Platelet size in man.

abstract：:The CD14-dependent and -independent dendritic cell (DC) pathways are instituted simultaneously when CD34(+) progenitor cells are treated with granulocyte-macrophage colony-stimulating factor (GM-CSF)/tumor necrosis factor (TNF) +/- stem cell factor (SCF) (GTS). If TNF activity is neutralized within 48 hours of cytokin...

journal_title：Blood

authors： Santiago-Schwarz F,McCarthy M,Tucci J,Carsons SE

更新日期：1998-08-01 00:00:00

abstract：:Light-mediated release of signaling ligands, such as chemoattractants, growth factors, and cytokines is an attractive strategy for investigation and therapeutic targeting of leukocyte communication and immune responses. We introduce a versatile optogenetic method to control ligand secretion, combining UV-conditioned e...

journal_title：Blood

authors： Sarris M,Olekhnovitch R,Bousso P

更新日期：2016-06-09 00:00:00

abstract：:Age-associated clonal hematopoiesis caused by acquired mutations in myeloid cancer-associated genes is highly prevalent in the normal population. Its etiology, biological impact on hematopoiesis, and oncogenic risk is poorly defined at this time. To gain insight into this phenomenon, we analyzed a cohort of 2530 relat...

journal_title：Blood

authors： Buscarlet M,Provost S,Zada YF,Barhdadi A,Bourgoin V,Lépine G,Mollica L,Szuber N,Dubé MP,Busque L

更新日期：2017-08-10 00:00:00

abstract：:We have used monoclonal antibodies (M Abs) and proteolytic fragmentation to localize structurally the functional sites of human von Willebrand factor (vWF) responsible for interaction with membrane glycoproteins GPIb, GPIIb/IIIa, and with collagen. SpII (215 kd) and SpIII (320 kd), the S aureus V-8 protease homodimeri...

journal_title：Blood

authors： Girma JP,Kalafatis M,Piétu G,Lavergne JM,Chopek MW,Edgington TS,Meyer D

更新日期：1986-05-01 00:00:00

abstract：:The causes of anemia and immunosuppression, major outcomes of malaria, are not well established. This study was undertaken to investigate whether erythropoietin (EP) production is adequate and whether the hemopoietic stem cells (CFU-S) were affected during the course of infection. Groups of female Balb/c mice infected...

journal_title：Blood

authors： Silverman PH,Schooley JC,Mahlmann LJ

更新日期：1987-02-01 00:00:00

abstract：:Heme-oxygenases (HOs) catalyze the conversion of heme into carbon monoxide and biliverdin. HO-1 is induced during hypoxia, ischemia/reperfusion, and inflammation, providing cytoprotection and inhibiting leukocyte migration to inflammatory sites. Although in vitro studies have suggested an additional role for HO-1 in a...

journal_title：Blood

authors： Bussolati B,Ahmed A,Pemberton H,Landis RC,Di Carlo F,Haskard DO,Mason JC

更新日期：2004-02-01 00:00:00

abstract：:Between February 1996 and December 2004, the German Leukemia Study Initiative registered 1766 consecutive patients for the acute myeloid leukemia (AML) 96 study, all of whom were diagnosed by central cytomorphology according to the French-American-British (FAB) and the new World Health Organization (WHO) classificatio...

journal_title：Blood

authors： Wandt H,Schäkel U,Kroschinsky F,Prange-Krex G,Mohr B,Thiede C,Pascheberg U,Soucek S,Schaich M,Ehninger G

更新日期：2008-02-15 00:00:00

abstract：:The effect of both congenital and acquired factor VII deficiency on the cuticle bleeding time (CBT) was evaluated in dogs. The CBT has been previously documented to be a sensitive indicator of factor VIII:C deficiency in hemophilic dogs. Serial CBT determinations were made on normal dogs treated with high-dose warfari...

journal_title：Blood

authors： Giles AR,Tinlin S,Brosseau L,Hoogendoorn H

更新日期：1985-05-01 00:00:00

abstract：:Factor V Leiden (FVL) is associated with venous thrombosis; however, an association between FVL and arterial thrombosis remains controversial. We investigated FVL as a risk factor for myocardial infarction (MI), ischemic stroke (IS), or non-MI ischemic heart disease (non-MI-IHD). The design was 3 case-control studies ...

journal_title：Blood

authors： Juul K,Tybjaerg-Hansen A,Steffensen R,Kofoed S,Jensen G,Nordestgaard BG

更新日期：2002-07-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal recessive disease marked by developmental defects, bone marrow failure, and cancer susceptibility. FA cells are hypersensitive to DNA cross-linking and alkylating agents and accumulate in the G2 phase of the cell cycle in response to these agents. FA cells also display genomic insta...

journal_title：Blood

authors： Kupfer GM,D'Andrea AD

更新日期：1996-08-01 00:00:00

abstract：:Fanconi anemia is a genetic disorder associated with diverse congenital abnormalities, progressive bone marrow failure, and increased risk of leukemia and other cancers. Affected persons often die before 30 years of age. Bone marrow transplantation is an effective treatment, but there are few data regarding factors as...

