Trogocytosis of multiple B-cell surface markers by CD22 targeting with epratuzumab.

abstract：:A 42-yr-old woman with systemic lupus erythematosus without bleeding diathesis developed a prolonged activated partial thromboplastin time that was not corrected by normal plasma. An inhibitor that acted rapidly and inactivated 0.5 U/ml plasma thromboplastin antecedent (PTA, factor XI) at a 1:200 plasma dilution was d...

journal_title：Blood

authors： Poon MC,Saito H,Koopman WJ

更新日期：1984-06-01 00:00:00

abstract：:The 8p11 myeloproliferative syndrome (EMS) is associated with translocations that disrupt the FGFR1 gene. To date, 8 fusion partners of FGFR1 have been identified. However, no primary leukemia cell lines were identified that contain any of these fusions. Here, we screened more than 40 acute myeloid leukemia cell lines...

journal_title：Blood

authors： Gu TL,Goss VL,Reeves C,Popova L,Nardone J,Macneill J,Walters DK,Wang Y,Rush J,Comb MJ,Druker BJ,Polakiewicz RD

更新日期：2006-12-15 00:00:00

abstract：:Although allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for patients with Fanconi anemia (FA), published series mostly refer to single-center experience with limited numbers of patients. We analyzed results in 795 patients with FA who underwent first HSCT between May 1972...

journal_title：Blood

authors： Peffault de Latour R,Porcher R,Dalle JH,Aljurf M,Korthof ET,Svahn J,Willemze R,Barrenetxea C,Mialou V,Soulier J,Ayas M,Oneto R,Bacigalupo A,Marsh JC,Peters C,Socie G,Dufour C,FA Committee of the Severe Aplastic Anemia W

更新日期：2013-12-19 00:00:00

abstract：:Endothelial cell prostacyclin (PGI2) inhibits platelet activation by raising platelet cyclic AMP. Previously, platelet activation was also shown to be blocked by plasmin formed by endothelium-derived tissue plasminogen activator (TPA). We have now studied interactions between PGI2 and plasmin in the control of platele...

journal_title：Blood

authors： Schafer AI,Zavoico GB,Loscalzo J,Maas AK

更新日期：1987-05-01 00:00:00

abstract：:A decrease in inhibitor titer has been reported in some patients with acquired factor VIII inhibitors treated with intravenous gammaglobulin (IGIV). We have conducted a prospective, multicenter study of high-dose IGIV in treatment of this disorder to determine efficacy. Nineteen patients received induction therapy wit...

journal_title：Blood

authors： Schwartz RS,Gabriel DA,Aledort LM,Green D,Kessler CM

更新日期：1995-07-15 00:00:00

abstract：:Follicular dendritic cells (FDCs) in the lymphoid follicle (LF) are essential to the sequential processes of B-cell proliferation, selection, and differentiation. Although the importance of some cytokines in these processes has been pointed out, there is little information about the follicular localization of their re...

journal_title：Blood

authors： Yamada K,Yamakawa M,Imai Y,Tsukamoto M

更新日期：1997-12-15 00:00:00

abstract：:Malignant transformation by oncogenes requires additional genetic/epigenetic changes to overcome enhanced susceptibility to apoptosis. In the present study, we report that Bif-1 (Sh3glb1), a gene encoding a membrane curvature–driving endophilin protein, is a haploinsufficient tumor suppressor that plays a key role in ...

journal_title：Blood

authors： Takahashi Y,Hori T,Cooper TK,Liao J,Desai N,Serfass JM,Young MM,Park S,Izu Y,Wang HG

更新日期：2013-02-28 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMC) from 17 patients receiving HLA-identical sibling bone marrow grafts were stimulated with host pretransplant PBMC. Cytotoxic T-cell lines (TCL) with specificity for host pretransplant PBMC were obtained from 9 of these patients, all presenting with severe graft-versus-host dise...

journal_title：Blood

authors： Niederwieser D,Grassegger A,Auböck J,Herold M,Nachbaur D,Rosenmayr A,Gächter A,Nussbaumer W,Gaggl S,Ritter M

更新日期：1993-04-15 00:00:00

abstract：:The primary objective was to describe the prevalence and characteristics of microbiologically defined infections and infection-related mortality (IRM) in 492 children with acute myeloid leukemia enrolled on CCG 2961. Secondary objectives were to determine the relationship between demographic, disease-related, and ther...

journal_title：Blood

authors： Sung L,Lange BJ,Gerbing RB,Alonzo TA,Feusner J

更新日期：2007-11-15 00:00:00

abstract：:Dosing of enzyme replacement therapy (ERT) for Gaucher disease type 1 is still a subject of debate and varies from 15 to 130 U/kg/mo, making a huge economic difference of 70,000 US dollars to 380,000 US dollars(euro55,000-300,000) per patient per year. To investigate whether this difference in dosing ultimately transl...

journal_title：Blood

authors： de Fost M,Hollak CE,Groener JE,Aerts JM,Maas M,Poll LW,Wiersma MG,Häussinger D,Brett S,Brill N,vom Dahl S

