Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS.

abstract：:Although the critical requirement for the transcription factor RUNX1/AML1 at the onset of hematopoietic development is well established, little is known about its transcriptional targets at this pivotal stage of blood development. Using microarrays, we identified the uncharacterized gene AI467606 as a gene whose expre...

journal_title：Blood

authors： Ferreras C,Lancrin C,Lie-A-Ling M,Kouskoff V,Lacaud G

更新日期：2011-07-21 00:00:00

abstract：:Severe aplastic anemia (SAA) can be successfully treated with allogeneic bone marrow transplantation (BMT) or immunosuppressive therapy. However, the majority of patients with SAA are not eligible for BMT because they lack an HLA-identical sibling. Conventional immunosuppressive therapy also has major limitations; man...

journal_title：Blood

authors： Brodsky RA,Sensenbrenner LL,Jones RJ

更新日期：1996-01-15 00:00:00

abstract：:Bax is a proapoptotic member of the Bcl-2 protein family. The incidence and prognostic significance of Bax protein expression in diffuse non-Hodgkin's lymphomas with a large cell component (DLCL) was determined by an immunohistochemical method by using paraffin-embedded tumors from a cohort of patients treated uniform...

journal_title：Blood

authors： Gascoyne RD,Krajewska M,Krajewski S,Connors JM,Reed JC

更新日期：1997-10-15 00:00:00

abstract：:There is growing evidence that lymphocyte trafficking contributes to the clinical course of chronic lymphocytic leukemia (CLL), but to date, only static in vitro cultures have been used to study these phenomena. To address this lack of data, we have developed a dynamic in vitro model in which CLL cells experience shea...

journal_title：Blood

authors： Walsby E,Buggins A,Devereux S,Jones C,Pratt G,Brennan P,Fegan C,Pepper C

更新日期：2014-06-05 00:00:00

abstract：:Marrow graft failure observed in association with histocompatibility differences between donor and recipient is often attributed to rejection mediated by host-derived cytolytic T lymphocytes. The data presented in this report indicate that persistent host antibodies specific for donor antigen may also mediate graft fa...

journal_title：Blood

authors： Barge AJ,Johnson G,Witherspoon R,Torok-Storb B

更新日期：1989-10-01 00:00:00

abstract：:The majority of mouse Vα14 invariant natural killer T (Vα14i NKT) cells produce several cytokines, including IFNγ and IL-4, very rapidly after activation. A subset of these cells, known as NKT17 cells, however, differentiates in the thymus to preferentially produce IL-17. Here, we show that the transcription factor-kn...

journal_title：Blood

authors： Engel I,Zhao M,Kappes D,Taniuchi I,Kronenberg M

更新日期：2012-11-29 00:00:00

abstract：:Primary cutaneous lymphomas have been successfully treated with interferons (IFNs), counterbalancing the T-helper 2 (Th2)-skewing state. We undertook a phase 1, open-label, dose-escalating trial of repeated intratumoral administration of TG1042 in patients with advanced primary cutaneous T-cell lymphomas (CTCLs) and m...

journal_title：Blood

authors： Dummer R,Hassel JC,Fellenberg F,Eichmüller S,Maier T,Slos P,Acres B,Bleuzen P,Bataille V,Squiban P,Burg G,Urosevic M

更新日期：2004-09-15 00:00:00

abstract：:The kidney is the main physiologic source of erythropoietin (EPO) in the adult and responds to decreases in tissue oxygenation with increased EPO production. Although studies in mice with liver-specific or global gene inactivation have shown that hypoxia-inducible factor 2 (Hif-2) plays a major role in the regulation ...

journal_title：Blood

authors： Kapitsinou PP,Liu Q,Unger TL,Rha J,Davidoff O,Keith B,Epstein JA,Moores SL,Erickson-Miller CL,Haase VH

更新日期：2010-10-21 00:00:00

abstract：:Human platelets contain tortuous channels in their cytoplasm, the surface-connected or open canalicular system (OCS), that communicate directly with the surrounding medium through openings on the surface membrane. Some workers have suggested that the OCS serves as the egress route for products secreted during the rele...

journal_title：Blood

authors： White JG

更新日期：1987-03-01 00:00:00

abstract：:Although NPM1 gene mutations leading to aberrant cytoplasmic expression of nucleophosmin (NPMc(+)) are the most frequent genetic lesions in acute myeloid leukemia, there is yet no experimental model demonstrating their oncogenicity in vivo. We report the generation and characterization of a transgenic mouse model expr...

journal_title：Blood

authors： Cheng K,Sportoletti P,Ito K,Clohessy JG,Teruya-Feldstein J,Kutok JL,Pandolfi PP

更新日期：2010-04-22 00:00:00

abstract：:Development of inhibitory antibodies is a serious complication of treatment with repeated factor IX infusions in a minority of patients with hemophilia B. Such antibodies detected in 8 patients have been characterized. Typing studies revealed that patients' immune response toward factor IX is highly heterogeneous and ...

