Effective contribution of transplanted vascular progenitor cells derived from embryonic stem cells to adult neovascularization in proper differentiation stage.

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a potent adjuvant in cancer vaccination; however, the specific role of endogenous GM-CSF remains unknown. We performed cell-based vaccination in 2 tumor models. First, we vaccinated C57BL/6 mice lacking either GM-CSF, IL-5, or beta-common chain (betac), a re...

journal_title：Blood

authors： Zarei S,Schwenter F,Luy P,Aurrand-Lions M,Morel P,Kopf M,Dranoff G,Mach N

更新日期：2009-06-25 00:00:00

abstract：:In a single institution, we have used recombinant interferon- (IFN-) to treat 116 newly diagnosed Philadelphia-positive (Ph+) chronic myeloid leukemia (CML) patients and analyzed the predictive factors for response and survival. The patients whose median age was 50.3 years (range, 9 to 70) were administered IFN- (5 mi...

journal_title：Blood

authors： Mahon FX,Fabères C,Pueyo S,Cony-Makhoul P,Salmi R,Boiron JM,Marit G,Bilhou-Nabera C,Carrère A,Montastruc M,Pigneux A,Bernard P,Reiffers J

更新日期：1998-12-01 00:00:00

abstract：:Hematologic engraftment and immune reconstitution were examined in patients who received cyclophosphamide and total body irradiation therapy followed by infusion of autologous bone marrow purged with anti-B1 monoclonal antibody (MoAb) and complement as therapy for non-Hodgkin's lymphoma. Hematologic engraftment was pr...

journal_title：Blood

authors： Anderson KC,Ritz J,Takvorian T,Coral F,Daley H,Gorgone BC,Freedman AS,Canellos GP,Schlossman SF,Nadler LM

更新日期：1987-02-01 00:00:00

abstract：:Extracellular histones have been shown to play an important pathogenic role in many diseases, primarily through their cytotoxicity toward nucleated cells and their ability to promote platelet activation with resultant thrombosis and thrombocytopenia. In contrast, little is known about the effect of extracellular histo...

journal_title：Blood

authors： Kordbacheh F,O'Meara CH,Coupland LA,Lelliott PM,Parish CR

更新日期：2017-12-28 00:00:00

abstract：:Using a polyclonal antiserum against canine CD34, we previously found that CD34 is expressed on canine bone marrow progenitor cells in a manner analogous to that found in humans. To further characterize CD34+ cells and to facilitate preclinical canine stem cell transplant studies, monoclonal antibodies (MoAbs) were ra...

journal_title：Blood

authors： McSweeney PA,Rouleau KA,Wallace PM,Bruno B,Andrews RG,Krizanac-Bengez L,Sandmaier BM,Storb R,Wayner E,Nash RA

更新日期：1998-03-15 00:00:00

abstract：:Lymphomas were studied in kindreds with autoimmune lymphoproliferative syndrome (ALPS; Canale-Smith syndrome), a disorder of lymphocyte homeostasis usually associated with germline Fas mutations. Fas (CD95/APO-1) is a cell surface receptor that initiates programmed cell death, or apoptosis, of activated lymphocytes. L...

journal_title：Blood

authors： Straus SE,Jaffe ES,Puck JM,Dale JK,Elkon KB,Rösen-Wolff A,Peters AM,Sneller MC,Hallahan CW,Wang J,Fischer RE,Jackson CE,Lin AY,Bäumler C,Siegert E,Marx A,Vaishnaw AK,Grodzicky T,Fleisher TA,Lenardo MJ

更新日期：2001-07-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) causes impairment of the immune system in part by targeting CD4(+) T cells for infection and dysfunction. HIV envelope (Env) present on free virions and infected cells causes dysfunction of uninfected bystander CD4(+) T cells via interaction with both CD4 and coreceptors. Env is ...

journal_title：Blood

authors： Fernando K,Hu H,Ni H,Hoxie JA,Weissman D

更新日期：2007-03-15 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation system, synthesized in endothelial cells, which has recently been shown to play an important role in the regulation of activated coagulation factors at the endothelial cell surface. In the present study we investigated t...

journal_title：Blood

authors： Hansen JB,Olsen R,Webster P

更新日期：1997-11-01 00:00:00

abstract：:Signaling mediated by various Notch receptors and their ligands regulates diverse biological processes, including lymphoid cell fate decisions. Notch1 is required during T-cell development, while Notch2 and the Notch ligand Delta-like1 control marginal zone B (MZB) cell development. We previously determined that Maste...

journal_title：Blood

authors： Wu L,Maillard I,Nakamura M,Pear WS,Griffin JD

更新日期：2007-11-15 00:00:00

abstract：:Inhibition of the tissue factor pathway has been shown to attenuate the activation of coagulation and to prevent death in a gram-negative bacteremia primate model of sepsis. It has been suggested that tissue factor influences inflammatory cascades other than the coagulation system. The authors sought to determine the ...