更新日期：2006-08-01 00:00:00

abstract：:Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil. Both had an objective hematologic response as determined by a return to normal hematocrit and platelet count. This was also reflected in the mononuclear cell fraction by the normalization of cholester...

journal_title：Blood

authors： Krigel R,Liebes LF,Pelle E,Silber R

更新日期：1982-07-01 00:00:00

abstract：:Recently, Dawson et al identified a previously unrecognized nuclear role of JAK2 in the phosphorylation of histone H3 in hematopoietic cell lines. We searched nuclear JAK2 in total bone marrow (BM) cells and in 4 sorted BM cell populations (CD34(+), CD15(+), CD41(+), and CD71(+)) of 10 myeloproliferative neoplasia (MP...

journal_title：Blood

authors： Rinaldi CR,Rinaldi P,Alagia A,Gemei M,Esposito N,Formiggini F,Martinelli V,Senyuk V,Nucifora G,Pane F

更新日期：2010-12-23 00:00:00

abstract：:Three patients developed blastic transformation of essential thrombocythemia (tET). Morphological studies in all patients showed that the majority of blasts had either myeloblastic or myelomonoblastic differentiation. Immunologic assays of hematopoietic cells were performed in two patients. In patient 1, 86% of periph...

journal_title：Blood

authors： Frei-Lahr D,Barton JC,Hoffman R,Burkett LL,Prchal JT

更新日期：1984-04-01 00:00:00

abstract：:Vinblastine was administered to anemic baboons to test whether stimulation of Hb F takes place following distortion of erythropoiesis by an M-stage-specific compound. The treatments elicited erythroid cell cytoreduction followed by regeneration. During the phase of reticulocyte reduction, gamma/gamma + beta biosynthet...

journal_title：Blood

authors： Veith R,Papayannopoulou T,Kurachi S,Stamatoyannopoulos G

更新日期：1985-08-01 00:00:00

abstract：:Although CD4(+)CD25(+) T cells (T regulatory cells [Tregs]) and natural killer T cells (NKT cells) each protect against graft-versus-host disease (GVHD), interactions between these 2 regulatory cell populations after allogeneic bone marrow transplantation (BMT) have not been studied. We show that host NKT cells can in...

journal_title：Blood

authors： Pillai AB,George TI,Dutt S,Strober S

更新日期：2009-04-30 00:00:00

abstract：:Inherited type 1 antithrombin (AT) deficiency is characterized by a reduction in both immunologically and functionally detectable protein. The disorder is associated with a high risk of thromboembolic disease. We have investigated the molecular basis of type 1 AT deficiency in three unrelated families. We have used th...

journal_title：Blood

authors： Jochmans K,Lissens W,Yin T,Michiels JJ,van der Luit L,Peerlinck K,De Waele M,Liebaers I

更新日期：1994-12-01 00:00:00

abstract：:Approximately 30% to 40% of patients with acute leukemia receiving repeated pooled random-donor platelet transfusions develop anti-HLA alloantibodies. Over time, however, serum anti-HLA concentrations decrease in approximately 50% of these patients, despite continued exposure to platelet and/or red blood cell transfus...

journal_title：Blood

authors： Atlas E,Freedman J,Blanchette V,Kazatchkine MD,Semple JW

更新日期：1993-01-15 00:00:00

abstract：:The rates of endocytosis, intracellular degradation, and cell-surface shedding of 125I-labeled monoclonal antibodies (MoAbs) HD-37 (anti-CD19), B1 (anti-CD20), MB-1 (anti-CD37), BC8 (anti-CD45), and DA4-4 (anti-mu) by B-lymphoma cells were compared by cellular radioimmunoassay, ultrastructural autoradiography, sodium ...

journal_title：Blood

authors： Press OW,Howell-Clark J,Anderson S,Bernstein I

更新日期：1994-03-01 00:00:00

abstract：:The effects of transforming growth factor-beta 1 (TGF-beta 1) on proliferation and hemoglobinization in K-562 cells, a human multipotential hematopoietic cell line, were studied. We found that TGF-beta 1 could induce hemoglobin accumulation in K-562 cells. Various clones were selected on the basis of the inducibility ...

journal_title：Blood

authors： Chen LL,Dean A,Jenkinson T,Mendelsohn J

更新日期：1989-11-15 00:00:00

abstract：:Chronic transfusion of packed red blood cells, in addition to other ongoing treatment with warfarin, acetyl salicylic acid, desferrioxamine, and other supportive measures, was given to a splenectomized hemoglobin E/beta-thalassemia woman with pulmonary arterial hypertension (PHT). Serial measurements of plasma thrombi...

journal_title：Blood

authors： Atichartakarn V,Chuncharunee S,Chandanamattha P,Likittanasombat K,Aryurachai K

更新日期：2004-04-01 00:00:00

abstract：:Active immunization with the idiotype of follicular lymphoma induces tumor-specific immunity. T cells induced in vivo by idiotype vaccination recognize human leukocyte antigen (HLA)--restricted hypervariable but not conserved idiotype peptides. We hypothesized that idiotype-directed T-cell immunity occurs naturally an...

