Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis.

abstract：:Fanconi anemia (FA) is a genetic disease characterized by congenital abnormalities, bone marrow failure, and susceptibility to leukemia and other cancers. FANCJ, one of 13 genes linked to FA, encodes a DNA helicase proposed to operate in homologous recombination repair and replicational stress response. The pathogenic...

journal_title：Blood

authors： Wu Y,Sommers JA,Suhasini AN,Leonard T,Deakyne JS,Mazin AV,Shin-Ya K,Kitao H,Brosh RM Jr

更新日期：2010-11-11 00:00:00

abstract：:Low molecular weight heparin (LMWH) is being tested as an experimental drug for improving pregnancy outcome in women with inherited thrombophilia and placenta-mediated pregnancy complications, such as recurrent pregnancy loss. The role of thrombotic processes in these disorders remains unproven, and the issue of antit...

journal_title：Blood

authors： An J,Waitara MS,Bordas M,Arumugam V,Hoffmann RG,Petrich BG,Sinha U,North PE,Sood R

更新日期：2013-03-14 00:00:00

abstract：:Serum from 398 myeloma patients at diagnosis and serial samples from 29 patients were analysed for hepatocyte growth factor (HGF). HGF was elevated at diagnosis in 43% of myeloma patients compared with healthy controls (median 1.00 ng/mL and 0.44 ng/mL, respectively; P < .00001). In the group with elevated HGF levels ...

journal_title：Blood

authors： Seidel C,Børset M,Turesson I,Abildgaard N,Sundan A,Waage A

更新日期：1998-02-01 00:00:00

abstract：:The risk for thrombosis is increased in patients with hereditary hydrocytosis, an uncommon variant of hereditary stomatocytosis. Erythrocytes from 2 patients with hydrocytosis were studied to gain insight into the mechanism of thrombosis in this disorder. Erythrocytes demonstrated abnormal osmotic scan ektacytometry a...

journal_title：Blood

authors： Gallagher PG,Chang SH,Rettig MP,Neely JE,Hillery CA,Smith BD,Low PS

更新日期：2003-06-01 00:00:00

abstract：:We have designed two subfamilies of lipophilic iron (III) chelators previously termed reversed siderophores (RSFs). The agents display physicochemical properties that favor extraction of iron beyond membrane barriers of Plasmodium falciparum-infected red blood cells. We studied the in vitro antimalarial potency of RSF...

journal_title：Blood

authors： Lytton SD,Mester B,Dayan I,Glickstein H,Libman J,Shanzer A,Cabantchik ZI

更新日期：1993-01-01 00:00:00

abstract：:Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of ALL in children. There are conflicting data on the incidence and prognosis of Ph-like ALL in adults. Patients with newly diagnosed B-cell ALL (B-ALL) who received frontline chemotherapy at MD Anderson Cancer Center underwent...

journal_title：Blood

authors： Jain N,Roberts KG,Jabbour E,Patel K,Eterovic AK,Chen K,Zweidler-McKay P,Lu X,Fawcett G,Wang SA,Konoplev S,Harvey RC,Chen IM,Payne-Turner D,Valentine M,Thomas D,Garcia-Manero G,Ravandi F,Cortes J,Kornblau S,O'Brien

更新日期：2017-02-02 00:00:00

abstract：:Receptor tyrosine kinases are known to be important in growth and differentiation. We have recently found that c-kit, the tyrosine kinase receptor for steel factor, also regulates cell-matrix adhesion. Because Steel factor helps regulate cell migration and localization, this may be an important biologic function. Inte...

journal_title：Blood

authors： Kinashi T,Escobedo JA,Williams LT,Takatsu K,Springer TA

更新日期：1995-09-15 00:00:00

abstract：:Some patients lose chimerism following nonmyeloablative hematopoietic cell transplantation (HCT), yet, surprisingly, enjoy sustained tumor remissions. We hypothesized that host-versus-graft (HVG) alloresponses might induce antitumor effects against recipient tumors. We explored this question in mice by administering r...