journal_title：Blood

authors： Christophe OD,Lenting PJ,Cherel G,Boon-Spijker M,Lavergne JM,Boertjes R,Briquel ME,de Goede-Bolder A,Goudemand J,Gaillard S,d'Oiron R,Meyer D,Mertens K

更新日期：2001-09-01 00:00:00

abstract：:Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), one of the most widely spread immune receptors, attenuates immune cell activation when bound to specific sites in collagen. The collagen-binding domain of LAIR-1 is homologous to that of glycoprotein VI (GPVI), a collagen receptor crucial for platelet activ...

journal_title：Blood

authors： Brondijk TH,de Ruiter T,Ballering J,Wienk H,Lebbink RJ,van Ingen H,Boelens R,Farndale RW,Meyaard L,Huizinga EG

更新日期：2010-02-18 00:00:00

abstract：:The Smad-signaling pathway downstream of the transforming growth factor-beta superfamily of ligands is an evolutionarily conserved signaling circuitry with critical functions in a wide variety of biologic processes. To investigate the role of this pathway in the regulation of hematopoietic stem cells (HSCs), we have b...

journal_title：Blood

authors： Blank U,Karlsson G,Moody JL,Utsugisawa T,Magnusson M,Singbrant S,Larsson J,Karlsson S

更新日期：2006-12-15 00:00:00

abstract：:Patients after allogeneic stem-cell transplantation (alloSCT) have an increased risk for invasive aspergillosis (IA). Here, recipients of an allograft with IA (n=81) or without IA (n=58) were screened for 84 single nucleotide polymorphisms in 18 immune relevant genes. We found 3 markers in chemokine (C-X-C motif) liga...

journal_title：Blood

authors： Mezger M,Steffens M,Beyer M,Manger C,Eberle J,Toliat MR,Wienker TF,Ljungman P,Hebart H,Dornbusch HJ,Einsele H,Loeffler J

更新日期：2008-01-15 00:00:00

abstract：:Joint bleeding after (sports) trauma, after major joint surgery, or as seen in hemophilia in general leads to arthropathy. Joint degeneration is considered to result from the direct effects of blood components on cartilage and indirectly from synovial inflammation. Blood-provided proinflammatory cytokines trigger chon...

journal_title：Blood

authors： van Vulpen LF,Schutgens RE,Coeleveld K,Alsema EC,Roosendaal G,Mastbergen SC,Lafeber FP

更新日期：2015-11-05 00:00:00

abstract：:Recent molecular analyses of leukemic blasts from pretreatment marrow or blood of patients with acute myeloid leukemia (AML) and a normal karyotype, the largest cytogenetic subset (ie, 40%-49%) of AML, have revealed a striking heterogeneity with regard to the presence of acquired gene mutations and changes in gene exp...

journal_title：Blood

authors： Mrózek K,Marcucci G,Paschka P,Whitman SP,Bloomfield CD

更新日期：2007-01-15 00:00:00

abstract：:T-cell depletion (TCD) of the donor marrow graft has been shown to reduce the severity of graft-versus-host disease (GVHD) in patients with chronic-phase (CP) chronic myelogenous leukemia (CML) undergoing HLA-identical sibling allogeneic marrow transplantation. However, there has been a corresponding reduction in the ...

journal_title：Blood

authors： Drobyski WR,Hessner MJ,Klein JP,Kabler-Babbitt C,Vesole DH,Margolis DA,Keever-Taylor CA

更新日期：1999-07-15 00:00:00

abstract：:We have verified the hypothesis that multiple myeloma (MM) may be disseminated by circulating clonogenic cells that selectively home to the bone marrow (BM) to receive the signal(s) leading to proliferation, terminal differentiation, and production of the osteoclast activating factors. Long-term cultures of stromal ce...

journal_title：Blood

authors： Caligaris-Cappio F,Bergui L,Gregoretti MG,Gaidano G,Gaboli M,Schena M,Zallone AZ,Marchisio PC

更新日期：1991-06-15 00:00:00

abstract：:Myeloma is a unique hematologic malignancy that exclusively homes in the bone marrow and induces massive osteoclastic bone destruction presumably by producing cytokines that promote the differentiation of the hematopoietic progenitors to osteoclasts (osteoclastogenesis). It is recognized that neighboring bone marrow s...

journal_title：Blood

authors： Michigami T,Shimizu N,Williams PJ,Niewolna M,Dallas SL,Mundy GR,Yoneda T

更新日期：2000-09-01 00:00:00

abstract：:Mutations that produce glucose-6-phosphate dehydrogenase (G6PD) deficiency have been identified in samples from patients with hemolytic disease in the United States, and in G6PD-deficient samples from Greece, the Canary Islands, the Czech and Slovak Republics, South China, and in samples from the Coriell Cell Reposito...

