Tumor cell heterogeneity in multiple myeloma: antigenic, morphologic, and functional studies of cells from blood and bone marrow.

abstract：:ETS2 and ERG are transcription factors, encoded on human chromosome 21 (Hsa21), that have been implicated in human cancer. People with Down syndrome (DS), who are trisomic for Hsa21, are predisposed to acute megakaryoblastic leukemia (AMKL). DS-AMKL blasts harbor a mutation in GATA1, which leads to loss of full-length...

journal_title：Blood

authors： Stankiewicz MJ,Crispino JD

更新日期：2009-04-02 00:00:00

abstract：:Recently, we reported a novel system whereby human pericytes are recruited to endothelial cell (EC)-lined tubes in 3-dimensional (3D) extracellular matrices to stimulate vascular maturation including basement membrane matrix assembly. Through the use of this serum-free, defined system, we demonstrate that pericyte mot...

journal_title：Blood

authors： Stratman AN,Schwindt AE,Malotte KM,Davis GE

更新日期：2010-11-25 00:00:00

abstract：:Cytotoxic T lymphocytes kill target cells via the polarized secretion of cytotoxic granules at the immune synapse. The lytic granules are initially recruited around the polarized microtubule-organizing center. In a dynein-dependent transport process, the granules move along microtubules toward the microtubule-organizi...

journal_title：Blood

authors： Kurowska M,Goudin N,Nehme NT,Court M,Garin J,Fischer A,de Saint Basile G,Ménasché G

更新日期：2012-04-26 00:00:00

abstract：:Infections during granulocytopenia are major complications of autologous bone marrow transplantation (ABMT). Since recombinant human granulocyte-macrophage colony-stimulating factor (rhuGM-CSF) has proved to accelerate bone marrow recovery after cytostatic chemotherapy, we studied its effects on hematopoietic regenera...

journal_title：Blood

authors： Link H,Boogaerts MA,Carella AM,Ferrant A,Gadner H,Gorin NC,Harabacz I,Harousseau JL,Hervé P,Holldack J

更新日期：1992-11-01 00:00:00

abstract：:The effect of recombinant human erythropoietin (rHuEpo) on megakaryopoiesis remains controversial. Treatment with rHuEpo in renal failure patients has been associated with a slight elevation of platelet counts. In animal studies, high doses of rHuEpo produced an increase of platelet counts followed by a gradual return...

journal_title：Blood

authors： Loo M,Beguin Y

更新日期：1999-05-15 00:00:00

abstract：:Glycoprotein V (GPV) is a membrane-associated, 82 Kd platelet glycoprotein that is hydrolyzed during thrombin activation to yield 69 Kd fragment. We have developed a rapid and simple method for isolation of the protein from platelet extracts using a combination of gel permeation, anion-exchange, and lectin affinity ch...

journal_title：Blood

authors： Shimomura T,Fujimura K,Maehama S,Takemoto M,Oda K,Fujimoto T,Oyama R,Suzuki M,Ichihara-Tanaka K,Titani K

更新日期：1990-06-15 00:00:00

abstract：:A single-stage disposable channel and seal that provides for leukocyte and granulocyte collection by continuous-flow cell separation (CFCS) has been designed by the IBM Corporation. This paper describes (1) the separation characteristics of whole blood as it responds to varying gravitational (G) forces and flow rates ...

journal_title：Blood

authors： Hester JP,Kellogg RM,Mulzet AP,Kruger VR,McCredie KB,Freireich EJ

更新日期：1979-07-01 00:00:00

abstract：:When overexpressed in primary erythroid progenitors, oncogenic Ras leads to the constitutive activation of its downstream signaling pathways, severe block of terminal erythroid differentiation, and cytokine-independent growth of primary erythroid progenitors. However, whether high-level expression of oncogenic Ras is ...

journal_title：Blood

authors： Zhang J,Liu Y,Beard C,Tuveson DA,Jaenisch R,Jacks TE,Lodish HF

更新日期：2007-06-15 00:00:00

abstract：:Neurexin I α (NRXN1α) and Dystroglycan (DAG1) are membrane receptors which serve as mutual ligands in the neuronal system. Neurexophilins (NXPHs) bind NRXN1α. NRXN1α was expressed in primitive populations in human CB (huCB) and murine BM (muBM). DAG1 is ubiquitously expressed in hematopoietic tissue; however, osteobla...

journal_title：Blood

authors： Kinzfogl J,Hangoc G,Broxmeyer HE

更新日期：2011-07-21 00:00:00

abstract：:Monitoring unfractionated heparin (UFH) is crucial to prevent over- or under-anticoagulation. However, the optimal parameters for monitoring UFH in children are not well established. The study objectives were to investigate (1) the relationship between UFH dose and its anticoagulant effect as assessed by anti-Xa, acti...

journal_title：Blood

authors： Hanslik A,Kitzmüller E,Tran US,Thom K,Karapetian H,Prutsch N,Voitl J,Michel-Behnke I,Newall F,Male C

