'Role of bone marrow stromal cells in the growth of human multiple myeloma.

Abstract:

:We have verified the hypothesis that multiple myeloma (MM) may be disseminated by circulating clonogenic cells that selectively home to the bone marrow (BM) to receive the signal(s) leading to proliferation, terminal differentiation, and production of the osteoclast activating factors. Long-term cultures of stromal cells have been developed from the BM of nine patients with MM. These cells were mostly fibroblast-like elements, interspersed with a proportion of scattered macrophages and rare osteoclasts. BM stromal cells were CD54+, produced high levels of interleukin-6 (IL-6) and measurable amounts of IL-1 beta, and were used as feeder layers for autologous peripheral blood mononuclear cells (PBMC). After 3 weeks of cocultures, monoclonal B lymphocytes and plasma cells, derived from PBMC, developed and the number of osteoclasts significantly increased. Both populations grew tightly adherent to the stromal cell layer and their expansion was matched by a sharp increase of IL-6 and by the appearance of IL-3 in the culture supernatant. These data attribute to BM stromal cells a critical role in supporting the growth of B lymphocytes, plasma cells, and osteoclasts and the in vivo dissemination of MM.

journal_name

Blood

journal_title

Blood

authors

Caligaris-Cappio F,Bergui L,Gregoretti MG,Gaidano G,Gaboli M,Schena M,Zallone AZ,Marchisio PC

subject

Has Abstract

pub_date

1991-06-15 00:00:00

pages

2688-93

issue

12

eissn

0006-4971

issn

1528-0020

journal_volume

77

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Allogeneic transplantation of CD34(+) selected cells from peripheral blood from human leukocyte antigen-identical siblings: detrimental effect of a high number of donor CD34(+) cells?

    abstract::Clinical results after T-cell-depleted allografts might be improved by modifying the graft content of progenitor and accessory cells. Although the association of the number of donor T cells with the clinical outcome has been studied extensively, the optimum number of progenitor cells that should be administered to pat...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v98.8.2352

    authors: Urbano-Ispizua A,Carreras E,Marín P,Rovira M,Martínez C,Fernández-Avilés F,Xicoy B,Hernández-Boluda JC,Montserrat E

    更新日期:2001-10-15 00:00:00

  • Role of light chain variable region in myeloma with light chain deposition disease: evidence from an experimental model.

    abstract::Light chain deposition disease (LCDD) results from a propensity of some human monoclonal L chains to form tissue deposits. We designed an experimental model for in vivo expression of human kappa L chain sequences in mice and compared a somatically mutated LCDD chain with a closely related control kappa chain, both enc...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Khamlichi AA,Rocca A,Touchard G,Aucouturier P,Preud'homme JL,Cogné M

    更新日期:1995-11-15 00:00:00

  • Pathologic effects of plasma from patients with thrombotic thrombocytopenic purpura on platelets and cultured vascular endothelial cells.

    abstract::The pathologic hallmarks of thrombotic thrombocytopenic purpura (TTP) include endothelial cell proliferation and subendothelial hyalin deposits in the microvasculature leading to symptomatic thrombotic occlusions. Plasma or sera from three consecutive patients with TTP were subjected to multiple analyses to determine ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Burns ER,Zucker-Franklin D

    更新日期:1982-10-01 00:00:00

  • Human CD8+ T cells store CXCR1 in a distinct intracellular compartment and up-regulate it rapidly to the cell surface upon activation.

    abstract::Activation and subsequent differentiation of naive CD8+ T cells lead to the development of memory subsets with distinct homing and effector capacities. On nonlymphoid homing subsets, expression of "inflammatory" chemokine receptors (such as CXCR3, CCR5, CX3CR1, and CXCR1) is believed to promote migration into sites of...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2005-04-1366

    authors: Gasser O,Missiou A,Eken C,Hess C

    更新日期:2005-12-01 00:00:00

  • A site involving the "hybrid" and PSI homology domains of GPIIIa (beta 3-integrin subunit) is a common target for antibodies associated with quinine-induced immune thrombocytopenia.