journal_title：Blood

authors： Rubio MT,Kim YM,Sachs T,Mapara M,Zhao G,Sykes M

更新日期：2003-09-15 00:00:00

abstract：:A longstanding endeavor to define the genetic lesions that drive myeloid malignances has stimulated a period of remarkable discovery. Enabled by technological advances that have sharply decreased the cost of DNA sequencing, the full compendium of common, recurrent somatic mutations in the coding genome of myeloid mali...

journal_title：Blood

authors： Lindsley RC,Ebert BL

更新日期：2013-11-28 00:00:00

abstract：:Auxiliary bone marrow cells are required for optimal murine megakaryocyte colony formation in addition to progenitor cells and a colony stimulating activity (CSA) present in WEHI-3 cell conditioned medium. These auxiliary cells are adherent, with a sedimentation rate of 5.8 mm hr-1 and buoyant density of 1.065-1.078 g...

journal_title：Blood

authors： Williams N,Jackson H,Ralph P,Nakoinz I

更新日期：1981-01-01 00:00:00

abstract：:We previously reported that sphingosine 1-phosphate (S1P) regulates peritoneal B-cell trafficking and subsequent intestinal IgA production, but the underlying mechanisms remain obscure. We demonstrate here that nuclear factor kappaB-inducing kinase (NIK) is involved in the regulation of S1P-mediated trafficking of per...

journal_title：Blood

authors： Kunisawa J,Gohda M,Kurashima Y,Ishikawa I,Higuchi M,Kiyono H

更新日期：2008-05-01 00:00:00

abstract：:Human alpha2-antiplasmin (alpha2AP), also known as alpha2-plasmin inhibitor, is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin. There are 2 N-terminal forms of alpha2AP that circulate in human plasma: a 464-residue protein with Met as the N-terminus, Met-alpha2AP, and a 452-residue version w...

journal_title：Blood

authors： Lee KN,Jackson KW,Christiansen VJ,Chung KH,McKee PA

更新日期：2004-05-15 00:00:00

abstract：:We have used monoclonal antibodies (M Abs) and proteolytic fragmentation to localize structurally the functional sites of human von Willebrand factor (vWF) responsible for interaction with membrane glycoproteins GPIb, GPIIb/IIIa, and with collagen. SpII (215 kd) and SpIII (320 kd), the S aureus V-8 protease homodimeri...

journal_title：Blood

authors： Girma JP,Kalafatis M,Piétu G,Lavergne JM,Chopek MW,Edgington TS,Meyer D

更新日期：1986-05-01 00:00:00

abstract：:Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) that leads to progressive bone marrow (BM) fibrosis. Although the cellular mutations involved in the pathogenesis of PMF have been extensively investigated, the sequential events that drive stromal activation and fibrosis by hematopoietic-stromal cross...

journal_title：Blood

authors： Gleitz HFE,Dugourd AJF,Leimkühler NB,Snoeren IAM,Fuchs SNR,Menzel S,Ziegler S,Kröger N,Triviai I,Büsche G,Kreipe H,Banjanin B,Pritchard JE,Hoogenboezem R,Bindels EM,Schumacher N,Rose-John S,Elf S,Saez-Rodriguez J,Kr

更新日期：2020-10-29 00:00:00

abstract：:The antiapoptotic proteins, Bcl-2 and Bcl-X(L), are expressed in most cases of acute myeloid leukemia (AML) and may contribute to drug resistance in AML. We tested the hypothesis that down-regulation of Bcl-2 alone by antisense oligodeoxynucleotides (Bcl-2-AS) induces apoptosis, even in the presence of other antiapopt...

journal_title：Blood

authors： Konopleva M,Tari AM,Estrov Z,Harris D,Xie Z,Zhao S,López-Berestein G,Andreeff M