更新日期：2015-10-29 00:00:00

abstract：:Lymphatic endothelial cells (LECs) induce peripheral tolerance by direct presentation to CD8 T cells (T(CD8)). We demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1, despite expressing ligands for the CD160, B- and T-lymphocyte attenuator, and lymphocyte activation gene-3 inhibitor...

journal_title：Blood

authors： Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH

更新日期：2012-12-06 00:00:00

abstract：:Similar to endothelial cells (ECs), vascular endothelial growth factor (VEGF) induces Bcl-2 expression on VEGF receptor-positive (VEGFR(+)) primary leukemias and cell lines, promoting survival. We investigated the molecular pathways activated by VEGF on such leukemias, by performing a gene expression analysis of VEGF-...

journal_title：Blood

authors： Dias S,Shmelkov SV,Lam G,Rafii S

更新日期：2002-04-01 00:00:00

abstract：:2-Chlorodeoxyadenosine, a new lymphocyte-selective, anti-neoplastic drug was administered to 18 patients with advanced chronic lymphocytic leukemia of B-cell origin. All patients were resistant to conventional treatment. A total of 44 courses of 2-chlorodeoxyadenosine were completed with minimal toxicity. An overall r...

journal_title：Blood

authors： Piro LD,Carrera CJ,Beutler E,Carson DA

更新日期：1988-09-01 00:00:00

abstract：:Endothelial cells (ECs) express 2 members of the cadherin family, VE and N-cadherin. Although VE-cadherin induces EC homotypic adhesion, N-cadherin function in ECs remains largely unknown. EC-specific inactivation of either VE or N-cadherin leads to early fetal lethality suggesting that these cadherins play a nonredun...

journal_title：Blood

authors： Giampietro C,Taddei A,Corada M,Sarra-Ferraris GM,Alcalay M,Cavallaro U,Orsenigo F,Lampugnani MG,Dejana E

更新日期：2012-03-01 00:00:00

abstract：:Several primary murine and human B lymphomas and cell lines were found to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a member of the mitogen-activated protein (MAP) kinase family. Proliferation of murine B lymphomas CH31, CH12.Lx, BKS-2, and WEHI-231 and the human B lymp...

journal_title：Blood

authors： Gururajan M,Chui R,Karuppannan AK,Ke J,Jennings CD,Bondada S

更新日期：2005-08-15 00:00:00

abstract：:Somatic hypermutation and class-switch recombination of the immunoglobulin (Ig) genes occur in germinal center (GC) B cells and are initiated through deamination of cytidine to uracil by activation-induced cytidine deaminase (AID). Resulting uracil-guanine mismatches are processed by uracil DNA glycosylase (UNG)-media...

journal_title：Blood

authors： Gu X,Booth CJ,Liu Z,Strout MP

更新日期：2016-01-07 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (VEGFR2) plays a key role in physiologic and pathologic angiogenesis. Plasma membrane (PM) levels of VEGFR2 are regulated by endocytosis and secretory transport through the Golgi apparatus. To date, the mechanism whereby the VEGFR2 traffics through the Golgi apparatus rema...

journal_title：Blood

authors： Manickam V,Tiwari A,Jung JJ,Bhattacharya R,Goel A,Mukhopadhyay D,Choudhury A

更新日期：2011-01-27 00:00:00

abstract：:Neutrophils recruited from the blood are key players in the innate immune response. Selectins play critical roles in neutrophil recruitment by mediating their tethering and rolling in inflamed venules. While the roles of P- and E-selectin in this process are well established, the mechanisms of L-selectin-mediated neut...

journal_title：Blood

authors： Shigeta A,Matsumoto M,Tedder TF,Lowe JB,Miyasaka M,Hirata T

更新日期：2008-12-15 00:00:00

abstract：:For many in vivo gene therapy clinical applications, it is desirable to control the expression of the transferred transgene using pharmacologic agents. To evaluate the feasibility of accomplishing this using corticosteroids, pharmacologic agents widely used in clinical medicine, we constructed replication deficient ad...

journal_title：Blood

authors： Narumi K,Suzuki M,Song W,Moore MA,Crystal RG

更新日期：1998-08-01 00:00:00

abstract：:Recent studies have identified nonredundant roles for basophils in immune responses including allergy and protective immunity. It is well known that activated basophils release granule contents such as histamine and proteases as do mast cells. However, the functional significance of basophil-derived proteases remains ...

journal_title：Blood

authors： Iki M,Tanaka K,Deki H,Fujimaki M,Sato S,Yoshikawa S,Yamanishi Y,Karasuyama H

更新日期：2016-12-22 00:00:00

abstract：:The cell-surface expression and the functional status of the CD95/Fas antigen on primitive hematopoietic progenitors (PHPs) freshly isolated from human fetal liver (FL) were studied. PHPs were phenotypically defined as CD34++ CD38 -/+ cells. The most immature subfractions of PHPs, CD34++CD38- and CD34+2CD38+ FL cells,...

