Murine hematopoietic stem cell distribution and proliferation in ablated and nonablated bone marrow transplantation.

Abstract:

:The engraftment of donor bone marrow (BM) cells in nonablated mice is inefficient. Niche availability has been thought to be the reason, and cytoablation with irradiation or cytotoxic agents is routinely used with the belief that this frees the preoccupied niches in recipients. In this study, donor cell redistribution and proliferation in ablated and nonablated mice were compared by implanting donor cells directly into the femur cavity of sedated mice. The redistribution of Lin(-) donor cells into BM was similar between ablated and nonablated mice. Poor engraftment in nonablated mice was shown to be the result of inefficient donor cell proliferation rather than because of a lack of space. Competitive repopulation assays demonstrated that the donor hematopoietic stem cells (HSCs) were present in nonirradiated recipients for at least 6 months after transplantation, but that they did not expand as did their counterparts in lethally irradiated mice. This study suggests that efficient bone marrow transplantation in nonablated recipients may be possible as a result of better understanding of HSC proliferative regulation and appropriate in vitro manipulation.

journal_name

Blood

journal_title

Blood

authors

Zhong JF,Zhan Y,Anderson WF,Zhao Y

doi

10.1182/blood-2002-04-1256

subject

Has Abstract

pub_date

2002-11-15 00:00:00

pages

3521-6

issue

10

eissn

0006-4971

issn

1528-0020

pii

2002-04-1256

journal_volume

100

pub_type

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