当前位置： SCI文献检索 > BLOOD期刊下所有文献 > The biology of nematode- and IL4Rα-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics.

The biology of nematode- and IL4Rα-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics.

Abstract：

:Alternatively activated macrophages (AAMϕ) are a major component of the response to helminth infection; however, their functions remain poorly defined. To better understand the helminth-induced AAMϕ phenotype, we performed a systems-level analysis of in vivo derived AAMϕ using an established mouse model. With next-generation RNA sequencing, we characterized the transcriptomes of peritoneal macrophages from BALB/c and IL4Rα(-/-) mice elicited by the nematode Brugia malayi, or via intraperitoneal thioglycollate injection. We defined expression profiles of AAMϕ-associated cytokines, chemokines, and their receptors, providing evidence that AAMϕ contribute toward recruitment and maintenance of eosinophilia. Pathway analysis highlighted complement as a potential AAMϕ-effector function. Up-regulated mitochondrial genes support in vitro evidence associating mitochondrial metabolism with alternative activation. We mapped macrophage transcription start sites, defining over-represented cis-regulatory motifs within AAMϕ-associated promoters. These included the binding site for PPAR transcription factors, which maintain mitochondrial metabolism. Surprisingly PPARγ, implicated in the maintenance of AAMϕ, was down-regulated on infection. PPARδ expression, however, was maintained. To explain how PPAR-mediated transcriptional activation could be maintained, we used lipidomics to quantify AAMϕ-derived eicosanoids, potential PPAR ligands. We identified the PPARδ ligand PGI(2) as the most abundant AAMϕ-derived eicosanoid and propose a PGI(2)-PPARδ axis maintains AAMϕ during B malayi implantation.

journal_name

Blood

journal_title

Blood

authors

Thomas GD,Rückerl D,Maskrey BH,Whitfield PD,Blaxter ML,Allen JE

doi

10.1182/blood-2012-07-442640

subject

Has Abstract

pub_date

2012-12-13 00:00:00

pages

e93-e104

issue

25

eissn

0006-4971

issn

1528-0020

pii

blood-2012-07-442640

journal_volume

120

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Aberrant and unstable expression of immunoglobulin genes in persons infected with human immunodeficiency virus.

    abstract：:We examined the IgM VH gene subgroup use-distribution in serial blood samples of 37 human immunodeficiency virus (HIV)-infected patients and a group of HIV-seronegative healthy adults. The IgM VH gene repertoires of healthy adults were relatively similar to one another and were stable over time. In contrast, individua...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bessudo A,Rassenti L,Havlir D,Richman D,Feigal E,Kipps TJ

    更新日期：1998-08-15 00:00:00

  • Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma.

    abstract：:Anaplastic large cell lymphoma (ALCL) is an aggressive lymphoma that is frequently associated with the t(2;5)(p23;q35), resulting in expression of a fusion protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), which can be detected by either monoclonal or polyclonal antibodies to the ALK protein. The clinical f...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Gascoyne RD,Aoun P,Wu D,Chhanabhai M,Skinnider BF,Greiner TC,Morris SW,Connors JM,Vose JM,Viswanatha DS,Coldman A,Weisenburger DD

    更新日期：1999-06-01 00:00:00

  • Expression of stem cell factor and c-kit in human neuroblastoma. The Children's Cancer Group.

    abstract：:During development, mice with mutations of stem cell factor (SCF) or its receptor c-kit exhibit defects in melanogenesis, as well as hematopoiesis and gonadogenesis. Because melanocytes derive from neural crest cells, the role of SCF and c-kit was investigated in the neural crest-derived childhood tumor neuroblastoma....

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Cohen PS,Chan JP,Lipkunskaya M,Biedler JL,Seeger RC

    更新日期：1994-11-15 00:00:00

  • Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents.

    abstract：:The response of human myeloid leukemia cells to treatment with 1-beta-arabinofuranosylcytosine (ara-C) includes the induction of apoptosis. Ara-C induced apoptosis is associated with proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and protein kinase C (PKC) delta. However, the signals involved in this respo...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Datta R,Banach D,Kojima H,Talanian RV,Alnemri ES,Wong WW,Kufe DW

    更新日期：1996-09-15 00:00:00

  • CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts.

    abstract：:Chemokines as well as the signaling through the adhesion molecules intercellular adhesion molecule (ICAM)-3 and CD43 are able to induce in T lymphocytes their switching from a spherical to a polarized motile morphology, with the formation of a uropod at the rear of the cell. We investigated here the role of CD43 in th...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Serrador JM,Nieto M,Alonso-Lebrero JL,del Pozo MA,Calvo J,Furthmayr H,Schwartz-Albiez R,Lozano F,González-Amaro R,Sánchez-Mateos P,Sánchez-Madrid F

