New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases.

Abstract:

:A large number of alterations in genes encoding receptor tyrosine kinase (RTK), namely FLT3, c-KIT, platelet-derived growth factor (PDGF) receptors, fibroblast growth factor (FGF) receptors, and the anaplastic large cell lymphoma kinase (ALK), have been found in hematopoietic malignancies. They have drawn much attention after the development of tyrosine kinase inhibitors. RTK gene alterations include point mutations and gene fusions that result from chromosomal rearrangements. In both cases, they activate the kinase domain in the absence of ligand, producing a permanent signal for cell proliferation. Recently, this simple model has been refined. First, by contrast to wild-type RTK, many mutated RTK do not seem to signal from the plasma membrane, but from various locations inside the cell. Second, their signal transduction properties are altered: the pathways that are crucial for cell transformation, such as signal transducer and activator of transcription (STAT) factors, do not necessarily contribute to the physiologic functions of these receptors. Finally, different mechanisms prevent the termination of the signal, which normally occurs through receptor ubiquitination and degradation. Several mutations inactivating CBL, a key RTK E3 ubiquitin ligase, have been recently described. In this review, we discuss the possible links among RTK trafficking, signaling, and degradation in leukemic cells.

journal_name

Blood

journal_title

Blood

authors

Toffalini F,Demoulin JB

doi

10.1182/blood-2010-04-279752

subject

Has Abstract

pub_date

2010-10-07 00:00:00

pages

2429-37

issue

14

eissn

0006-4971

issn

1528-0020

pii

blood-2010-04-279752

journal_volume

116

pub_type

杂志文章,评审

相关文献

BLOOD文献大全
  • Oligodeoxynucleotide-mediated inhibition of c-myb gene expression in autografted bone marrow: a pilot study.

    abstract::Antisense oligodeoxynucleotide (ODN) drugs might be more effective if their delivery was optimized and they were targeted to short-lived proteins encoded by messenger RNA (mRNA) species with equally short half-lives. To test this hypothesis, an ODN targeted to the c-myb proto-oncogene was developed and used to purge m...

    journal_title:Blood

    pub_type: 临床试验,杂志文章

    doi:10.1182/blood.v99.4.1150

    authors: Luger SM,O'Brien SG,Ratajczak J,Ratajczak MZ,Mick R,Stadtmauer EA,Nowell PC,Goldman JM,Gewirtz AM

    更新日期:2002-02-15 00:00:00

  • Implications of discrepancy in morphologic diagnosis of myelodysplastic syndrome between referral and tertiary care centers.

    abstract::Patients referred to tertiary care centers occasionally may have their diagnostic procedures repeated and have a final diagnosis that differs from that of the referring center. The aim of this study was to evaluate discordance rates and their clinical implications in the diagnosis of patients with myelodysplastic synd...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-03-342642

    authors: Naqvi K,Jabbour E,Bueso-Ramos C,Pierce S,Borthakur G,Estrov Z,Ravandi F,Faderl S,Kantarjian H,Garcia-Manero G

    更新日期:2011-10-27 00:00:00

  • Fucose binding lectin for characterizing acute myeloid leukemia progenitor cells.

    abstract::The reactivity of acute myeloid leukemia cells (AML) was determined in 29 patients using the fucose binding lectin Ulex europaeus agglutinin (UEA) as surface marker. We show a marked heterogeneity in the UEA-binding abilities of the cells in these patients as determined by fluorescence analysis of the blasts labeled w...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Delwel R,Touw I,Bot F,Löwenberg B

    更新日期:1986-07-01 00:00:00

  • A case of paroxysmal nocturnal hemoglobinuria caused by a germline mutation and a somatic mutation in PIGT.

    abstract::To ascertain the genetic basis of a paroxysmal nocturnal hemoglobinuria (PNH) case without somatic mutations in PIGA, we performed deep next-generation sequencing on all exons of known genes of the glycosylphosphatidylinositol (GPI) anchor synthesis pathway. We identified a heterozygous germline splice site mutation i...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2013-01-481499

    authors: Krawitz PM,Höchsmann B,Murakami Y,Teubner B,Krüger U,Klopocki E,Neitzel H,Hoellein A,Schneider C,Parkhomchuk D,Hecht J,Robinson PN,Mundlos S,Kinoshita T,Schrezenmeier H

    更新日期:2013-08-15 00:00:00

  • Iron incorporation into ferritin and hemoglobin during differentiation of murine erythroleukemia cells.

    abstract::Hemoglobin and ferritin iron content have been followed during differentiation in tissue cultures of murine erythroleukemia cells (MELC) using the techniques of Mössbauer spectroscopy and electron microscopy. In undifferentiated cells grown without DMSO, only iron stored in ferritin was detected. The amount of iron in...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Ofer S,Fibach E,Kessel M,Bauminger ER,Cohen SG,Eikelboom J,Rachmilewitz EA

