Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression.

abstract：:Choosing Wisely® is a medical stewardship and quality improvement initiative led by the American Board of Internal Medicine Foundation in collaboration with leading medical societies in the United States. The ASH is an active participant in the Choosing Wisely® project. Using an iterative process and an evidence-based...

journal_title：Blood

authors： Hicks LK,Bering H,Carson KR,Kleinerman J,Kukreti V,Ma A,Mueller BU,O'Brien SH,Pasquini M,Sarode R,Solberg L Jr,Haynes AE,Crowther MA

更新日期：2013-12-05 00:00:00

abstract：:A study of the Bernard-Soulier syndrome in two unrelated families using different polyclonal antibodies in a sensitive immunoblot assay showed residual amounts of platelet membrane glycoprotein (GP) lb in the eight homozygotes, as well as the near-absence of GPlb beta and GPIX. The eight heterozygotes studied showed a...

journal_title：Blood

authors： Drouin J,McGregor JL,Parmentier S,Izaguirre CA,Clemetson KJ

更新日期：1988-09-01 00:00:00

abstract：:Proinflammatory cytokines such as TNFα are elevated in patients with myeloproliferative neoplasms (MPN), but their contribution to disease pathogenesis is unknown. Here we reveal a central role for TNFα in promoting clonal dominance of JAK2(V617F) expressing cells in MPN. We show that JAK2(V617F) kinase regulates TNFα...

journal_title：Blood

authors： Fleischman AG,Aichberger KJ,Luty SB,Bumm TG,Petersen CL,Doratotaj S,Vasudevan KB,LaTocha DH,Yang F,Press RD,Loriaux MM,Pahl HL,Silver RT,Agarwal A,O'Hare T,Druker BJ,Bagby GC,Deininger MW

更新日期：2011-12-08 00:00:00

abstract：:Washed human platelets were labeled with 125I by the lactoperoxidase-catalyzed method and solubilized in 1% Triton X-100. The soluble proteins were analyzed by crossed-immunoelectrophoresis in 1% agarose, employing a rabbit antibody raised against whole human platelets. Analysis of autoradiograms developed from dried ...

journal_title：Blood

authors： Kunicki TJ,Nurden AT,Pidard D,Russell NR,Caen JP

更新日期：1981-12-01 00:00:00

abstract：:Selectins are carbohydrate-binding adhesion molecules that play important roles in control of leukocyte traffic. Glycosyltransferases involved in selectin ligand biosynthesis include the alpha1,3-fucosyltransferases FucT-VII and FucT-IV, one or more sialyltransferases, and at least one O-linked branching enzyme. Previ...

journal_title：Blood

authors： Snapp KR,Heitzig CE,Ellies LG,Marth JD,Kansas GS

更新日期：2001-06-15 00:00:00

abstract：:Genes of the major histocompatibility complex (MHC) are associated with susceptibility to different immune and nonimmune mediated diseases. We had reported that the drug adverse reaction, clozapine-induced agranulocytosis (CA), is associated with different HLA types and HSP70 variants in Ashkenazi Jewish and non-Jewis...

journal_title：Blood

authors： Turbay D,Lieberman J,Alper CA,Delgado JC,Corzo D,Yunis JJ,Yunis EJ

更新日期：1997-06-01 00:00:00

abstract：:Activation of endothelial cells, important in processes such as angiogenesis, is regulated by cell surface receptors, including those in the tyrosine kinase (RTK) family. Receptor activity, in turn, can be modulated by phosphorylation, turnover, or proteolytic release of a soluble extracellular domain. Previously, we ...

journal_title：Blood

authors： Yabkowitz R,Meyer S,Black T,Elliott G,Merewether LA,Yamane HK

更新日期：1999-03-15 00:00:00

abstract：:Recent studies have shown that soluble factors elaborated by human T lymphocytes enhance erythroid burst formation by human peripheral blood null cells. This study demonstrates that media conditioned by a long-term T lymphocyte line augmented the growth of erythroid colonies in vitro in the presence of erythropoietin ...