journal_title：Blood

authors： de Jonge E,Dekkers PE,Creasey AA,Hack CE,Paulson SK,Karim A,Kesecioglu J,Levi M,van Deventer SJ,van Der Poll T

更新日期：2000-02-15 00:00:00

abstract：:Erythropoiesis was investigated in 32 children wih short stature and in eight children with skeletal dysplasia by studying blood hemoglobin in relation to growth and to serum concentrations of insulin-like growth factor I (IGF-I), IGF binding protein-3 (IGFBP-3), and erythropoietin (EPO) before, during, and after 12 m...

journal_title：Blood

authors： Vihervuori E,Virtanen M,Koistinen H,Koistinen R,Seppälä M,Siimes MA

更新日期：1996-03-01 00:00:00

abstract：:To determine whether the erythropoietin receptor (Epo-R) plays a role in the course of malignant erythropoietic disorders, this gene was studied in murine and human erythroleukemia cells. An altered Epo-R gene was found in a murine Friend erythroleukemia cell line, FCL1, due to a spleen focus-forming virus (SFFV) long...

journal_title：Blood

authors： Chretien S,Moreau-Gachelin F,Apiou F,Courtois G,Mayeux P,Dutrillaux B,Cartron JP,Gisselbrecht S,Lacombe C

更新日期：1994-04-01 00:00:00

abstract：:Nonsteroidal antiinflammatory agents (NSAIA) have been shown to exert potent chemopreventive activity against colon, lung, and breast cancers. In this study, we show that at pharmacological concentrations (1 to 3 mmol/L) sodium salicylate (Na-Sal) can potently induce programmed cell death in several human myeloid leuk...

journal_title：Blood

authors： Klampfer L,Cammenga J,Wisniewski HG,Nimer SD

更新日期：1999-04-01 00:00:00

abstract：:Reprogramming of somatic cells to desired cell types holds great promise in regenerative medicine. However, production of transplantable hematopoietic stem cells (HSCs) in vitro by defined factors has not yet been achieved. Therefore, it is critical to fully understand the molecular mechanisms of HSC development in vi...

journal_title：Blood

authors： Wang L,Liu T,Xu L,Gao Y,Wei Y,Duan C,Chen GQ,Lin S,Patient R,Zhang B,Hong D,Liu F

更新日期：2013-07-18 00:00:00

abstract：:One hundred seventy-nine patients with acute nonlymphoblastic leukemia in first remission (n = 75), chronic myelocytic leukemia in chronic or accelerated phase (n = 48) or leukemia in advanced stage (n = 56) were given HLA-identical marrow grafts and randomized to receive methotrexate or cyclosporine for prevention of...

journal_title：Blood

authors： Storb R,Deeg HJ,Fisher L,Appelbaum F,Buckner CD,Bensinger W,Clift R,Doney K,Irle C,McGuffin R

更新日期：1988-02-01 00:00:00

abstract：:CD10/neutral endopeptidase 24.11 (NEP) regulates peptidemediated proliferation of lymphoid progenitors and certain epithelial cells and is itself regulated by cellular proliferation. To further characterize mechanisms by which cell-surface signaling might regulate CD10/NEP expression, we determined whether CD10/NEP wa...

journal_title：Blood

authors： Ganju RK,Shpektor RG,Brenner DG,Shipp MA

更新日期：1996-12-01 00:00:00

abstract：:An understanding of mechanisms regulating hematopoietic stem cell engraftment is of pivotal importance to the clinical use of cultured and genetically modified transplants. Human cord blood (CB) cells with lymphomyeloid repopulating activity in NOD/SCID mice were recently shown to undergo multiple self-renewal divisio...

journal_title：Blood

authors： Glimm H,Oh IH,Eaves CJ

更新日期：2000-12-15 00:00:00

abstract：:Src homology 2 domain-containing phosphatase 2 (Shp2), encoded by Ptpn11, is a member of the nonreceptor protein-tyrosine phosphatase family, and functions in cell survival, proliferation, migration, and differentiation in many tissues. Here we report that loss of Ptpn11 in murine hematopoietic cells leads to bone mar...

journal_title：Blood

authors： Chan G,Cheung LS,Yang W,Milyavsky M,Sanders AD,Gu S,Hong WX,Liu AX,Wang X,Barbara M,Sharma T,Gavin J,Kutok JL,Iscove NN,Shannon KM,Dick JE,Neel BG,Braun BS

更新日期：2011-04-21 00:00:00

abstract：:Activated protein C (APC) reduces mortality in severe sepsis patients. APC exerts anticoagulant activities via inactivation of factors Va and VIIIa and cytoprotective activities via endothelial protein C receptor and protease-activated receptor-1. APC mutants with selectively altered and opposite activity profiles, th...

journal_title：Blood

authors： Mosnier LO,Zampolli A,Kerschen EJ,Schuepbach RA,Banerjee Y,Fernández JA,Yang XV,Riewald M,Weiler H,Ruggeri ZM,Griffin JH