    更新日期：1998-06-15 00:00:00

  • Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions.

    abstract：:Recently, we have identified scavenger receptor class A member I (SR-AI) as a receptor for coagulation factor X (FX), mediating the formation of an FX reservoir at the macrophage surface. Here, we demonstrate that the FX/SR-AI-complex comprises a third protein, pentraxin-2 (PTX2). The presence of PTX2 is essential to ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2016-06-724351

    authors： Muczynski V,Aymé G,Regnault V,Vasse M,Borgel D,Legendre P,Bazaa A,Harel A,Loubière C,Lenting PJ,Denis CV,Christophe OD

    更新日期：2017-04-27 00:00:00

  • 131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission.

    abstract：:In an attempt to improve outcomes for patients with acute myeloid leukemia (AML) after allogeneic hematopoietic cell transplantation (HCT), we conducted a phase 1/2 study in which targeted irradiation delivered by 131I-anti-CD45 antibody was combined with targeted busulfan (BU; area-under-curve, 600-900 ng/mL) and cyc...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-06-2317

    authors： Pagel JM,Appelbaum FR,Eary JF,Rajendran J,Fisher DR,Gooley T,Ruffner K,Nemecek E,Sickle E,Durack L,Carreras J,Horowitz MM,Press OW,Gopal AK,Martin PJ,Bernstein ID,Matthews DC

    更新日期：2006-03-01 00:00:00

  • Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing.

    abstract：:Many researchers have speculated that the clinical progression from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) is driven by defects in dendritic cell (DC) function. However, evidence supporting this assumption is controversial, and no mechanism for the putative DC dysfunction ha...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2015-01-623975

    authors： Leone P,Berardi S,Frassanito MA,Ria R,De Re V,Cicco S,Battaglia S,Ditonno P,Dammacco F,Vacca A,Racanelli V

    更新日期：2015-09-17 00:00:00

  • Human herpesvirus 6: infection and disease following autologous and allogeneic bone marrow transplantation.

    abstract：:Human herpesvirus 6 activity (HHV-6) was studied in 15 allogeneic and 11 autologous marrow transplantation patients. After transplantation, HHV-6 was isolated from the peripheral blood mononuclear cells of 12 of 26 patients (6 allogeneic and 6 autologous). All isolates were variant B. Eleven of 26 and 12 of 19 patient...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Kadakia MP,Rybka WB,Stewart JA,Patton JL,Stamey FR,Elsawy M,Pellett PE,Armstrong JA

    更新日期：1996-06-15 00:00:00

  • Immunophenotypic analysis of B cells in PNH: insights into the generation of circulating naive and memory B cells.

    abstract：:Peripheral blood B cells in patients with paroxysmal nocturnal hemoglobinuria (PNH) comprise variable mixtures of normal B cells produced before the onset of disease and glycosylphosphatidylinositol (GPI)-deficient B cells derived from the PNH hematopoietic stem cell. In a detailed phenotypic analysis of 29 patients w...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Richards SJ,Morgan GJ,Hillmen P

    更新日期：2000-11-15 00:00:00

  • Lymphocyte dysfunction in chronic graft-versus-host disease.

    abstract：:Three recipients of HLA-identical bone marrow transplants developed chronic graft-versus-host disease (cGVHD) and hypergammaglobulinemia. All three had evidence of abnormal B-lymphocyte function, including a polyclonal increase in immunoglobulins (Ig), antinuclear antibodies, rheumatoid factor, lymphocytotoxins, and i...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Saxon A,McIntyre RE,Stevens RH,Gale RP

    更新日期：1981-10-01 00:00:00

  • New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases.

    abstract：:A large number of alterations in genes encoding receptor tyrosine kinase (RTK), namely FLT3, c-KIT, platelet-derived growth factor (PDGF) receptors, fibroblast growth factor (FGF) receptors, and the anaplastic large cell lymphoma kinase (ALK), have been found in hematopoietic malignancies. They have drawn much attenti...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2010-04-279752

    authors： Toffalini F,Demoulin JB

    更新日期：2010-10-07 00:00:00

  • Intermittent, repetitive corticosteroid-induced upregulation of platelet levels after adenovirus-mediated transfer to the liver of a chimeric glucocorticoid-responsive promoter controlling the thrombopoietin cDNA.

    abstract：:For many in vivo gene therapy clinical applications, it is desirable to control the expression of the transferred transgene using pharmacologic agents. To evaluate the feasibility of accomplishing this using corticosteroids, pharmacologic agents widely used in clinical medicine, we constructed replication deficient ad...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Narumi K,Suzuki M,Song W,Moore MA,Crystal RG

