Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma.

abstract：:The membrane-anchored CX3C chemokine fractalkine (FKN) is expressed on activated endothelium and is associated with the development of atherosclerosis. The potential of FKN in mediating platelet adhesion beyond platelet activation remains unexplored to date. A flow-based adhesion assay was used to study the adhesion o...

journal_title：Blood

authors： Meyer dos Santos S,Klinkhardt U,Scholich K,Nelson K,Monsefi N,Deckmyn H,Kuczka K,Zorn A,Harder S

更新日期：2011-05-05 00:00:00

abstract：:As mouse models have become commonplace for studying hemostasis and thrombosis, we considered whether the mouse system had utility for assessing genetic alterations in platelet receptors. Platelets from 5 mouse strains (C57BL/6 [C57], FVB/N [FVB], BALB/c, C3H/He, and 129Sv) showed only minor differences in the express...

journal_title：Blood

authors： Li TT,Larrucea S,Souza S,Leal SM,López JA,Rubin EM,Nieswandt B,Bray PF

更新日期：2004-05-01 00:00:00

abstract：:Secondary chromosomal aberrations were surveyed in non-Hodgkin's lymphomas (NHL) reported in the literature with one of the following, presently recognized, primary abnormalities: t(2;5), +3, t(3;14), del(6q), +X, and -Y. Of 2,175 NHLs with clonal karyotypic changes, 908 (42%) had one of the 13 selected primary chromo...

journal_title：Blood

authors： Johansson B,Mertens F,Mitelman F

更新日期：1995-11-15 00:00:00

abstract：:CD27, a transmembrane disulfide-linked 55-kD homodimer, belongs to the nerve growth factor-receptor family, a group of homologous molecules involved in lymphocyte differentiation and selection. It is expressed on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells. We investigated the expressio...

journal_title：Blood

authors： van Oers MH,Pals ST,Evers LM,van der Schoot CE,Koopman G,Bonfrer JM,Hintzen RQ,von dem Borne AE,van Lier RA

更新日期：1993-12-01 00:00:00

abstract：:CD22 is an important immunotherapeutic target on B-cell malignancies, particularly hairy cell leukemia (HCL), but its soluble extracellular domain, sCD22, has not yet been reported in the blood. By immunoaffinity and enzyme-linked immunosorbent assay techniques using anti-CD22 monoclonal antibodies, we identified the ...

journal_title：Blood

authors： Matsushita K,Margulies I,Onda M,Nagata S,Stetler-Stevenson M,Kreitman RJ

更新日期：2008-09-15 00:00:00

abstract：:We aimed to determine the prognostic impact of monosomal karyotype (MK) in acute myeloid leukemia (AML) in the context of the current World Health Organization (WHO) classification and to evaluate the outcome of MK(+) patients after allogeneic HSCT. Of 1058 patients with abnormal cytogenetics, 319 (30%) were MK MK(+)....

journal_title：Blood

authors： Kayser S,Zucknick M,Döhner K,Krauter J,Köhne CH,Horst HA,Held G,von Lilienfeld-Toal M,Wilhelm S,Rummel M,Germing U,Götze K,Nachbaur D,Schlegelberger B,Göhring G,Späth D,Morlok C,Teleanu V,Ganser A,Döhner H,Schlenk

更新日期：2012-01-12 00:00:00

abstract：:Macrophage colony-stimulating factor (M-CSF or CSF-1) and granulocyte-macrophage CSF (GM-CSF) have been shown to increase human monocyte urokinase-type plasminogen-activator (u-PA) activity with possible consequences for cell migration and tissue remodeling; because monocyte u-PA activity is likely to be controlled in...

journal_title：Blood

authors： Hamilton JA,Whitty GA,Stanton H,Wojta J,Gallichio M,McGrath K,Ianches G

更新日期：1993-12-15 00:00:00

abstract：:Myeloablative conditioning results in thymic epithelial cell (TEC) injury, slow T-cell reconstitution, and a high risk of opportunistic infections. Keratinocyte growth factor (KGF) stimulates TEC proliferation and, when given preconditioning, reduces TEC injury. Thymocytes and TECs express androgen receptors, and expo...

journal_title：Blood

authors： Kelly RM,Highfill SL,Panoskaltsis-Mortari A,Taylor PA,Boyd RL,Holländer GA,Blazar BR

