Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation.

abstract：:We have investigated the role of the Rho and Rac family small guanine triphosphate (GTP) exchange factors (RhoGEFs), Vav1 and Vav2, in the activation of platelets by the immunoreceptor tyrosine-based activation motif (ITAM)-coupled collagen receptor GPVI and by the G protein-coupled receptor agonist thrombin. The glyc...

journal_title：Blood

authors： Pearce AC,Wilde JI,Doody GM,Best D,Inoue O,Vigorito E,Tybulewicz VL,Turner M,Watson SP

更新日期：2002-11-15 00:00:00

abstract：:De novo presentation of acute myeloid leukemia (AML) expressing the Philadelphia (Ph) chromosomal abnormality is rare and is associated with a dismal prognosis. To date, reported cases of Ph(+) AML have expressed either the e13a2 or e14a2 BCR-ABL fusion transcripts. We report a unique case of de novo AML expressing th...

journal_title：Blood

authors： Ritchie DS,McBean M,Westerman DA,Kovalenko S,Seymour JF,Dobrovic A

更新日期：2008-03-01 00:00:00

abstract：:Patients with antineutrophil cytoplasmic antibodies (ANCAs) frequently develop severe vasculitis and glomerulonephritis. Although ANCAs, particularly antimyeloperoxidase (anti-MPO), have been shown to promote leukocyte adhesion in postcapillary venules, their ability to promote adhesion in the glomerular vasculature i...

journal_title：Blood

authors： Kuligowski MP,Kwan RY,Lo C,Wong C,James WG,Bourges D,Ooi JD,Abeynaike LD,Hall P,Kitching AR,Hickey MJ

更新日期：2009-06-18 00:00:00

abstract：:Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in bleeding disorders characterized by a macrothrombocytopenia. To understand the role of myosin in normal platelet functions and in pathology, we generated mice with disruption of MYH9 in megakaryocytes. MYH9Delta mice displayed macrothro...

journal_title：Blood

authors： Léon C,Eckly A,Hechler B,Aleil B,Freund M,Ravanat C,Jourdain M,Nonne C,Weber J,Tiedt R,Gratacap MP,Severin S,Cazenave JP,Lanza F,Skoda R,Gachet C

更新日期：2007-11-01 00:00:00

abstract：:Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is emerging as a new regulator of immune responses and inflammatory vascular diseases. Although IL-33 and its cognate receptor ST2 appear to be expressed in vascular cells, the precise role of IL-33 in the vasculature has not been determined. In this study,...

journal_title：Blood

authors： Choi YS,Choi HJ,Min JK,Pyun BJ,Maeng YS,Park H,Kim J,Kim YM,Kwon YG

更新日期：2009-10-01 00:00:00

abstract：:The Bernard-Soulier syndrome is an inherited bleeding disorder that is due to a deficiency in platelet glycoprotein Ib. Bernard-Soulier platelets fail to agglutinate in response to ristocetin despite normal levels of factor VIII:von Willebrand factor. We report a patient who developed severe refractory thrombocytopeni...

journal_title：Blood

authors： Devine DV,Currie MS,Rosse WF,Greenberg CS

更新日期：1987-08-01 00:00:00

abstract：:About 80% of all cases of Fanconi anemia (FA) can be accounted for by complementation groups A and C. To understand the relationship between these groups, we analyzed the expression pattern of the mouse FA group-A gene (Fanca) during embryogenesis and compared it with the known pattern of the group-C gene (Fancc). Nor...

journal_title：Blood

authors： Abu-Issa R,Eichele G,Youssoufian H

更新日期：1999-07-15 00:00:00

abstract：:Among 1153 new adult cases of peripheral/T-cell lymphoma from 1990-2002 at 22 centers in 13 countries, 136 cases (11.8%) of extranodal natural killer (NK)/T-cell lymphoma were identified (nasal 68%, extranasal 26%, aggressive/unclassifiable 6%). The disease frequency was higher in Asian than in Western countries and i...

journal_title：Blood

authors： Au WY,Weisenburger DD,Intragumtornchai T,Nakamura S,Kim WS,Sng I,Vose J,Armitage JO,Liang R,International Peripheral T-Cell Lymphoma Project.

更新日期：2009-04-23 00:00:00

abstract：:STI571 induces sustained hematologic remission in patients with chronic myeloid leukemia (CML) in chronic phase. However, in advanced phases, especially blast crisis, the leukemia usually becomes resistant within months. It has been investigated whether resistance to STI571 is stable and immutable or whether it can be...

journal_title：Blood

authors： Tipping AJ,Mahon FX,Lagarde V,Goldman JM,Melo JV

更新日期：2001-12-15 00:00:00

abstract：:A global phase 3 study evaluated the pharmacokinetics, efficacy, and safety of recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in 63 previously treated male patients (12-61 years) with severe hemophilia B (factor IX [FIX] activity ≤2%). The study included 2 groups: group 1 patients recei...

