Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes.

abstract：:Using urea-solubilized human fibrin monomer as an immunogen, we raised in mice a battery of monoclonal antibodies that reacted with the immunogen but not with urea-treated or native fibrinogen. Although they all failed to react with acid-solubilized fibrin monomer (acid-FM) alone, an antibody designated as IF-43 was f...

journal_title：Blood

authors： Soe G,Kohno I,Inuzuka K,Itoh Y,Matsuda M

更新日期：1996-09-15 00:00:00

abstract：:Studies in mice have shown that proinflammatory Th17 cells can cause acute graft-versus-host disease (aGVHD) related tissue damage; however, whether they play a role in human aGVHD remains unclear. In a prospective study, we measured the proportion of Th17 cells in the blood and skin of patients at the onset of aGVHD....

journal_title：Blood

authors： Broady R,Yu J,Chow V,Tantiworawit A,Kang C,Berg K,Martinka M,Ghoreishi M,Dutz J,Levings MK

更新日期：2010-12-16 00:00:00

abstract：:The diagnosis of recurrent ipsilateral deep vein thrombosis (DVT) is challenging, because persistent intravascular abnormalities after previous DVT often hinder a diagnosis by compression ultrasonography. Magnetic resonance direct thrombus imaging (MRDTI), a technique without intravenous contrast and with a 10-minute ...

journal_title：Blood

authors： van Dam LF,Dronkers CEA,Gautam G,Eckerbom Å,Ghanima W,Gleditsch J,von Heijne A,Hofstee HMA,Hovens MMC,Huisman MV,Kolman S,Mairuhu ATA,Nijkeuter M,van de Ree MA,van Rooden CJ,Westerbeek RE,Westerink J,Westerlund E,Krof

更新日期：2020-04-16 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT). When GVHD is controlled by T-cell-depleted grafts or immunosuppressants, BM transplant recipients often suffer from an increased rate of leukemic relapse and impaired reconstitution of immunity. Using a mouse BMT ...

journal_title：Blood

authors： Imado T,Iwasaki T,Kataoka Y,Kuroiwa T,Hara H,Fujimoto J,Sano H

更新日期：2004-09-01 00:00:00

abstract：:Gimap4, a member of the newly identified GTPase of the immunity-associated protein family (Gimap), is strongly induced by the pre-T-cell receptor in precursor T lymphocytes, transiently shut off in double-positive thymocytes, and reappears after TCR-mediated positive selection. Here, we show that Gimap4 remains expres...

journal_title：Blood

authors： Schnell S,Démollière C,van den Berk P,Jacobs H

更新日期：2006-07-15 00:00:00

abstract：:Ribosomal protein S19 (RPS19) is frequently mutated in Diamond-Blackfan anemia (DBA), a rare congenital hypoplastic anemia. Recent studies have shown that RPS19 expression decreases during terminal erythroid differentiation. Currently no information is available on the subcellular localization of normal RPS19 and the ...

journal_title：Blood

authors： Da Costa L,Tchernia G,Gascard P,Lo A,Meerpohl J,Niemeyer C,Chasis JA,Fixler J,Mohandas N

更新日期：2003-06-15 00:00:00

abstract：:Fanconi anemia (FA) is a genetic disease characterized by congenital abnormalities, bone marrow failure, and susceptibility to leukemia and other cancers. FANCJ, one of 13 genes linked to FA, encodes a DNA helicase proposed to operate in homologous recombination repair and replicational stress response. The pathogenic...

journal_title：Blood

authors： Wu Y,Sommers JA,Suhasini AN,Leonard T,Deakyne JS,Mazin AV,Shin-Ya K,Kitao H,Brosh RM Jr

更新日期：2010-11-11 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal recessive syndrome featuring diverse symptoms including progressive bone marrow failure and early occurrence of acute myeloid leukemia. Nine genetic subtypes have been described for FA (A, B, C, D1, D2, E, F, G, and L), all of which have been connected to distinct disease genes, exc...