更新日期：2000-06-15 00:00:00

abstract：:We recently identified aberrant cytoplasmic expression of nucleophosmin (NPM) as the immunohistochemical marker of a large subgroup of acute myeloid leukemia (AML) (about one-third of adult AML) that is characterized by normal karyotype and mutations occurring at the exon-12 of the NPM gene. In this paper, we have elu...

journal_title：Blood

authors： Falini B,Bolli N,Shan J,Martelli MP,Liso A,Pucciarini A,Bigerna B,Pasqualucci L,Mannucci R,Rosati R,Gorello P,Diverio D,Roti G,Tiacci E,Cazzaniga G,Biondi A,Schnittger S,Haferlach T,Hiddemann W,Martelli MF,Gu W,

更新日期：2006-06-01 00:00:00

abstract：:Peripheral eosinophilia is almost invariably observed during the course of interleukin-2 (IL-2) therapy and is frequently accompanied by the development of a capillary leak syndrome characterized by edema, weight gain, and oliguria. We studied five patients with advanced malignancy treated with IL-2. Eosinophilia was ...

journal_title：Blood

authors： van Haelst Pisani C,Kovach JS,Kita H,Leiferman KM,Gleich GJ,Silver JE,Dennin R,Abrams JS

更新日期：1991-09-15 00:00:00

abstract：:Patients aged ≥60 years with treatment-naive Hodgkin lymphoma (HL) have few treatment options and inferior survival due to treatment-related toxicities and comorbidities. This phase 2, nonrandomized, open-label study evaluated brentuximab vedotin (BV) monotherapy (results previously reported), BV plus dacarbazine (DTI...

journal_title：Blood

authors： Friedberg JW,Forero-Torres A,Bordoni RE,Cline VJM,Patel Donnelly D,Flynn PJ,Olsen G,Chen R,Fong A,Wang Y,Yasenchak CA

更新日期：2017-12-28 00:00:00

abstract：:As B-cell chronic lymphocytic leukemia (B-CLL) progresses, malignant cells extravasate and infiltrate lymphoid tissues. Several molecules, including gelatinase B/MMP-9, contribute to these processes. Although mainly a secreted protease, some MMP-9 is present at the B-CLL cell surface and the function, mode of anchorin...

journal_title：Blood

authors： Redondo-Muñoz J,Ugarte-Berzal E,García-Marco JA,del Cerro MH,Van den Steen PE,Opdenakker G,Terol MJ,García-Pardo A

更新日期：2008-07-01 00:00:00

abstract：:The molecular determinants regulating the specification of human embryonic stem cells (hESCs) into hematopoietic cells remain elusive. HOXA9 plays a relevant role in leukemogenesis and hematopoiesis. It is highly expressed in hematopoietic stem and progenitor cells (HSPCs) and is downregulated upon differentiation. Ho...

journal_title：Blood

authors： Ramos-Mejía V,Navarro-Montero O,Ayllón V,Bueno C,Romero T,Real PJ,Menendez P

更新日期：2014-11-13 00:00:00

abstract：:An in vitro system has been developed that mimics the passage of erythrocytes from the bone marrow to the circulation. Bone marrow egress and its proper regulation are vital physiologic processes. However, because of the inaccessibility of the marrow, it is difficult to evaluate the various factors important in contro...

journal_title：Blood

authors： Waugh RE,Sassi M

更新日期：1986-07-01 00:00:00

abstract：:T cells are known to interact cooperatively with monocytes to produce Colony-Stimulating Factors (CSF), although T cell-mediated signals leading to CSF secretion by monocytes are not completely understood. We have made use of Northern blot hybridization and specific bioassays to study the effects of the T cell product...

journal_title：Blood

authors： Wieser M,Bonifer R,Oster W,Lindemann A,Mertelsmann R,Herrmann F

更新日期：1989-04-01 00:00:00

abstract：:We show the molecular and functional characterization of a novel population of lineage-negative CD34-negative (Lin(-)CD34(-)) hematopoietic stem cells from chronic myelogenous leukemia (CML) patients at diagnosis. Molecular karyotyping and quantitative analysis of BCR-ABL transcript demonstrated that approximately one...

