A,Bajel A,Balasubramanian P,Shaji RV,Srivastava VM,Srivastava A,Chandy M

更新日期：2006-04-01 00:00:00

abstract：:Little is known about the molecular characteristics of alloantigens recognized by alloreactive T cells mediating hematologic stem cell graft rejection. In particular, it has never been shown that such alloantigens can be encoded by HLA-DP beta alleles. Indeed, matching for HLA-DP antigens is generally not considered t...

journal_title：Blood

authors： Fleischhauer K,Zino E,Mazzi B,Sironi E,Servida P,Zappone E,Benazzi E,Bordignon C

更新日期：2001-08-15 00:00:00

abstract：:To test the hypothesis that skeletal muscle myosins can directly influence blood coagulation and thrombosis, ex vivo studies of the effects of myosin on thrombogenesis in fresh human blood were conducted. Addition of myosin to blood augmented the thrombotic responses of human blood flowing over collagen-coated surface...

journal_title：Blood

authors： Deguchi H,Sinha RK,Marchese P,Ruggeri ZM,Zilberman-Rudenko J,McCarty OJT,Cohen MJ,Griffin JH

更新日期：2016-10-06 00:00:00

abstract：:Inflammatory responses represent a hallmark of numerous pathologies including sepsis, bacterial infection, insulin resistance, and malign obesity. Here we describe an unexpected coactivator function for the nuclear receptor interacting protein 140 (RIP140) for nuclear factor kappaB (NFkappaB), a master transcriptional...

journal_title：Blood

authors： Zschiedrich I,Hardeland U,Krones-Herzig A,Berriel Diaz M,Vegiopoulos A,Müggenburg J,Sombroek D,Hofmann TG,Zawatzky R,Yu X,Gretz N,Christian M,White R,Parker MG,Herzig S

更新日期：2008-07-15 00:00:00

abstract：:In B cells, expression of CIITA and resulting major histocompatibility complex II (MHCII) is mediated exclusively by promoter III (CIITA-PIII) activation. Recent studies have established that CIITA-PIII also participates in the expression of CIITA in activated human T cells, dendritic cells, and monocytes. In this stu...

journal_title：Blood

authors： van der Stoep N,Quinten E,Marcondes Rezende M,van den Elsen PJ

更新日期：2004-11-01 00:00:00

abstract：:We have verified the hypothesis that multiple myeloma (MM) may be disseminated by circulating clonogenic cells that selectively home to the bone marrow (BM) to receive the signal(s) leading to proliferation, terminal differentiation, and production of the osteoclast activating factors. Long-term cultures of stromal ce...

journal_title：Blood

authors： Caligaris-Cappio F,Bergui L,Gregoretti MG,Gaidano G,Gaboli M,Schena M,Zallone AZ,Marchisio PC

更新日期：1991-06-15 00:00:00

abstract：:Thirty-eight children between the ages of 0.8 and 17 years with acute nonlymphoblastic leukemia in first remission induced by chemotherapy were given cyclophosphamide, total body irradiation, and bone marrow transplants from HLA-matched donors. Six patients died of pneumonia, one died of metabolic problems, and one di...

journal_title：Blood

authors： Sanders JE,Thomas ED,Buckner CD,Flournoy N,Stewart PS,Clift RA,Lum L,Bensinger WI,Storb R,Appelbaum FR

更新日期：1985-08-01 00:00:00

abstract：:We show that lentiviral delivery of human gamma-globin gene under beta-globin regulatory control elements in hematopoietic stem cells (HSCs) results in sufficient postnatal fetal hemoglobin (HbF) expression to correct sickle cell anemia (SCA) in the Berkeley "humanized" sickle mouse. Upon de-escalating the amount of t...

journal_title：Blood

authors： Perumbeti A,Higashimoto T,Urbinati F,Franco R,Meiselman HJ,Witte D,Malik P

更新日期：2009-08-06 00:00:00

abstract：:Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We report the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of mavorixafor from a phase 2 open-label dose-escalatio...

journal_title：Blood

authors： Dale DC,Firkin F,Bolyard AA,Kelley M,Makaryan V,Gorelick KJ,Ebrahim T,Garg V,Tang W,Jiang H,Skerlj R,Beaussant Cohen S

更新日期：2020-12-24 00:00:00

abstract：:During innate immune responses, the inflammatory CC chemokine receptors CCR1, CCR2, and CCR5 mediate the recruitment of blood monocytes to infected tissues by promoting cell migration in response to chemokines CCL2-5. Toll-like receptors also play an essential role, allowing pathogen recognition by the recruited monoc...

journal_title：Blood

authors： Fox JM,Letellier E,Oliphant CJ,Signoret N

更新日期：2011-02-10 00:00:00

abstract：:Interleukin-13 (IL-13) induced a potent mitogenic response in IL-3-dependent TF-1 cells and DNA synthesis to a lesser extent in MO7E and FDC-P1 cells. IL-13 stimulation of these lines, like IL-4 and insulin-like growth factor-1 (IGF-1), resulted in tyrosine phosphorylation of a 170-kD substrate. The tyrosine-phosphory...

journal_title：Blood

authors： Wang LM,Michieli P,Lie WR,Liu F,Lee CC,Minty A,Sun XJ,Levine A,White MF,Pierce JH

更新日期：1995-12-01 00:00:00

abstract：:Activated platelets release their granule content in a concentrated fashion at sites of injury. We examined whether ectopically expressed factor VIII in developing megakaryocytes would be stored in alpha-granules and whether its release from circulating platelets would effectively ameliorate bleeding in a factor VIIIn...

journal_title：Blood

authors： Yarovoi HV,Kufrin D,Eslin DE,Thornton MA,Haberichter SL,Shi Q,Zhu H,Camire R,Fakharzadeh SS,Kowalska MA,Wilcox DA,Sachais BS,Montgomery RR,Poncz M

更新日期：2003-12-01 00:00:00

abstract：:Leukocyte adhesion deficiency type II (LADII) is a rare inherited disorder of fucose metabolism. Patients with LADII lack fucosylated glycoconjugates, including the carbohydrate ligands of the selectins, leading to an immunodeficiency caused by the lack of selectin-mediated leukocyte-endothelial interactions. A simple...

journal_title：Blood

authors： Lühn K,Marquardt T,Harms E,Vestweber D

更新日期：2001-01-01 00:00:00