    更新日期:1981-08-01 00:00:00

  • How I treat postthrombotic syndrome.

    abstract::Postthrombotic syndrome (PTS) is a chronic complication of deep venous thrombosis (DVT) that reduces quality of life and has important socioeconomic consequences. More than one-third of patients with DVT will develop PTS, and 5% to 10% of patients will develop severe PTS, which may manifest as venous ulceration. The p...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2009-07-199174

    authors: Kahn SR

    更新日期:2009-11-19 00:00:00

  • Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia.

    abstract::Antibodies play a fundamental role in diagnostic immunophenotyping of leukemias and in cell-targeting therapy. However, this versatility is not reflected in imaging diagnostics. In the present study, we labeled anti–human mAbs monochromatically against selected human myeloid markers expressed on acute myeloid leukemia...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2012-05-429555

    authors: McCormack E,Mujić M,Osdal T,Bruserud Ø,Gjertsen BT

    更新日期:2013-02-14 00:00:00

  • Hematopoietic stem cell transplantation for de novo erythroleukemia: a study of the European Group for Blood and Marrow Transplantation (EBMT).

    abstract::De novo erythroleukemia (EL) is a rare disease. Reported median survival are poor and vary from 4 to 14 months. The value of hematopoietic stem cell transplantation (HSCT) for EL is unknown. This EBMT registry study reports on the largest series of patients with EL treated with HSCT in first complete remission-103 aut...

    journal_title:Blood

    pub_type: 杂志文章,多中心研究

    doi:10.1182/blood.V100.9.3135

    authors: Fouillard L,Labopin M,Gorin NC,Polge E,Prentice HG,Meloni G,Reiffers J,Pigneux A,Willemze R,Schattenberg A,Sica S,Lagrange M,Fenneteau O,Perot C,Frassoni F,Acute Leukemia Working Party of the EBMT.

    更新日期:2002-11-01 00:00:00

  • Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation.

    abstract::Macrophages as inflammatory cells are involved in the pathogenesis of atherosclerosis that today is recognized as an inflammatory disease. Activation of coagulation leads to the late complication of atherosclerosis, namely atherothrombosis with its clinical manifestations stroke, unstable angina, myocardial infarction...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-01-200915

    authors: Kastl SP,Speidl WS,Katsaros KM,Kaun C,Rega G,Assadian A,Hagmueller GW,Hoeth M,de Martin R,Ma Y,Maurer G,Huber K,Wojta J

    更新日期:2009-09-24 00:00:00

  • Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments.

    abstract::The mutant tg/tg mice, which do not express mi transcription factor (MITF), lack mast cells in most tissues. Since MITF is expressed in both mast cells and tissues where mast cells develop, there is a possibility that the tg/tg mice may show abnormalities in both mast cell precursors and tissue environments. We examin...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-01-0247

    authors: Morii E,Oboki K,Ishihara K,Jippo T,Hirano T,Kitamura Y

    更新日期:2004-09-15 00:00:00

  • Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission.

    abstract::We used the polymerase chain reaction (PCR) to detect ALL1-AF4 rearrangements, the molecular hallmark of t(4;11) in a series of 46 pre-pre-B (CD19+, CD24+, CD10/CD20/cylgM/sIgM-) acute lymphoblastic leukemias (ALL). Eighteen patients (39%) exhibited fusion transcripts including 4 of 12 children and 14 of 34 adults. Th...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Janssen JW,Ludwig WD,Borkhardt A,Spadinger U,Rieder H,Fonatsch C,Hossfeld DK,Harbott J,Schulz AS,Repp R

    更新日期:1994-12-01 00:00:00

  • Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia.

    abstract::Eph receptors and their ephrin ligands are involved in normal hematopoietic development and tumorigenesis. Using methylated CpG island amplification/DNA promoter microarray, we identified several EPH receptor and EPHRIN genes as potential hypermethylation targets in acute lymphoblastic leukemia (ALL). We subsequently ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-05-222208

    authors: Kuang SQ,Bai H,Fang ZH,Lopez G,Yang H,Tong W,Wang ZZ,Garcia-Manero G

    更新日期:2010-03-25 00:00:00

  • T cell chronic lymphocytic leukemia with lymphocytes of unusual immunologic phenotype and function.

    abstract::This report discusses a case of T cell chronic lymphocytic leukemia (T-CLL) in an elderly white man whose lymphocytes expressed a post-thymic phenotype except for the coexpression of T4 and T8 on 80% to 95% of the cells. Because of the uncommon phenotype, in vitro functional assays were performed that showed decreased...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Simpkins H,Kiprov DD,Davis JL 3rd,Morand P,Puri S,Grahn EP