    abstract::Drug-dependent antibodies (DDAbs) can cause the precipitous destruction of platelets if a patient is exposed to the drug for which the antibodies are specific. The molecular character of the epitopes recognized is poorly understood, and the mechanism by which drugs promote tight binding of these antibodies to platelet...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-07-2336

    authors: Peterson JA,Nyree CE,Newman PJ,Aster RH

    更新日期:2003-02-01 00:00:00

  • iNKT and memory B-cell alterations in HHV-8 multicentric Castleman disease.

    abstract::Human herpesvirus 8 (HHV-8) is the causative agent of Kaposi sarcoma (KS) and multicentric Castleman disease (MCD), a life-threatening, virally induced B-cell lymphoproliferative disorder. HHV-8 is a B-lymphotropic γ-herpesvirus closely related to the Epstein-Barr virus (EBV). Invariant natural killer T (iNKT) cells a...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2016-06-719716

    authors: Sbihi Z,Dossier A,Boutboul D,Galicier L,Parizot C,Emarre A,Hoareau B,Dupin N,Marcelin AG,Oudin A,Fieschi C,Agbalika F,Autran B,Oksenhendler E,Carcelain G

    更新日期:2017-02-16 00:00:00

  • Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines.

    abstract::Induced pluripotent stem cells (iPSCs) hold great promise for modeling human hematopoietic diseases. However, intrinsic variability in the capacities of different iPSC lines for hematopoietic development complicates comparative studies and is currently unexplained. We created and analyzed 3 separate iPSC clones from f...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2013-02-484444

    authors: Mills JA,Wang K,Paluru P,Ying L,Lu L,Galvão AM,Xu D,Yao Y,Sullivan SK,Sullivan LM,Mac H,Omari A,Jean JC,Shen S,Gower A,Spira A,Mostoslavsky G,Kotton DN,French DL,Weiss MJ,Gadue P

    更新日期:2013-09-19 00:00:00

  • Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.

    abstract::Plasminogen activation rates are enhanced by cell surface binding. We previously demonstrated that exogenous plasminogen binds to phosphatidylserine-exposing and spread platelets. Platelets contain plasminogen in their α-granules, but secretion of plasminogen from platelets has not been studied. Recently, a novel tran...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.2020007263

    authors: Whyte CS,Morrow GB,Baik N,Booth NA,Jalal MM,Parmer RJ,Miles LA,Mutch NJ

    更新日期:2021-01-14 00:00:00

  • Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease.

    abstract::Graft-versus-host disease (GVHD), a life-threatening complication after allogeneic hematopoietic stem cell transplantation, is caused by alloreactive donor T cells that trigger host tissue damage. The inflammatory environment inside recipients is critical for GVHD pathogenesis, but the underpinning mechanisms remain e...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-04-281659

    authors: Zhao F,Zhang Y,Wang H,Jin M,He S,Shi Y,Guo Y,Zhang Y

    更新日期:2011-02-03 00:00:00

  • Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist.

    abstract::The human interleukin-3 receptor (IL-3R) is expressed on myeloid, lymphoid, and vascular endothelial cells, where it transduces IL-3-dependent signals leading to cell activation. Although IL-3R activation may play a role in hematopoiesis and immunity, its aberrant expression or excessive stimulation may contribute to ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Sun Q,Woodcock JM,Rapoport A,Stomski FC,Korpelainen EI,Bagley CJ,Goodall GJ,Smith WB,Gamble JR,Vadas MA,Lopez AF

    更新日期:1996-01-01 00:00:00

  • Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells.

    abstract::Granulocyte colony-stimulating factor (G-CSF) may affect T-cell homeostasis by multiple mechanisms, inducing polarization of cytokine secretion, inhibition of T-cell proliferation, and enhancement of T-cell apoptosis. We analyzed the production of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1)...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2001-12-0291

    authors: Rutella S,Pierelli L,Bonanno G,Sica S,Ameglio F,Capoluongo E,Mariotti A,Scambia G,d'Onofrio G,Leone G

