Abstract:
:Aggregation of blood platelets contributes to the arrest of bleeding at sites of vascular injury, but it can occlude atherosclerotic arteries and precipitate diseases such as myocardial infarction. The bonds that link platelets under flow conditions were identified using confocal videomicroscopy in real time. Glycoprotein (GP) Ibalpha and von Willebrand factor (vWF) acted in synergy with alphaIIbbeta3 and fibrinogen to sustain platelet accrual at the apex of thrombi where three-dimensional growth resulted in increasing shear rates. The specific function of distinct adhesion pathways in response to changing hemodynamic conditions helps to explain hemostatic and thrombotic processes.
journal_name
Bloodjournal_title
Bloodauthors
Ruggeri ZM,Dent JA,Saldívar Esubject
Has Abstractpub_date
1999-07-01 00:00:00pages
172-8issue
1eissn
0006-4971issn
1528-0020journal_volume
94pub_type
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