Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses.

abstract：:Peripheral blood leukemia cells from patients with acute monoblastic leukemia (AMoL) were tested for killer cell activity against target cells that detected natural killer cell-mediated or monocyte-mediated spontaneous cytotoxicity. The fibrosarcoma cell line Wehi 164, pretreated with actinomycin D to induce susceptib...

journal_title：Blood

authors： Ziegler-Heitbrock HW,Munker R,Thiel E,Krebs I,Riethmüller G

更新日期：1985-01-01 00:00:00

abstract：:Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific immunoglobulin G (IgG...

journal_title：Blood

authors： Jandus P,Boligan KF,Smith DF,de Graauw E,Grimbacher B,Jandus C,Abdelhafez MM,Despont A,Bovin N,Simon D,Rieben R,Simon HU,Cummings RD,von Gunten S

更新日期：2019-11-28 00:00:00

abstract：:We report 2 novel, cryptic chromosomal abnormalities in precursor B-cell acute lymphoblastic leukemia (BCP-ALL): a translocation, either t(X;14)(p22;q32) or t(Y;14)(p11;q32), in 33 patients and an interstitial deletion, either del(X)(p22.33p22.33) or del(Y)(p11.32p11.32), in 64 patients, involving the pseudoautosomal ...

journal_title：Blood

authors： Russell LJ,Capasso M,Vater I,Akasaka T,Bernard OA,Calasanz MJ,Chandrasekaran T,Chapiro E,Gesk S,Griffiths M,Guttery DS,Haferlach C,Harder L,Heidenreich O,Irving J,Kearney L,Nguyen-Khac F,Machado L,Minto L,Majid A,

更新日期：2009-09-24 00:00:00

abstract：:Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in bleeding disorders characterized by a macrothrombocytopenia. To understand the role of myosin in normal platelet functions and in pathology, we generated mice with disruption of MYH9 in megakaryocytes. MYH9Delta mice displayed macrothro...

journal_title：Blood

authors： Léon C,Eckly A,Hechler B,Aleil B,Freund M,Ravanat C,Jourdain M,Nonne C,Weber J,Tiedt R,Gratacap MP,Severin S,Cazenave JP,Lanza F,Skoda R,Gachet C

更新日期：2007-11-01 00:00:00

abstract：:In subjects mismatched in the HLA alleles C*03:03/C*03:04 no allogeneic cytotoxic T-lymphocyte responses are detected in vitro. Hematopoietic stem cell transplantation (HSCT) with unrelated donors (UDs) showed no association between the HLA-C allele mismatches (CAMMs) and adverse outcomes; antigen mismatches at this a...

journal_title：Blood

authors： Fernandez-Viña MA,Wang T,Lee SJ,Haagenson M,Aljurf M,Askar M,Battiwalla M,Baxter-Lowe LA,Gajewski J,Jakubowski AA,Marino S,Oudshoorn M,Marsh SG,Petersdorf EW,Schultz K,Turner EV,Waller EK,Woolfrey A,Umejiego J,Spell

更新日期：2014-02-20 00:00:00

abstract：:2-Chlorodeoxyadenosine, a new lymphocyte-selective, anti-neoplastic drug was administered to 18 patients with advanced chronic lymphocytic leukemia of B-cell origin. All patients were resistant to conventional treatment. A total of 44 courses of 2-chlorodeoxyadenosine were completed with minimal toxicity. An overall r...

journal_title：Blood

authors： Piro LD,Carrera CJ,Beutler E,Carson DA

更新日期：1988-09-01 00:00:00

abstract：:A study in 121 infants with severe combined immunodeficiency (SCID) was performed to determine the prevalence of an engraftment by transplacentally acquired maternal T cells and to explore clinical and immunological findings related to this abnormality. Each newly diagnosed patient with SCID presenting with circulatin...

journal_title：Blood

authors： Müller SM,Ege M,Pottharst A,Schulz AS,Schwarz K,Friedrich W

更新日期：2001-09-15 00:00:00

abstract：:We have previously demonstrated a significant inverse correlation between circulating thrombopoietin (TPO) levels and peripheral platelet (PLT) counts in patients with thrombocytopenia secondary to megakaryocytic hypoplasia but not in patients with immune thrombocytopenic purpura (ITP; Chang et al, Blood 88:3354, 1996...

journal_title：Blood

authors： Chang M,Qian JX,Lee SM,Joubran J,Fernandez G,Nichols J,Knoppel A,Buzby JS

更新日期：1999-04-15 00:00:00

abstract：:Dendritic cell (DC) homeostasis in peripheral tissues reflect a balance between DC generation, migration, and death. The current model of DC ontogeny indicates that pre-cDCs are committed to become terminal conventional DCs (cDCs). Here, we report the unexpected finding that proliferating immunostimulatory CD11c(+) MH...

journal_title：Blood

authors： Diao J,Mikhailova A,Tang M,Gu H,Zhao J,Cattral MS

更新日期：2012-05-24 00:00:00

abstract：:Commercial porcine factor VIII concentrate (Hyate:C) is effective in treatment of patients with hemophilia A who have circulating antibodies to factor VIII. The molecular forms of factor VIII in the concentrate were identified and evaluated in light of the known properties of porcine and human factor VIII. The factor ...