journal_title：Blood

authors： Hamburger AW

更新日期：1980-10-01 00:00:00

abstract：:An unusual group of human B-cell tumors with cellular features of chronic lymphocytic leukemia or lymphoplasmacytoid leukemia, together with high levels of a monoclonal IgG serum protein, has been investigated. Analysis of tumor-derived VH genes of neoplastic B lymphocytes was used to determine the clonal relationship...

journal_title：Blood

authors： Sahota SS,Garand R,Bataille R,Smith AJ,Stevenson FK

更新日期：1998-01-01 00:00:00

abstract：:The three-dimensional tertiary structure of human von Willebrand Factor (vWF) on a hydrophobic surface under aqueous conditions and different shear stress regimes was studied by atomic force microscopy (AFM). vWF was imaged by AFM at molecular level resolution under negligible shear stress, under a local applied shear...

journal_title：Blood

authors： Siedlecki CA,Lestini BJ,Kottke-Marchant KK,Eppell SJ,Wilson DL,Marchant RE

更新日期：1996-10-15 00:00:00

abstract：:Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and the interaction of phenotypic variation with hepcidin is unknown. The effect of thalassemia carriage o...

journal_title：Blood

authors： Jones E,Pasricha SR,Allen A,Evans P,Fisher CA,Wray K,Premawardhena A,Bandara D,Perera A,Webster C,Sturges P,Olivieri NF,St Pierre T,Armitage AE,Porter JB,Weatherall DJ,Drakesmith H

更新日期：2015-01-29 00:00:00

abstract：:Recently, we reported a novel system whereby human pericytes are recruited to endothelial cell (EC)-lined tubes in 3-dimensional (3D) extracellular matrices to stimulate vascular maturation including basement membrane matrix assembly. Through the use of this serum-free, defined system, we demonstrate that pericyte mot...

journal_title：Blood

authors： Stratman AN,Schwindt AE,Malotte KM,Davis GE

更新日期：2010-11-25 00:00:00

abstract：:L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion by myeloid-derived suppressor cells producing arginase I is seen in patients with cancer inducing T-cell anergy. We studied how L-Arg starvation could regulate T-cell-cycle progression. Stim...

journal_title：Blood

authors： Rodriguez PC,Quiceno DG,Ochoa AC

更新日期：2007-02-15 00:00:00

abstract：:Dendritic cells (DCs) are antigen-presenting cells with the capacity to prime naive T cells for efficient cellular responses against pathogens such as HIV-1. DCs are also susceptible to HIV-1 infection, which may impair their ability to induce immunity. Here, we examined the ability of HIV-1-infected, in vitro-derived...

journal_title：Blood

authors： Smed-Sörensen A,Loré K,Walther-Jallow L,Andersson J,Spetz AL

更新日期：2004-11-01 00:00:00

abstract：:To elucidate the role of retinoic acid (RA) in anti-CD40 + interleukin-4 (IL-4)-mediated B-cell activation, the effect of 10(-12) to 10(-6) mol/L RA was studied in anti-CD40 (1 microgram/mL) + IL-4 (5 ng/mL)-mediated proliferation and Ig synthesis by human peripheral blood mononuclear cells (PBMC) and B cells in healt...

journal_title：Blood

authors： Worm M,Krah JM,Manz RA,Henz BM

更新日期：1998-09-01 00:00:00

abstract：:Endothelial sialomucin CD34 functions as an L-selectin ligand mediating lymphocyte extravasation only when properly glycosylated to express a sulfated carbohydrate epitope, 6-sulfo sialyl Lewis x (6-sulfo SLe(x)). It is thought that multivalent 6-sulfo SLe(x) expression promotes high-affinity binding to L-selectin by ...

journal_title：Blood

authors： Hernandez Mir G,Helin J,Skarp KP,Cummings RD,Mäkitie A,Renkonen R,Leppänen A

