Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

abstract：:Peripheral blood and bone marrow mononuclear cells from patients with refractory anemia (RA) or RA with sideroblasts (defined according to the revised French-American-British classification with less than 5% blast cells in the bone marrow) were analyzed using a panel of monoclonal antibodies directed against leukocyte...

journal_title：Blood

authors： Hokland P,Kerndrup G,Griffin JD,Ellegaard J

更新日期：1986-04-01 00:00:00

abstract：:The development of inhibitory antibodies to factor VIII in patients affected by a mild form of hemophilia A (factor VIII > 0.05 IU/mL) is considered a rare event. In this study, we evaluated the relationship between genotype and anti-factor VIII antibody formation in a patient with mild hemophilia A. Mutation analysis...

journal_title：Blood

authors： Fijnvandraat K,Turenhout EA,van den Brink EN,ten Cate JW,van Mourik JA,Peters M,Voorberg J

更新日期：1997-06-15 00:00:00

abstract：:High molecular weight (HMW) kininogen, the cofactor for activation of the contact system of plasma proteolysis, transports and optimally positions prekallikrein and factor XI on a negatively charged surface, allowing those zymogens to be activated by surface-bound factor XIIa. HMW kininogen circulates in plasma as a p...

journal_title：Blood

authors： Chang JJ,Scott CF,Colman RW

更新日期：1986-03-01 00:00:00

abstract：:The aim of this study was to investigate whether interleukin (IL)-6 induces the production of IL-1 and tumor necrosis factor (TNF) antagonists. Serial plasma samples were obtained from cancer patients participating in phase I and II trials of recombinant IL-6 administered as a 120-hour continuous intravenous (IV) infu...

journal_title：Blood

authors： Tilg H,Trehu E,Atkins MB,Dinarello CA,Mier JW

更新日期：1994-01-01 00:00:00

abstract：:Ravulizumab (ALXN1210), a new complement C5 inhibitor, provides immediate, complete, and sustained C5 inhibition. This phase 3, open-label study assessed the noninferiority of ravulizumab to eculizumab in complement inhibitor-naive adults with paroxysmal nocturnal hemoglobinuria (PNH). Patients with lactate dehydrogen...

journal_title：Blood

authors： Lee JW,Sicre de Fontbrune F,Wong Lee Lee L,Pessoa V,Gualandro S,Füreder W,Ptushkin V,Rottinghaus ST,Volles L,Shafner L,Aguzzi R,Pradhan R,Schrezenmeier H,Hill A

更新日期：2019-02-07 00:00:00

abstract：:Studying human antigen-specific memory B cells has been challenging because of low frequencies in peripheral blood, slow proliferation, and lack of antibody secretion. Therefore, most studies have relied on conversion of memory B cells into antibody-secreting cells by in vitro culture. To facilitate direct ex vivo iso...

journal_title：Blood

authors： Franz B,May KF Jr,Dranoff G,Wucherpfennig K

更新日期：2011-07-14 00:00:00

abstract：:Hemophilia B is a bleeding disorder caused by a deficiency of clotting factor IX (FIX). A colony of FIX deficient Lhasa Apso dogs has been established and the molecular basis of hemophilia B has been determined. The plasma factor IX levels were < 1% of normal canine levels in affected dogs. A complex deletion mutation...

journal_title：Blood

authors： Mauser AE,Whitlark J,Whitney KM,Lothrop CD Jr

更新日期：1996-11-01 00:00:00

abstract：:Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is emerging as a new regulator of immune responses and inflammatory vascular diseases. Although IL-33 and its cognate receptor ST2 appear to be expressed in vascular cells, the precise role of IL-33 in the vasculature has not been determined. In this study,...

journal_title：Blood

authors： Choi YS,Choi HJ,Min JK,Pyun BJ,Maeng YS,Park H,Kim J,Kim YM,Kwon YG

更新日期：2009-10-01 00:00:00

abstract：:Gene therapy holds a major promise. However, until now, this promise was fulfilled only in few cases, in rare genetic diseases. One very common clinical condition is anemia. Patients with anemia of chronic renal failure are treated with erythropoietin. The objective of this study was to develop a therapeutic platform ...

journal_title：Blood

authors： Lippin Y,Dranitzki-Elhalel M,Brill-Almon E,Mei-Zahav C,Mizrachi S,Liberman Y,Iaina A,Kaplan E,Podjarny E,Zeira E,Harati M,Casadevall N,Shani N,Galun E

更新日期：2005-10-01 00:00:00

abstract：:This study was designed to assess the presence of endogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) within adherent layers of human Dexter-type cultures and to investigate the effect on granulomonopoiesis of adding exogenous GM-CSF to the culture medium. The presence of GM-CSF was demonstrated using...

