Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells.

abstract：:Rabbit kidney tissue either from normal rabbits or from rabbits "programmed" by phlebotomy or varying periods of hypoxia was cultured and shown to release into the culture medium an erythropoietically active substance. The cultures established from rabbits programmed by 6-12 hr of hypoxia yielded the highest levels of...

journal_title：Blood

authors： Ogle JW,Lange RD,Dunn CD

更新日期：1978-07-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and children, yet significant numbers of patients relapse and die of disease. In this study, we identify the dependence of AML blasts on arginine for proliferation. We show that AML blasts constitutively express the arginine transporters ...

journal_title：Blood

authors： Mussai F,Egan S,Higginbotham-Jones J,Perry T,Beggs A,Odintsova E,Loke J,Pratt G,U KP,Lo A,Ng M,Kearns P,Cheng P,De Santo C

更新日期：2015-04-09 00:00:00

abstract：:Plasmodium falciparum-infected erythrocytes (IRBC) roll on the adhesion molecule P-selectin in vitro under flow conditions that approximate the shear stress in capillary and postcapillary venules in which cytoadherence occurs in vivo. The pathological significance of this adhesive interaction is currently unknown. In ...

journal_title：Blood

authors： Ho M,Schollaardt T,Niu X,Looareesuwan S,Patel KD,Kubes P

更新日期：1998-06-15 00:00:00

abstract：:The effects of immunoglobulin G (IgG) from patients with the antiphospholipid syndrome (APS) upon monocyte activation have not been fully characterized. We carried out a comprehensive proteomic analysis of human monocytes treated with IgG from patients with different manifestations of the APS. Using 2-dimensional diff...

journal_title：Blood

authors： Ripoll VM,Lambrianides A,Pierangeli SS,Poulton K,Ioannou Y,Heywood WE,Mills K,Latchman DS,Isenberg DA,Rahman A,Giles IP

更新日期：2014-12-11 00:00:00

abstract：:Regulatory CD25(+)CD4+ T cells (Treg cells) are a central element of peripheral tolerance. Little is known, however, about phenotypic and functional characteristics of these cells with regard to memory. In this study we show that the chemokine receptor CCR6 is expressed on a distinct subset of mouse Treg cells. Simila...

journal_title：Blood

authors： Kleinewietfeld M,Puentes F,Borsellino G,Battistini L,Rötzschke O,Falk K

更新日期：2005-04-01 00:00:00

abstract：:In individuals with sickle cell disease, a variable number of irreversibly sickled cells (ISC) is present that may contribute to the pathophysiology of sickle cell anemia. The present study was undertaken to determine the possible role of membrane lipid peroxidation in the genesis of ISC. After 24 hr of simple aerobic...

journal_title：Blood

authors： Jain SK,Shohet SB

更新日期：1984-02-01 00:00:00

abstract：:Natural suppressor (NS) activity, the capacity of unprimed cells to suppress immunologic responses, is present in mouse, rabbit, and human bone marrow (BM). In this study we characterize NS activity in bone marrow cells of the rhesus monkey. Greatest NS activity was found in low-density cells (1.0600 to 1.0655 g/mL) o...

journal_title：Blood

authors： Sugiura K,Ikehara S,Gengozian N,Inaba M,Sardiña EE,Ogata H,Seong SM,Good RA

更新日期：1990-03-01 00:00:00

abstract：:Erythropoietin (Epo) binding to the Epo receptor (EpoR) elicits downstream signaling that is essential for red blood cell production. One important negative regulatory mechanism to terminate Epo signaling is Epo-induced EpoR endocytosis and degradation. Defects in this mechanism play a key role in the overproduction o...

journal_title：Blood

authors： Bulut GB,Sulahian R,Yao H,Huang LJ

更新日期：2013-12-05 00:00:00

abstract：:Rabbit platelets were aggregated by adenosine diphosphate (ADP), allowed to deaggregate and then separated into density subpopulations by centrifugation through discontinuous Stractan density gradients. Although ADP causes little or no release of the contents of the amine storage granules of rabbit platelets, ADP caus...

journal_title：Blood

authors： Packham MA,Perry DW,Kinlough-Rathbone RL,Rand ML,Guccione MA,Evans RM,Mustard JF

更新日期：1985-03-01 00:00:00

abstract：:In diffuse large B-cell lymphoma (DLBCL), previous studies have suggested that, while concordant bone marrow (BM) involvement confers a poor prognosis, discordant BM involvement does not. Whether this correlation is independent of the non-Hodgkin lymphoma International Prognostic Index (IPI) was previously unknown. We...

journal_title：Blood

authors： Chung R,Lai R,Wei P,Lee J,Hanson J,Belch AR,Turner AR,Reiman T

更新日期：2007-08-15 00:00:00

abstract：:In this issue of Blood, Neufeld and colleagues present promising results on the safety and efficacy of a novel iron chelator for the treatment of transfusional iron overload. ...