journal_title：Blood

authors： Strothmeyer AM,Papaioannou D,Dühren-von Minden M,Navarrete M,Zirlik K,Heining-Mikesch K,Veelken H

更新日期：2010-09-09 00:00:00

abstract：:Oncogenic transformation of CD4(+) T cells by human T-cell lymphotropic virus type 1 (HTLV-1) is understood as the initial step to adult T-cell leukemia/lymphoma, a process that is mainly initiated by perturbation of cellular signaling by the viral Tax oncoprotein, a potent transcriptional regulator. In search of nove...

journal_title：Blood

authors： Kress AK,Kalmer M,Rowan AG,Grassmann R,Fleckenstein B

更新日期：2011-03-31 00:00:00

abstract：:The Ikaros gene (Ikzf1) encodes a family of zinc-finger transcription factors implicated in hematopoietic cell differentiation. Here we show that Ikaros suppresses the development of basophils, which are proinflammatory cells of the myeloid lineage. In the absence of extrinsic basophil-inducing signals, Ikaros(-/-) (I...

journal_title：Blood

authors： Rao KN,Smuda C,Gregory GD,Min B,Brown MA

更新日期：2013-10-10 00:00:00

abstract：:The plasminogen activator inhibitor PAI-1 is markedly elevated in vivo and in vitro upon exposure to the inflammatory mediators tumor necrosis factor alpha (TNF alpha), interleukin-1 (IL-1), and bacterial lipopolysaccharide. Here we report that the isoflavone compound genistein prevents the increase in synthesis of PA...

journal_title：Blood

authors： van Hinsbergh VW,Vermeer M,Koolwijk P,Grimbergen J,Kooistra T

更新日期：1994-11-01 00:00:00

abstract：:Mutations in NBEAL2, the gene encoding the scaffolding protein Nbeal2, are causal of gray platelet syndrome (GPS), a rare recessive bleeding disorder characterized by platelets lacking α-granules and progressive marrow fibrosis. We present here the interactome of Nbeal2 with additional validation by reverse immunoprec...

journal_title：Blood

authors： Mayer L,Jasztal M,Pardo M,Aguera de Haro S,Collins J,Bariana TK,Smethurst PA,Grassi L,Petersen R,Nurden P,Favier R,Yu L,Meacham S,Astle WJ,Choudhary J,Yue WW,Ouwehand WH,Guerrero JA

更新日期：2018-03-01 00:00:00

abstract：:Migration to lymph nodes and secretion of cytokines are critical functions of mature dendritic cells (DCs); however, these 2 functions are not necessarily linked. This is the first report showing that quantitative differences in identical signaling pathways determine DC migration and cytokine secretion. Using differen...

journal_title：Blood

authors： Luft T,Maraskovsky E,Schnurr M,Knebel K,Kirsch M,Görner M,Skoda R,Ho AD,Nawroth P,Bierhaus A

更新日期：2004-08-15 00:00:00

abstract：:The POEMS syndrome (coined to refer to polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) remains poorly understood. Ambiguity exists over the features necessary to establish the diagnosis, treatment efficacy, and prognosis. We identified 99 patients with POEMS syndrome. Minimal criteria were a...

journal_title：Blood

authors： Dispenzieri A,Kyle RA,Lacy MQ,Rajkumar SV,Therneau TM,Larson DR,Greipp PR,Witzig TE,Basu R,Suarez GA,Fonseca R,Lust JA,Gertz MA

更新日期：2003-04-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a rare pediatric myeloid neoplasm characterized by excessive proliferation of myelomonocytic cells. Somatic mutations in genes involved in GM-CSF signal transduction, such as NRAS, KRAS, PTPN11, NF1, and CBL, have been identified in more than 70% of children with JMML. In the...

journal_title：Blood

authors： Doisaki S,Muramatsu H,Shimada A,Takahashi Y,Mori-Ezaki M,Sato M,Kawaguchi H,Kinoshita A,Sotomatsu M,Hayashi Y,Furukawa-Hibi Y,Yamada K,Hoshino H,Kiyoi H,Yoshida N,Sakaguchi H,Narita A,Wang X,Ismael O,Xu Y,Nishio N

更新日期：2012-08-16 00:00:00

abstract：:An acquired gain-of-function mutation in the Janus kinase 2 (JAK2-V617F) is frequently found in patients with myeloproliferative disorders (MPDs). To test the hypothesis that JAK2-V617F is the disease-initiating mutation, we examined whether all cells of clonal origin carry the JAK2-V617F mutation. Using allele-specif...

journal_title：Blood

authors： Kralovics R,Teo SS,Li S,Theocharides A,Buser AS,Tichelli A,Skoda RC

更新日期：2006-08-15 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is highly expressed in vascular remodeling processes and accelerates reendothelialization after mechanical denudation. Two VEGF tyrosine kinase receptors have been reported-fms-like-tyrosine kinase-1 (Flt-1) and kinase domain region (KDR). Little is known about the regulation ...

journal_title：Blood

authors： Vidal F,Aragonés J,Alfranca A,de Landázuri MO

更新日期：2000-06-01 00:00:00