journal_title：Blood

authors： Lemoli RM,Salvestrini V,Bianchi E,Bertolini F,Fogli M,Amabile M,Tafuri A,Salati S,Zini R,Testoni N,Rabascio C,Rossi L,Martin-Padura I,Castagnetti F,Marighetti P,Martinelli G,Baccarani M,Ferrari S,Manfredini R

更新日期：2009-12-10 00:00:00

abstract：:Immunoglobulin class switching from IgM to IgG in response to peptides is generally T cell-dependent and vaccination in T cell-deficient individuals is inefficient. We show that a vaccine consisting of a dense array of peptides on liposomes induced peptide-specific IgG responses totally independent of T-cell help. Ind...

journal_title：Blood

authors： Pihlgren M,Silva AB,Madani R,Giriens V,Waeckerle-Men Y,Fettelschoss A,Hickman DT,López-Deber MP,Ndao DM,Vukicevic M,Buccarello AL,Gafner V,Chuard N,Reis P,Piorkowska K,Pfeifer A,Kündig TM,Muhs A,Johansen P

更新日期：2013-01-03 00:00:00

abstract：:Cyclopentenone prostaglandins are potent inhibitors of nuclear factor-kappa B (NF-kappa B), a transcription factor with a critical role in promoting inflammation and connected with multiple aspects of oncogenesis and cancer cell survival. In the present report, we investigated the role of NF-kappa B in the antineoplas...

journal_title：Blood

authors： Piva R,Gianferretti P,Ciucci A,Taulli R,Belardo G,Santoro MG

更新日期：2005-02-15 00:00:00

abstract：:Production of a red blood cell's hemoglobin depends on mitochondrial heme synthesis. However, mature red blood cells are devoid of mitochondria and rely on glycolysis for ATP production. The molecular basis for the selective elimination of mitochondria from mature red blood cells remains controversial. Recent evidence...

journal_title：Blood

authors： Kundu M,Lindsten T,Yang CY,Wu J,Zhao F,Zhang J,Selak MA,Ney PA,Thompson CB

更新日期：2008-08-15 00:00:00

abstract：:Various n-formylated peptides function as receptor-specific chemoattractants for both granulocytes and monocytes. Because these agents are important tools in the study of leukocyte function in vitro, we chose to examine their effects on leukocyte procoagulant activity. The synthetic chemotactic peptide N-formyl-methio...

journal_title：Blood

authors： Janco RL,Morris PJ

更新日期：1985-03-01 00:00:00

abstract：:The interleukin-4 receptor (IL-4R) is expressed as a 140-Kd membrane glycoprotein that binds IL-4 with high affinity. Recently, cDNA clones for the murine IL-4R have been isolated. One clone encodes an integral membrane protein, while another encodes a protein in which translation is terminated before the transmembran...

journal_title：Blood

authors： Jacobs CA,Lynch DH,Roux ER,Miller R,Davis B,Widmer MB,Wignall J,VandenBos T,Park LS,Beckmann MP

更新日期：1991-06-01 00:00:00

abstract：:Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their use as vectors for immunotherapy vaccines. However, it is unclear whether and to what degree in vitro-generated DCs are representative o...

journal_title：Blood

authors： Maraskovsky E,Daro E,Roux E,Teepe M,Maliszewski CR,Hoek J,Caron D,Lebsack ME,McKenna HJ

更新日期：2000-08-01 00:00:00

abstract：:Macrophage mannose receptor (MR) participates in pathogen recognition, clearance of endogenous serum glycoproteins, and antigen presentation. MR is also present on lymphatic vessels, where its function is unknown. Here we show that migration of lymphocytes from the skin into the draining lymph nodes through the affere...

journal_title：Blood

authors： Marttila-Ichihara F,Turja R,Miiluniemi M,Karikoski M,Maksimow M,Niemelä J,Martinez-Pomares L,Salmi M,Jalkanen S

更新日期：2008-07-01 00:00:00