    更新日期:2002-10-01 00:00:00

  • Demonstration of reversible priming of human neutrophils using platelet-activating factor.

    abstract::Exposure of neutrophils to agents such as lipopolysaccharide, tumor necrosis factor-alpha (TNF-alpha), and the granulocyte-macrophage colony-stimulating factor causes a major upregulation of subsequent agonist-induced NADPH oxidase activation. This priming effect is a prerequisite for neutrophil-mediated tissue damage...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Kitchen E,Rossi AG,Condliffe AM,Haslett C,Chilvers ER

    更新日期:1996-12-01 00:00:00

  • Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU.

    abstract::Human bone marrow (BM) cells contain low levels of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, which may explain their susceptibility to nitrosourea-induced cytotoxicity and the development of secondary leukemia after nitrosourea treatment. Isolated CD34+ myeloid progenitors were also found to have l...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Gerson SL,Phillips W,Kastan M,Dumenco LL,Donovan C

    更新日期:1996-09-01 00:00:00

  • Deficiency in the A-subunit of coagulation factor XIII: two novel point mutations demonstrate different effects on transcript levels.

    abstract::Congenital deficiency in coagulation factor XIII is a rare autosomal recessive bleeding disorder. Although the defect was characterized over 30 years ago, little is known about the molecular basis of the disorder. Here, we show two novel point mutations in the gene of the A-subunit of factor XIII in the genetically is...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Mikkola H,Syrjälä M,Rasi V,Vahtera E,Hämäläinen E,Peltonen L,Palotie A

    更新日期:1994-07-15 00:00:00

  • Excessive fluid accumulation during stem cell mobilization: a novel prognostic factor of first-year survival after stem cell transplantation in AL amyloidosis patients.

    abstract::High-dose melphalan followed by stem cell transplantation (HDM-SCT) has become the treatment of choice for patients with immunoglobulin light chain amyloidosis (AL). Unfortunately, treatment mortality can be excessive in certain subpopulations. We have noted that patients who gained more than 2% body weight during mob...

    journal_title:Blood

    pub_type: 临床试验,杂志文章

    doi:10.1182/blood-2005-03-1206

    authors: Leung N,Leung TR,Cha SS,Dispenzieri A,Lacy MQ,Gertz MA

    更新日期:2005-11-15 00:00:00

  • HIV-1 reprograms the migration of macrophages.

    abstract::Macrophages are motile leukocytes, targeted by HIV-1, thought to play a critical role in host dissemination of the virus. However, whether infection impacts their migration capacity remains unknown. We show that 2-dimensional migration and the 3-dimensional (3D) amoeboid migration mode of HIV-1-infected human monocyte...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2014-08-596775

    authors: Vérollet C,Souriant S,Bonnaud E,Jolicoeur P,Raynaud-Messina B,Kinnaer C,Fourquaux I,Imle A,Benichou S,Fackler OT,Poincloux R,Maridonneau-Parini I

    更新日期:2015-03-05 00:00:00

  • Hydroxyurea in the management of the hematologic complications of chronic granulocytic leukemia.

    abstract::The effect of hydroxyurea in 35 patients with chronic granulocytic leukemia (CGL), who either had entered an accelerated phase of the disease or had experienced excessive myelosuppression following alkylating agents, was studied. By either intravenous or oral administration, the drug was successful in reducing periphe...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Schwartz JH,Cannellos GP

    更新日期:1975-07-01 00:00:00

  • SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity.

    abstract::Tumors have several mechanisms to escape from the immune system. One of these involves expression of intracellular anticytotoxic proteins that modulate the execution of cell death. Previously, we have shown that the serine protease inhibitor (serpin) SPI-6, which inactivates the cytotoxic protease granzyme B (GrB), is...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-03-0791

    authors: Bots M,Kolfschoten IG,Bres SA,Rademaker MT,de Roo GM,Krüse M,Franken KL,Hahne M,Froelich CJ,Melief CJ,Offringa R,Medema JP

