Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach.

abstract：:A common genetic risk factor for venous thrombosis among Caucasoid subpopulations is a polymorphism, nt G1691A, in blood coagulation factor V that replaces Arg506 with Gln and imparts resistance of factor Va to the anticoagulant, activated protein C. Haplotype analyses using six dimorphic sites in the factor V gene fo...

journal_title：Blood

authors： Zivelin A,Griffin JH,Xu X,Pabinger I,Samama M,Conard J,Brenner B,Eldor A,Seligsohn U

更新日期：1997-01-15 00:00:00

abstract：:The iron storage macrophage has been isolated from the marrow of Imferon-treated mice and studied in vitro by morphologic, histochemical, and functional tests and isotope labeling techniques. These macrophages on stained preparations are large, many times binucleate cells (up to 150 mu), and show Prussian blue reactiv...

journal_title：Blood

authors： Fedorko ME

更新日期：1975-03-01 00:00:00

abstract：:Bone marrow CD34(+) cell apoptosis (annexin V), proliferation (Ki-67), and Bcl-2-related protein expression was evaluated by flow cytometry in 102 patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia secondary to MDS (MDS-AML) and in 30 normal donors (NBM). Apoptosis was significantly increased in r...

journal_title：Blood

authors： Parker JE,Mufti GJ,Rasool F,Mijovic A,Devereux S,Pagliuca A

更新日期：2000-12-01 00:00:00

abstract：:Approximately 4% to 5% of all bone marrow (BM) cells and 8% to 9% of low density BM cells from FVB/N and BALB/c mice (Ly-6a haplotype) show high to intermediate expression of Ly-6E.1 antigen, recognized by the Sca-1 antibody. Functional properties of enriched cells expressing Ly-6E.1-allelic form of Sca-1 antigen were...

journal_title：Blood

authors： Jurecic R,Van NT,Belmont JW

更新日期：1993-11-01 00:00:00

abstract：:Eosinophils are important in antibody-mediated immune defense against parasites based on interaction with Ig receptors (FcR). Of the three classes of IgG FcR in humans, hFc gamma RI, II, and III, solely hFc gamma RII (CD32) is expressed on freshly isolated eosinophils. Despite an expression level similar to that found...

journal_title：Blood

authors： Koenderman L,Hermans SW,Capel PJ,van de Winkel JG

更新日期：1993-05-01 00:00:00

abstract：:Autologous hematopoietic cell transplant (AHCT) for HIV-infected patients is largely limited to centers with HIV-specific expertise. The Blood and Marrow Transplant Clinical Trials Network 0803/AIDS Malignancy Consortium 071 trial is a multicenter phase 2 study of AHCT for patients with HIV-related lymphoma (HRL). Eli...

journal_title：Blood

authors： Alvarnas JC,Le Rademacher J,Wang Y,Little RF,Akpek G,Ayala E,Devine S,Baiocchi R,Lozanski G,Kaplan L,Noy A,Popat U,Hsu J,Morris LE Jr,Thompson J,Horowitz MM,Mendizabal A,Levine A,Krishnan A,Forman SJ,Navarro WH,

更新日期：2016-08-25 00:00:00

abstract：:Malignant cells are capable of influencing the microenvironment in a manner that facilitates tumor cell survival. Bidirectional crosstalk between chronic lymphocytic leukemic (CLL) cells and marrow-derived mesenchymal stromal cells (MSCs) activates both cell types. In this study, we observed that the conditioned mediu...

journal_title：Blood

authors： Ding W,Knox TR,Tschumper RC,Wu W,Schwager SM,Boysen JC,Jelinek DF,Kay NE

更新日期：2010-10-21 00:00:00

abstract：:Epratuzumab, a humanized anti-CD22 antibody, is currently in clinical trials of B-cell lymphomas and autoimmune diseases, demonstrating therapeutic activity in non-Hodgkin lymphoma (NHL) and systemic lupus erythematosus (SLE). Thus, epratuzumab offers a promising option for CD22-targeted immunotherapy, yet its mechani...

journal_title：Blood

authors： Rossi EA,Goldenberg DM,Michel R,Rossi DL,Wallace DJ,Chang CH

更新日期：2013-10-24 00:00:00

abstract：:One hundred twenty-five cases of Hodgkin's disease from the United States (79), Mexico City (31), and Costa Rica (15) were analyzed for the presence of Epstein-Barr virus (EBV) by in situ hybridization to EBER1 transcripts. EBV was more frequently detected in the Reed-Sternberg (RS) cells of mixed cellularity Hodgkin'...

journal_title：Blood

authors： Gulley ML,Eagan PA,Quintanilla-Martinez L,Picado AL,Smir BN,Childs C,Dunn CD,Craig FE,Williams JW Jr,Banks PM

更新日期：1994-03-15 00:00:00

abstract：:CD4(+), CD56(+) DC2 malignancies constitute a novel disease entity, which has recently been shown to arise from a transformed lymphoid-related plasmacytoid dendritic cell (DC2). Diagnosis is primarily based on a particular immunophenotype with tumor cells expressing CD4 and CD56 antigens in the absence of common lymph...

