Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups.

abstract：:Telomere length has been linked to disease stage and degree of (pan-)cytopenia in patients with bone marrow failure syndromes. The aim of the current study was to analyze the impact of replicative stress on telomere length in residual glycosylphosphatidylinositol-positive (GPI+) versus GPI- hematopoiesis in patients w...

journal_title：Blood

authors： Beier F,Balabanov S,Buckley T,Dietz K,Hartmann U,Rojewski M,Kanz L,Schrezenmeier H,Brümmendorf TH

更新日期：2005-07-15 00:00:00

abstract：:Megakaryopoiesis is the hierarchical differentiation of hematopoietic stem cells into megakaryocytes. Differentiating megakaryocytes undergo maturation characterized by endomitosis and produce numerous platelets through proplatelet formation. C-type lectin-like receptor 2 (CLEC-2) is a podoplanin (PDPN) receptor mainl...

journal_title：Blood

authors： Tamura S,Suzuki-Inoue K,Tsukiji N,Shirai T,Sasaki T,Osada M,Satoh K,Ozaki Y

更新日期：2016-03-31 00:00:00

abstract：:Blockade of the CD40/CD154 signal is a potential immunomodulatory strategy for T-cell-mediated diseases. As a part of a phase 1, multicenter, dose-escalating trial of humanized monoclonal antibody to CD154 (IDEC-131/E6040) in patients with refractory immune thrombocytopenic purpura (ITP), the autoimmune response to gl...

journal_title：Blood

authors： Kuwana M,Nomura S,Fujimura K,Nagasawa T,Muto Y,Kurata Y,Tanaka S,Ikeda Y

更新日期：2004-02-15 00:00:00

abstract：:Recently, we have identified scavenger receptor class A member I (SR-AI) as a receptor for coagulation factor X (FX), mediating the formation of an FX reservoir at the macrophage surface. Here, we demonstrate that the FX/SR-AI-complex comprises a third protein, pentraxin-2 (PTX2). The presence of PTX2 is essential to ...

journal_title：Blood

authors： Muczynski V,Aymé G,Regnault V,Vasse M,Borgel D,Legendre P,Bazaa A,Harel A,Loubière C,Lenting PJ,Denis CV,Christophe OD

更新日期：2017-04-27 00:00:00

abstract：:To characterize juvenile chronic myelogenous leukemia (JCML), the proliferative properties of bone marrow (BM) and peripheral blood (PB) cells from nine patients were studied using assays for CFU-C and CFU-GEMM and liquid cultures. All specimens showed two reproducible abnormalities: impaired growth of normal hematopo...

journal_title：Blood

authors： Estrov Z,Grunberger T,Chan HS,Freedman MH

更新日期：1986-05-01 00:00:00

abstract：:Although receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) signaling has been shown to prolong the survival of mature dendritic cells (DCs), the association of RANKL pathway with Fas-mediated apoptosis is obscure. Here, we found that bone marrow-derived DCs (BMDCs) from the Fas-deficient strain MRL/lpr m...

journal_title：Blood

authors： Izawa T,Ishimaru N,Moriyama K,Kohashi M,Arakaki R,Hayashi Y

更新日期：2007-07-01 00:00:00

abstract：:Keeping track of individual cell identifications is imperative to the study of dynamic single-cell behavior over time. Highly motile hematopoietic stem and progenitor cells (HSPCs) migrate quickly and do not adhere, and thus must be imaged very frequently to keep cell identifications. Even worse, they are also flushed...

journal_title：Blood

authors： Loeffler D,Wang W,Hopf A,Hilsenbeck O,Bourgine PE,Rudolf F,Martin I,Schroeder T

更新日期：2018-03-29 00:00:00

abstract：:The regulation of CCR6 (chemokine receptor 6) expression during B-cell ontogeny and antigen-driven B-cell differentiation was analyzed. None of the CD34(+)Lin(-) hematopoietic stem cell progenitors or the CD34(+)CD19(+) (pro-B) or the CD19(+)CD10(+) (pre-B/immature B cells) B-cell progenitors expressed CCR6. CCR6 is a...

journal_title：Blood

authors： Krzysiek R,Lefevre EA,Bernard J,Foussat A,Galanaud P,Louache F,Richard Y

更新日期：2000-10-01 00:00:00

abstract：:The incidence of neutralizing isoantibody formation to infused factor VIII in a cohort of 67 hemophilia A patients, born between January 1, 1971 and April 30, 1990, who had been treated exclusively with lyophilized cryoprecipitate, was 6% (5.3 per 1,000 patient years of observation). The age-dependent cumulative risk ...

