Intravenously applied IgG stimulates complement attenuation in a complement-dependent autoimmune disease at the amplifying C3 convertase level.

abstract：:Because there is no known genetic abnormality common to all patients with myeloma, it is important to understand how genetic heterogeneity may lead to differences in signal transduction, cell cycle, and response to therapy. Model cell lines have been used to study the effect that mutations in p53 and ras can have on g...

journal_title：Blood

authors： Rowley M,Liu P,Van Ness B

更新日期：2000-11-01 00:00:00

abstract：:Dosing of enzyme replacement therapy (ERT) for Gaucher disease type 1 is still a subject of debate and varies from 15 to 130 U/kg/mo, making a huge economic difference of 70,000 US dollars to 380,000 US dollars(euro55,000-300,000) per patient per year. To investigate whether this difference in dosing ultimately transl...

journal_title：Blood

authors： de Fost M,Hollak CE,Groener JE,Aerts JM,Maas M,Poll LW,Wiersma MG,Häussinger D,Brett S,Brill N,vom Dahl S

更新日期：2006-08-01 00:00:00

abstract：:Expression of the myeloperoxidase (MPO) gene is tightly regulated in a tissue- and development-specific manner. Accumulation of MPO messenger RNA (mRNA) occurs only at the late myeloblastic and promyelocytic stages of myeloid differentiation and is negligible at other stages of myeloid development and in other tissues...

journal_title：Blood

authors： Lübbert M,Miller CW,Koeffler HP

更新日期：1991-07-15 00:00:00

abstract：:In this issue of Blood, Rollin et al demonstrate that heparin-induced thrombocytopenia and thrombosis (HIT) patients homozygous for arginine (R) at position 131 in the immunoglobulin (Ig)G receptor FcγRIIA have a significantly higher incidence of thrombosis, and show that plasma IgG may play a key role in modulating t...

journal_title：Blood

authors： Padmanabhan A

更新日期：2015-04-09 00:00:00

abstract：:Angiotensin I-converting enzyme (ACE) inhibitors can affect hematopoiesis by several mechanisms including inhibition of angiotensin II formation and increasing plasma concentrations of AcSDKP (acetyl-N-Ser-Asp-Lys-Pro), an ACE substrate and a negative regulator of hematopoiesis. We tested whether ACE inhibition could ...

journal_title：Blood

authors： Charrier S,Michaud A,Badaoui S,Giroux S,Ezan E,Sainteny F,Corvol P,Vainchenker W

更新日期：2004-08-15 00:00:00

abstract：:Stat5 proteins are critical signaling molecules activated by many cytokines. Within the immune system, Stat5 plays important roles related to the development of thymocytes and proliferation of T cells. Stat5 has been implicated in malignant transformation, and moreover, the activated tyrosine phosphorylated form of St...

journal_title：Blood

authors： Bessette K,Lang ML,Fava RA,Grundy M,Heinen J,Horne L,Spolski R,Al-Shami A,Morse HC 3rd,Leonard WJ,Kelly JA

更新日期：2008-01-01 00:00:00

abstract：:Calreticulin mutations (CALR(MUT)) are found in a significant proportion of patients with essential thrombocythemia (ET) lacking JAK2(V617F) or MPL mutations. They are associated with substantially different hematological and clinical features and define a distinct subtype of ET. We show here that their presence is si...

journal_title：Blood

authors： Allen C,Lambert JR,Linch DC,Gale RE

更新日期：2014-09-25 00:00:00

abstract：:Follicular lymphoma (FL) is a low-grade B-cell non-Hodgkin's lymphoma (NHL) that frequently transforms into diffuse aggressive NHL. The majority of FLs display a t(14; 18) translocation that places the bcl-2 gene into juxtaposition with the lg heavy-chain (H) gene locus. Morphologically transformed malignant FL cells ...

journal_title：Blood

authors： Matolcsy A,Casali P,Warnke RA,Knowles DM

更新日期：1996-11-15 00:00:00

abstract：:Omenn syndrome (OS) is an inherited disorder characterized by an absence of circulating B cells and an infiltration of the skin and the intestine by activated oligoclonal T lymphocytes, indicating that a profound defect in the lymphoid developmental program could be accountable for this condition. Inherited mutations ...

journal_title：Blood

authors： Corneo B,Moshous D,Güngör T,Wulffraat N,Philippet P,Le Deist FL,Fischer A,de Villartay JP

更新日期：2001-05-01 00:00:00

abstract：:Fifty-one children with acute lymphoblastic leukemia (ALL) in second or subsequent remission after a first remission of at least 24 months underwent purged, autologous bone marrow transplantation (ABMT). Bone marrow was harvested in remission and purged in vitro with monoclonal antibodies specific for leukemia-associa...

journal_title：Blood

authors： Billett AL,Kornmehl E,Tarbell NJ,Weinstein HJ,Gelber RD,Ritz J,Sallan SE

