Reversing anti-factor Xa agents and the unmet needs in trauma patients.

Abstract:

:Andexanet alfa, a reversing agent for anticoagulants that inhibit factor Xa, has recently been licensed in the United States. We discuss the impact of this licensure on current practice and review in detail the problems of a neglected and growing clinical area: reversing the anticoagulation effect of factor Xa inhibitors in bleeding trauma patients. We identify areas of practice that need research so that care of bleeding trauma patients receiving direct factor Xa inhibitors can be improved.

journal_name

Blood

journal_title

Blood

authors

Hunt BJ,Neal MD,Stensballe J

doi

10.1182/blood-2018-06-850396

subject

Has Abstract

pub_date

2018-12-06 00:00:00

pages

2441-2445

issue

23

eissn

0006-4971

issn

1528-0020

pii

blood-2018-06-850396

journal_volume

132

pub_type

杂志文章,评审

相关文献

BLOOD文献大全
  • Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia: final results of AML-13, a randomized phase-3 study.

    abstract::The role of glycosylated recombinant human granulocyte colony-stimulating factor (G-CSF) in the induction treatment of older adults with acute myeloid leukemia (AML) is still uncertain. In this trial, a total of 722 patients with newly diagnosed AML, median age 68 years, were randomized into 4 treatment arms: (A) no G...

    journal_title:Blood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1182/blood-2004-09-3728

    authors: Amadori S,Suciu S,Jehn U,Stasi R,Thomas X,Marie JP,Muus P,Lefrère F,Berneman Z,Fillet G,Denzlinger C,Willemze R,Leoni P,Leone G,Casini M,Ricciuti F,Vignetti M,Beeldens F,Mandelli F,De Witte T,EORTC\/GIMEMA Leukemi

    更新日期:2005-07-01 00:00:00

  • Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.

    abstract::NRAS is frequently mutated in hematologic malignancies. We generated Mx1-Cre, Lox-STOP-Lox (LSL)-Nras(G12D) mice to comprehensively analyze the phenotypic, cellular, and biochemical consequences of endogenous oncogenic Nras expression in hematopoietic cells. Here we show that Mx1-Cre, LSL-Nras(G12D) mice develop an in...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-04-280750

    authors: Li Q,Haigis KM,McDaniel A,Harding-Theobald E,Kogan SC,Akagi K,Wong JC,Braun BS,Wolff L,Jacks T,Shannon K

    更新日期:2011-02-10 00:00:00

  • Transforming growth factor-beta regulates c-kit message stability and cell-surface protein expression in hematopoietic progenitors.

    abstract::The cell-surface receptor c-kit and its cognate ligand stem-cell factor (SCF) or steel factor (SLF) are important for the maintenance of hematopoiesis both in vitro and in vivo. Transforming growth factor-beta (TGF-beta) has been shown to be a potent inhibitor of SLF-mediated synergistic growth of murine Lin-Sca-1+ pr...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Dubois CM,Ruscetti FW,Stankova J,Keller JR

    更新日期:1994-06-01 00:00:00

  • A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphoma.

    abstract::Prediagnostic serum concentration of soluble CD30 (sCD30), a marker for chronic B-cell stimulation, has been associated with increased risk of developing AIDS-related non-Hodgkin lymphoma (NHL) in a recent study of HIV(+) patients. To investigate among healthy persons whether serum sCD30 is associated with NHL risk, w...

    journal_title:Blood

    pub_type: 杂志文章,多中心研究

    doi:10.1182/blood-2009-04-217521

    authors: Purdue MP,Lan Q,Martinez-Maza O,Oken MM,Hocking W,Huang WY,Baris D,Conde B,Rothman N

    更新日期:2009-09-24 00:00:00

  • CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia.

    abstract::CCAAT/enhancer binding proteins (C/EBPs) are a family of factors that regulate cell growth and differentiation. These factors, particularly C/EBPalpha and C/EBPepsilon, have important roles in normal myelopoiesis. In addition, loss of C/EBP activity appears to have a role in the pathogenesis of myeloid disorders inclu...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-05-1374

    authors: Truong BT,Lee YJ,Lodie TA,Park DJ,Perrotti D,Watanabe N,Koeffler HP,Nakajima H,Tenen DG,Kogan SC

    更新日期:2003-02-01 00:00:00

  • TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Resear

    abstract::Currently availabel staging systems for non-Hodgkin lymphomas are not useful for clinical staging classification of most primary cutaneous lymphomas. The tumor, node, metastases (TNM) system used for mycosis fungoides (MF) and Sézary syndrome (SS) is not appropriate for other primary cutaneous lymphomas. A usable, uni...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2006-10-054601

    authors: Kim YH,Willemze R,Pimpinelli N,Whittaker S,Olsen EA,Ranki A,Dummer R,Hoppe RT,ISCL and the EORTC.