更新日期：2009-07-16 00:00:00

abstract：:The von Willebrand receptor complex, which is composed of the glycoproteins Ibα, Ibβ, GPV, and GPIX, plays an essential role in the earliest steps in hemostasis. During the last 4 decades, it has become apparent that loss of function of any 1 of 3 of the genes encoding these glycoproteins (namely, GP1BA, GP1BB, and GP...

journal_title：Blood

authors： Sivapalaratnam S,Westbury SK,Stephens JC,Greene D,Downes K,Kelly AM,Lentaigne C,Astle WJ,Huizinga EG,Nurden P,Papadia S,Peerlinck K,Penkett CJ,Perry DJ,Roughley C,Simeoni I,Stirrups K,Hart DP,Tait RC,Mumford AD,NI

更新日期：2017-01-26 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of immunosuppression, e.g. post-transplant lymphoproliferative disorders (PTLD) or HIV (AIDS-related PCNSL). These cases are poorly characteri...

journal_title：Blood

authors： Gandhi MK,Hoang T,Law SC,Brosda S,O'Rourke K,Tobin JWD,Vari F,Murigneux V,Fink JL,Gunawardana J,Gould CM,Oey H,Bednarska K,Delecluse S,Trappe RU,de Long LM,Sabdia MB,Bhagat G,Hapgood G,Blyth E,Clancy LE,Wight J

更新日期：2020-11-17 00:00:00

abstract：:Acquired factor XIII (FXIII) deficiency due to autoantibody against FXIII is a very rare severe hemorrhagic diathesis. Antibodies directed against the A subunit of FXIII, which interfere with different functions of FXIII, have been described. Here, for the first time, we report an autoantibody against the B subunit of...

journal_title：Blood

authors： Ajzner E,Schlammadinger A,Kerényi A,Bereczky Z,Katona E,Haramura G,Boda Z,Muszbek L

更新日期：2009-01-15 00:00:00

abstract：:Based on our previous demonstration that quinine could be used clinically to reverse P-glycoprotein-mediated resistance, we designed a multicenter, randomized trial aiming to determine whether quinine would improve the survival of adult patients (15-60 years old) with de novo acute myelogenous leukemia (AML). These pa...

journal_title：Blood

authors： Solary E,Drenou B,Campos L,de Crémoux P,Mugneret F,Moreau P,Lioure B,Falkenrodt A,Witz B,Bernard M,Hunault-Berger M,Delain M,Fernandes J,Mounier C,Guilhot F,Garnache F,Berthou C,Kara-Slimane F,Harousseau JL,Groupe O

更新日期：2003-08-15 00:00:00

abstract：:A mutant strain of Escherichia coli (E. coli ML-35) was used to follow the kinetics of phagocytosis, perforation of the bacterial cell envelope, and inactivation of bacterial proteins by human neutrophils. This particular E. coli mutant strain has no lactose permease, but constitutively forms the cytoplasmic enzyme be...

journal_title：Blood

authors： Hamers MN,Bot AA,Weening RS,Sips HJ,Roos D

更新日期：1984-09-01 00:00:00

abstract：:It has been proposed that CD4 T-cell responses to Staphylococcus aureus (SA) can inadvertently enhance neoplastic progression in models of skin cancer and cutaneous T-cell lymphoma (CTCL). In this prospective study, we explored the effect of transient antibiotic treatment on tumor cells and disease activity in 8 patie...

journal_title：Blood

authors： Lindahl LM,Willerslev-Olsen A,Gjerdrum LMR,Nielsen PR,Blümel E,Rittig AH,Celis P,Herpers B,Becker JC,Stausbøl-Grøn B,Wasik MA,Gluud M,Fredholm S,Buus TB,Johansen C,Nastasi C,Peiffer L,Kubat L,Bzorek M,Eriksen JO,K

更新日期：2019-09-26 00:00:00

abstract：:Src homology 2 domain-containing phosphatase 2 (Shp2), encoded by Ptpn11, is a member of the nonreceptor protein-tyrosine phosphatase family, and functions in cell survival, proliferation, migration, and differentiation in many tissues. Here we report that loss of Ptpn11 in murine hematopoietic cells leads to bone mar...

