Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer.

Abstract:

:A 64-yr-old female developed acute myeloblastic leukemia following radiation and drug therapy for colon carcinoma. The patient was heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD) and displayed types A and B isoenzymes in nonhematopoietic tissue. In contrast, only type B G-6-PD was observed in peripheral blood white cells. In addition, a karyotypic abnormality was found in peripheral blood and marrow cells but not in skin fibroblasts. The data are consistent with a clonal origin of this leukemia.

journal_name

Blood

journal_title

Blood

authors

Wiggans RG,Jacobson RJ,Fialkow PJ,Woolley PV 3rd,Macdonald JS,Schein PS

subject

Has Abstract

pub_date

1978-10-01 00:00:00

pages

659-63

issue

4

eissn

0006-4971

issn

1528-0020

journal_volume

52

pub_type

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