journal_title：Blood

authors： Leroux D,Mugneret F,Callanan M,Radford-Weiss I,Dastugue N,Feuillard J,Le Mée F,Plessis G,Talmant P,Gachard N,Uettwiller F,Pages MP,Mozziconacci MJ,Eclache V,Sibille C,Avet-Loiseau H,Lafage-Pochitaloff M

更新日期：2002-06-01 00:00:00

abstract：:Reactivation of fetal hemoglobin remains a critical goal in the treatment of patients with sickle cell disease and β-thalassemia. Previously, we discovered that silencing of the fetal γ-globin gene requires the erythroid-specific eIF2α kinase heme-regulated inhibitor (HRI), suggesting that HRI might present a pharmaco...

journal_title：Blood

authors： Huang P,Peslak SA,Lan X,Khandros E,Yano JA,Sharma M,Keller CA,Giardine B,Qin K,Abdulmalik O,Hardison RC,Shi J,Blobel GA

更新日期：2020-06-11 00:00:00

abstract：:Multiple myeloma is characterized by increased osteoclast activity that results in bone destruction and lytic lesions. With the prolonged overall patient survival achieved by new treatment modalities, additional drugs are required to inhibit bone destruction. We focused on a novel and more potent structural analog of ...

journal_title：Blood

authors： Feng R,Anderson G,Xiao G,Elliott G,Leoni L,Mapara MY,Roodman GD,Lentzsch S

更新日期：2007-03-01 00:00:00

abstract：:Fanconi anemia (FA) is the most frequent inherited cause of bone marrow failure (BMF). Most FA patients experience hematopoietic stem cell attrition and cytopenia during childhood, which along with intrinsic chromosomal instability, favor clonal evolution and the frequent emergence in their teens or young adulthood of...

journal_title：Blood

authors： Peffault de Latour R,Soulier J

更新日期：2016-06-16 00:00:00

abstract：:Multiple myeloma is a clonal plasma cell malignancy that accounts for slightly more than 10% of all hematologic cancers. In this paper, we present a historically focused review of the disease, from the description of the first case in 1844 to the present. The evolution of drug therapy and stem-cell transplantation for...

journal_title：Blood

authors： Kyle RA,Rajkumar SV

更新日期：2008-03-15 00:00:00

abstract：:Humans and mice with impaired perforin-dependent cytotoxic function may develop excessive T-cell activation and the fatal disorder hemophagocytic lymphohistiocytosis (HLH) after infection. Though cytotoxic lymphocytes can kill antigen-presenting cells, the physiological mechanism of perforin-mediated immune regulation...

journal_title：Blood

authors： Terrell CE,Jordan MB

更新日期：2013-06-27 00:00:00

abstract：:Allelic loss at nonrandom chromosomal sites is thought to mark the position of tumor suppressor genes involved in the pathogenesis and progression of human malignancies. Solid tumors in particular have been found to harbor multiple genetic changes resulting in loss of function mutations. Tumor suppressor genes have al...

journal_title：Blood

authors： Bullrich F,Veronese ML,Kitada S,Jurlander J,Caligiuri MA,Reed JC,Croce CM

更新日期：1996-10-15 00:00:00

abstract：:Analysis of fresh human tumors have indicated that patients with B type lymphoproliferative diseases and the majority of patients with acute lymphoblastic leukemia (ALL) express elevated levels of p53 production. It is suggested that in these human malignancies, p53 may provide a novel tool for monitoring cancer activ...

journal_title：Blood

authors： Prokocimer M,Shaklai M,Bassat HB,Wolf D,Goldfinger N,Rotter V

更新日期：1986-07-01 00:00:00

abstract：:Growth of human B-cell precursors (BCP) was achieved by plating fetal CD10+ surface-mu (s mu)- cells in liquid medium onto bone marrow-derived fibroblastic stromal cell layers deprived of hematopoietic cells. Proliferation of the fetal BCP was strongly potentiated by the addition of interleukin-7 (IL-7) to the culture...

journal_title：Blood

authors： Moreau I,Duvert V,Banchereau J,Saeland S

更新日期：1993-03-01 00:00:00

abstract：:Peripheral blood cells from nine patients with B-chronic lymphocytic leukemia (B-CLL) were treated in vitro with bryostatin 1 (a macrocyclic lactone derived from a marine invertebrate). Like the phorbol ester 12-0-tetradecanoyl-phorbol 13-acetate (TPA), bryostatin 1 activates protein kinase C (PKC), which plays a cent...

journal_title：Blood

authors： Drexler HG,Gignac SM,Jones RA,Scott CS,Pettit GR,Hoffbrand AV

更新日期：1989-10-01 00:00:00

abstract：:BRCA1 is critical for maintenance of genomic stability and interacts directly with several proteins that regulate hematopoietic stem cell function and are part of the Fanconi anemia (FA) double-strand break DNA repair pathway. The effects of complete BRCA1 deficiency on bone marrow (BM) function are unknown. To test t...