    更新日期:2007-07-15 00:00:00

  • Changes in regulation of human monocyte proteins in response to IgG from patients with antiphospholipid syndrome.

    abstract::The effects of immunoglobulin G (IgG) from patients with the antiphospholipid syndrome (APS) upon monocyte activation have not been fully characterized. We carried out a comprehensive proteomic analysis of human monocytes treated with IgG from patients with different manifestations of the APS. Using 2-dimensional diff...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2014-05-577569

    authors: Ripoll VM,Lambrianides A,Pierangeli SS,Poulton K,Ioannou Y,Heywood WE,Mills K,Latchman DS,Isenberg DA,Rahman A,Giles IP

    更新日期:2014-12-11 00:00:00

  • Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits.

    abstract::Despite the established utility of serum transferrin receptor (sTfR), serum ferritin, and the sTfR/log ferritin ratio (TfR-F Index) in the diagnosis of iron deficiency (ID) anemia, the numeric values of these parameters, which are indicative of subclinical ID, remain to be clearly defined. In this study, 65 apparently...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Suominen P,Punnonen K,Rajamäki A,Irjala K

    更新日期:1998-10-15 00:00:00

  • A clinical, hematologic, and immunologic analysis of 21 HTLV-II-infected intravenous drug users.

    abstract::Infection with human T-cell leukemia virus type II (HTLV-II) has been associated with rare chronic T-cell malignancies and has recently been demonstrated in a significant proportion of American intravenous drug abusers (IVDA). Identification of an HTLV-II-infected cohort of IVDA has allowed analysis of the HTLV-II car...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Rosenblatt JD,Plaeger-Marshall S,Giorgi JV,Swanson P,Chen IS,Chin E,Wang HJ,Canavaggio M,Hausner MA,Black AC

    更新日期:1990-07-15 00:00:00

  • Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C.

    abstract::We have investigated the role of the Rho and Rac family small guanine triphosphate (GTP) exchange factors (RhoGEFs), Vav1 and Vav2, in the activation of platelets by the immunoreceptor tyrosine-based activation motif (ITAM)-coupled collagen receptor GPVI and by the G protein-coupled receptor agonist thrombin. The glyc...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.V100.10.3561

    authors: Pearce AC,Wilde JI,Doody GM,Best D,Inoue O,Vigorito E,Tybulewicz VL,Turner M,Watson SP

    更新日期:2002-11-15 00:00:00

  • Heterogeneity of the T-cell receptor delta gene indicating subclone formation in acute precursor B-cell leukemias.

    abstract::Precursor B-cell acute lymphoblastic leukemias (B-ALLs) have been shown to be oligoclonal at the Ig heavy-chain (IgH) gene level in up to 40% of cases by Southern blot hybridization. In contrast, oligoclonality as deduced from diversity of T-cell receptor (TcR)-delta gene rearrangements of the immature types (ie, V de...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Ghali DW,Panzer S,Fischer S,Argyriou-Tirita A,Haas OA,Kovar H,Gadner H,Panzer-Grümayer ER

    更新日期:1995-05-15 00:00:00

  • von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke.

    abstract::Stroke is a leading cause of death and disability. The only therapy available is recombinant tissue plasminogen activator, but side effects limit its use. Platelets play a crucial role during stroke, and the inflammatory reaction promotes neurodegeneration. von Willebrand factor (VWF), an adhesion molecule for platele...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-03-213264

    authors: Zhao BQ,Chauhan AK,Canault M,Patten IS,Yang JJ,Dockal M,Scheiflinger F,Wagner DD

    更新日期:2009-10-08 00:00:00

  • Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients.

    abstract::The t(11;14)(q13;q32) results in up-regulation of cyclin D1 and is the most common translocation detected in multiple myeloma, where it is also associated with a lymphoplasmacytic morphology. We performed an interphase fluorescent in situ hybridization (FISH) study to determine the clinical and biologic significance o...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v99.10.3735

    authors: Fonseca R,Blood EA,Oken MM,Kyle RA,Dewald GW,Bailey RJ,Van Wier SA,Henderson KJ,Hoyer JD,Harrington D,Kay NE,Van Ness B,Greipp PR

    更新日期:2002-05-15 00:00:00

  • Defects in hemostasis in P-selectin-deficient mice.

    abstract::Recently, our laboratory showed that platelets, like leukocytes, roll on activated endothelium expressing P-selectin, thus suggesting a role for P-selectin in hemostasis (Frenette et at, Proc Natl Acad Sci USA 92:7450, 1995). We report here that the P-selectin--deficient mice show a 40% prolongation of the bleeding ti...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Subramaniam M,Frenette PS,Saffaripour S,Johnson RC,Hynes RO,Wagner DD

