The inherited diseases of hemoglobin are an emerging global health burden.

abstract：:Purified human high-mol-wt kininogen (HMWK), the cofactor of the contact phase of blood coagulation, migrated as a single band (approximately 110,000 mol wt) in a continuous buffer sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), but appeared as two separated bands (approximately 120,000 and 105,0...

journal_title：Blood

authors： Berrettini M,Lämmle B,White T,Heeb MJ,Schwarz HP,Zuraw B,Curd J,Griffin JH

更新日期：1986-08-01 00:00:00

abstract：:Ikaros plays an important role in the control of differentiation and proliferation of all lymphoid lineages. The expression of short isoforms lacking DNA-binding motifs alters the differentiation capacities of hematopoietic progenitors, arresting lineage commitment. We sought to determine whether molecular abnormaliti...

journal_title：Blood

authors： Iacobucci I,Lonetti A,Messa F,Cilloni D,Arruga F,Ottaviani E,Paolini S,Papayannidis C,Piccaluga PP,Giannoulia P,Soverini S,Amabile M,Poerio A,Saglio G,Pane F,Berton G,Baruzzi A,Vitale A,Chiaretti S,Perini G,Foà R

更新日期：2008-11-01 00:00:00

abstract：:The mutation status and usage of specific VH genes such as V3-21 and V1-69 are potentially independent pathogenic and prognostic factors in chronic lymphocytic leukemia (CLL). To investigate the role of antigenic stimulation, we analyzed the expression of genes involved in B-cell receptor (BCR) signaling/activation, c...

journal_title：Blood

authors： Kienle D,Benner A,Kröber A,Winkler D,Mertens D,Bühler A,Seiler T,Jäger U,Lichter P,Döhner H,Stilgenbauer S

更新日期：2006-03-01 00:00:00

abstract：:A method is described that allows for the routine long-term (greater than 3 mo) growth of normal, immature human myeloid cells in liquid suspension culture. The techniques employ cell separation, utilization of special growth conditions (RPMI with hydrocortisone and vitamin D), and cord blood as the source of leukocyt...

journal_title：Blood

authors： Salahuddin SZ,Markham PD,Ruscetti FW,Gallo RC

更新日期：1981-11-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) is detected in the plasma of approximately 40% of patients undergoing hematopoietic cell transplantation (HCT) and sporadically causes encephalitis in this population. The effect of HHV-6 reactivation on central nervous system function has not been fully characterized. This prospective stud...

journal_title：Blood

authors： Zerr DM,Fann JR,Breiger D,Boeckh M,Adler AL,Xie H,Delaney C,Huang ML,Corey L,Leisenring WM

更新日期：2011-05-12 00:00:00

abstract：:Chromosome 7 translocations, deletions, or monosomy are associated with myelodysplasia (MDS) and acute myeloid leukemia both in children and adults. These chromosomal anomalies represent one of the most common cytogenetic abnormalities associated with these diseases and usually herald a poor prognosis. In this study t...

journal_title：Blood

authors： Johnson EJ,Scherer SW,Osborne L,Tsui LC,Oscier D,Mould S,Cotter FE

更新日期：1996-05-01 00:00:00

abstract：:Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe). These end-products are responsible for much of the biologic activity of HO-1, including anti-inflammatory, antiapo-ptotic, antiproliferative, and antioxidant effects. We have identified an additional cytoprote...

journal_title：Blood

authors： Kinderlerer AR,Pombo Gregoire I,Hamdulay SS,Ali F,Steinberg R,Silva G,Ali N,Wang B,Haskard DO,Soares MP,Mason JC

更新日期：2009-02-12 00:00:00

abstract：:Hydroxyurea treatment of sickle cell mice improved their survival from pneumococcal pneumonia, counteracting the abnormally elevated inflammatory response and reducing invasion of bacteria into the bloodstream, through down regulation of E-selectin. ...