journal_title：Blood

authors： Vasanthakumar A,Arnovitz S,Marquez R,Lepore J,Rafidi G,Asom A,Weatherly M,Davis EM,Neistadt B,Duszynski R,Vardiman JW,Le Beau MM,Godley LA,Churpek JE

更新日期：2016-01-21 00:00:00

abstract：:Deletion of Runx1 in adult mice produces a myeloproliferative phenotype. We now find that Runx1 gene deletion increases marrow monocyte while reducing granulocyte progenitors and that exogenous RUNX1 rescues granulopoiesis. Deletion of Runx1 reduces Cebpa mRNA in lineage-negative marrow cells and in granulocyte-monocy...

journal_title：Blood

authors： Guo H,Ma O,Speck NA,Friedman AD

更新日期：2012-05-10 00:00:00

abstract：:Glycoprotein (GP) Ibalpha, a member of the leucine-rich repeat (LRR) protein family, mediates platelet adhesion to immobilized von Willebrand factor (VWF). We investigated the role in VWF binding of charged residues in the LRR region of GP Ibalpha that are conserved in human, canine, and murine proteins. Substitution ...

journal_title：Blood

authors： Peng Y,Shrimpton CN,Dong JF,López JA

更新日期：2005-09-15 00:00:00

abstract：:A variant subline (KG-1a) of the human acute myelogenous leukemia (AML) cell line (KG-1) has been isolated. The cells retain the same constitutive markers as the parent line, including HLA antigens, isoenzymes, and karyotype. The cells from the subline are morphologically and histochemically undifferentiated blast cel...

journal_title：Blood

authors： Koeffler HP,Billing R,Lusis AJ,Sparkes R,Golde DW

更新日期：1980-08-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is an often-fatal disorder characterized by the overactivation of T cells and macrophages that excessively produce proinflammatory cytokines, including interferon-γ (IFN-γ). Previously, we reported that the JAK inhibitor ruxolitinib dampens T-cell activation and lessens inflamm...

journal_title：Blood

authors： Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE

更新日期：2019-07-11 00:00:00

abstract：:The anemia of chronic disease (ACD) results from 3 major processes: slightly shortened red cell survival, impaired reticuloendothelial system iron mobilization, and impaired erythropoiesis. Hepcidin is an acute-phase protein with specific iron regulatory properties, which, along with the anemia seen with increased hep...

journal_title：Blood

authors： Dallalio G,Law E,Means RT Jr

更新日期：2006-04-01 00:00:00

abstract：:The plasma membrane calcium pump (PMCA) is the only active Ca2+ transporter in human red blood cells (RBCs). Previous measurements of maximal Ca2+ extrusion rates (Vmax) reported only mean values in the RBC population. Despite early evidence for differences in Ca2+ extrusion capacity among RBCs, the precise Vmax distr...

journal_title：Blood

authors： Lew VL,Daw N,Perdomo D,Etzion Z,Bookchin RM,Tiffert T

更新日期：2003-12-01 00:00:00

abstract：:Cytomegalovirus (CMV) has been a major cause of morbidity and mortality after allogeneic stem cell transplantation (SCT). The importance of the recipient's serologic status is paramount. However, the importance of the donor's serologic status in CMV-seropositive recipients is controversial. We analyzed the influence o...

journal_title：Blood

authors： Ljungman P,Brand R,Einsele H,Frassoni F,Niederwieser D,Cordonnier C

更新日期：2003-12-15 00:00:00

abstract：:Approximately 20% of childhood B-precursor acute lymphoblastic leukemia (ALL) has a TEL-AML1 fusion gene, often in association with deletions of the nonrearranged TEL allele. TEL-AML1 gene fusion appears to be an initiating event and usually occurs before birth, in utero. This subgroup of ALL generally presents with l...

journal_title：Blood

authors： Ford AM,Fasching K,Panzer-Grümayer ER,Koenig M,Haas OA,Greaves MF

更新日期：2001-08-01 00:00:00

abstract：:We have studied adenovirus-mediated cytotoxicity after infection of malignant cells obtained from patients with chronic lymphocytic leukemia (CLL). Our studies indicate that adenoviruses can infect primary CLL cells and that infection of CLL cells with a replication-competent strain of human adenovirus 5 (Ad5dl309) re...

journal_title：Blood

authors： Medina DJ,Sheay W,Goodell L,Kidd P,White E,Rabson AB,Strair RK

更新日期：1999-11-15 00:00:00

abstract：:The molecular basis of most beta-thalassemia syndromes has been defined, while the spectrum of mutations causing delta-thalassemia is not well characterized. In an attempt to identify such mutations, the region encompassing the delta-globin gene from three Greek Cypriot families suspected of having delta-thalassemia w...

journal_title：Blood

authors： Trifillis P,Ioannou P,Schwartz E,Surrey S

更新日期：1991-12-15 00:00:00