    更新日期:1996-02-15 00:00:00

  • Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.

    abstract::Early B-cell factor 1 (Ebf1) is a transcription factor with documented dose-dependent functions in normal and malignant B-lymphocyte development. To understand more about the roles of Ebf1 in malignant transformation, we investigated the impact of reduced functional Ebf1 dosage on mouse B-cell progenitors. Gene expres...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2014-12-617282

    authors: Prasad MA,Ungerbäck J,Åhsberg J,Somasundaram R,Strid T,Larsson M,Månsson R,De Paepe A,Lilljebjörn H,Fioretos T,Hagman J,Sigvardsson M

    更新日期:2015-06-25 00:00:00

  • Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion.

    abstract::Increasing evidence across malignancies suggests that infiltrating T cells at the site of disease are crucial to tumor control. We hypothesized that marrow-infiltrating immune populations play a critical role in response to donor lymphocyte infusion (DLI), an established and potentially curative immune therapy whose p...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2013-08-523001

    authors: Bachireddy P,Hainz U,Rooney M,Pozdnyakova O,Aldridge J,Zhang W,Liao X,Hodi FS,O'Connell K,Haining WN,Goldstein NR,Canning CM,Soiffer RJ,Ritz J,Hacohen N,Alyea EP 3rd,Kim HT,Wu CJ

    更新日期:2014-02-27 00:00:00

  • Genetic evidence for an additional factor required for erythropoietin-induced signal transduction.

    abstract::Erythropoietin (EPO) and its receptor (EPOR) are required for the development of mature erythrocytes. After binding of ligand, the EPOR activates a variety of signaling pathways that ultimately control cellular proliferation, survival, and specific gene expression. Although erythroid progenitors appear to be the princ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Gaffen SL,Lai SY,Longmore GD,Liu KD,Goldsmith MA

    更新日期:1999-07-01 00:00:00

  • T helper 2-dominant antilymphoma immune response is associated with fatal outcome.

    abstract::The precise role of the endogenous immune system in modulating cancer development remains unclear. Tumor cells are generally thought to be nonimmunogenic because they are of 'self' origin. However, tumor-reactive lymphocytes can be isolated from patients with many types of cancer. It is unclear what role these lymphoc...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Lee PP,Zeng D,McCaulay AE,Chen YF,Geiler C,Umetsu DT,Chao NJ

    更新日期:1997-08-15 00:00:00

  • Reciprocal expression of CD38 and CD34 by adult murine hematopoietic stem cells.

    abstract::The effects of activation of adult murine stem cells on their expression of CD38 were studied using a murine transplantation model. First, the published finding that the majority of long-term engrafting cells from normal adult steady-state marrow are CD38(+) was confirmed. Next, it was determined that the majority of ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v97.9.2618

    authors: Tajima F,Deguchi T,Laver JH,Zeng H,Ogawa M

    更新日期:2001-05-01 00:00:00

  • Delayed alloimmunization using random single donor platelet transfusions: a prospective study in thrombocytopenic patients with acute leukemia.

    abstract::A randomized study was performed in 54 thrombocytopenic patients with acute leukemia. Alloimmunization of recipients of random multiple-donor platelet concentrates (MD group) was compared to that of patients receiving random single-donor platelets (SD group). In the SD patients, formation of alloantibodies (mostly ant...

    journal_title:Blood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Gmür J,von Felten A,Osterwalder B,Honegger H,Hörmann A,Sauter C,Deubelbeiss K,Berchtold W,Metaxas M,Scali G,Frick PG

    更新日期:1983-08-01 00:00:00

  • Involvement of CD36 on erythrocytes as a rosetting receptor for Plasmodium falciparum-infected erythrocytes.

    abstract::Plasmodium falciparum-infected erythrocytes (parasitized red blood cells [PRBCs]) can adhere to uninfected erythrocytes (RBCs) to form rosettes, and adhere to the endothelial cell (EC) surface antigen CD36. These adherence phenomena have previously been considered quite different. We show that anti-CD36 monoclonal ant...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Handunnetti SM,van Schravendijk MR,Hasler T,Barnwell JW,Greenwalt DE,Howard RJ

    更新日期:1992-10-15 00:00:00

  • Macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor stimulate the synthesis of plasminogen-activator inhibitors by human monocytes.