    更新日期：1998-08-01 00:00:00

  • Plasmids in bacteria exposed to activated neutrophils mediate mutagenesis when transferred to new hosts.

    abstract：:The plasmid pUC18 contains a lacZ alpha-complementation gene that codes for a small peptide that can complement the delta M15 mutation of the Escherichia coli lacZ (beta-galactosidase) gene, converting bacteria carrying that mutated gene from the lacZ- to the lacZ+ phenotype. This plasmid was used in experiments desig...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： De Togni P,Fox HB,Morrissey S,Tansey LR,Levy SB,Babior BM

    更新日期：1988-02-01 00:00:00

  • Normal iron absorption and decreased red cell iron uptake in the aged.

    abstract：:Absorption of iron was studied with a double-isotope technique that allowed differentiation between "mucosal uptake," "mucosal transfer," and ultimate "retention" of iron. A physiologic dose of ferrous sulfate was administered to 25 healthy young adults, 40 active aged persons, and 20 patients with uncomplicated iron ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Marx JJ

    更新日期：1979-02-01 00:00:00

  • Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma.

    abstract：:Little is known about mechanisms involved in skin-specific homing of cutaneous T-cell lymphoma (CTCL). Chemokine/chemokine receptor interactions have been implicated in the homing of lymphoma cells to various tissue sites. We investigated tissue samples and tumor cell suspensions of patients with CD30(+) CTCL (n = 8) ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2002-02-0475

    authors： Kleinhans M,Tun-Kyi A,Gilliet M,Kadin ME,Dummer R,Burg G,Nestle FO

    更新日期：2003-02-15 00:00:00

  • von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy.

    abstract：:von Willebrand disease (VWD) is the most common autosomally inherited bleeding disorder. The disease represents a range of quantitative and qualitative pathologies of the adhesive glycoprotein von Willebrand factor (VWF). The pathogenic mechanisms responsible for the type 2 qualitative variants of VWF are now well cha...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2013-06-498303

    authors： Lillicrap D

    更新日期：2013-11-28 00:00:00

  • Use of alpha-2a-interferon to treat cytogenetic relapse of chronic myeloid leukemia after marrow transplantation.

    abstract：:Fourteen patients with cytogenetic relapse of chronic myeloid leukemia (CML) after transplantation with unmanipulated bone marrow were treated with alpha-2a-interferon. There were eight men and six women, median age, 33 years. Twelve patients received marrow from a related allogeneic donor and two received marrow from...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：

    authors： Higano CS,Chielens D,Raskind W,Bryant E,Flowers ME,Radich J,Clift R,Appelbaum F

    更新日期：1997-10-01 00:00:00

  • Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy.

    abstract：:Administration of lymphodepletion chemotherapy followed by CD19-specific chimeric antigen receptor (CAR)-modified T cells is a remarkably effective approach to treating patients with relapsed and refractory CD19(+) B-cell malignancies. We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring re...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2015-08-665547

    authors： Gardner R,Wu D,Cherian S,Fang M,Hanafi LA,Finney O,Smithers H,Jensen MC,Riddell SR,Maloney DG,Turtle CJ

    更新日期：2016-05-19 00:00:00

  • Molecular defects in hemophilia A: identification and characterization of mutations in the factor VIII gene and family analysis.

    abstract：:Hemophilia A is an X-linked bleeding disorder caused by a deficiency or abnormality of factor VIII, affecting approximately 1 male in 10,000. A subgroup of the patients develops inhibitors against factor VIII during substitution therapy. Because a considerable percentage of all cases is thought to result from de novo ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Higuchi M,Kochhan L,Schwaab R,Egli H,Brackmann HH,Horst J,Olek K

    更新日期：1989-08-15 00:00:00

  • Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors.

    abstract：:The morphologic, immunophenotypic, genotypic, genomic, and functional features of an undifferentiated acute leukemia with stem cell features are reported. At light and electron microscopy, the leukemic population was represented by primitive progenitor cells with no evidence of differentiation. The blasts were CD34(+)...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v99.12.4634

    authors： Testa U,Torelli GF,Riccioni R,Muta AO,Militi S,Annino L,Mariani G,Guarini A,Chiaretti S,Ritz J,Mandelli F,Peschle C,Foa R

    更新日期：2002-06-15 00:00:00

  • Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1.

    abstract：:The production of interleukin-1beta (IL-1beta), a powerful mediator of inflammation, is tightly regulated at several levels. However, in some pathologic conditions, a pharmacologic treatment is required to control the toxicity of excessive extracellular IL-1beta. Because of the heavy side effects of most therapies use...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Hamon Y,Luciani MF,Becq F,Verrier B,Rubartelli A,Chimini G