journal_title：Blood

authors： Gluckman E,Auerbach AD,Horowitz MM,Sobocinski KA,Ash RC,Bortin MM,Butturini A,Camitta BM,Champlin RE,Friedrich W,Good RA,Gordon-Smith EC,Harris RE,Klein JP,Ortega JJ,Pasquini R,Ramsay NK,Speck B,Vowels MR,Zhang MJ,

更新日期：1995-10-01 00:00:00

abstract：:McCullough and colleagues show that problems with cord banking still exist. To improve the results of cord transplantations, more attention should be given to ensuring quality standards rather than just collecting more units. ...

journal_title：Blood

authors： Querol S

更新日期：2009-08-20 00:00:00

abstract：:The engraftment of donor bone marrow (BM) cells in nonablated mice is inefficient. Niche availability has been thought to be the reason, and cytoablation with irradiation or cytotoxic agents is routinely used with the belief that this frees the preoccupied niches in recipients. In this study, donor cell redistribution...

journal_title：Blood

authors： Zhong JF,Zhan Y,Anderson WF,Zhao Y

更新日期：2002-11-15 00:00:00

abstract：:Neuropilin-1 (Npn-1) is a receptor shared by class 3 semaphorins and heparin-binding forms of vascular endothelial growth factor (VEGF), protein families that regulate endothelial and neuronal-cell function. Ligand interaction with Npn-1 dictates the choice of signal transducer; plexins transduce semaphorin signals, a...

journal_title：Blood

authors： Narazaki M,Tosato G

更新日期：2006-05-15 00:00:00

abstract：:Tissue inhibitor of metalloproteinases-1 (TIMP-1), the major physiological matrix metalloproteinase inhibitor and a potent antimetastatic factor, also stimulates the growth of erythroid progenitors (erythroid-potentiating activity). We analyzed the relationship between the growth factor activity and protease inhibitio...

journal_title：Blood

authors： Chesler L,Golde DW,Bersch N,Johnson MD

更新日期：1995-12-15 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) can bind to two distinct transmembrane receptors, the p55 and p75 TNF receptors. We compared the capability of two mutant TNF proteins with exclusive affinity for the p55 or p75 TNF receptor with that of wild type TNF, to activate the hemostatic mechanism in baboons. Both activa...

journal_title：Blood

authors： van der Poll T,Jansen PM,Van Zee KJ,Welborn MB 3rd,de Jong I,Hack CE,Loetscher H,Lesslauer W,Lowry SF,Moldawer LL

更新日期：1996-08-01 00:00:00

abstract：:A recent clinical trial for adrenoleukodystrophy (ALD) showed the efficacy and safety of lentiviral vector (LV) gene transfer in hematopoietic stem progenitor cells. However, several common insertion sites (CIS) were found in patients' cells, suggesting that LV integrations conferred a selective advantage. We performe...

journal_title：Blood

authors： Biffi A,Bartolomae CC,Cesana D,Cartier N,Aubourg P,Ranzani M,Cesani M,Benedicenti F,Plati T,Rubagotti E,Merella S,Capotondo A,Sgualdino J,Zanetti G,von Kalle C,Schmidt M,Naldini L,Montini E

更新日期：2011-05-19 00:00:00

abstract：:Functional studies on native human dendritic cells (DCs) are hampered by technical difficulties in preparing fresh DCs. Recently, with the help of the monoclonal antibody M-DC8, we succeeded in isolating a major subpopulation of human blood DCs by a one-step immunomagnetic separation procedure. These cells strongly ex...

journal_title：Blood

authors： Schmitz M,Zhao S,Schäkel K,Bornhäuser M,Ockert D,Rieber EP

更新日期：2002-08-15 00:00:00

abstract：:Hemopoietic cells in chronic granulocytic leukemia (CGL) frequently contain a chromosome translocation involving chromosome 22 and another autosome, usually number 9. The translocated chromosome 22 is known as the Philadelphia (Ph) chromosome. The appearance of a second Ph chromosome is the most common cytogenetic abn...

journal_title：Blood

authors： Bagby GC Jr,Kaiser-McCaw B,Hecht F,Koler RD,Linman JW

更新日期：1978-06-01 00:00:00

abstract：:We report the outcome of allogeneic bone marrow transplantation (BMT) as treatment for severe combined immunodeficiency disease (SCID) in 31 patients grafted from 1968 until 1992. The patients received a graft from an HLA-identical related (n = 10), an HLA-haplo-identical related (n = 19), or a closely HLA-matched unr...

journal_title：Blood

authors： van Leeuwen JE,van Tol MJ,Joosten AM,Schellekens PT,van den Bergh RL,Waaijer JL,Oudeman-Gruber NJ,van der Weijden-Ragas CP,Roos MT,Gerritsen EJ

更新日期：1994-12-01 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATLL) is an incurable disease where most patients succumb within the first year of diagnosis. Both standard chemotherapy regimens and mAbs directed against ATLL tumor markers do not alter this aggressive clinical course. Therapeutic development would be facilitated by the discovery of g...