    更新日期:1985-01-01 00:00:00

  • Association of an interleukin abnormality with the T cell defect in Hodgkin's disease.

    abstract::The cellular immune defect in untreated Hodgkin's disease (HD) has long been recognized. This defect appears to be responsible for at least some of the morbidity and ultimately the mortality associated with the disease. In recent years, many studies have shown that the T cell component of the immune response is the ap...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Ford RJ,Tsao J,Kouttab NM,Sahasrabuddhe CG,Mehta SR

    更新日期:1984-08-01 00:00:00

  • Hodgkin disease: pharmacologic intervention of the CD40-NF kappa B pathway by a protease inhibitor.

    abstract::The malignant Reed-Sternberg cell of Hodgkin disease is an aberrant B cell that persists in an immunolgically mediated inflammatory infiltrate. Despite its nonproductive immunoglobulin genes, the Reed-Sternberg cell avoids the usual apoptotic fate of defective immune cells through an unknown mechanism. A likely candid...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Annunziata CM,Safiran YJ,Irving SG,Kasid UN,Cossman J

    更新日期:2000-10-15 00:00:00

  • Increased calcium permeability of cold-stored erythrocytes.

    abstract::The calcium, sodium, and magnesium permeability of erythrocytes from blood stored at 4 degrees C in various anticoagulant media has been studied and compared to that of fresh erythrocytes. Passive influx of CA2+ was measured at 37 degrees C in cells pretreated to abolish Ca2+ pumping and was up to fivefold greater for...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Wiley JS,McCulloch KE,Bowden DS

    更新日期:1982-07-01 00:00:00

  • Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients.

    abstract::Fifty-eight acute promyelocytic leukemia (APL) patients (11 newly diagnosed and 47 relapsed) were studied for arsenic trioxide (As2O3) treatment. Clinical complete remission (CR) was obtained in 8 of 11 (72.7%) newly diagnosed cases. However, As2O3 treatment resulted in hepatic toxicity in 7 cases including 2 deaths, ...

    journal_title:Blood

    pub_type: 临床试验,杂志文章

    doi:

    authors: Niu C,Yan H,Yu T,Sun HP,Liu JX,Li XS,Wu W,Zhang FQ,Chen Y,Zhou L,Li JM,Zeng XY,Yang RR,Yuan MM,Ren MY,Gu FY,Cao Q,Gu BW,Su XY,Chen GQ,Xiong SM,Zhang TD,Waxman S,Wang ZY,Chen Z,Hu J,Shen ZX,Chen SJ

    更新日期:1999-11-15 00:00:00

  • Treatment of hairy cell leukemia with recombinant alpha interferon: II. In vivo down-regulation of alpha interferon receptors on tumor cells.

    abstract::Interferons (IFNs) initiate their effects by interacting with specific high-affinity cell surface receptors, but little is known about the physiology of IFN receptor interaction in vivo. Treatment of patients suffering from hairy cell leukemia (HCL) with human recombinant alpha IFN results in significant tumor regress...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Billard C,Sigaux F,Castaigne S,Valensi F,Flandrin G,Degos L,Falcoff E,Aguet M

    更新日期:1986-03-01 00:00:00

  • Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cells.

    abstract::Natural killer (NK) cells contribute to host immunity, including tumor surveillance, through the production of interferon gamma (IFN-gamma). Although there is some knowledge about molecular mechanisms that induce IFN-gamma in NK cells, considerably less is known about the mechanisms that reduce its expression. Here, w...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2006-10-050096

    authors: Becknell B,Hughes TL,Freud AG,Blaser BW,Yu J,Trotta R,Mao HC,Caligiuri de Jesús ML,Alghothani M,Benson DM Jr,Lehman A,Jarjoura D,Perrotti D,Bates MD,Caligiuri MA

    更新日期:2007-03-15 00:00:00

  • In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm.

    abstract::In essential thrombocythemia (ET), the JAK2-V617F mutation is usually restricted to a subpopulation of neutrophils and platelets, and production of JAK2 wild-type (WT) platelets is not suppressed. Nonmutated precursor cells may, therefore, be susceptible to the acquisition of further JAK2 mutations. We used a common s...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-03-209916

    authors: Lambert JR,Everington T,Linch DC,Gale RE

    更新日期:2009-10-01 00:00:00

  • Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression.

    abstract::Recent data suggest that CD8+ T-cell effector activity is an important component in the control of HIV replication in elite controllers (ECs). One critical element of CD8+ T-cell effector function and differentiation is the T-box transcription factor T-bet. In the present study, we assessed T-bet expression, together ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-12-322727

    authors: Hersperger AR,Martin JN,Shin LY,Sheth PM,Kovacs CM,Cosma GL,Makedonas G,Pereyra F,Walker BD,Kaul R,Deeks SG,Betts MR