journal_title：Blood

authors： Hsu LL

更新日期：2012-02-23 00:00:00

abstract：:Fetal hemoglobin (HbF, α2γ2) induction is a well-validated strategy for sickle cell disease (SCD) treatment. Using a small-molecule screen, we found that UNC0638, a selective inhibitor of EHMT1 and EHMT2 histone methyltransferases, induces γ-globin expression. EHMT1/2 catalyze mono- and dimethylation of lysine 9 on hi...

journal_title：Blood

authors： Renneville A,Van Galen P,Canver MC,McConkey M,Krill-Burger JM,Dorfman DM,Holson EB,Bernstein BE,Orkin SH,Bauer DE,Ebert BL

更新日期：2015-10-15 00:00:00

abstract：:Between 1990 and 1996, we conducted a randomized trial in adults with newly diagnosed acute myeloid leukemia (AML) in order to compare relapse-free interval (RFI) after double induction (arm B), timed-sequential induction (arm C), or control "3 + 7" induction (arm A). Patients achieving complete remission (CR) after i...

journal_title：Blood

authors： Castaigne S,Chevret S,Archimbaud E,Fenaux P,Bordessoule D,Tilly H,de Revel T,Simon M,Dupriez B,Renoux M,Janvier M,Micléa JM,Thomas X,Bastard C,Preudhomme C,Bauters F,Degos L,Dombret H

更新日期：2004-10-15 00:00:00

abstract：:Oncogenic forms of NRAS are frequently associated with hematologic malignancies and other cancers, making them important therapeutic targets. Inhibition of individual downstream effector molecules (eg, RAF kinase) have been complicated by the rapid development of resistance or activation of bypass pathways. For the pu...

journal_title：Blood

authors： Nonami A,Sattler M,Weisberg E,Liu Q,Zhang J,Patricelli MP,Christie AL,Saur AM,Kohl NE,Kung AL,Yoon H,Sim T,Gray NS,Griffin JD

更新日期：2015-05-14 00:00:00

abstract：:The transcription factor c-Maf is extensively involved in the pathophysiology of multiple myeloma (MM), a fatal malignancy of plasma cells. In the present study, affinity chromatography and mass spectrometry were used to identify c-Maf ubiquitination-associated proteins, from which the E3 ligase HERC4 was found to int...

journal_title：Blood

authors： Zhang Z,Tong J,Tang X,Juan J,Cao B,Hurren R,Chen G,Taylor P,Xu X,Shi CX,Du J,Hou J,Wang G,Wu D,Stewart AK,Schimmer AD,Moran MF,Mao X

更新日期：2016-03-31 00:00:00

abstract：:An inverse relationship between BCL-2 expression and cell cycle transition has been suggested by recent studies in murine models. To investigate the clinical relevance of these laboratory studies, a group of 116 paraffin-embedded non-Hodgkin's lymphoma (NHL) biopsy specimens (Working Formulation Groups D-H, and J) fro...

journal_title：Blood

authors： Winter JN,Andersen J,Reed JC,Krajewski S,Variakojis D,Bauer KD,Fisher RI,Gordon LI,Oken MM,Jiang S,Jeffries D,Domer P

更新日期：1998-02-15 00:00:00

abstract：:We previously reported the characterization of human osteoclast-associated receptor (hOSCAR), a novel Fc receptor gamma-chain (FcRgamma)-associated receptor expressed by myeloid cells. Here we show that ligation of hOSCAR by specific antibodies promotes dendritic cell (DC) survival by an extracellular signal-regulated...

journal_title：Blood

authors： Merck E,de Saint-Vis B,Scuiller M,Gaillard C,Caux C,Trinchieri G,Bates EE

更新日期：2005-05-01 00:00:00

abstract：:Subclones homozygous for JAK2V617F are more common in polycythemia vera (PV) than essential thrombocythemia (ET), but their prevalence and significance remain unclear. The JAK2 mutation status of 6495 BFU-E, grown in low erythropoietin conditions, was determined in 77 patients with PV or ET. Homozygous-mutant colonies...