journal_title：Blood

authors： Peerlinck K,Rosendaal FR,Vermylen J

更新日期：1993-06-15 00:00:00

abstract：:We have used a single intensive chemotherapy regimen in the treatment of young patients with diffuse, aggressive, malignant lymphomas. There were two major histologic types of lymphoma in our series: lymphoblastic lymphomas, which presented most often with mediastinal tumor (64%), and undifferentiated lymphomas (mostl...

journal_title：Blood

authors： Magrath IT,Janus C,Edwards BK,Spiegel R,Jaffe ES,Berard CW,Miliauskas J,Morris K,Barnwell R

更新日期：1984-05-01 00:00:00

abstract：:Protein S, an inhibitor of coagulation, interacts reversibly with C4b binding protein (C4bBP). The physiologic role of this complex formation remains unknown. In this study we examined the possibility that protein S would facilitate C4bBP binding to the surface of neutrophils where, in turn, this complex could help pr...

journal_title：Blood

authors： Furmaniak-Kazmierczak E,Hu CY,Esmon CT

更新日期：1993-01-15 00:00:00

abstract：:Allogeneic hematopoietic stem-cell transplantation (HSCT) remains an effective strategy for inducing durable remission in chronic myeloid leukemia (CML). Reduced-intensity conditioning (RIC) regimens extend HSCT to older patients and those with comorbidities who would otherwise not be suitable candidates for HSCT. The...

journal_title：Blood

authors： Kebriaei P,Detry MA,Giralt S,Carrasco-Yalan A,Anagnostopoulos A,Couriel D,Khouri IF,Anderlini P,Hosing C,Alousi A,Champlin RE,de Lima M

更新日期：2007-11-01 00:00:00

abstract：:The Leu-8 molecule, the human homologue of the murine MEL-14 peripheral lymph node homing receptor, is expressed on neutrophils in both species and may be important in localization of cells to sites of inflammation. Most circulating human neutrophils express the Leu-8 molecule, and activation of neutrophils with phorb...

journal_title：Blood

authors： Berg M,James SP

更新日期：1990-12-01 00:00:00

abstract：:We treated 109 patients with adult acute lymphoblastic leukemia (ALL) diagnosed by histochemical and immunologic techniques. Patients were excluded only for age greater than 50 years and Burkitt's leukemia. Treatment included a four-drug remission induction phase followed by alternating cycles of noncrossresistant che...

journal_title：Blood

authors： Linker CA,Levitt LJ,O'Donnell M,Forman SJ,Ries CA

更新日期：1991-12-01 00:00:00

abstract：:In this issue of Blood, Nagai et al provide evidence that adult T-cell leukemia is hierarchically organized and sustained by a small population of transformed T memory stem cells. ...

journal_title：Blood

authors： Gattinoni L

更新日期：2015-06-04 00:00:00

abstract：:We describe the identification, experimental transmission, and pathogenesis of a naturally occurring powerfully immunosuppressive isolate of feline leukemia virus (designated here as FeLV-FAIDS) which induces fatal acquired immunodeficiency syndrome (AIDS) in 100% (25 of 25) of persistently viremic experimentally infe...

journal_title：Blood

authors： Hoover EA,Mullins JI,Quackenbush SL,Gasper PW

更新日期：1987-12-01 00:00:00

abstract：:Gemtuzumab ozogamicin (GO) contains an anti-CD33 antibody to facilitate uptake of a toxic calicheamicin-gamma(1) derivative. While recent in vitro data demonstrated a quantitative relationship between CD33 expression and GO cytotoxicity, previous correlative studies failed to identify a significant association between...

journal_title：Blood

authors： Walter RB,Gooley TA,van der Velden VH,Loken MR,van Dongen JJ,Flowers DA,Bernstein ID,Appelbaum FR

更新日期：2007-05-15 00:00:00

abstract：:Oncogenic activation of NOTCH1 signaling plays a central role in the pathogenesis of T-cell acute lymphoblastic leukemia, with mutations on this signaling pathway affecting more than 60% of patients at diagnosis. However, the transcriptional regulatory circuitries driving T-cell transformation downstream of NOTCH1 rem...

journal_title：Blood

authors： Schnell SA,Ambesi-Impiombato A,Sanchez-Martin M,Belver L,Xu L,Qin Y,Kageyama R,Ferrando AA

更新日期：2015-04-30 00:00:00

abstract：:In vitro models of granulopoiesis involving the inducible expression of either CCAAT enhancer binding protein alpha (C/EBP alpha) or C/EBP epsilon in myeloid cells have been shown to lead to the induction of a granulocytic maturation program accompanied by the expression of myeloid-specific genes. Since members of the...