    abstract::Macrophage colony-stimulating factor (M-CSF or CSF-1) and granulocyte-macrophage CSF (GM-CSF) have been shown to increase human monocyte urokinase-type plasminogen-activator (u-PA) activity with possible consequences for cell migration and tissue remodeling; because monocyte u-PA activity is likely to be controlled in...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Hamilton JA,Whitty GA,Stanton H,Wojta J,Gallichio M,McGrath K,Ianches G

    更新日期:1993-12-15 00:00:00

  • Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation.

    abstract::Complement plays a key role in host defense, but its dysregulation can cause autologous tissue injury. Complement activation is normally controlled by regulatory proteins, including factor H (FH) in plasma and membrane cofactor protein (MCP) on the cell surface. Mutations in FH and MCP are linked to atypical hemolytic...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2016-07-728253

    authors: Ueda Y,Mohammed I,Song D,Gullipalli D,Zhou L,Sato S,Wang Y,Gupta S,Cheng Z,Wang H,Bao J,Mao Y,Brass L,Zheng XL,Miwa T,Palmer M,Dunaief J,Song WC

    更新日期:2017-03-02 00:00:00

  • In pediatric patients, age has more impact on dosing of vitamin K antagonists than VKORC1 or CYP2C9 genotypes.

    abstract::Anticoagulation with vitamin K antagonists (VKAs) is problematic because of difficulties in safely managing dosing. Polymorphisms in cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase genes (VKORC1) have been shown to affect VKA dosing in adults. The association of these polymorphisms on VKA dosing in childr...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-05-283861

    authors: Nowak-Göttl U,Dietrich K,Schaffranek D,Eldin NS,Yasui Y,Geisen C,Mitchell LG

    更新日期:2010-12-23 00:00:00

  • Differential regulation of tissue factor and plasminogen activator inhibitor by human mononuclear cells.

    abstract::Fibrin is a hallmark of immune-mediated tissue lesions. The presence of fibrin in such lesions implies both the formation of fibrin via coagulation and the accompanying restriction of fibrinolysis, allowing fibrin to persist. Previous work has shown that human monocytes exposed to an inflammatory stimulus such as lipo...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Schwartz BS,Bradshaw JD

    更新日期:1989-10-01 00:00:00

  • GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells.

    abstract::Maintaining a steady pool of self-renewing hematopoietic stem cells (HSCs) is critical for sustained production of multiple blood lineages. Many transcription factors and molecules involved in chromatin and epigenetic modifications have been found to be critical for HSC self-renewal and differentiation; however, their...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-09-306563

    authors: Yu S,Cui K,Jothi R,Zhao DM,Jing X,Zhao K,Xue HH

    更新日期:2011-02-17 00:00:00

  • Cyclosporin-A is selectively cytotoxic to human leukemic T cells in vitro.

    abstract::We have studied the antileukemic effects of cyclosporin-A (CyA) on the cells of a number of human hematopoietic biopsies and established cell lines in vitro. Cya killed the tumor cells but not the nonmalignant control cells from three of four patients with T-lymphocytic leukemia/lymphoma at concentrations comparable t...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Tötterman TH,Danersund A,Nilsson K,Killander A

    更新日期:1982-05-01 00:00:00

  • Myc is essential for transformation by TEL/platelet-derived growth factor receptor beta (PDGFRbeta).

    abstract::The t(5;12) translocation identified in patients with chronic myelomonocytic leukemia (CMML) encodes a TEL/platelet-derived growth factor receptor beta (PDGFRbeta) fusion protein. A key hypothesis for how the TEL/PDGFRbeta fusion protein would function as an oncogene is that it represents a constitutively active versi...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Bourgeade MF,Défachelles AS,Cayre YE

    更新日期:1998-05-01 00:00:00

  • A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice.

    abstract::In vivo lentiviral vector (LV)-mediated gene delivery would represent a great step forward in the field of gene therapy. Therefore, we have engineered a novel LV displaying SCF and a mutant cat endogenous retroviral glycoprotein, RDTR. These RDTR/SCF-LVs outperformed RDTR-LVs for transduction of human CD34(+) cells (h...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-04-346619

    authors: Frecha C,Costa C,Nègre D,Amirache F,Trono D,Rio P,Bueren J,Cosset FL,Verhoeyen E

    更新日期:2012-02-02 00:00:00

  • Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1.

    abstract::Mice deficient in intercellular adhesion molecule-1 (ICAM-1), lacking membranous ICAM-1, show a normal development but abnormalities of inflammatory and immune functions. Although the membrane-bound form of ICAM-1 is not detectable in the mutant strain, circulating ICAM-1 (cICAM) is present in serum from ICAM-1-defici...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: van Den Engel NK,Heidenthal E,Vinke A,Kolb H,Martin S

    更新日期:2000-02-15 00:00:00