journal_title：Blood

authors： Xu W,Westwood B,Bartsocas CS,Malcorra-Azpiazu JJ,Indrák K,Beutler E

更新日期：1995-01-01 00:00:00

abstract：:Seventeen patients with therapy-related myelodysplastic syndrome (t-MDS) or therapy-related acute nonlymphocytic leukemia (t-ANLL) were treated with single-agent high-dose cytarabine (HDAC; 1 to 3 g/m2 every 12 hours for 12 doses). The initial neoplasm was still present in eight patients when t-MDS/t-ANLL developed. F...

journal_title：Blood

authors： Larson RA,Wernli M,Le Beau MM,Daly KM,Pape LH,Rowley JD,Vardiman JW

更新日期：1988-10-01 00:00:00

abstract：:A small quantity of extracellular calcium is required for the stimulation of lymphocytes by mitogens such as plant lectins. Lectin binding to the lymphocyte surface and early postbinding events that eventually lead to DNA synthesis are calcium dependent. Mitogenic lectins such as PHA and Con-A rapidly increase the siz...

journal_title：Blood

authors： Lichtman AH,Segel GB,Lichtman MA

更新日期：1983-03-01 00:00:00

abstract：:CTLA-4 is a critical inhibitory "checkpoint" molecule of immune activation. Several recent reports have described patients with immune dysregulation and lymphoproliferative disease resulting from 2 different genetic diseases that directly or indirectly cause CTLA-4 deficiency. Numerous articles have also been publishe...

journal_title：Blood

authors： Lo B,Fritz JM,Su HC,Uzel G,Jordan MB,Lenardo MJ

更新日期：2016-08-25 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) is the major regulator of granulopoiesis and acts through binding to its specific receptor (G-CSF-R) on neutrophilic granulocytes. Previous studies of signaling from the 4 G-CSF-R cytoplasmic tyrosine residues used model cell lines that may have idiosyncratic, nonphysiolog...

journal_title：Blood

authors： Akbarzadeh S,Ward AC,McPhee DO,Alexander WS,Lieschke GJ,Layton JE

更新日期：2002-02-01 00:00:00

abstract：:Endotoxin-free purified recombinant human erythroid-potentiating activity (EPA) was administered to normal and bled mice. In anemic ICR mice EPA treatment led to a significant increase in the number of reticulocytes in the peripheral blood and erythroid precursors in the spleen. Stimulation of CFU-E and BFU-E in the s...

journal_title：Blood

authors： Niskanen E,Gasson JC,Teates CD,Golde DW

更新日期：1988-08-01 00:00:00

abstract：:Lymphoepithelioid lymphoma (Lennert's lymphoma) was first described as a special variant of Hodgkin's disease. This lesion is characterized by a high percentage of epithelioid and T cells and rarely contains the classical Hodgkin's/Reed-Sternberg cells. Cytogenetic abnormalities indicate that Lennert's lymphoma is of ...

journal_title：Blood

authors： Feller AC,Griesser GH,Mak TW,Lennert K

更新日期：1986-09-01 00:00:00

abstract：:About 50% of the Philadelphia-positive acute leukemias undergo molecular rearrangements outside the now classical bcr sequence (or M-BCR-1) rearranged in chronic myeloid leukemia (CML). Most of the breakpoints on chromosome 22 have been shown to be clustered in a 10.8-kb region of the first intron of the BCR gene (cal...

journal_title：Blood

authors： Chen SJ,Chen Z,Hillion J,Grausz D,Loiseau P,Flandrin G,Berger R

更新日期：1989-04-01 00:00:00

abstract：:Murine autoreactive anti-Smith (Sm) B cells are negatively regulated by anergy and developmental arrest, but are also positively selected into the marginal zone (MZ) and B-1 B-cell populations. Despite positive selection, anti-Sm production occurs only in autoimmune-prone mice. To investigate autoreactive B-cell activ...

journal_title：Blood

authors： Qian Y,Conway KL,Lu X,Seitz HM,Matsushima GK,Clarke SH

更新日期：2006-08-01 00:00:00

abstract：:B-cell chronic lymphocytic leukemia (B-CLL) is defined by the accumulation of CD5(+) B cells in the periphery and bone marrow. This disease is not characterized by highly proliferative cells but rather by the presence of leukemic cells with significant resistance to apoptosis and, therefore, prolonged survival. B-lymp...

journal_title：Blood

authors： Novak AJ,Bram RJ,Kay NE,Jelinek DF

更新日期：2002-10-15 00:00:00

abstract：:The extravasation of leukocytes from the lumen of the vessel to a site of inflammation requires specific binding events. The interaction of leukocytes with endothelium, via specific receptors, may provide intracellular signals that activate extravasating cells. In the present study, we have investigated the production...

journal_title：Blood

authors： Lukacs NW,Strieter RM,Elner V,Evanoff HL,Burdick MD,Kunkel SL

更新日期：1995-10-01 00:00:00