journal_title：Blood

authors： Levitus M,Rooimans MA,Steltenpool J,Cool NF,Oostra AB,Mathew CG,Hoatlin ME,Waisfisz Q,Arwert F,de Winter JP,Joenje H

更新日期：2004-04-01 00:00:00

abstract：:From ten patients with advanced malignant disease involving the bone marrow, autologous hematopoietic stem cells were collected from the peripheral blood during eight four-hour pheresis procedures and cryopreserved. No manipulations to increase the number of stem cells circulating in the blood were used during the col...

journal_title：Blood

authors： Kessinger A,Armitage JO,Landmark JD,Smith DM,Weisenburger DD

更新日期：1988-03-01 00:00:00

abstract：:Concurrent activation of the T-cell receptor (TCR) and complement regulator CD46 on human CD4+ T lymphocytes induces Tr1-like regulatory T cells that suppress through IL-10 secretion bystander T-cell proliferation. Here we show that, despite their IL-10 production, CD46-induced T-regulatory T cells (Tregs) do not supp...

journal_title：Blood

authors： Barchet W,Price JD,Cella M,Colonna M,MacMillan SK,Cobb JP,Thompson PA,Murphy KM,Atkinson JP,Kemper C

更新日期：2006-02-15 00:00:00

abstract：:The paradoxical correlation between thrombosis and the lupus anticoagulant (LAC) effect is an enigmatic feature of the antiphospholipid (aPL) syndrome. The Dutch authors previously reported that thrombosis-related anti-beta2-glycoprotein I (beta2GPI) antibodies recognize domain I and cause LAC. The American authors re...

journal_title：Blood

authors： de Laat B,Wu XX,van Lummel M,Derksen RH,de Groot PG,Rand JH

更新日期：2007-02-15 00:00:00

abstract：:The morphologic, immunophenotypic, genotypic, genomic, and functional features of an undifferentiated acute leukemia with stem cell features are reported. At light and electron microscopy, the leukemic population was represented by primitive progenitor cells with no evidence of differentiation. The blasts were CD34(+)...

journal_title：Blood

authors： Testa U,Torelli GF,Riccioni R,Muta AO,Militi S,Annino L,Mariani G,Guarini A,Chiaretti S,Ritz J,Mandelli F,Peschle C,Foa R

更新日期：2002-06-15 00:00:00

abstract：:Normal human erythroid cell maturation requests the transcription factor GATA-1 and a transient activation of caspase-3, with GATA-1 being protected from caspase-3-mediated cleavage by interaction with the chaperone heat shock protein 70 (Hsp70) in the nucleus. Erythroid cell dysplasia observed in early myelodysplasti...

journal_title：Blood

authors： Frisan E,Vandekerckhove J,de Thonel A,Pierre-Eugène C,Sternberg A,Arlet JB,Floquet C,Gyan E,Kosmider O,Dreyfus F,Gabet AS,Courtois G,Vyas P,Ribeil JA,Zermati Y,Lacombe C,Mayeux P,Solary E,Garrido C,Hermine O,Fonte

更新日期：2012-02-09 00:00:00

abstract：:In this issue of Blood, Bromberg et al and Greenbaum et al delete the gene encoding the cell adhesion molecule N-cadherin in osteoblastic cells forming the hematopoietic stem cell (HSC) niche to demonstrate that N-cadherin has no role in regulating hematopoiesis. ...

journal_title：Blood

authors： Levesque JP

更新日期：2012-07-12 00:00:00

abstract：:The tetraspanin family member CD151 forms complexes with integrins and regulates cell adhesion and migration. While CD151 is highly expressed in megakaryocytes and to a lesser extent in platelets, its physiologic role in platelets is unclear. In this study, we investigate the physical and functional importance of CD15...

