p53 at the crossroads of MPN treatment.

Abstract:

:In this issue of Blood, Lu et al describe the cooperation between an orally bioavailable mouse double minute 2 (MDM2) antagonist (RG7112) and the pegylated interferon α (Peg-IFNα 2a) to target JAK2V617F hematopoietic progenitors and stem cells. Their work provides a rationale for the treatment of patients suffering from myeloproliferative neoplasms (MPNs).

journal_name

Blood

journal_title

Blood

authors

Plo I

doi

10.1182/blood-2014-06-579623

subject

Has Abstract

pub_date

2014-07-31 00:00:00

pages

668-9

issue

5

eissn

0006-4971

issn

1528-0020

pii

124/5/668

journal_volume

124

pub_type

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