journal_title：Blood

authors： Chan G,Cheung LS,Yang W,Milyavsky M,Sanders AD,Gu S,Hong WX,Liu AX,Wang X,Barbara M,Sharma T,Gavin J,Kutok JL,Iscove NN,Shannon KM,Dick JE,Neel BG,Braun BS

更新日期：2011-04-21 00:00:00

abstract：:Hoyeraal Hreidarsson syndrome (HHS) is a form of dyskeratosis congenita (DC) characterized by bone marrow failure, intrauterine growth retardation, developmental delay, microcephaly, cerebellar hypoplasia, immunodeficiency, and extremely short telomeres. As with DC, mutations in genes encoding factors required for tel...

journal_title：Blood

authors： Gramatges MM,Qi X,Sasa GS,Chen JJ,Bertuch AA

更新日期：2013-05-02 00:00:00

abstract：:Obinutuzumab is a type 2, glycoengineered, anti-CD20 antibody recently approved with chlorambucil for the initial therapy of chronic lymphocytic leukemia (CLL). In this nonrandomized, parallel-cohort, phase 1b, multicenter study, we explored the safety and preliminary efficacy of obinutuzumab-bendamustine (G-B) or obi...

journal_title：Blood

authors： Brown JR,O'Brien S,Kingsley CD,Eradat H,Pagel JM,Lymp J,Hirata J,Kipps TJ

更新日期：2015-04-30 00:00:00

abstract：:For activation T cells engage antigen-presenting cells (APCs) in lymphatic tissues. The contact duration and kinetics (static versus dynamic) vary considerably in different model systems; however, it is unclear whether T cells, APCs, or the environment are responsible for the observed discrepancies. Using 3-D collagen...

journal_title：Blood

authors： Gunzer M,Weishaupt C,Hillmer A,Basoglu Y,Friedl P,Dittmar KE,Kolanus W,Varga G,Grabbe S

更新日期：2004-11-01 00:00:00

abstract：:In the current study, we investigated whether the naive, poly I:C or interleukin-2 (IL-2)-induced natural killer (NK)/lymphokine-activated killer (LAK) cells use perforin and/or Fas ligand (FasL) to mediated cytotoxicity. We correlated these findings with the ability of mice to reject syngeneic Fas+ and Fas- tumor cel...

journal_title：Blood

authors： Bradley M,Zeytun A,Rafi-Janajreh A,Nagarkatti PS,Nagarkatti M

更新日期：1998-12-01 00:00:00

abstract：:Approximately 40% of children with acute myeloid leukemia (AML) who respond to initial therapy subsequently relapse. Multidimensional flow cytometry employing a standardized panel of monoclonal antibodies enables the detection of small numbers of occult leukemic cells that persist during therapy using technology adapt...

journal_title：Blood

authors： Sievers EL,Lange BJ,Alonzo TA,Gerbing RB,Bernstein ID,Smith FO,Arceci RJ,Woods WG,Loken MR

更新日期：2003-05-01 00:00:00

abstract：:Natural killer (NK) cell activation is the result of a balance between positive and negative signals triggered by specific membrane receptors. We report here the activation of NK cells induced through the transmembrane glycoprotein CD43 (leukosialin, sialophorin). Engagement of CD43 by specific antibodies stimulated t...

journal_title：Blood

authors： Nieto M,Rodríguez-Fernández JL,Navarro F,Sancho D,Frade JM,Mellado M,Martínez-A C,Cabañas C,Sánchez-Madrid F

更新日期：1999-10-15 00:00:00

abstract：:Over the years, methods of cytogenetic analysis evolved and became part of routine laboratory testing, providing valuable diagnostic and prognostic information in hematologic disorders. Karyotypic aberrations contribute to the understanding of the molecular pathogenesis of disease and thereby to rational application o...

journal_title：Blood

authors： Maciejewski JP,Mufti GJ

更新日期：2008-08-15 00:00:00