journal_title：Blood

authors： Godfrey AL,Chen E,Pagano F,Ortmann CA,Silber Y,Bellosillo B,Guglielmelli P,Harrison CN,Reilly JT,Stegelmann F,Bijou F,Lippert E,McMullin MF,Boiron JM,Döhner K,Vannucchi AM,Besses C,Campbell PJ,Green AR

更新日期：2012-09-27 00:00:00

abstract：:Tumor cells from six patients with immunoglobulin G (IgG) multiple myeloma were analyzed for surface antigens, cytoplasmic paraprotein, morphology, and response to various culture conditions. The tumor marker was the paraprotein idiotype. Low numbers of tumor cells were found in the blood of most of the patients. In s...

journal_title：Blood

authors： King MA,Nelson DS

更新日期：1989-05-15 00:00:00

abstract：:Proteolytic events at the cell surface are essential in the regulation of signal transduction pathways. During the past years, the family of type II transmembrane serine proteases (TTSPs) has acquired an increasing relevance because of their privileged localization at the cell surface, although our current understandi...

journal_title：Blood

authors： Folgueras AR,de Lara FM,Pendás AM,Garabaya C,Rodríguez F,Astudillo A,Bernal T,Cabanillas R,López-Otín C,Velasco G

更新日期：2008-09-15 00:00:00

abstract：:The number of bone marrow fibroblast colony formations decreases in most cases of acute leukemia before the initiation of chemotherapy. This study was undertaken to clarify the mechanism of suppression of fibroblast colony formation in leukemic patients. Titration of the number of bone marrow cells did not indicate a ...

journal_title：Blood

authors： Nagao T,Yamauchi K,Komatsuda M,Noguchi K,Shimizu M,Yonekura S,Nozaki H

更新日期：1983-12-01 00:00:00

abstract：:The leukemia-specific AML1/ETO fusion gene has been shown to be detected by reverse transcriptase polymerase chain reaction (RT-PCR) analysis in patients with t(8;21) acute myelogenous leukemia (AML) in long-term remission. In the present study, the AML1/ETO mRNA could be detected by RT-PCR in bone marrow (BM) and/or ...

journal_title：Blood

authors： Miyamoto T,Nagafuji K,Akashi K,Harada M,Kyo T,Akashi T,Takenaka K,Mizuno S,Gondo H,Okamura T,Dohy H,Niho Y

更新日期：1996-06-01 00:00:00

abstract：:Rabbit polyclonal antibodies were raised against synthetic peptides corresponding to hydrophilic regions of the human Rhesus (Rh) IX cDNA-encoded polypeptide predicted to be extracellularly or intracellularly exposed in the topologic model of the Rh blood group protein. Four antibodies encompassing residues 33-45 (MPC...

journal_title：Blood

authors： Hermand P,Mouro I,Huet M,Bloy C,Suyama K,Goldstein J,Cartron JP,Bailly P

更新日期：1993-07-15 00:00:00

abstract：:The tyrosine kinase receptor fetal liver kinase 1 (Flk-1) plays a crucial role in vasculogenesis and angiogenesis, but its target genes remain elusive. Comparing Flk-1(+/+) with Flk-1(-/-) embryonic stem (ES) cells, we identified transcripts regulated by the vascular endothelial growth factor A (VEGF-A)/Flk-1 pathway ...

journal_title：Blood

authors： Zippo A,De Robertis A,Bardelli M,Galvagni F,Oliviero S

更新日期：2004-06-15 00:00:00

abstract：:We examined whether activated protein C (APC) reduces ischemia/reperfusion (I/R)-induced renal injury by inhibiting leukocyte activation. In a rat model, intravenous administration of APC markedly reduced I/R-induced renal dysfunction and histological changes, whereas intravenous administration of dansyl glutamylglycy...