journal_title：Blood

authors： Khanna-Gupta A,Zibello T,Sun H,Gaines P,Berliner N

更新日期：2003-05-01 00:00:00

abstract：:The malignant Reed-Sternberg cell of Hodgkin disease is an aberrant B cell that persists in an immunolgically mediated inflammatory infiltrate. Despite its nonproductive immunoglobulin genes, the Reed-Sternberg cell avoids the usual apoptotic fate of defective immune cells through an unknown mechanism. A likely candid...

journal_title：Blood

authors： Annunziata CM,Safiran YJ,Irving SG,Kasid UN,Cossman J

更新日期：2000-10-15 00:00:00

abstract：:Hepatitis C virus (HCV) infection is not uncommon in cancer patients. Over the past 5 years, treatment of chronic HCV infection in patients with hematologic malignancies has evolved rapidly as safe and effective direct-acting antivirals (DAAs) have become the standard-of-care treatment. Today, chronic HCV infection sh...

journal_title：Blood

authors： Torres HA,McDonald GB

更新日期：2016-09-15 00:00:00

abstract：:The incidence and role of p53 abnormalities have not been reported in splenic lymphoma with villous lymphocytes (SLVL), the leukemic counterpart of splenic marginal zone lymphoma. Because p53 abnormalities correlate with progressive and refractory disease in cancer and isochromosome 17q has been described in SLVL, a l...

journal_title：Blood

authors： Gruszka-Westwood AM,Hamoudi RA,Matutes E,Tuset E,Catovsky D

更新日期：2001-06-01 00:00:00

abstract：:Megakaryoblastic leukemia 1 (MKL1), identified as part of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF). Here we show that Mkl1 expression is up-regulated during mur...

journal_title：Blood

authors： Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS

更新日期：2009-03-19 00:00:00

abstract：:Despite major therapeutic advances, most mature B-cell malignancies remain incurable. Compelling evidence suggests that crosstalk with accessory stromal cells in specialized tissue microenvironments, such as the bone marrow and secondary lymphoid organs, favors disease progression by promoting malignant B-cell growth ...

journal_title：Blood

authors： Burger JA,Ghia P,Rosenwald A,Caligaris-Cappio F

更新日期：2009-10-15 00:00:00

abstract：:An immune pathophysiology for acquired aplastic anemia (AA) has been inferred from the responsiveness of the patients to immunosuppressive therapies and experimental laboratory data. To address the transcriptome of hematopoietic cells in AA, we undertook GeneChip analysis of the extremely limited numbers of progenitor...

journal_title：Blood

authors： Zeng W,Chen G,Kajigaya S,Nunez O,Charrow A,Billings EM,Young NS

更新日期：2004-01-01 00:00:00

abstract：:Maintenance of myeloid cell homeostasis requires continuous turnover of phagocytes from the bloodstream, yet whether environmental signals influence phagocyte longevity in the absence of inflammation remains unknown. Here, we show that the gut microbiota regulates the steady-state cellular lifespan of neutrophils and ...

journal_title：Blood

authors： Hergott CB,Roche AM,Tamashiro E,Clarke TB,Bailey AG,Laughlin A,Bushman FD,Weiser JN

更新日期：2016-05-19 00:00:00

abstract：:We present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8- [double-negative, DN], T-cell receptor [TCR] alpha beta+). In the ATL cells of these patients, neither gene nor surface expression of CD4 and CD8 antigens was detected. Clinical and laboratory data showed no differ...

journal_title：Blood

authors： Suzushima H,Asou N,Nishimura S,Nishikawa K,Wang JX,Okubo T,Naito M,Hattori T,Takatsuki K

更新日期：1993-02-15 00:00:00

abstract：:A nonanemic chronic lymphocytic leukemia patient with nearly 500,000 lymphocytes/microL underwent leukapheresis when she presented with CNS symptoms and retinal vascular engorgement. Respiratory distress developed during the cell separator run, which led us to ask whether the procedure could have changed the adhesive ...

journal_title：Blood

authors： Hammerschmidt DE,Jeanneret C,Husak M,Lobell M,Jacob HS

更新日期：1988-05-01 00:00:00

abstract：:It has been suggested that autotransplantation of splenic tissue following trauma may result in splenic implanta that protect the human host from severe infection with encapsulated bacteria. To test this hypothesis, Sprague-Dawley rats underwent sham operation, splenectomy, or splenectomy followed by autotransplantati...

journal_title：Blood

authors： Moxon ER,Schwartz AD

更新日期：1980-11-01 00:00:00

abstract：:Deficiency of folate or vitamin B(12) (cobalamin) causes megaloblastic anemia, a disease characterized by pancytopenia due to the excessive apoptosis of hematopoietic progenitor cells. Clinical and experimental studies of megaloblastic anemia have demonstrated an impairment of DNA synthesis and repair in hematopoietic...

journal_title：Blood

authors： Koury MJ,Price JO,Hicks GG

更新日期：2000-11-01 00:00:00