    更新日期:2005-02-01 00:00:00

  • Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response.

    abstract::Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognized variability in clinical outcome, genetic features, and cells of origin. To date, transcriptional profiling has been used to highlight similarities between DLBCL tumor cells and normal B-cell subtypes and associate genes and pathways with ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-07-2947

    authors: Monti S,Savage KJ,Kutok JL,Feuerhake F,Kurtin P,Mihm M,Wu B,Pasqualucci L,Neuberg D,Aguiar RC,Dal Cin P,Ladd C,Pinkus GS,Salles G,Harris NL,Dalla-Favera R,Habermann TM,Aster JC,Golub TR,Shipp MA

    更新日期:2005-03-01 00:00:00

  • Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB.

    abstract::Most bone marrow (BM) malignancies develop in association with an angiogenic phenotype and increased numbers of endothelial cells. The molecular mechanisms involved in the modulation and recruitment of BM endothelium are largely unknown and may provide novel therapeutic targets for neoplastic diseases. We observed tha...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2005-06-2208

    authors: Costa LF,Balcells M,Edelman ER,Nadler LM,Cardoso AA

    更新日期:2006-01-01 00:00:00

  • Thrombosis in the setting of obesity or inflammatory bowel disease.

    abstract::Obesity and inflammatory bowel disease (IBD) are systemic inflammatory disorders that predispose to arterial and venous thrombosis through similar prothrombotic mechanisms. Obesity and IBD are chronic risk factors that lead to a persistently elevated risk of thrombosis, although the thrombotic risk with IBD appears to...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2016-05-716720

    authors: Lentz SR

    更新日期:2016-11-17 00:00:00

  • Magnetic resonance imaging for diagnosis of recurrent ipsilateral deep vein thrombosis.

    abstract::The diagnosis of recurrent ipsilateral deep vein thrombosis (DVT) is challenging, because persistent intravascular abnormalities after previous DVT often hinder a diagnosis by compression ultrasonography. Magnetic resonance direct thrombus imaging (MRDTI), a technique without intravenous contrast and with a 10-minute ...

    journal_title:Blood

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1182/blood.2019004114

    authors: van Dam LF,Dronkers CEA,Gautam G,Eckerbom Å,Ghanima W,Gleditsch J,von Heijne A,Hofstee HMA,Hovens MMC,Huisman MV,Kolman S,Mairuhu ATA,Nijkeuter M,van de Ree MA,van Rooden CJ,Westerbeek RE,Westerink J,Westerlund E,Krof

    更新日期:2020-04-16 00:00:00

  • Induction of mixed erythroid-megakaryocyte colonies and bipotential blast cell colonies by recombinant human erythropoietin in serum-free culture.

    abstract::The effects of recombinant human erythropoietin (rEp) on murine hematopoietic progenitors were studied using a serum-free culture. A high concentration of rEp stimulated the formation of mixed erythroid-megakaryocyte colonies (EM colonies) and blast cell colonies, as well as erythroid colonies, erythroid bursts, and m...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Nishi N,Nakahata T,Koike K,Takagi M,Naganuma K,Akabane T

    更新日期:1990-10-01 00:00:00

  • 5-lipoxygenase expression in dendritic cells generated from CD34(+) hematopoietic progenitors and in lymphoid organs.

    abstract::The 5-lipoxygenase (5-LO) pathway in human CD34(+) hematopoietic progenitor cells, which were induced to differentiate into dendritic cells (DCs) by cytokines in vitro and in DCs of lymphoid tissues in situ, was examined. Extracts prepared from HPCs contained low levels of 5-LO or 5-LO-activating protein. Granulocyte-...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Spanbroek R,Hildner M,Steinhilber D,Fusenig N,Yoneda K,Rådmark O,Samuelsson B,Habenicht AJ