journal_title：Blood

authors： Mizutani A,Okajima K,Uchiba M,Noguchi T

更新日期：2000-06-15 00:00:00

abstract：:Vascular calcification is a marker of increased cardiovascular risk. Vitamin K-dependent matrix Gla protein (MGP) is important in inhibiting calcification. Because MGP activation is vitamin K dependent, we performed a cross-sectional study investigating the relationship between the use of vitamin K antagonists and ext...

journal_title：Blood

authors： Rennenberg RJ,van Varik BJ,Schurgers LJ,Hamulyak K,Ten Cate H,Leiner T,Vermeer C,de Leeuw PW,Kroon AA

更新日期：2010-06-17 00:00:00

abstract：:Viral infections are common and are potentially life-threatening in patients with moderate to severe primary immunodeficiency disorders. Because T-cell immunity contributes to the control of many viral pathogens, adoptive immunotherapy with virus-specific T cells (VSTs) has been a logical and effective way of combatin...

journal_title：Blood

authors： Keller MD,Bollard CM

更新日期：2020-02-27 00:00:00

abstract：:Follicular lymphoma (FL) is an indolent malignancy of germinal center B cells. Although the overall survival of FL patients has recently improved with the introduction of novel therapies, there is significant heterogeneity in patient outcome and a need for rationally designed therapeutic strategies that target disease...

journal_title：Blood

authors： Green MR

更新日期：2018-02-08 00:00:00

abstract：:In multiple myeloma (MM), both vascular endothelial (VEGF) and basic fibroblast growth factor (bFGF) promote tumor growth and survival. We have used the novel indolinone BIBF 1000 to study effects of simultaneous inhibition of VEGF, FGF and transforming growth factor-beta on MM cells and their interactions with bone m...

journal_title：Blood

authors： Bisping G,Kropff M,Wenning D,Dreyer B,Bessonov S,Hilberg F,Roth GJ,Munzert G,Stefanic M,Stelljes M,Scheffold C,Müller-Tidow C,Liebisch P,Lang N,Tchinda J,Serve HL,Mesters RM,Berdel WE,Kienast J

更新日期：2006-03-01 00:00:00

abstract：:The development of novel technologies for high-throughput DNA sequencing is having a major impact on our ability to measure and define normal and pathologic variation in humans. This review discusses advances in DNA sequencing that have been applied to benign hematologic disorders, including those affecting the red bl...

journal_title：Blood

authors： Sankaran VG,Gallagher PG

更新日期：2013-11-21 00:00:00

abstract：:Perioperative management of antithrombotic therapy is a situation that occurs frequently and requires consideration of the patient, the procedure, and an expanding array of anticoagulant and antiplatelet agents. Preoperative assessment must address each patient's risk for thromboembolic events balanced against the ris...

journal_title：Blood

authors： Ortel TL

更新日期：2012-12-06 00:00:00

abstract：:Endothelial sialomucin CD34 functions as an L-selectin ligand mediating lymphocyte extravasation only when properly glycosylated to express a sulfated carbohydrate epitope, 6-sulfo sialyl Lewis x (6-sulfo SLe(x)). It is thought that multivalent 6-sulfo SLe(x) expression promotes high-affinity binding to L-selectin by ...

journal_title：Blood

authors： Hernandez Mir G,Helin J,Skarp KP,Cummings RD,Mäkitie A,Renkonen R,Leppänen A

更新日期：2009-07-16 00:00:00

abstract：:We have examined the effect of graft-versus-host disease (GVHD) on the reconstitution of donor hematopoiesis in a murine bone marrow transplant (BMT) model of GVHD to minor histocompatibility antigens. GVHD had no effect on peripheral blood counts, which normalized by 1 month after BMT, and did not affect numbers of h...

journal_title：Blood

authors： van Dijken PJ,Wimperis J,Crawford JM,Ferrara JL

更新日期：1991-11-15 00:00:00