journal_title：Blood

authors： Lau LM,Wee JL,Wright MD,Moseley GW,Hogarth PM,Ashman LK,Jackson DE

更新日期：2004-10-15 00:00:00

abstract：:We demonstrated that Flk-1(+) cells derived from mouse embryonic stem (ES) cells can differentiate into both endothelial cells (ECs) and mural cells (MCs) to suffice as vascular progenitor cells (VPCs). In the present study, we investigated the importance of the stage of ES cell differentiation on effective participat...

journal_title：Blood

authors： Yurugi-Kobayashi T,Itoh H,Yamashita J,Yamahara K,Hirai H,Kobayashi T,Ogawa M,Nishikawa S,Nishikawa S,Nakao K

更新日期：2003-04-01 00:00:00

abstract：:A major limitation to the widespread use of hematopoietic stem cells (HSC) is the relatively crude level of our knowledge of how to maintain these cells in vitro without loss of the long-term multilineage growth and differentiation properties required for their clinical utility. An experimental and theoretical framewo...

journal_title：Blood

authors： Zandstra PW,Lauffenburger DA,Eaves CJ

更新日期：2000-08-15 00:00:00

abstract：:Interleukin-13 (IL-13) induced a potent mitogenic response in IL-3-dependent TF-1 cells and DNA synthesis to a lesser extent in MO7E and FDC-P1 cells. IL-13 stimulation of these lines, like IL-4 and insulin-like growth factor-1 (IGF-1), resulted in tyrosine phosphorylation of a 170-kD substrate. The tyrosine-phosphory...

journal_title：Blood

authors： Wang LM,Michieli P,Lie WR,Liu F,Lee CC,Minty A,Sun XJ,Levine A,White MF,Pierce JH

更新日期：1995-12-01 00:00:00

abstract：:Acute promyelocytic leukemias (APLs) are characterized by a translocation that involves chromosomes 15 and 17. The translocation breakpoints have recently been identified and shown to involve the RAR-alpha gene on 17 and myl on 15. Here we report Southern blotting analysis of 26 APLs, including cases with normal karyo...

journal_title：Blood

authors： Biondi A,Rambaldi A,Alcalay M,Pandolfi PP,Lo Coco F,Diverio D,Rossi V,Mencarelli A,Longo L,Zangrilli D

更新日期：1991-04-01 00:00:00

abstract：:The engraftment of donor bone marrow (BM) cells in nonablated mice is inefficient. Niche availability has been thought to be the reason, and cytoablation with irradiation or cytotoxic agents is routinely used with the belief that this frees the preoccupied niches in recipients. In this study, donor cell redistribution...

journal_title：Blood

authors： Zhong JF,Zhan Y,Anderson WF,Zhao Y

更新日期：2002-11-15 00:00:00

abstract：:Control of intensity and duration of erythropoietin (Epo) signaling is necessary to tightly regulate red blood cell production. We have recently shown that the ubiquitin/proteasome system plays a major role in the control of Epo-R signaling. Indeed, after Epo stimulation, Epo-R is ubiquitinated and its intracellular p...

journal_title：Blood

authors： Meyer L,Deau B,Forejtníková H,Duménil D,Margottin-Goguet F,Lacombe C,Mayeux P,Verdier F

更新日期：2007-06-15 00:00:00

abstract：:Prothrombin activation can proceed through the intermediates meizothrombin or prethrombin-2. To assess the contributions that these 2 intermediates make to prothrombin activation in tissue factor (Tf)-activated blood, immunoassays were developed that measure the meizothrombin antithrombin (mTAT) and α-thrombin antithr...

journal_title：Blood

authors： Whelihan MF,Zachary V,Orfeo T,Mann KG

更新日期：2012-11-01 00:00:00

abstract：:We have identified a distinct population of colony-forming cells that give rise to mononuclear cells expressing an enzyme marker and other features of the osteoclast in bone marrow cultures stimulated by conditioned medium of a murine tumor cell line. These colony-forming cells were defined as osteoclast colony-formin...

