Abstract:
:Studies in mice have shown that proinflammatory Th17 cells can cause acute graft-versus-host disease (aGVHD) related tissue damage; however, whether they play a role in human aGVHD remains unclear. In a prospective study, we measured the proportion of Th17 cells in the blood and skin of patients at the onset of aGVHD. We found no difference in the proportion or amount of IL-17 produced by T cells in the blood of patients with aGVHD (n = 20) compared with time-matched patients without GVHD (n = 14). Moreover, Th17 cells were not increased in the skin of patients with cutaneous aGVHD (n = 7) compared with healthy controls (n = 10). In contrast, we found significantly more interferon-γ-producing T cells in the skin of patients with aGVHD compared with controls. These data support the long-standing paradigm that tissue localized interferon-γ-producing cells are the perpetrators of aGVHD.
journal_name
Bloodjournal_title
Bloodauthors
Broady R,Yu J,Chow V,Tantiworawit A,Kang C,Berg K,Martinka M,Ghoreishi M,Dutz J,Levings MKdoi
10.1182/blood-2010-07-295436subject
Has Abstractpub_date
2010-12-16 00:00:00pages
5748-51issue
25eissn
0006-4971issn
1528-0020pii
blood-2010-07-295436journal_volume
116pub_type
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