journal_title：Blood

authors： Taher AT,Musallam KM

更新日期：2012-04-05 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematologic disorder with multiple and varied clinical manifestations. The biochemical defect in PNH resides in the incomplete enzymatic assembly of glycosylphosphatidylinositol (GPI) anchors used for surface protein attachment. In all patients tested thu...

journal_title：Blood

authors： Ware RE,Rosse WF,Howard TA

更新日期：1994-05-01 00:00:00

abstract：:In this study, we show that microRNA-150 (miR-150) is significantly downregulated in advanced cutaneous T-cell lymphoma (CTCL), and that this downregulation is strongly associated with tumor invasion/metastasis. Inoculation of CTCL cell lines into nonobese diabetic/Shi-scid interleukin 2γ (IL-2γ) null mice led to CTCL...

journal_title：Blood

authors： Ito M,Teshima K,Ikeda S,Kitadate A,Watanabe A,Nara M,Yamashita J,Ohshima K,Sawada K,Tagawa H

更新日期：2014-03-06 00:00:00

abstract：:The erythroblastic island (EI), formed by a central macrophage and developing erythroblasts (EBs), was first described decades ago and was recently shown to play an in vivo role in homeostatic and pathological erythropoiesis. The exact molecular mechanisms, however, mediating the interactions between macrophages and E...

journal_title：Blood

authors： Wei Q,Boulais PE,Zhang D,Pinho S,Tanaka M,Frenette PS

更新日期：2019-03-14 00:00:00

abstract：:Unbalanced translocations as well as interstitial deletions of the short arm of chromosome 12 [del(12p)] are found as recurring chromosomal changes in a broad spectrum of hematopoietic malignancies. These changes result in the hemizygous deletion of genetic material from 12p. We mapped a yeast artificial chromosome co...

journal_title：Blood

authors： Sato Y,Suto Y,Pietenpol J,Golub TR,Gilliland DG,Davis EM,Le Beau MM,Roberts JM,Vogelstein B,Rowley JD

更新日期：1995-08-15 00:00:00

abstract：:In an experimental model we demonstrated that endothelial cells of all organs are targets of the alloimmune reaction. Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial ...

journal_title：Blood

authors： Ertault-Daneshpouy M,Leboeuf C,Lemann M,Bouhidel F,Ades L,Gluckman E,Socié G,Janin A

更新日期：2004-06-15 00:00:00

abstract：:The CD11a/CD18 (leukocyte function-associated antigen 1 [LFA-1]) integrin mediates critical leukocyte adhesive interactions during immune and inflammatory responses. The CD11a promoter directs CD11a/CD18 integrin expression, and its activity in lymphoid cells depends on a functional RUNX1/AML-1-binding site (AML-110) ...

journal_title：Blood

authors： Puig-Kröger A,Sanchez-Elsner T,Ruiz N,Andreu EJ,Prosper F,Jensen UB,Gil J,Erickson P,Drabkin H,Groner Y,Corbi AL

更新日期：2003-11-01 00:00:00

abstract：:In this issue of Blood, Allinne et al propose the nucleolin-dependent activation of the translocated CCND1 allele in mantle cell lymphoma (MCL) because of its relocalization to a transcriptionally favorable area in the perinucleolar region. ...

journal_title：Blood

authors： Beà S

更新日期：2014-03-27 00:00:00

abstract：:The t(8;21) and inv(16)/t(16;16) rearrangements affecting the core-binding factors RUNX1 and CBFB, respectively, are found in 15% to 20% of adult de novo acute myeloid leukemia (AML) cases and are associated with a favorable prognosis. Since the expression of the fusion genes CBFB/MYH11 or RUNX1/RUNX1T1 alone is not s...

journal_title：Blood

authors： Opatz S,Polzer H,Herold T,Konstandin NP,Ksienzyk B,Zellmeier E,Vosberg S,Graf A,Krebs S,Blum H,Hopfner KP,Kakadia PM,Schneider S,Dufour A,Braess J,Sauerland MC,Berdel WE,Büchner T,Woermann BJ,Hiddemann W,Spiekerma

更新日期：2013-09-05 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a typically aggressive myeloid neoplasm of childhood that is clinically characterized by overproduction of monocytic cells that can infiltrate organs, including the spleen, liver, gastrointestinal tract, and lung. JMML is categorized as an overlap myelodysplastic syndrome/mye...

journal_title：Blood

authors： Chang TY,Dvorak CC,Loh ML

更新日期：2014-10-16 00:00:00

abstract：:We have previously reported on a unique patient in whom homozygosity for a mutation at IRF8 (IRF8(K108E)) causes a severe immunodeficiency. Laboratory evaluation revealed a highly unusual myeloid compartment, remarkable for the complete absence of CD141 and CD161 monocytes, absence of CD11c1 conventional dendritic cel...

