VH gene analysis of clonally related IgM and IgG from human lymphoplasmacytoid B-cell tumors with chronic lymphocytic leukemia features and high serum monoclonal IgG.

abstract：:The iron absorption from ferritin and hemosiderin biosynthetically labeled with radioiron was studied in 108 subjects. The geometric mean absorption of ferritin iron in both normal and iron-deficient subjects was 1.9 percent. Its mean absorption ranged from 0.9 percent in normal subjects to 2.5 percent in subjects wit...

journal_title：Blood

authors： Layrisse M,Martínez-Torres C,Renzy M,Leets I

更新日期：1975-05-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a typically aggressive myeloid neoplasm of childhood that is clinically characterized by overproduction of monocytic cells that can infiltrate organs, including the spleen, liver, gastrointestinal tract, and lung. JMML is categorized as an overlap myelodysplastic syndrome/mye...

journal_title：Blood

authors： Chang TY,Dvorak CC,Loh ML

更新日期：2014-10-16 00:00:00

abstract：:Platelet-type von Willebrand disease (vWD) is a congenital bleeding disorder characterized by heightened ristocetin-induced platelet aggregation caused by abnormally high affinity between the platelet membrane glycoprotein (GP) Ib/IX complex and von Willebrand factor (vWF). Two distinct point mutations, Gly233 to Val ...

journal_title：Blood

authors： Moriki T,Murata M,Kitaguchi T,Anbo H,Handa M,Watanabe K,Takahashi H,Ikeda Y

更新日期：1997-07-15 00:00:00

abstract：:Human erythrocyte p55 is a peripheral membrane protein that contains three distinct domains in its primary structure: an N-terminal domain, an SH3 motif, and a C-terminal guanylate kinase domain. We used naturally mutated red blood cells (RBCs) with primary genetic defects resulting in the absence of protein 4.1 (4.1[...

journal_title：Blood

authors： Alloisio N,Dalla Venezia N,Rana A,Andrabi K,Texier P,Gilsanz F,Cartron JP,Delaunay J,Chishti AH

更新日期：1993-08-15 00:00:00

abstract：:The endothelium, as the interface between blood and all tissues, plays a critical role in inflammation. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid, highly abundant in plasma, that potently regulates endothelial responses through interaction with its receptors (S1PRs). Here, we studied the role of S1PR2 ...

journal_title：Blood

authors： Zhang G,Yang L,Kim GS,Ryan K,Lu S,O'Donnell RK,Spokes K,Shapiro N,Aird WC,Kluk MJ,Yano K,Sanchez T

更新日期：2013-07-18 00:00:00

abstract：:Important predictors of adverse outcomes of thrombosis in children, including postthrombotic syndrome (PTS), have recently been identified. Given this knowledge and the encouraging preliminary pediatric experience with systemic thrombolysis, we sought to retrospectively analyze our institutional experience with a thro...

journal_title：Blood

authors： Goldenberg NA,Durham JD,Knapp-Clevenger R,Manco-Johnson MJ

更新日期：2007-07-01 00:00:00

abstract：:We examined whether activated protein C (APC) reduces ischemia/reperfusion (I/R)-induced renal injury by inhibiting leukocyte activation. In a rat model, intravenous administration of APC markedly reduced I/R-induced renal dysfunction and histological changes, whereas intravenous administration of dansyl glutamylglycy...

journal_title：Blood

authors： Mizutani A,Okajima K,Uchiba M,Noguchi T

更新日期：2000-06-15 00:00:00

abstract：:The evidence for a regulatory role of acidic isoferritins on hemopoiesis is not entirely consistent with our knowledge of ferritin biochemistry, and no clear picture of this phenomeonon has emerged. In the present study, we have been unable to confirm a consistent effect of purified heart (acidic), spleen (basic), or ...

journal_title：Blood

authors： Sala G,Worwood M,Jacobs A

更新日期：1986-02-01 00:00:00

abstract：:Transcriptional control has been identified as a key mechanism regulating the formation and subsequent behavior of hematopoietic stem cells. We have used a comparative genomics approach to identify transcriptional regulatory elements of the LMO2 gene, a transcriptional cofactor originally identified through its involv...

journal_title：Blood

authors： Landry JR,Kinston S,Knezevic K,Donaldson IJ,Green AR,Göttgens B

更新日期：2005-10-15 00:00:00

abstract：:Epratuzumab, a humanized anti-CD22 antibody, is currently in clinical trials of B-cell lymphomas and autoimmune diseases, demonstrating therapeutic activity in non-Hodgkin lymphoma (NHL) and systemic lupus erythematosus (SLE). Thus, epratuzumab offers a promising option for CD22-targeted immunotherapy, yet its mechani...