journal_title：Blood

authors： Charbord P,Tamayo E,Saeland S,Duvert V,Poulet J,Gown AM,Herve P

更新日期：1991-09-01 00:00:00

abstract：:Antibody-induced antigenic modulation (AIAM) of CD10 and CD19 was studied on NALM-6, RAJI, and JOK-1 cell lines using fluorescence microscopy (FM), flow cytometry (FCM), and immunoelectron microscopy (IEM). Cross-linking with monoclonal antibodies (MoAbs) induced rapid redistribution of CD10 and CD19 on the cell surfa...

journal_title：Blood

authors： Pulczynski S,Boesen AM,Jensen OM

更新日期：1993-03-15 00:00:00

abstract：:Reticular dysgenesis is a rare inherited immunodeficiency characterized by the lack of blood monocytes and neutrophils and low lymphocyte counts, contrasting with normal red blood cell counts and normal or decreased platelet counts. Whether dendritic cells or macrophages, both of which derive primarily from blood mono...

journal_title：Blood

authors： Emile JF,Geissmann F,Martin OC,Radford-Weiss I,Lepelletier Y,Heymer B,Espanol T,de Santes KB,Bertrand Y,Brousse N,Casanova JL,Fischer A

更新日期：2000-07-01 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) remains a serious complication following allogeneic stem-cell transplantation (SCT), and is mediated by infiltration of alloreactive donor T cells into recipient tissue. Chemokines and their receptors play a central role in controlling the recruitment of T cells into discrete ti...

journal_title：Blood

authors： Piper KP,Horlock C,Curnow SJ,Arrazi J,Nicholls S,Mahendra P,Craddock C,Moss PA

更新日期：2007-12-01 00:00:00

abstract：:In 21 patients with lymphoproliferative disease of granular lymphocytes (LDGL), we investigated the expression and the function of molecules belonging to TNF-receptor and TNF-ligand superfamilies (CD30/CD30L; CD40/CD40L; CD27/CD70; Fas [CD95]/FasL[CD95L]). Fourteen patients were characterized by a proliferation of gra...

journal_title：Blood

authors： Zambello R,Trentin L,Facco M,Siviero M,Galvan S,Piazza F,Perin A,Agostini C,Semenzato G

更新日期：2000-07-15 00:00:00

abstract：:ELL-12, a liposome formulation of the ether-lipid 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH(3)), is a nonmyelosuppressive antiproliferative agent that is more effective and less toxic than the ether lipid itself in tumor model systems. We found that ELL-12 induced apoptosis in Jurkat, H9, and U-9...

journal_title：Blood

authors： Cuvillier O,Mayhew E,Janoff AS,Spiegel S

更新日期：1999-11-15 00:00:00

abstract：:By using an enzyme-linked immunosorbent assay, the presence of the soluble form of the interleukin-2 receptor (sIL-2R) was evaluated in the peripheral blood of 54 patients with B cell chronic lymphocytic leukemia (B-CLL). Serum levels of sIL-2R were correlated with clinical features, relevant hematologic and immunolog...

journal_title：Blood

authors： Semenzato G,Foa R,Agostini C,Zambello R,Trentin L,Vinante F,Benedetti F,Chilosi M,Pizzolo G

更新日期：1987-08-01 00:00:00

abstract：:Endotoxin-free purified recombinant human erythroid-potentiating activity (EPA) was administered to normal and bled mice. In anemic ICR mice EPA treatment led to a significant increase in the number of reticulocytes in the peripheral blood and erythroid precursors in the spleen. Stimulation of CFU-E and BFU-E in the s...

journal_title：Blood

authors： Niskanen E,Gasson JC,Teates CD,Golde DW

更新日期：1988-08-01 00:00:00

abstract：:Intravenously applied normal human immunoglobulin G (IgG) has anti-inflammatory effects in the treatment of autoimmune diseases. Systemic inflammation can originate from an overreacting amplification loop of the complement system. In blood, C3b2-containing complexes maintain complement amplification much better than t...

journal_title：Blood

authors： Lutz HU,Stammler P,Bianchi V,Trüeb RM,Hunziker T,Burger R,Jelezarova E,Späth PJ

更新日期：2004-01-15 00:00:00

abstract：:Interleukin (IL)-32 was originally identified in natural killer cells and IL-2-activated human T lymphocytes. As T cells are activated in allogeneic transplantation, we determined the role of IL-32 in human mixed lymphocyte cultures (MLCs) and GVHD. In allogeneic MLCs, IL-32 increased two-fold in responding T cells, a...

journal_title：Blood

authors： Marcondes AM,Li X,Tabellini L,Bartenstein M,Kabacka J,Sale GE,Hansen JA,Dinarello CA,Deeg HJ

更新日期：2011-11-03 00:00:00

abstract：:Some multilineage hemopoietic colonies contain, in addition to myeloid cells, T lymphocytes. These proliferate extensively in liquid suspension culture under the influence of a T cell growth factor provided by phytohemagglutinin-T cell-conditioned medium (PHA-TCM). The clonal origin of these myeloid and lymphoid compo...