journal_title：Blood

authors： Santagostino E,Martinowitz U,Lissitchkov T,Pan-Petesch B,Hanabusa H,Oldenburg J,Boggio L,Negrier C,Pabinger I,von Depka Prondzinski M,Altisent C,Castaman G,Yamamoto K,Álvarez-Roman MT,Voigt C,Blackman N,Jacobs I,PROLONG

更新日期：2016-04-07 00:00:00

abstract：:Epstein-Barr virus (EBV) infections may induce a diverse clinical picture, ranging from the well characterized infectious mononucleosis (IM) syndrome to the rare X-linked lymphoproliferative syndrome. We describe two unrelated children, a 21-mo-old white boy and a 15-mo-old black girl, who presented with the clinical ...

journal_title：Blood

authors： Herrod HG,Dow LW,Sullivan JL

更新日期：1983-06-01 00:00:00

abstract：:Vascular endothelial growth factor-A is widely used in clinical trials for the treatment of cardiac ischemia. VEGF-A was recently suggested to act in a proinflammatory manner, which could aggravate adjacent atherogenesis in VEGF-A-based therapy. To assess potential bystander effects, VEGF-A was focally overexpressed i...

journal_title：Blood

authors： Lucerna M,Zernecke A,de Nooijer R,de Jager SC,Bot I,van der Lans C,Kholova I,Liehn EA,van Berkel TJ,Yla-Herttuala S,Weber C,Biessen EA

更新日期：2007-01-01 00:00:00

abstract：:Aggregation of blood platelets contributes to the arrest of bleeding at sites of vascular injury, but it can occlude atherosclerotic arteries and precipitate diseases such as myocardial infarction. The bonds that link platelets under flow conditions were identified using confocal videomicroscopy in real time. Glycopro...

journal_title：Blood

authors： Ruggeri ZM,Dent JA,Saldívar E

更新日期：1999-07-01 00:00:00

abstract：:We demonstrate a methodology for tracing the clonal history of hematopoietic stem and progenitor cells (HSPCs) behavior in live tissues in 4 dimensions (4D). This integrates genetic combinatorial marking using lentiviral vectors encoding various fluorescent proteins (FPs) with advanced imaging methods. Five FPs: Cerul...

journal_title：Blood

authors： Malide D,Métais JY,Dunbar CE

更新日期：2012-12-20 00:00:00

abstract：:Ibrutinib is highly efficacious and used at 420 mg/d for treatment of chronic lymphocytic leukemia (CLL). We previously demonstrated a decline in Bruton's tyrosine kinase (BTK) protein levels in CLL cells after 1 cycle of ibrutinib, suggesting ibrutinib dose could be lowered after the first cycle without loss of biolo...

journal_title：Blood

authors： Chen LS,Bose P,Cruz ND,Jiang Y,Wu Q,Thompson PA,Feng S,Kroll MH,Qiao W,Huang X,Jain N,Wierda WG,Keating MJ,Gandhi V

更新日期：2018-11-22 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate natural killer (NK) cells in a human leukocyte antigen (HLA)-dependent manner. KIR/HLA mismatched hematopoietic stem cell transplants induce alloreactive NK cells, which prevent leukemia relapse. Certain KIR/HLA combinations protect against HIV-1 infection, but the ...

journal_title：Blood

authors： Jennes W,Verheyden S,Mertens JW,Camara M,Seydi M,Dieye TN,Mboup S,Demanet C,Kestens L

更新日期：2013-02-14 00:00:00

abstract：:Microscopic intracellular detection of Epstein-Barr virus (EBV) messenger RNA in Reed-Sternberg cells of Hodgkin's disease (HD) was possible by in situ hybridization, in tissue sections prepared by a method termed modified acetone methyl benzoate xylene (ModAMeX). The ModAMeX method was initially developed for simulta...

journal_title：Blood

authors： Brousset P,Chittal S,Schlaifer D,Icart J,Payen C,Rigal-Huguet F,Voigt JJ,Delsol G

更新日期：1991-04-15 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with remarkable preclinical and clinical antitumor activity in multiple myeloma (MM) patients. The initial rationale for its use in MM was inhibition of nuclear factor (NF)-kappaB activity by blocking proteasomal degradation of inhibitor of kappaBalpha (IkappaBalpha). Bortezomib in...

journal_title：Blood

authors： Hideshima T,Ikeda H,Chauhan D,Okawa Y,Raje N,Podar K,Mitsiades C,Munshi NC,Richardson PG,Carrasco RD,Anderson KC

更新日期：2009-07-30 00:00:00

abstract：:Mammalian 15-lipoxygenases, which have been implicated in the differentiation of hematopoietic cells are commonly regarded as cytosolic enzymes. Studying the interaction of the purified rabbit reticulocyte 15-lipoxygenase with various types of biomembranes, we found that the enzyme binds to biomembranes when calcium i...

journal_title：Blood

authors： Brinckmann R,Schnurr K,Heydeck D,Rosenbach T,Kolde G,Kühn H

更新日期：1998-01-01 00:00:00

abstract：:Macrophages are reservoirs of HIV-1 infection, proposed to transmit virus to CD4(+) T cells, the primary target of the virus. Here we report that human monocyte-derived macrophages (MDMs) rapidly spread HIV-1 to autologous CD4(+) T cells resulting in productive infection. Transmission takes place across transient adhe...