journal_title：Blood

authors： Rossi EA,Goldenberg DM,Michel R,Rossi DL,Wallace DJ,Chang CH

更新日期：2013-10-24 00:00:00

abstract：:Adenovirus infections occur in 5% to 21% of patients following stem cell transplantation (SCT), with an associated mortality of up to 50%. However, a lack of prospective studies has hampered further developments in the understanding and management of this infection in the posttransplantation setting. We prospectively ...

journal_title：Blood

authors： Chakrabarti S,Mautner V,Osman H,Collingham KE,Fegan CD,Klapper PE,Moss PA,Milligan DW

更新日期：2002-09-01 00:00:00

abstract：:The American Society of Hematology (ASH) turns 50 years old in 2008, and we have much to celebrate. Over those years the Society established its principles: to promote both the art and science of hematology and to hold a high-quality Educational Meeting. ASH membership has grown from a few hundred curious attendees at...

journal_title：Blood

authors： Jaffé ER,Kaushansky K

更新日期：2008-01-01 00:00:00

abstract：:During the past decade it was recognized that homeobox gene families such as the clustered Hox genes play pivotal roles both in normal and malignant hematopoiesis. More recently, similar roles have also become apparent for members of the ParaHox gene cluster, evolutionarily closely related to the Hox gene cluster. Thi...

journal_title：Blood

authors： Rawat VP,Humphries RK,Buske C

更新日期：2012-07-19 00:00:00

abstract：:Characterization of lymphocytes including B cells during early versus chronic HIV infection is important for understanding the impact of chronic viremia on immune cell function. In this setting, we investigated B cells before and after reduction of HIV plasma viremia by antiretroviral therapy (ART). At baseline, perip...

journal_title：Blood

authors： Moir S,Buckner CM,Ho J,Wang W,Chen J,Waldner AJ,Posada JG,Kardava L,O'Shea MA,Kottilil S,Chun TW,Proschan MA,Fauci AS

更新日期：2010-12-16 00:00:00

abstract：:ELL-12, a liposome formulation of the ether-lipid 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH(3)), is a nonmyelosuppressive antiproliferative agent that is more effective and less toxic than the ether lipid itself in tumor model systems. We found that ELL-12 induced apoptosis in Jurkat, H9, and U-9...

journal_title：Blood

authors： Cuvillier O,Mayhew E,Janoff AS,Spiegel S

更新日期：1999-11-15 00:00:00

abstract：:Two patients developed thrombocytopenia associated with an in vitro platelet to leukocyte adherence phenomenon (PLAP). In one patient, whole serum, intact plasma, and the IgG fraction of the serum could induce the PLAP of normal platelets in normal whole blood or buffy coat preparations. Passage of serum over a Sephar...

journal_title：Blood

authors： Greipp PR,Gralnick HR

更新日期：1976-03-01 00:00:00

abstract：:To evaluate the importance of the thymus for the reconstitution of immunity in recipients of a T-cell-depleted bone marrow, we measured the appearance of CD4(+)CD45RA(+)RO(-) naive T cells (thymic rebound), restoration of the diversity of the T-cell-receptor (TCR) repertoire and the response to vaccinations with tetan...

journal_title：Blood

authors： Roux E,Dumont-Girard F,Starobinski M,Siegrist CA,Helg C,Chapuis B,Roosnek E

更新日期：2000-09-15 00:00:00

abstract：:The effect of cyclosporine A (CyA) on the ability of the human immunodeficiency virus type 1 (HIV-1) to infect the H-9 T-cell leukemic line, as well as interleukin-2 (IL-2)-grown human peripheral blood-derived lymphocytes, has been studied. Pretreatment of H-9 cells and human lymphocytes with CyA over 24 hours complet...

journal_title：Blood

authors： Wainberg MA,Dascal A,Blain N,Fitz-Gibbon L,Boulerice F,Numazaki K,Tremblay M

更新日期：1988-12-01 00:00:00

abstract：:Human granulocyte-macrophage colony-stimulating factor (GM-CSF) enhances numerous functions of mature neutrophils (PMN) including phagocytosis, superoxide responses to chemotaxins, antibody-dependent cellular cytotoxicity, and expression of complement receptors. A central question concerns whether the mechanism of enh...

journal_title：Blood

authors： Fletcher MP,Gasson JC

更新日期：1988-03-01 00:00:00

abstract：:T-cell depletion (TCD) of the donor marrow graft has been shown to reduce the severity of graft-versus-host disease (GVHD) in patients with chronic-phase (CP) chronic myelogenous leukemia (CML) undergoing HLA-identical sibling allogeneic marrow transplantation. However, there has been a corresponding reduction in the ...

journal_title：Blood

authors： Drobyski WR,Hessner MJ,Klein JP,Kabler-Babbitt C,Vesole DH,Margolis DA,Keever-Taylor CA

更新日期：1999-07-15 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is a severe renal disease that is associated with defective complement regulation caused by multiple factors. We previously described the deficiency of factor H-related proteins CFHR1 and CFHR3 as predisposing factor for aHUS. Here we identify in an extended cohort of 147 aHUS...