journal_title：Blood

authors： Lollar P,Parker CG,Tracy RP

更新日期：1988-01-01 00:00:00

abstract：:ADP-induced TXA2 generation requires the costimulation of P2Y1, P2Y12, and the GPIIb/IIIa receptors. Signaling events downstream of the P2Y receptors that contribute to ADP-induced TXA2 generation have not been clearly delineated. In this study, we have investigated the role of G-protein-gated inwardly rectifying pota...

journal_title：Blood

authors： Shankar H,Kahner BN,Prabhakar J,Lakhani P,Kim S,Kunapuli SP

更新日期：2006-11-01 00:00:00

abstract：:X-linked hyper IgM syndrome (XHM) is a combined immune deficiency disorder caused by genetic alterations in CD40 ligand. The purpose of this study was to investigate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the treatment of the disease. Three children were administered rCD40L subcutaneously 3 tim...

journal_title：Blood

authors： Jain A,Kovacs JA,Nelson DL,Migueles SA,Pittaluga S,Fanslow W,Fan X,Wong DW,Massey J,Hornung R,Brown MR,Spinner JJ,Liu S,Davey V,Hill HA,Ochs H,Fleisher TA

更新日期：2011-10-06 00:00:00

abstract：:ADAMTS13 metalloprotease cleaves von Willebrand factor (VWF), thereby inhibiting platelet aggregation and arterial thrombosis. An inability to cleave ultralarge VWF resulting from hereditary or acquired deficiency of plasma ADAMTS13 activity leads to a potentially fatal syndrome, thrombotic thrombocytopenic purpura (T...

journal_title：Blood

authors： Pickens B,Mao Y,Li D,Siegel DL,Poncz M,Cines DB,Zheng XL

更新日期：2015-05-21 00:00:00

abstract：:The 5-lipoxygenase (5-LO) pathway in human CD34(+) hematopoietic progenitor cells, which were induced to differentiate into dendritic cells (DCs) by cytokines in vitro and in DCs of lymphoid tissues in situ, was examined. Extracts prepared from HPCs contained low levels of 5-LO or 5-LO-activating protein. Granulocyte-...

journal_title：Blood

authors： Spanbroek R,Hildner M,Steinhilber D,Fusenig N,Yoneda K,Rådmark O,Samuelsson B,Habenicht AJ

更新日期：2000-12-01 00:00:00

abstract：:PRKAR1A (R1A)-retinoic acid receptor-alpha (R1A-RARalpha) is the sixth RARalpha-containing fusion protein in acute promyelocytic leukemia (APL). Using the murine bone-marrow retroviral transduction/transformation assay, we showed that R1A-RARalpha fusion protein could transform bone-marrow progenitor/stem cells. In ge...

journal_title：Blood

authors： Qiu JJ,Lu X,Zeisig BB,Ma Z,Cai X,Chen S,Gronemeyer H,Tweardy DJ,So CW,Dong S

更新日期：2010-01-21 00:00:00

abstract：:The endosteal niche is critical for the maintenance of hematopoietic stem cells (HSCs). However, it consists of a heterogeneous population in terms of differentiation stage and function. In this study, we characterized endosteal cell populations and examined their ability to maintain HSCs. Bone marrow endosteal cells ...

journal_title：Blood

authors： Nakamura Y,Arai F,Iwasaki H,Hosokawa K,Kobayashi I,Gomei Y,Matsumoto Y,Yoshihara H,Suda T

更新日期：2010-09-02 00:00:00

abstract：:Dickkopf-1 (DKK1), a soluble inhibitor of Wnt signaling secreted by multiple myeloma (MM) cells contributes to osteolytic bone disease by inhibiting the differentiation of osteoblasts. In this study, we tested the effect of anti-DKK1 therapy on bone metabolism and tumor growth in a SCID-rab system. SCID-rab mice were ...

journal_title：Blood

authors： Yaccoby S,Ling W,Zhan F,Walker R,Barlogie B,Shaughnessy JD Jr

更新日期：2007-03-01 00:00:00

abstract：:Activation of the mitogen-activated protein (MAP) kinase pathway has been associated with both cell proliferation and differentiation. Constitutively activated forms of Mek (MAP kinase/Erk kinase) and Erk (MAP kinase) have been previously shown capable of inducing differentiation or proliferation in nonhematopoietic c...

journal_title：Blood

authors： Melemed AS,Ryder JW,Vik TA

更新日期：1997-11-01 00:00:00

abstract：:The treatment of multiple myeloma is considered a continuously evolving paradigm as a result of the growing availability of new and highly effective drugs, including first- and second-generation proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies. Clinical trials advocate long-term rather than sh...

journal_title：Blood

authors： Delforge M,Ludwig H

更新日期：2017-04-27 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) genomic sequences were recently detected by polymerase chain reaction (PCR) and in situ hybridization in bone marrow stromal cells grown from multiple myeloma (MM) patients, but not in cells from control subjects (Rettig et al, Science 276:1851, 1997). We sought to confirm these observation...