journal_title：Blood

authors： Bárcena A,Park SW,Banapour B,Muench MO,Mechetner E

更新日期：1996-09-15 00:00:00

abstract：:Pacritinib (SB1518) is a Janus kinase 2 (JAK2), JAK2(V617F), and Fms-like tyrosine kinase 3 inhibitor that does not inhibit JAK1. It demonstrated a favorable safety profile with promising efficacy in phase 1 studies in patients with primary and secondary myelofibrosis (MF). This multicenter phase 2 study further chara...

journal_title：Blood

authors： Komrokji RS,Seymour JF,Roberts AW,Wadleigh M,To LB,Scherber R,Turba E,Dorr A,Zhu J,Wang L,Granston T,Campbell MS,Mesa RA

更新日期：2015-04-23 00:00:00

abstract：:IL-17 and its receptor are founding members of a novel family of inflammatory cytokines. IL-17 plays a pathogenic role in rheumatoid arthritis (RA)-associated bone destruction. However, IL-17 is also an important regulator of host defense through granulopoiesis and neutrophil trafficking. Therefore, the role of IL-17 ...

journal_title：Blood

authors： Yu JJ,Ruddy MJ,Wong GC,Sfintescu C,Baker PJ,Smith JB,Evans RT,Gaffen SL

更新日期：2007-05-01 00:00:00

abstract：:All-trans retinoic acid (RA) induces complete remission in a high proportion of patients with acute promyelocytic leukemia (APL). Nevertheless, most of these patients develop RA resistance and relapse. The mechanisms of RA resistance by APL cells are still unclear. To understand the characteristics of human leukemia, ...

journal_title：Blood

authors： Kizaki M,Matsushita H,Takayama N,Muto A,Ueno H,Awaya N,Kawai Y,Asou H,Kamada N,Ikeda Y

更新日期：1996-09-01 00:00:00

abstract：:Inhibition of the tissue factor pathway has been shown to attenuate the activation of coagulation and to prevent death in a gram-negative bacteremia primate model of sepsis. It has been suggested that tissue factor influences inflammatory cascades other than the coagulation system. The authors sought to determine the ...

journal_title：Blood

authors： de Jonge E,Dekkers PE,Creasey AA,Hack CE,Paulson SK,Karim A,Kesecioglu J,Levi M,van Deventer SJ,van Der Poll T

更新日期：2000-02-15 00:00:00

abstract：:Pyrimidine 5' nucleotidase (P5'N-1) deficiency is an autosomal recessive condition causing hemolytic anemia characterized by marked basophilic stippling and the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. It is implicated in the anemia of lead poisoning and is possibly associa...

journal_title：Blood

authors： Marinaki AM,Escuredo E,Duley JA,Simmonds HA,Amici A,Naponelli V,Magni G,Seip M,Ben-Bassat I,Harley EH,Thein SL,Rees DC

更新日期：2001-06-01 00:00:00

abstract：:The platelet release reaction plays a critical role in thrombosis and contributes to the events that follow hemostasis. Previous studies have shown that platelet secretion is mediated by Soluble NSF Attachment Protein Receptor (SNARE) proteins from granule and plasma membranes. The SNAREs form transmembrane complexes ...

journal_title：Blood

authors： Ye S,Karim ZA,Al Hawas R,Pessin JE,Filipovich AH,Whiteheart SW

更新日期：2012-09-20 00:00:00

abstract：:Virally infected cells degrade intracellular viral proteins proteolytically and present the resulting peptides in association with major histocompatibility complex (MHC) class I molecules to CD8+ cytotoxic T lymphocytes (CTLs). These cells are normally prone to CTL-mediated elimination. However, several viruses have e...

journal_title：Blood

authors： Zeidler R,Eissner G,Meissner P,Uebel S,Tampé R,Lazis S,Hammerschmidt W

更新日期：1997-09-15 00:00:00

abstract：:Persistent NF-κB activation is a hallmark of the malignant Hodgkin/Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL). Genomic lesions, Epstein-Barr virus infection, soluble factors, and tumor-microenvironment interactions contribute to this activation. Here, in an unbiased approach to identify the cHL cel...

journal_title：Blood

authors： von Hoff L,Kärgel E,Franke V,McShane E,Schulz-Beiss KW,Patone G,Schleussner N,Kolesnichenko M,Hübner N,Daumke O,Selbach M,Akalin A,Mathas S,Scheidereit C

更新日期：2019-03-28 00:00:00

abstract：:Antigenic stimulation through the B-cell antigen receptor (BCR) is considered to promote the expansion of chronic lymphocytic leukemia (CLL) B cells. The spleen tyrosine kinase (Syk), a key component of BCR signaling, can be blocked by R406, a small-molecule Syk inhibitor, that displayed activity in CLL patients in a ...

journal_title：Blood

authors： Quiroga MP,Balakrishnan K,Kurtova AV,Sivina M,Keating MJ,Wierda WG,Gandhi V,Burger JA

更新日期：2009-07-30 00:00:00