    更新日期：1997-10-15 00:00:00

  • Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut.

    abstract：:Increasing evidence indicates that the gut microbiota is closely associated with acute graft-versus-host disease (aGVHD) in stem cell transplantation (SCT). Fecal microbiota transplantation (FMT) could represent an alternative treatment option for aGVHD. However, FMT for SCT patients carries a potential risk of infect...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：10.1182/blood-2016-05-717652

    authors： Kakihana K,Fujioka Y,Suda W,Najima Y,Kuwata G,Sasajima S,Mimura I,Morita H,Sugiyama D,Nishikawa H,Hattori M,Hino Y,Ikegawa S,Yamamoto K,Toya T,Doki N,Koizumi K,Honda K,Ohashi K

    更新日期：2016-10-20 00:00:00

  • Inhibition of the intrinsic factor X activating complex by protein S: evidence for a specific binding of protein S to factor VIII.

    abstract：:Protein S is a vitamin K-dependent nonenzymatic anticoagulant protein that acts as a cofactor to activated protein C. Recently it was shown that protein S inhibits the prothrombinase reaction independent of activated protein C. In this study, we show that protein S can also inhibit the intrinsic factor X activation vi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Koppelman SJ,Hackeng TM,Sixma JJ,Bouma BN

    更新日期：1995-08-01 00:00:00

  • The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element.

    abstract：:Cellular interleukin 6 (IL-6) is an important growth factor for Kaposi sarcoma- associated herpesvirus (KSHV)-associated neoplasms, which include human immunodeficiency virus (HIV)-related and -unrelated cases of Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Increased ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v99.2.649

    authors： An J,Lichtenstein AK,Brent G,Rettig MB

    更新日期：2002-01-15 00:00:00

  • Comparison of in vitro growth characteristics of blast cell progenitors (CFU-L) in patients with myelodysplastic syndromes and acute myeloid leukemia.

    abstract：:Current knowledge is inadequate to explain the different patterns of blast cell accumulation in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We compared the growth patterns of blast cell progenitors (CFU-L) in 23 patients with advanced MDS and 32 patients with de novo AML. Circulating blast progen...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Aul C,Gattermann N,Schneider W

    更新日期：1992-08-01 00:00:00

  • Factor V Leiden: The Copenhagen City Heart Study and 2 meta-analyses.

    abstract：:Factor V Leiden (FVL) is associated with venous thrombosis; however, an association between FVL and arterial thrombosis remains controversial. We investigated FVL as a risk factor for myocardial infarction (MI), ischemic stroke (IS), or non-MI ischemic heart disease (non-MI-IHD). The design was 3 case-control studies ...

    journal_title：Blood

    pub_type： 杂志文章,meta分析

    doi：10.1182/blood-2002-01-0111

    authors： Juul K,Tybjaerg-Hansen A,Steffensen R,Kofoed S,Jensen G,Nordestgaard BG

    更新日期：2002-07-01 00:00:00

  • alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner.

    abstract：:To define the role of the alpha2beta1 integrin in pathologic angiogenesis, we investigated tumor-associated growth and angiogenesis in wild-type and alpha2-null mice. Our findings reveal that the alpha2beta1 integrin plays an important role in angiogenesis via regulation of VEGFR1 expression. When challenged with B16F...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2007-06-094680

    authors： Zhang Z,Ramirez NE,Yankeelov TE,Li Z,Ford LE,Qi Y,Pozzi A,Zutter MM

    更新日期：2008-02-15 00:00:00

  • Not fibrin(ogen), but fibrinogen or fibrin.

    abstract：:In this issue of Blood, Prasad et al describe a mouse model with a mutation in the Aα chain of fibrinogen such that no fibrin polymer is formed in vivo, allowing for the first time the differentiation of the role of fibrinogen vs fibrin oligomer or polymer in antimicrobial host defense and in hemostasis/thrombosis. ...

    journal_title：Blood

    pub_type： 评论,杂志文章

    doi：10.1182/blood-2015-08-662551

    authors： Litvinov RI,Weisel JW

    更新日期：2015-10-22 00:00:00

  • Reproductive capacity in iron overloaded women with thalassemia major.

    abstract：:The pathophysiology of iron-induced compromised fertility in women with thalassemia major (TM) was evaluated in 26 adult TM females. Low gonadotropin secretion resulted in reduced ovarian antral follicle count and ovarian volume, but levels of anti-müllerian hormone (AMH), a sensitive marker for ovarian reserve indepe...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2011-06-360271

    authors： Singer ST,Vichinsky EP,Gildengorin G,van Disseldorp J,Rosen M,Cedars MI

    更新日期：2011-09-08 00:00:00