journal_title：Blood

authors： Józsi M,Licht C,Strobel S,Zipfel SL,Richter H,Heinen S,Zipfel PF,Skerka C

更新日期：2008-02-01 00:00:00

abstract：:Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in the Western world. FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical outcome. To further our understanding of the genetic basis of FL, we performed whole-exome sequencing of 23 highly purified FL cases and 1 transfo...

journal_title：Blood

authors： Yildiz M,Li H,Bernard D,Amin NA,Ouillette P,Jones S,Saiya-Cork K,Parkin B,Jacobi K,Shedden K,Wang S,Chang AE,Kaminski MS,Malek SN

更新日期：2015-01-22 00:00:00

abstract：:Although plasmacytoid dendritic cells (pDCs) are involved in HIV-1 pathogenesis, the precise mechanism of interaction between pDCs and HIV-1 in vivo is not clear. The conflicting reports in HIV-1-infected patients highlight the importance of studying the interaction between HIV-1 and pDCs in relevant in vivo models. T...

journal_title：Blood

authors： Zhang L,Jiang Q,Li G,Jeffrey J,Kovalev GI,Su L

更新日期：2011-06-09 00:00:00

abstract：:The ontogeny of a 57-Kd cationic antimicrobial protein (CAP57) that has substantial similarities to bactericidal permeability increasing protein (BPI) has been determined immunocytochemically. CAP57 was detected in the granules of mature peripheral blood neutrophils. However, it was absent from other cells of the peri...

journal_title：Blood

authors： Pereira HA,Spitznagel JK,Winton EF,Shafer WM,Martin LE,Guzman GS,Pohl J,Scott RW,Marra MN,Kinkade JM Jr

更新日期：1990-08-15 00:00:00

abstract：:Severe congenital neutropenia (CN) is a preleukemic bone marrow failure syndrome with a 20% risk of evolving into leukemia or myelodysplastic syndrome (MDS). Patterns of acquisition of leukemia-associated mutations were investigated using next-generation deep-sequencing in 31 CN patients who developed leukemia or MDS....

journal_title：Blood

authors： Skokowa J,Steinemann D,Katsman-Kuipers JE,Zeidler C,Klimenkova O,Klimiankou M,Unalan M,Kandabarau S,Makaryan V,Beekman R,Behrens K,Stocking C,Obenauer J,Schnittger S,Kohlmann A,Valkhof MG,Hoogenboezem R,Göhring G,Rein

更新日期：2014-04-03 00:00:00

abstract：:The Wrb antigen is a high-frequency human erythrocyte antigen invariably absent from En (a-) erythrocytes, which lack glycophorin A. However, glycophorin A from En (a+) Wr (a+b-) red cells has an amino acid sequence identical to that of glycophorin A from Wr (b+) erythrocytes. Evidence has suggested that the Wrb antig...

journal_title：Blood

authors： Telen MJ,Chasis JA

更新日期：1990-08-15 00:00:00

abstract：:Patients with polycythemia vera (PV) have a JAK2 (a cytosolic tyrosine kinase) mutation and an increased risk of vascular thrombosis related to red blood cell (RBC) mass and platelet activation. We investigated functional RBC abnormalities that could be involved in thrombosis. RBC adhesion to human umbilical vein endo...

journal_title：Blood

authors： Wautier MP,El Nemer W,Gane P,Rain JD,Cartron JP,Colin Y,Le Van Kim C,Wautier JL

更新日期：2007-08-01 00:00:00

abstract：:We took advantage of the proliferative and permissive environment of the developing preimmune fetus to develop a noninjury large animal model in sheep, in which the transplantation of defined populations of human hematopoietic stem cells resulted in the establishment of human hematopoiesis and led to the formation of ...

journal_title：Blood

authors： Almeida-Porada G,Porada CD,Chamberlain J,Torabi A,Zanjani ED

更新日期：2004-10-15 00:00:00

abstract：:An inhibitor of procoagulant and fibrinolytic enzymes was derived from cabbage seeds by a procedure using acetone precipitation, ion-exchange chromatography, and gel filtration. The cabbage seed inhibitor was a 10-Kd monomeric protein with intrachain disulfide bonds. This preparation prevented clot formation in whole ...

journal_title：Blood

authors： Carter TH,Everson BA,Ratnoff OD

更新日期：1990-01-01 00:00:00

abstract：:The malaria parasite Plasmodium falciparum releases the ring-infected erythrocyte surface antigen (RESA) inside the red cell on entry. The protein migrates to the host cell membrane, where it binds to spectrin, but neither the nature of the interaction nor its functional consequences have previously been defined. Here...

journal_title：Blood

authors： Pei X,Guo X,Coppel R,Bhattacharjee S,Haldar K,Gratzer W,Mohandas N,An X

更新日期：2007-08-01 00:00:00