journal_title：Blood

authors： Lim B,Jamal N,Tritchler D,Messner HA

更新日期：1984-06-01 00:00:00

abstract：:One hundred forty-two patients between the ages of 1 and 17 years who survived disease-free more than 1 year after marrow transplantation for hematologic malignancy had growth and development evaluations from one to 14 years posttransplant (median 4 years). Prior to transplant all children received multiagent chemothe...

journal_title：Blood

authors： Sanders JE,Pritchard S,Mahoney P,Amos D,Buckner CD,Witherspoon RP,Deeg HJ,Doney KC,Sullivan KM,Appelbaum FR

更新日期：1986-11-01 00:00:00

abstract：:Microparticles (MPs) are submicron extracellular vesicles exposing phosphatidylserine (PS), detected at high concentration in the circulation of sickle cell anemia (SS) patients. Several groups studied the biological effects of MPs generated ex vivo. Here, we analyzed for the first time the impact of circulating MPs o...

journal_title：Blood

authors： Garnier Y,Ferdinand S,Garnier M,Cita KC,Hierso R,Claes A,Connes P,Hardy-Dessources MD,Lapouméroulie C,Lemonne N,Etienne-Julan M,El Nemer W,Romana M

更新日期：2020-07-09 00:00:00

abstract：:To obtain information relevant to the question of bone marrow transplantation, we examined the prognostic significance of disease features recorded at the time of diagnosis among 625 patients, aged 5 to 45, with Philadelphia chromosome-positive, nonblastic chronic granulocytic leukemia. The actuarial death rate for th...

journal_title：Blood

authors： Sokal JE,Baccarani M,Tura S,Fiacchini M,Cervantes F,Rozman C,Gomez GA,Galton DA,Canellos GP,Braun TJ

更新日期：1985-12-01 00:00:00

abstract：:Norovirus (NV) infections are a frequent cause of gastroenteritis (GE), but data on this disease in immunocompromised patients are limited. We analyzed an NV outbreak, which affected immunosuppressed patients in the context of chemotherapy or HSCT. On recognition, 7 days after admission of the index patient, preventiv...

journal_title：Blood

authors： Schwartz S,Vergoulidou M,Schreier E,Loddenkemper C,Reinwald M,Schmidt-Hieber M,Flegel WA,Thiel E,Schneider T

更新日期：2011-06-02 00:00:00

abstract：:In individuals with sickle cell disease, a variable number of irreversibly sickled cells (ISC) is present that may contribute to the pathophysiology of sickle cell anemia. The present study was undertaken to determine the possible role of membrane lipid peroxidation in the genesis of ISC. After 24 hr of simple aerobic...

journal_title：Blood

authors： Jain SK,Shohet SB

更新日期：1984-02-01 00:00:00

abstract：:Andexanet alfa, a reversing agent for anticoagulants that inhibit factor Xa, has recently been licensed in the United States. We discuss the impact of this licensure on current practice and review in detail the problems of a neglected and growing clinical area: reversing the anticoagulation effect of factor Xa inhibit...

journal_title：Blood

authors： Hunt BJ,Neal MD,Stensballe J

更新日期：2018-12-06 00:00:00

abstract：:Oncogenic rearrangements of the tyrosine kinase receptor anaplastic lymphoma kinase (ALK), most commonly represented by the nucleophosmin/ALK fusion protein (NPM/ALK), are involved in the pathogenesis of anaplastic large-cell lymphomas (ALCLs). In an effort to identify new intracellular transducers operative in ALK-po...

journal_title：Blood

authors： Bacchiocchi R,Baldanzi G,Carbonari D,Capomagi C,Colombo E,van Blitterswijk WJ,Graziani A,Fazioli F

更新日期：2005-09-15 00:00:00

abstract：:Primary diffuse large B-cell lymphomas (DLBCLs) are aggressive tumors accounting for approximately 40% of B-cell malignancies. The immunoglobulin (Ig) variable region genes have undergone rearrangement and are commonly somatically mutated. The majority show intraclonal variation which indicates that somatic mutation h...

journal_title：Blood

authors： Ottensmeier CH,Stevenson FK

更新日期：2000-10-01 00:00:00

abstract：:One major obstacle to the effective treatment of cancer is to distinguish between tumor cells and normal cells. The chimeric molecules created by cancer-associated chromosomal abnormalities are ideal therapeutic targets because they are unique to the disease. We describe the use of a novel approach based on the cataly...

journal_title：Blood

authors： Cobaleda C,Sánchez-García I

更新日期：2000-02-01 00:00:00

abstract：:The t(11;14)(q13;q32) results in up-regulation of cyclin D1 and is the most common translocation detected in multiple myeloma, where it is also associated with a lymphoplasmacytic morphology. We performed an interphase fluorescent in situ hybridization (FISH) study to determine the clinical and biologic significance o...

journal_title：Blood

authors： Fonseca R,Blood EA,Oken MM,Kyle RA,Dewald GW,Bailey RJ,Van Wier SA,Henderson KJ,Hoyer JD,Harrington D,Kay NE,Van Ness B,Greipp PR

更新日期：2002-05-15 00:00:00