更新日期：2008-06-15 00:00:00

abstract：:The transcription of insulin-like growth factor 2 (IGF-2) is affected by genomic imprinting, a multistep process through which the parental origin of a gene influences its transcription. The maternal copy of IGF-2 is silenced in most human tissues, but in the choroid plexus and the adult liver both alleles of IGF-2 ar...

journal_title：Blood

authors： Morison IM,Eccles MR,Reeve AE

更新日期：2000-11-01 00:00:00

abstract：:An in vitro system has been developed that mimics the passage of erythrocytes from the bone marrow to the circulation. Bone marrow egress and its proper regulation are vital physiologic processes. However, because of the inaccessibility of the marrow, it is difficult to evaluate the various factors important in contro...

journal_title：Blood

authors： Waugh RE,Sassi M

更新日期：1986-07-01 00:00:00

abstract：:Although an increase in protein phosphorylation on tyrosine was first noted as a result of cell transformation or the application of growth factors to cells, recent reports have shown high levels of tyrosine kinases in nondividing tissues. For that reason, we have investigated whether normal human polymorphonuclear le...

journal_title：Blood

authors： Kraft AS,Berkow RL

更新日期：1987-08-01 00:00:00

abstract：:From 1990 to 1996, a total of 386 adult patients with early/intermediate Hodgkin disease (HD) were randomly assigned to receive 3 cycles of adriamycin, bleomycin, vinblastine, dacarbazine (an alkylating agent), and methylprednisolone (ABVDm, arm A) or epirubicin, bleomycin, vinblastine, methotrexate, and methylprednis...

journal_title：Blood

authors： le Maignan C,Desablens B,Delwail V,Dib M,Berthou C,Vigier M,Ghandour C,Atmani S,Casassus P,Maisonneuve H,Le Mevel A,Traulle C,Bernard M,Briere J,Colonna P,Andrieu JM

更新日期：2004-01-01 00:00:00

abstract：:The von Willebrand factor propeptide, vW AgII, has been shown to be required for the formation of vWF multimers and sorting of vWF to storage granules; whether these 2 processes are independent events has been unclear. Chimeric constructs of human and canine vWF were developed to further define these processes and to ...

journal_title：Blood

authors： Haberichter SL,Fahs SA,Montgomery RR

更新日期：2000-09-01 00:00:00

abstract：:Despite increasing knowledge on the mechanisms of invariant natural killer T (iNKT)-cell development in the thymus, the function of recent thymic emigrant (RTE) iNKT cells remains largely unexplored, principally because of a lack of bona fide markers to distinguish RTE from long-lived iNKT cells. Whether the recently ...

journal_title：Blood

authors： Milpied P,Massot B,Renand A,Diem S,Herbelin A,Leite-de-Moraes M,Rubio MT,Hermine O

更新日期：2011-09-15 00:00:00

abstract：:It is currently debated whether the mechanism of action of therapeutic doses of recombinant factor VIIa (rFVIIa, Novo-Seven) relies on the tissue factor (TF)-independent activity of the enzyme. The present study was conducted to investigate the in vivo hemostatic effects of rFVIIa and 3 analogs thereof with superior i...

journal_title：Blood

authors： Tranholm M,Kristensen K,Kristensen AT,Pyke C,Røjkjaer R,Persson E

更新日期：2003-11-15 00:00:00

abstract：:In diffuse large B-cell lymphoma (DLBCL), the number of circulating monocytes and neutrophils represents an independent prognostic factor. These cell subsets include monocytic and granulocytic myeloid-derived suppressor cells (M- and G-MDSCs) defined by their ability to suppress T-cell responses. MDSCs are a heterogen...

journal_title：Blood

authors： Azzaoui I,Uhel F,Rossille D,Pangault C,Dulong J,Le Priol J,Lamy T,Houot R,Le Gouill S,Cartron G,Godmer P,Bouabdallah K,Milpied N,Damaj G,Tarte K,Fest T,Roussel M

更新日期：2016-08-25 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) is a disease in which autoantibodies against red blood cells (RBCs) lead to their premature destruction. Most clinically significant autoantibodies are of the immunoglobulin G (IgG) type, which leads primarily to the uptake and destruction of RBCs by splenic and hepatic macrophages. ...