journal_title：Blood

authors： Salem S,Langlais D,Lefebvre F,Bourque G,Bigley V,Haniffa M,Casanova JL,Burk D,Berghuis A,Butler KM,Leahy TR,Hambleton S,Gros P

更新日期：2014-09-18 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease arising from a hematopoietic stem cell expressing the BCR/ABL fusion protein. Leukemic and dendritic cells (DCs) develop from the same transformed hematopoietic progenitors. How BCR/ABL interferes with the immunoregulatory function of DCs in ...

journal_title：Blood

authors： Mumprecht S,Claus C,Schürch C,Pavelic V,Matter MS,Ochsenbein AF

更新日期：2009-05-07 00:00:00

abstract：:Outgrowth, long-term self-renewal, and terminal maturation of human erythroid progenitors derived from umbilical cord blood in serum-free medium can be modulated by steroid hormones. Homogeneous erythroid cultures, as characterized by flow cytometry and dependence on a specific mixture of physiologic proliferation fac...

journal_title：Blood

authors： Leberbauer C,Boulmé F,Unfried G,Huber J,Beug H,Müllner EW

更新日期：2005-01-01 00:00:00

abstract：:Fluid shear stress generated by steady laminar blood flow protects vessels from atherosclerosis. Krüppel-like factor 2 (KLF2) and endothelial nitric oxide synthase (eNOS) are fluid shear stress-responsive genes and key mediators in flow anti-inflammatory and antiatherosclerotic actions. However, the molecular mechanis...

journal_title：Blood

authors： Wang W,Ha CH,Jhun BS,Wong C,Jain MK,Jin ZG

更新日期：2010-04-08 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is a severe renal disease that is associated with defective complement regulation caused by multiple factors. We previously described the deficiency of factor H-related proteins CFHR1 and CFHR3 as predisposing factor for aHUS. Here we identify in an extended cohort of 147 aHUS...

journal_title：Blood

authors： Józsi M,Licht C,Strobel S,Zipfel SL,Richter H,Heinen S,Zipfel PF,Skerka C

更新日期：2008-02-01 00:00:00

abstract：:The underlying pathways that lead to relapse in childhood acute lymphoblastic leukemia (ALL) are unknown. To comprehensively characterize the molecular evolution of relapsed childhood B-precursor ALL, we used human 500K single-nucleotide polymorphism arrays to identify somatic copy number alterations (CNAs) in 20 diag...

journal_title：Blood

authors： Yang JJ,Bhojwani D,Yang W,Cai X,Stocco G,Crews K,Wang J,Morrison D,Devidas M,Hunger SP,Willman CL,Raetz EA,Pui CH,Evans WE,Relling MV,Carroll WL

更新日期：2008-11-15 00:00:00

abstract：:The Epstein-Barr virus (EBV) is associated with distinct forms of human lymphoid malignancies, including the endemic (eBL) and sporadic forms of Burkitt's lymphoma (sBL) and acquired immunodeficiency syndrome-associated non-Hodgkin lymphoma (AIDS-NHL). However, whether EBV has a pathogenetic role in these tumors or is...

journal_title：Blood

authors： Neri A,Barriga F,Inghirami G,Knowles DM,Neequaye J,Magrath IT,Dalla-Favera R

更新日期：1991-03-01 00:00:00

abstract：:Myeloma immunosurveillance remains incompletely understood. We have demonstrated proteolytic processing of the matrix proteoglycan, versican (VCAN), in myeloma tumors. Whereas intact VCAN exerts tolerogenic activities through Toll-like receptor 2 (TLR2) binding, the immunoregulatory consequences of VCAN proteolysis re...

journal_title：Blood

authors： Hope C,Foulcer S,Jagodinsky J,Chen SX,Jensen JL,Patel S,Leith C,Maroulakou I,Callander N,Miyamoto S,Hematti P,Apte SS,Asimakopoulos F

更新日期：2016-08-04 00:00:00

abstract：:Impaired fibrinolysis, resulting from increased plasminogen activator inhibitor-1 (PAI-1) or reduced tissue-type plasminogen activator (t-PA) plasma levels, may predispose the individual to subacute thrombosis in sepsis and inflammation. The objective of these studies was to show that adenovirus-mediated gene transfer...

journal_title：Blood

authors： Carmeliet P,Stassen JM,Van Vlaenderen I,Meidell RS,Collen D,Gerard RD

更新日期：1997-08-15 00:00:00

abstract：:Besides regulating leukocyte trafficking in normal and injured tissues, several chemokines may positively or negatively regulate angiogenesis. Here we report that CCL16 activates an angiogenic program in vascular endothelial cells by activating CCR1. CCL16 induces dose-dependent random and directional migration of end...

journal_title：Blood

authors： Strasly M,Doronzo G,Cappello P,Valdembri D,Arese M,Mitola S,Moore P,Alessandri G,Giovarelli M,Bussolino F

更新日期：2004-01-01 00:00:00