    更新日期:2011-04-07 00:00:00

  • Mucosal iron transport by rat intestine.

    abstract::Using highly sensitive 2-site immunoradiometric assays, we examined the relationship between iron absorption from closed intestinal loops and transferrin and ferritin concentrations in isolated duodenal mucosal cells. As in prior studies, mucosal ferritin correlates inversely with iron absorption and directly with bod...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Savin MA,Cook JD

    更新日期:1980-12-01 00:00:00

  • The microenvironment in mature B-cell malignancies: a target for new treatment strategies.

    abstract::Despite major therapeutic advances, most mature B-cell malignancies remain incurable. Compelling evidence suggests that crosstalk with accessory stromal cells in specialized tissue microenvironments, such as the bone marrow and secondary lymphoid organs, favors disease progression by promoting malignant B-cell growth ...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2009-06-225326

    authors: Burger JA,Ghia P,Rosenwald A,Caligaris-Cappio F

    更新日期:2009-10-15 00:00:00

  • Ferritin iron absorption in man.

    abstract::The iron absorption from ferritin and hemosiderin biosynthetically labeled with radioiron was studied in 108 subjects. The geometric mean absorption of ferritin iron in both normal and iron-deficient subjects was 1.9 percent. Its mean absorption ranged from 0.9 percent in normal subjects to 2.5 percent in subjects wit...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Layrisse M,Martínez-Torres C,Renzy M,Leets I

    更新日期:1975-05-01 00:00:00

  • Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis.

    abstract::p27 is a cyclin-dependent kinase inhibitor that plays a critical role in regulating G(1)/S progression, and whose activity is, in part, regulated through interactions with D-type cyclins. Mantle cell lymphoma (MCL) is characterized by the t(11;14) translocation resulting in deregulated cyclin D1. We previously showed ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-01-0263

    authors: Quintanilla-Martinez L,Davies-Hill T,Fend F,Calzada-Wack J,Sorbara L,Campo E,Jaffe ES,Raffeld M

    更新日期:2003-04-15 00:00:00

  • Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension.

    abstract::Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial dysfunction and vascular remodeling. Recently, bone marrow progenitor cells have been localized to PAH lungs, raising the question of their role in disease progression. Independently, serotonin (5-HT) and its receptors hav...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-06-358374

    authors: Launay JM,Hervé P,Callebert J,Mallat Z,Collet C,Doly S,Belmer A,Diaz SL,Hatia S,Côté F,Humbert M,Maroteaux L

    更新日期:2012-02-16 00:00:00

  • Cyclophosphamide, fludarabine, alemtuzumab, and rituximab as salvage therapy for heavily pretreated patients with chronic lymphocytic leukemia.

    abstract::Patients with relapsed chronic lymphocytic leukemia (CLL) and high-risk features, such as fludarabine refractoriness, complex karyotype, or abnormalities of chromosome 17p, experience poor outcomes after standard fludaradine-based regimens. Alemtuzumab is a chimeric CD52 monoclonal antibody with activity in CLL patien...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-03-341032

    authors: Badoux XC,Keating MJ,Wang X,O'Brien SM,Ferrajoli A,Faderl S,Burger J,Koller C,Lerner S,Kantarjian H,Wierda WG

    更新日期:2011-08-25 00:00:00

  • A murine stromal cell line allows the proliferation of very primitive human CD34++/CD38- progenitor cells in long-term cultures and semisolid assays.

    abstract::Analysis of molecular mechanisms associated with stem cell commitment and differentiation requires an in vitro assay that identifies the most primitive hematopoietic stem cells in human bone marrow. Such primitive stem cells usually do not form colonies in short-term semisolid assays and are best identified by their a...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Issaad C,Croisille L,Katz A,Vainchenker W,Coulombel L

    更新日期:1993-06-01 00:00:00

  • Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro.

    abstract::Leukocyte transendothelial migration (TEM) is a critical event during inflammation. CD47 has been implicated in myeloid cell migration across endothelium and epithelium. CD47 binds to signal regulatory protein (SIRP), SIRPalpha and SIRPgamma. So far, little is known about the role of endothelial CD47 in T-cell TEM in ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-01-134429

    authors: Stefanidakis M,Newton G,Lee WY,Parkos CA,Luscinskas FW

    更新日期:2008-08-15 00:00:00

  • Structural requirements of platelet chemokines for neutrophil activation.

    abstract::Using recombinantly expressed proteins and synthetic peptides, we examined the structural/functional features of the platelet chemokines, neutrophil-activating peptide-2 (NAP-2) and platelet factor 4 (PF4); that were important in their activation of neutrophils. Previous studies with the chemokine interleukin-8 (IL-8)...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Yan Z,Zhang J,Holt JC,Stewart GJ,Niewiarowski S,Poncz M

    更新日期:1994-10-01 00:00:00