    更新日期:2000-12-01 00:00:00

  • The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium.

    abstract::The CC chemokine receptor 8 (CCR8) is expressed on monocytes and type 2 T lymphocytes. CCR8 is the sole receptor for the human CC chemokine I-309, as well as for viral monocyte inflammatory protein-I (vMIP-I), a human chemokine homologue induced in human cells by the Kaposi sarcoma-related human herpesvirus-8. Recentl...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v97.1.39

    authors: Haque NS,Fallon JT,Taubman MB,Harpel PC

    更新日期:2001-01-01 00:00:00

  • Peripheral blood mononuclear cells of a patient with advanced Hodgkin's lymphoma give rise to permanently growing Hodgkin-Reed Sternberg cells.

    abstract::A novel Hodgkin's disease (HD) derived cell line, L1236, was established from the peripheral blood of a patient with advanced Hodgkin's disease. Analysis of immunoglobulin (Ig) gene rearrangements revealed a biallelic Ig heavy chain and a monoallelic Ig kappa light chain gene rearrangement, pointing to a B-lymphoid or...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Wolf J,Kapp U,Bohlen H,Kornacker M,Schoch C,Stahl B,Mücke S,von Kalle C,Fonatsch C,Schaefer HE,Hansmann ML,Diehl V

    更新日期:1996-04-15 00:00:00

  • Regulation of mouse mast cell protease 6 gene expression by transcription factor encoded by the mi locus.

    abstract::The mi locus of mice encodes a member of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF). Because the expression of the mouse mast cell protease 6 (MMCP-6) gene is remarkably reduced in mast cells of mi/mi mutant mice, we investigated the effect of M...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Morii E,Tsujimura T,Jippo T,Hashimoto K,Takebayashi K,Tsujino K,Nomura S,Yamamoto M,Kitamura Y

    更新日期:1996-10-01 00:00:00

  • Familial and congenital polycythemia in three unrelated families.

    abstract::Three families with polycythemia inherited through apparently different modes are described. Secondary causes of polycythemia were ruled out. Erythropoietin (EPO) levels were normal or low, even after phlebotomy. In vitro erythroid colony growth in standard assay cultures containing EPO was normal; however, in the abs...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Emanuel PD,Eaves CJ,Broudy VC,Papayannopoulou T,Moore MR,D'Andrea AD,Prchal JF,Eaves AC,Prchal JT

    更新日期:1992-06-01 00:00:00

  • Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial.

    abstract::Immune function has been restored in 9 of 10 children with X-linked severe combined immunodeficiency by gamma c gene transfer in CD34+ cells. The distribution of both T-cell receptor (TCR) V beta family usage and TCR V beta complementarity-determining region 3 (CDR3) length revealed a broadly diversified T-cell repert...

    journal_title:Blood

    pub_type: 临床试验,杂志文章

    doi:10.1182/blood-2004-07-2648

    authors: Schmidt M,Hacein-Bey-Abina S,Wissler M,Carlier F,Lim A,Prinz C,Glimm H,Andre-Schmutz I,Hue C,Garrigue A,Le Deist F,Lagresle C,Fischer A,Cavazzana-Calvo M,von Kalle C

    更新日期:2005-04-01 00:00:00

  • Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by cancer and leukemia group B.

    abstract::The efficacy of the addition of intensive therapy with daunorubicin (45 mg/m2 IV on days 1, 2, 3) to an otherwise identical induction program consisting of vincristine, prednisone, and L-asparaginase was assessed in 177 previously untreated adults (greater than or equal to 20 years of age) with acute lymphocytic leuke...

    journal_title:Blood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Gottlieb AJ,Weinberg V,Ellison RR,Henderson ES,Terebelo H,Rafla S,Cuttner J,Silver RT,Carey RW,Levy RN

    更新日期:1984-07-01 00:00:00