Abstract:
:The development of novel technologies for high-throughput DNA sequencing is having a major impact on our ability to measure and define normal and pathologic variation in humans. This review discusses advances in DNA sequencing that have been applied to benign hematologic disorders, including those affecting the red blood cell, the neutrophil, and other white blood cell lineages. Relevant examples of how these approaches have been used for disease diagnosis, gene discovery, and studying complex traits are provided. High-throughput DNA sequencing technology holds significant promise for impacting clinical care. This includes development of improved disease detection and diagnosis, better understanding of disease progression and stratification of risk of disease-specific complications, and development of improved therapeutic strategies, particularly patient-specific pharmacogenomics-based therapy, with monitoring of therapy by genomic biomarkers.
journal_name
Bloodjournal_title
Bloodauthors
Sankaran VG,Gallagher PGdoi
10.1182/blood-2013-07-460337subject
Has Abstractpub_date
2013-11-21 00:00:00pages
3575-82issue
22eissn
0006-4971issn
1528-0020pii
blood-2013-07-460337journal_volume
122pub_type
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