journal_title：Blood

authors： Groot F,Welsch S,Sattentau QJ

更新日期：2008-05-01 00:00:00

abstract：:T-cell homing to secondary lymphoid tissues generally depends on chemokine-induced firm adhesion in high endothelial venules (HEVs) and is primarily mediated through the CC chemokine receptor 7 (CCR7) on lymphocytes. The CCR7 ligand designated CCL21 is considered the most important trigger because it appears constitut...

journal_title：Blood

authors： Carlsen HS,Haraldsen G,Brandtzaeg P,Baekkevold ES

更新日期：2005-07-15 00:00:00

abstract：:The interleukin (IL)-22R1 chain of the heterodimeric IL-22 receptor is not expressed on normal leukocytes, but this receptor is expressed on T cells from anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large cell lymphoma (ALCL) patients. To investigate the consequences of aberrant expression of this receptor ...

journal_title：Blood

authors： Savan R,McFarland AP,Reynolds DA,Feigenbaum L,Ramakrishnan K,Karwan M,Shirota H,Klinman DM,Dunleavy K,Pittaluga S,Anderson SK,Donnelly RP,Wilson WH,Young HA

更新日期：2011-01-13 00:00:00

abstract：:The incidence and severity of acute graft-versus-host disease (GVHD) after allogeneic transplantation using peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor (G-CSF) appear to be no worse than those after bone marrow transplantation, despite the presence of large numbers of T cells i...

journal_title：Blood

authors： Pan L,Delmonte J Jr,Jalonen CK,Ferrara JL

更新日期：1995-12-15 00:00:00

abstract：:During thrombopoiesis, maturing megakaryocytes (MKs) migrate within the complex bone marrow stromal microenvironment from the proliferative osteoblastic niche to the capillary-rich vascular niche where proplatelet formation and platelet release occurs. This physiologic process involves proliferation, differentiation, ...

journal_title：Blood

authors： Dhanjal TS,Pendaries C,Ross EA,Larson MK,Protty MB,Buckley CD,Watson SP

更新日期：2007-05-15 00:00:00

abstract：:The W locus of mice encodes the c-kit receptor tyrosine kinase. Heterozygous WJic/+ and Wn/+ mice and homozygous Wf/Wf mice were similar in appearance; all of them have large depigmented areas lacking any well-defined pattern. The WJic, Wn, and Wf mutant alleles were characterized and their molecular nature was correl...

journal_title：Blood

authors： Tsujimura T,Koshimizu U,Katoh H,Isozaki K,Kanakura Y,Tono T,Adachi S,Kasugai T,Tei H,Nishimune Y

更新日期：1993-05-15 00:00:00

abstract：:A microperfusion system containing a glass capillary, the inner surface of which is coated with a phospholipid bilayer containing tissue factor, was used to explore the requirement for factors VIIa and Xa in the complex formed with the lipoprotein-associated coagulation inhibitor (LACI). Various combinations of factor...

journal_title：Blood

authors： Gemmell CH,Broze GJ Jr,Turitto VT,Nemerson Y

更新日期：1990-12-01 00:00:00

abstract：:Myelofibrosis (MF) is a BCR-ABL1-negative myeloproliferative neoplasm characterized by clonal myeloproliferation, dysregulated kinase signaling, and release of abnormal cytokines. In recent years, important progress has been made in the knowledge of the molecular biology and the prognostic assessment of MF. Convention...

journal_title：Blood

authors： Cervantes F

更新日期：2014-10-23 00:00:00

abstract：:Platelets play a crucial role in the physiology of primary hemostasis and pathophysiologic processes such as arterial thrombosis. Accumulating evidence suggests a role of reactive oxygen species (ROSs) in platelet activation. Here we show that platelets activated with different agonists produced intracellular ROSs, wh...

journal_title：Blood

authors： Begonja AJ,Gambaryan S,Geiger J,Aktas B,Pozgajova M,Nieswandt B,Walter U

更新日期：2005-10-15 00:00:00

abstract：:The shape and parameters of platelet size distributions were studied in 50 normal persons and 97 patients in order to test the proposed thesis that platelet size heterogeneity results mainly from aging in the circulation. This thesis was contradicted (1) by size distributions of age-homogeneous, newly-born cell popula...

journal_title：Blood

authors： Paulus JM

更新日期：1975-09-01 00:00:00

abstract：:Anti-CD22 moxetumomab pasudotox achieved 46% complete remissions (CRs) in previously reported phase 1 testing in relapsed/refractory hairy cell leukemia (HCL; n = 28). The importance of minimal residual disease (MRD) after CR in HCL is unknown. A 21-patient extension cohort received 50 µg/kg every other day for 3 dose...

journal_title：Blood

authors： Kreitman RJ,Tallman MS,Robak T,Coutre S,Wilson WH,Stetler-Stevenson M,FitzGerald DJ,Santiago L,Gao G,Lanasa MC,Pastan I

更新日期：2018-05-24 00:00:00