更新日期：1993-03-15 00:00:00

abstract：:Sickle cell disease (SCD) is characterized by a single point mutation in the seventh codon of the β-globin gene. Site-specific correction of the sickle mutation in hematopoietic stem cells would allow for permanent production of normal red blood cells. Using zinc-finger nucleases (ZFNs) designed to flank the sickle mu...

journal_title：Blood

authors： Hoban MD,Cost GJ,Mendel MC,Romero Z,Kaufman ML,Joglekar AV,Ho M,Lumaquin D,Gray D,Lill GR,Cooper AR,Urbinati F,Senadheera S,Zhu A,Liu PQ,Paschon DE,Zhang L,Rebar EJ,Wilber A,Wang X,Gregory PD,Holmes MC,Reik A

更新日期：2015-04-23 00:00:00

abstract：:Leukocyte rolling is the earliest observable even in their recruitment from the circulation to inflamed tissue. This rolling is mediated largely by interaction between the selectin family of adhesion molecules and their glycosylated ligands. Although the nature of these ligands and their interaction with the selectins...

journal_title：Blood

authors： Norman KE,Anderson GP,Kolb HC,Ley K,Ernst B

更新日期：1998-01-15 00:00:00

abstract：:The chemokine receptors (CCRs) CCR4 and CCR10, and the cutaneous lymphocyte antigen (CLA), have each been proposed as critical mediators of skin-specific TH lymphocyte homing in mice and humans. CLA initiates skin homing by mediating E-selectin-dependent tethering and rolling within cutaneous venules, but the specific...

journal_title：Blood

authors： Soler D,Humphreys TL,Spinola SM,Campbell JJ

更新日期：2003-03-01 00:00:00

abstract：:Twenty-four patients whose cells contained a variety of 11q23 rearrangements, including translocations, insertions, and an inversion, were studied using fluorescence in situ hybridization with cosmid, phage, and plasmid probes mapped to 11q22-24. In 17 patients, the breakpoints of the common 11q23 translocations invol...

journal_title：Blood

authors： Kobayashi H,Espinosa R 3rd,Thirman MJ,Gill HJ,Fernald AA,Diaz MO,Le Beau MM,Rowley JD

更新日期：1993-07-15 00:00:00

abstract：:The model of erythroleukemia caused by Spi-1/PU.1 transgenesis in mice is a multistage disease. A preleukemic step is characterized by an acute proliferation of proerythroblasts due to the arrest of differentiation provoked by Spi-1/PU.1. Later on, a blastic crisis occurs associated with somatic oncogenic mutations in...

journal_title：Blood

authors： Monni R,Haddaoui L,Naba A,Gallais I,Arpin M,Mayeux P,Moreau-Gachelin F

更新日期：2008-03-15 00:00:00

abstract：:Graft-versus-host disease (GVHD) is driven by extensive activation and proliferation of alloreactive donor T cells causing significant morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are a potent immunoregulatory T-cell subset in both human...

journal_title：Blood

authors： Schneidawind D,Baker J,Pierini A,Buechele C,Luong RH,Meyer EH,Negrin RS

更新日期：2015-05-28 00:00:00

abstract：:Chemotherapy-related myeloid neoplasia (t-MN) is a significant late toxicity concern after cancer therapy. In the randomized intergroup phase 3 E2997 trial, initial therapy of chronic lymphocytic leukemia with fludarabine plus cyclophosphamide (FC) compared with fludarabine alone yielded higher complete and overall re...

journal_title：Blood

authors： Smith MR,Neuberg D,Flinn IW,Grever MR,Lazarus HM,Rowe JM,Dewald G,Bennett JM,Paietta EM,Byrd JC,Hussein MA,Appelbaum FR,Larson RA,Litzow MR,Tallman MS

更新日期：2011-09-29 00:00:00

abstract：:Insulin-like growth factor 1 (IGF-1) enhances thymopoiesis but given the broad distribution of IGF-1 receptors (IGF-1Rs), its mechanism of action has remained unclear. To identify points of thymic regulation by IGF-1, we examined its effects on T-cell precursors, thymocytes, and thymic epithelial cells (TECs) in norma...

journal_title：Blood

authors： Chu YW,Schmitz S,Choudhury B,Telford W,Kapoor V,Garfield S,Howe D,Gress RE

更新日期：2008-10-01 00:00:00

abstract：:Chronic transfusion of packed red blood cells, in addition to other ongoing treatment with warfarin, acetyl salicylic acid, desferrioxamine, and other supportive measures, was given to a splenectomized hemoglobin E/beta-thalassemia woman with pulmonary arterial hypertension (PHT). Serial measurements of plasma thrombi...

journal_title：Blood

authors： Atichartakarn V,Chuncharunee S,Chandanamattha P,Likittanasombat K,Aryurachai K