journal_title：Blood

authors： Tisdale JF,Stewart AK,Dickstein B,Little RF,Dubé I,Cappe D,Dunbar CE,Brown KE

更新日期：1998-10-15 00:00:00

abstract：:The role of hematopoietic growth factors in lineage commitment and differentiation is unclear. We present evidence that heterologous expression of an erythroid specific receptor allows granulocytic differentiation of a myeloid cell line. We have previously characterized a truncation mutant of the erythropoietin recept...

journal_title：Blood

authors： Harris KW,Hu XJ,Schultz S,Arcasoy MO,Forget BG,Clare N

更新日期：1998-08-15 00:00:00

abstract：:The proteolytic cleavage and subsequent inactivation of recombinant human factor VIII (rhFVIII) and human factor VIIIa (rhFVIIIa) by recombinant human activated protein C (rAPC) was analyzed in the presence and absence of human protein S and human factor V (FV). Membrane-bound rhFVIIIa spontaneously looses most of its...

journal_title：Blood

authors： Lu D,Kalafatis M,Mann KG,Long GL

更新日期：1996-06-01 00:00:00

abstract：:Plasma fibronectin (Fn) induces phagocytosis of C3b-opsonized sheep erythrocytes (EC3b) by human peripheral blood monocytes. However, Fn does not induce erythrophagocytosis of EC3b by human polymorphonuclear leukocytes (PMN), unless the PMN have been exposed to C5a or N-formyl-methionyl-leucyl-phenylalanine. Because o...

journal_title：Blood

authors： Pommier CG,O'Shea J,Chused T,Takahashi T,Ochoa M,Nutman TB,Bianco C,Brown EJ

更新日期：1984-10-01 00:00:00

abstract：:Liver X receptors (LXRs) are transcription factors involved in the regulation of cholesterol homeostasis. LXR ligands have athero-protective properties independent of their effects on cholesterol metabolism. Platelets are involved in the initiation of atherosclerosis and despite being anucleate express nuclear recepto...

journal_title：Blood

authors： Spyridon M,Moraes LA,Jones CI,Sage T,Sasikumar P,Bucci G,Gibbins JM

更新日期：2011-05-26 00:00:00

abstract：:This study reassesses the occurrence of Epstein-Barr virus (EBV) diversity and coinfection versus dominance of a single viral strain within immunocompetent normal carriers. Polymerase chain reaction analysis of several different polymorphic loci of the EBV genome was performed on collections of peripheral blood mononu...

journal_title：Blood

authors： Srivastava G,Wong KY,Chiang AK,Lam KY,Tao Q

更新日期：2000-04-01 00:00:00

abstract：:Platelet-associated C3 (PA-C3) was measured with a quantitative immunofluorescence assay. With this assay, PA-C3 levels were determined for 78 normal volunteers, 30 patients with immune thrombocytopenic purpura (ITP), and 20 patients with nonimmune thrombocytopenias. Platelet-associated IgG (PA-IgG) levels were also m...

journal_title：Blood

authors： Myers TJ,Kim BK,Steiner M,Baldini MG

更新日期：1982-05-01 00:00:00

abstract：:To evaluate the relationship between myeloperoxidase (MPO) gene expression and specific lineages of hematopoietic differentiation, we analyzed expression of the MPO gene in a variety of normal and leukemic human cells. As a first step, we synthesized several oligonucleotide probes and isolated cDNA clones for the MPO ...

journal_title：Blood

authors： Zaki SR,Austin GE,Swan D,Srinivasan A,Ragab AH,Chan WC

更新日期：1989-11-01 00:00:00

abstract：:A patient, CAL, with gamma heavy chain disease is presented who has had a complete remission lasting over 2 yr with combination chemotherapy consisting of pulsatile cyclophosphamide and prednisone. The patient exhibited many features of an atuoimmune process including a vasculitis, low serum complement levels, a posit...

journal_title：Blood

authors： Lyons RM,Chaplin H,Tillack TW,Majerus PW

更新日期：1975-07-01 00:00:00

abstract：:Acquisition of mature T cell function and the T cell antigen receptor repertoire occur in the thymus. In an effort to delineate the cascade of events leading to T cell maturation, we analyzed a series of clonal human precursor T cell neoplasms representing early, middle, and late stages of intrathymic differentiation....

journal_title：Blood

authors： Pittaluga S,Uppenkamp M,Cossman J

更新日期：1987-04-01 00:00:00

abstract：:Granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) control the proliferation of human acute myeloid leukemia (AML) cells in vitro. Previously, we have shown that receptors for GM-CSF and IL-3 are often coexpressed on AML cells. Here we present experiments with purified AML blasts, norma...

journal_title：Blood

authors： Budel LM,Elbaz O,Hoogerbrugge H,Delwel R,Mahmoud LA,Löwenberg B,Touw IP

更新日期：1990-04-01 00:00:00