Abstract:
:The prognostic implications of t(9;22)(q34;q11) were assessed at a median follow-up of 3.5 years in 434 children receiving intensive treatment for acute lymphoblastic leukemia (ALL). Four-year event-free and overall survivals were 81% and 88%, respectively, in 419 children lacking t(9;22), but were 0% and 20%, respectively, in 15 children with t(9;22) (P less than .001). Poor outcome for children with t(9;22)-positive ALL was particularly notable because we have reported improved survival in other historically poor prognosis ALL cytogenetic categories when treated with similarly intensive therapy. We recommend that very intensive treatment approaches, including bone marrow transplantation in first remission, be considered for all children with t(9;22)-positive ALL.
journal_name
Bloodjournal_title
Bloodauthors
Fletcher JA,Lynch EA,Kimball VM,Donnelly M,Tantravahi R,Sallan SEsubject
Has Abstractpub_date
1991-02-01 00:00:00pages
435-9issue
3eissn
0006-4971issn
1528-0020journal_volume
77pub_type
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