更新日期：2009-06-04 00:00:00

abstract：:Until recently, the identification of cellular factors that govern the developmental program of human stem cells has been difficult due to the absence of repopulation assays that detect human stem cells. The transplantation of human bone marrow (BM) or cord blood (CB) into non-obese diabetic (NOD)/severe-combined immu...

journal_title：Blood

authors： Kapp U,Bhatia M,Bonnet D,Murdoch B,Dick JE

更新日期：1998-09-15 00:00:00

abstract：:Clinical resistance to imatinib mesylate is commonly observed in patients with advanced Philadelphia chromosome- positive (Ph(+)) leukemias. Acquired resistance is typically associated with reactivation of BCR-ABL due to kinase domain mutations or gene amplification, indicating that BCR-ABL remains a viable target for...

journal_title：Blood

authors： Gorre ME,Ellwood-Yen K,Chiosis G,Rosen N,Sawyers CL

更新日期：2002-10-15 00:00:00

abstract：:The capacity to convert exogenous leukotriene A4 to lipoxins (LXs) was investigated in platelet suspensions from patients with myeloproliferative disorders (MPD) (n = 22) and healthy control subjects (n = 14). Platelets isolated from the controls produced mainly LXA4, but also 6(S)-LXA4 and the all-trans isomers of li...

journal_title：Blood

authors： Stenke L,Edenius C,Samuelsson J,Lindgren JA

更新日期：1991-12-01 00:00:00

abstract：:The effect of donor/recipient histocompatibility on relapse in patients receiving T-cell-depleted (TCD) grafts for chronic myelogenous leukemia (CML) was evaluated. Specifically, we sought to determine whether TCD results in an attenuation of the graft-versus-leukemia (GVL) effect on recipients of unrelated marrow gra...

journal_title：Blood

authors： Hessner MJ,Endean DJ,Casper JT,Horowitz MM,Keever-Taylor CA,Roth M,Flomenberg N,Drobyski WR

更新日期：1995-11-15 00:00:00

abstract：:Recent studies have established that during embryonic development, hematopoietic progenitors and stem cells are generated from hemogenic endothelium precursors through a process termed endothelial to hematopoietic transition (EHT). The transcription factor RUNX1 is essential for this process, but its main downstream e...

journal_title：Blood

authors： Lancrin C,Mazan M,Stefanska M,Patel R,Lichtinger M,Costa G,Vargel O,Wilson NK,Möröy T,Bonifer C,Göttgens B,Kouskoff V,Lacaud G

更新日期：2012-07-12 00:00:00

abstract：:McCullough and colleagues show that problems with cord banking still exist. To improve the results of cord transplantations, more attention should be given to ensuring quality standards rather than just collecting more units. ...

journal_title：Blood

authors： Querol S

更新日期：2009-08-20 00:00:00

abstract：:Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their use as vectors for immunotherapy vaccines. However, it is unclear whether and to what degree in vitro-generated DCs are representative o...

journal_title：Blood

authors： Maraskovsky E,Daro E,Roux E,Teepe M,Maliszewski CR,Hoek J,Caron D,Lebsack ME,McKenna HJ

更新日期：2000-08-01 00:00:00

abstract：:The reduction of nitroblue tetrazolium dye by human neutrophils was measured in the presence of serum in which the complement system had been activated through the alternate pathway by interaction with inulin. Neutrophils incubated with serum inulin supernatants reduced the dye and showed a general increase in oxidati...

journal_title：Blood

authors： Strauss RG,Mauer AM,Asbrock T,Spitzer RE,Stitzel AE

更新日期：1975-06-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that stimulates the proliferation, maturation, and functional activity of myeloid cells in peripheral blood and bone marrow. Expression of GM-CSF is tightly regulated and is limited to cells stimulated directly (T cells, macroph...

journal_title：Blood

authors： Fraser JK,Tran S,Nimer SD,Gasson JC

更新日期：1994-10-15 00:00:00

abstract：:Thrombophilia screening is controversial. In a retrospective family cohort, where probands had thrombosis and a thrombophilic defect, 2479 relatives were tested for thrombophilia. In antithrombin-, protein C-, and protein S-deficient relatives, annual incidences of venous thrombosis were 1.77% (95% CI, 1.14-2.60), 1.5...

journal_title：Blood

authors： Lijfering WM,Brouwer JL,Veeger NJ,Bank I,Coppens M,Middeldorp S,Hamulyák K,Prins MH,Büller HR,van der Meer J

更新日期：2009-05-21 00:00:00

abstract：:Derivative chromosome 9 deletions are seen in 10% to 15% of patients with chronic myelogenous leukemia and have been associated with a poor prognosis; however, no studies have been performed in the context of a randomized clinical trial. We developed a DNA-based deletion screen and investigated 339 chronic phase patie...

journal_title：Blood

authors： Kreil S,Pfirrmann M,Haferlach C,Waghorn K,Chase A,Hehlmann R,Reiter A,Hochhaus A,Cross NC,German Chronic Myelogenous Leukemia (CML) Study Group.

更新日期：2007-08-15 00:00:00