journal_title：Blood

authors： Elliott NE,Cleveland SM,Grann V,Janik J,Waldmann TA,Davé UP

更新日期：2011-10-06 00:00:00

abstract：:We previously reported a benefit for all-trans retinoic acid (ATRA) in both induction and maintenance therapy in patients with acute promyelocytic leukemia (APL). To determine the durability of this benefit and identify important prognostic factors, long-term follow-up of the North American Intergroup APL trial is rep...

journal_title：Blood

authors： Tallman MS,Andersen JW,Schiffer CA,Appelbaum FR,Feusner JH,Woods WG,Ogden A,Weinstein H,Shepherd L,Willman C,Bloomfield CD,Rowe JM,Wiernik PH

更新日期：2002-12-15 00:00:00

abstract：:We designed a trial in which postremission therapy of young patients with de novo acute myeloid leukemia (AML) was decided combining cytogenetics/genetics and postconsolidation levels of minimal residual disease (MRD). After induction and consolidation, favorable-risk patients (FR) were to receive autologous stem cell...

journal_title：Blood

authors： Venditti A,Piciocchi A,Candoni A,Melillo L,Calafiore V,Cairoli R,de Fabritiis P,Storti G,Salutari P,Lanza F,Martinelli G,Luppi M,Mazza P,Martelli MP,Cuneo A,Albano F,Fabbiano F,Tafuri A,Chierichini A,Tieghi A,Frac

更新日期：2019-09-19 00:00:00

abstract：:The most frequently recurring translocations in mucosa-associated lymphoid tissue (MALT) B-cell non-Hodgkin lymphoma, t(11;18)(q21;q21) and t(14;18)(q32; q21), lead to formation of an API2-MALT1 fusion or IgH-mediated MALT1 overexpression. Various approaches have implicated these proteins in nuclear factor kappaB (NF-...

journal_title：Blood

authors： Ho L,Davis RE,Conne B,Chappuis R,Berczy M,Mhawech P,Staudt LM,Schwaller J

更新日期：2005-04-01 00:00:00

abstract：:Myelodysplastic syndrome (MDS) is a preneoplastic condition that frequently develops into overt acute myeloid leukemia (AML). The P39 MDS/AML cell line manifested constitutive NF-kappaB activation. In this cell line, NF-kappaB inhibition by small interfering RNAs specific for p65 or chemical inhibitors including borte...

journal_title：Blood

authors： Braun T,Carvalho G,Coquelle A,Vozenin MC,Lepelley P,Hirsch F,Kiladjian JJ,Ribrag V,Fenaux P,Kroemer G

更新日期：2006-02-01 00:00:00

abstract：:Severe elevation of red blood cell number is often associated with hypertension and thromboembolism resulting in severe cardiovascular complications. However, some individuals such as high altitude dwellers cope well with an increased hematocrit level. We analyzed adaptive mechanisms to excessive erythrocytosis in our...

journal_title：Blood

authors： Vogel J,Kiessling I,Heinicke K,Stallmach T,Ossent P,Vogel O,Aulmann M,Frietsch T,Schmid-Schönbein H,Kuschinsky W,Gassmann M

更新日期：2003-09-15 00:00:00

abstract：:Recently, we reported a novel system whereby human pericytes are recruited to endothelial cell (EC)-lined tubes in 3-dimensional (3D) extracellular matrices to stimulate vascular maturation including basement membrane matrix assembly. Through the use of this serum-free, defined system, we demonstrate that pericyte mot...

journal_title：Blood

authors： Stratman AN,Schwindt AE,Malotte KM,Davis GE

更新日期：2010-11-25 00:00:00

abstract：:Activated neutrophils have the ability to upregulate the expression of many genes, in particular those encoding cytokines and chemokines, and to subsequently release the corresponding proteins. Although little is known to date concerning the regulation of gene transcription in neutrophils, it is noteworthy that many o...

journal_title：Blood

authors： McDonald PP,Bald A,Cassatella MA

更新日期：1997-05-01 00:00:00

abstract：:Recent studies in humans have highlighted the importance of a distinct cellular entity, the plasmacytoid dendritic cell (PDC). To identify genes for which expression is restricted to human PDCs, a cDNA subtraction technique was applied using cDNA from activated monocyte-derived DCs (MDDCs) as competitor. In the 650 se...

journal_title：Blood

authors： Rissoan MC,Duhen T,Bridon JM,Bendriss-Vermare N,Péronne C,de Saint Vis B,Brière F,Bates EE

更新日期：2002-11-01 00:00:00

abstract：:The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated immunoglobulin receptor. By means of phenotypic analysis, complementarity-determining region 3 (CDR3) spectratyping during a T-in...

journal_title：Blood

authors： Weller S,Braun MC,Tan BK,Rosenwald A,Cordier C,Conley ME,Plebani A,Kumararatne DS,Bonnet D,Tournilhac O,Tchernia G,Steiniger B,Staudt LM,Casanova JL,Reynaud CA,Weill JC

更新日期：2004-12-01 00:00:00