journal_title：Blood

authors： Lee MY,Lottsfeldt JL,Fevold KL

更新日期：1992-10-01 00:00:00

abstract：:Primitive chronic myeloid leukemia cells display a unique autocrine interleukin 3 (IL-3)/granulocyte-colony-stimluating factor (G-CSF) mechanism that may explain their abnormal proliferation and differentiation control. Here we show that BCR-ABL transduction of primitive Sca-1(+) lin(-) mouse bone marrow (BM) cells ca...

journal_title：Blood

authors： Jiang X,Ng E,Yip C,Eisterer W,Chalandon Y,Stuible M,Eaves A,Eaves CJ

更新日期：2002-11-15 00:00:00

abstract：:1-deamino-8-d-arginine vasopressin (desmopressin [DDAVP]) is clinically efficacious in patients with mild platelet function disorders but it is not known which mechanisms mediate this effect. Our aim was to evaluate the impact of in vivo DDAVP administration in these patients. We assessed von Willebrand factor (VWF), ...

journal_title：Blood

authors： Colucci G,Stutz M,Rochat S,Conte T,Pavicic M,Reusser M,Giabbani E,Huynh A,Thürlemann C,Keller P,Alberio L

更新日期：2014-03-20 00:00:00

abstract：:Activation of sialic-acid-binding immunoglobulin-like lectin-G (Siglec-G) by noninfectious damage-associated molecular patterns controls innate immune responses. However, whether it also regulates T-cell-mediated adaptive immune responses is not known. Graft-versus-host reaction is a robust adaptive immune response ca...

journal_title：Blood

authors： Toubai T,Hou G,Mathewson N,Liu C,Wang Y,Oravecz-Wilson K,Cummings E,Rossi C,Evers R,Sun Y,Wu J,Choi SW,Fang D,Zheng P,Liu Y,Reddy P

更新日期：2014-05-29 00:00:00

abstract：:Immune reconstitution of autologous hematopoietic stem-cell transplant recipients with the progeny of mature T cells in the graft leads to profound changes in the emerging functional T-cell repertoire. In the steady state, the host is frequently tolerant to tumor antigens, reflecting dominant suppression of naive and ...

journal_title：Blood

authors： Mirmonsef P,Tan G,Zhou G,Morino T,Noonan K,Borrello I,Levitsky HI

更新日期：2008-02-15 00:00:00

abstract：:Endothelial sialomucin CD34 functions as an L-selectin ligand mediating lymphocyte extravasation only when properly glycosylated to express a sulfated carbohydrate epitope, 6-sulfo sialyl Lewis x (6-sulfo SLe(x)). It is thought that multivalent 6-sulfo SLe(x) expression promotes high-affinity binding to L-selectin by ...

journal_title：Blood

authors： Hernandez Mir G,Helin J,Skarp KP,Cummings RD,Mäkitie A,Renkonen R,Leppänen A

更新日期：2009-07-16 00:00:00

abstract：:We have been transducing mouse hematopoietic cells with the human MDR1 (MDR) gene in retroviral vectors to determine the optimal conditions for retroviral gene transfer as a model system for potential human gene therapy. In these studies, we have demonstrated transduction and expression of the human MDR gene using eco...

journal_title：Blood

authors： Richardson C,Ward M,Podda S,Bank A

更新日期：1994-07-15 00:00:00

abstract：:Bax is a proapoptotic member of the Bcl-2 protein family. The incidence and prognostic significance of Bax protein expression in diffuse non-Hodgkin's lymphomas with a large cell component (DLCL) was determined by an immunohistochemical method by using paraffin-embedded tumors from a cohort of patients treated uniform...

journal_title：Blood

authors： Gascoyne RD,Krajewska M,Krajewski S,Connors JM,Reed JC

更新日期：1997-10-15 00:00:00