更新日期：2004-04-01 00:00:00

abstract：:Transplantation with 2-5 × 10(6) mobilized CD34(+)cells/kg body weight lowers transplantation costs and mortality. Mobilization is most commonly performed with recombinant human G-CSF with or without chemotherapy, but a proportion of patients/donors fail to mobilize sufficient cells. BM disease, prior treatment, and a...

journal_title：Blood

authors： To LB,Levesque JP,Herbert KE

更新日期：2011-10-27 00:00:00

abstract：:No consensus exists on whether acyclovir prophylaxis should be given for varicella-zoster virus (VZV) prophylaxis after hematopoietic cell transplantation because of the concern of "rebound" VZV disease after discontinuation of prophylaxis. To determine whether rebound VZV disease is an important clinical problem and ...

journal_title：Blood

authors： Erard V,Guthrie KA,Varley C,Heugel J,Wald A,Flowers ME,Corey L,Boeckh M

更新日期：2007-10-15 00:00:00

abstract：:Plasma cell myeloma is a more complex neoplasm than suggested by the relative uniformity of its dominant plasma cells, which represent the terminal stage of normal B-cell differentiation. Phenotypic, molecular, and cellular genetic data favor the presence of a myeloma stem cell early in hematopoietic development so th...

journal_title：Blood

authors： Barlogie B,Epstein J,Selvanayagam P,Alexanian R

更新日期：1989-03-01 00:00:00

abstract：:Chronic graft-versus-host disease (GVHD) requires long-term immunosuppressive therapy after hematopoietic cell transplantation. We retrospectively analyzed a cohort of 751 patients with chronic GVHD to identify characteristics associated with the duration of immunosuppressive treatment. Among the 274 patients who disc...

journal_title：Blood

authors： Stewart BL,Storer B,Storek J,Deeg HJ,Storb R,Hansen JA,Appelbaum FR,Carpenter PA,Sanders JE,Kiem HP,Nash RA,Petersdorf EW,Moravec C,Morton AJ,Anasetti C,Flowers ME,Martin PJ

更新日期：2004-12-01 00:00:00

abstract：:Lipoxygenases (LXs) catalyze formation of leukotrienes and hydroxy-eicosatetraenoic acids (HETEs), proinflammatory, and spasmogenic autacoids that are critical for host defense systems. We studied the expression and regulation of LX genes (12-LX, 5-LX, and 15-LX) and the 5-lipoxygenase activating protein (FLAP) in hum...

journal_title：Blood

authors： Kaminski WE,Jendraschak E,Baumann K,Kiefl R,Fischer S,Marcus AJ,Broekman MJ,von Schacky C

更新日期：1996-01-01 00:00:00

abstract：:Among dendritic cell (DC) subsets, CD8alpha(+) DCs and plasmacytoid DCs (pDCs) produce high levels of IL12 and type I interferons (IFNs), respectively, and confer early innate immunity. Development of CD8alpha(+) DCs and pDCs requires the interferon regulatory factor 8 (IRF8). Recently, a spontaneous point mutation wa...

journal_title：Blood

authors： Tailor P,Tamura T,Morse HC 3rd,Ozato K

更新日期：2008-02-15 00:00:00

abstract：:It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries. As these countries go through an epidemiologic transition, with a reduction in childhood and infant mortality due to ...

journal_title：Blood

authors： Weatherall DJ

更新日期：2010-06-03 00:00:00

abstract：:Natural killer (NK) cells have held great promise for the immunotherapy of cancer for more than 3 decades. However, to date only modest clinical success has been achieved manipulating the NK cell compartment in patients with malignant disease. Progress in the field of NK cell receptors has revolutionized our concept o...

journal_title：Blood

authors： Farag SS,Fehniger TA,Ruggeri L,Velardi A,Caligiuri MA

更新日期：2002-09-15 00:00:00

abstract：:Thrombopoietin (Tpo) has proliferative and maturational effects on immature and more committed cells, respectively. We previously reported a role for Tpo as a survival factor in the factor-dependent human cell line M07e by demonstrating that Tpo suppresses apoptosis in the absence of induced proliferation. Wild-type p...

journal_title：Blood

authors： Ritchie A,Gotoh A,Gaddy J,Braun SE,Broxmeyer HE

更新日期：1997-12-01 00:00:00

abstract：:The cell-surface expression and the functional status of the CD95/Fas antigen on primitive hematopoietic progenitors (PHPs) freshly isolated from human fetal liver (FL) were studied. PHPs were phenotypically defined as CD34++ CD38 -/+ cells. The most immature subfractions of PHPs, CD34++CD38- and CD34+2CD38+ FL cells,...

journal_title：Blood

authors： Bárcena A,Park SW,Banapour B,Muench MO,Mechetner E

更新日期：1996-09-15 00:00:00

abstract：:Human T-cell leukemia virus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL) transforms human T cells both in vivo and in vitro. However, the long latency period between infection and development of ATL, as well as the small fraction of the infected population that actually develops this disease, su...

journal_title：Blood

authors： Mori N,Kashanchi F,Prager D

更新日期：1997-12-15 00:00:00