journal_title：Blood

authors： Jordan MB,van Rooijen N,Izui S,Kappler J,Marrack P

更新日期：2003-01-15 00:00:00

abstract：:Oncogenic forms of NRAS are frequently associated with hematologic malignancies and other cancers, making them important therapeutic targets. Inhibition of individual downstream effector molecules (eg, RAF kinase) have been complicated by the rapid development of resistance or activation of bypass pathways. For the pu...

journal_title：Blood

authors： Nonami A,Sattler M,Weisberg E,Liu Q,Zhang J,Patricelli MP,Christie AL,Saur AM,Kohl NE,Kung AL,Yoon H,Sim T,Gray NS,Griffin JD

更新日期：2015-05-14 00:00:00

abstract：:Laminin is a heterotrimeric glycoprotein that plays a central role in promoting neutrophil chemotaxis, motility, and attachment to basement membrane. Rabbit peritoneal exudate neutrophils stain positively for laminin, which is presumed to be of exogenous origin and bound to laminin receptors on the cell surface. We ex...

journal_title：Blood

authors： Tweardy DJ,Sasaki M,Cardamone JJ Jr,McCoy JP Jr,Bonidie MJ,Signorella AP

更新日期：1990-10-01 00:00:00

abstract：:Neonatal alloimmune thrombocytopenia (NAIT) can cause severe bleeding in the central nervous system (CNS) and death or severe neurologic sequelae. The expression of the PLA1 antigen is detectable as early as 19 weeks of gestation. Alloimmunization can therefore lead to fetal thrombocytopenia very early in pregnancy. U...

journal_title：Blood

authors： Kaplan C,Daffos F,Forestier F,Cox WL,Lyon-Caen D,Dupuy-Montbrun MC,Salmon C

更新日期：1988-07-01 00:00:00

abstract：:We have isolated and characterized the human cardiac mast cell (CMC) and compared this novel mast cell (MC type with MC obtained from uterus, skin, and lung. Heart tissue was obtained from 14 patients with cardiomyopathy (CMP, heart transplantation). CMC were isolated by enzymatic digestion using collagenase, pronase-...

journal_title：Blood

authors： Sperr WR,Bankl HC,Mundigler G,Klappacher G,Grossschmidt K,Agis H,Simon P,Laufer P,Imhof M,Radaszkiewicz T,Glogar D,Lechner K,Valent P

更新日期：1994-12-01 00:00:00

abstract：:The presence of circulating tumor idiotype interferes with the in vivo effectiveness of anti-idiotype antibodies. We developed two assays that permit identification of patients with high levels of serum idiotype without the need for first producing an anti-idiotype antibody. A cell suspension made from the tumor was c...

journal_title：Blood

authors： Miller RA,Lowder JN,Gralow J,Meeker T,Levy R

更新日期：1987-04-01 00:00:00

abstract：:We administered gemtuzumab ozogamycin ("mylotarg"; 9 mg/m(2) day 1 or 5) and all-trans retinoic acid (ATRA) to 19 patients with untreated acute promyelocytic leukemia (APL). There were 3 patients who also received idarubicin because of a white blood cell (WBC) count of more than 30 000/microL. In complete remission (C...

journal_title：Blood

authors： Estey EH,Giles FJ,Beran M,O'Brien S,Pierce SA,Faderl SH,Cortes JE,Kantarjian HM

更新日期：2002-06-01 00:00:00

abstract：:Studying human antigen-specific memory B cells has been challenging because of low frequencies in peripheral blood, slow proliferation, and lack of antibody secretion. Therefore, most studies have relied on conversion of memory B cells into antibody-secreting cells by in vitro culture. To facilitate direct ex vivo iso...

journal_title：Blood

authors： Franz B,May KF Jr,Dranoff G,Wucherpfennig K

更新日期：2011-07-14 00:00:00

abstract：:A decrease in inhibitor titer has been reported in some patients with acquired factor VIII inhibitors treated with intravenous gammaglobulin (IGIV). We have conducted a prospective, multicenter study of high-dose IGIV in treatment of this disorder to determine efficacy. Nineteen patients received induction therapy wit...

journal_title：Blood

authors： Schwartz RS,Gabriel DA,Aledort LM,Green D,Kessler CM

更新日期：1995-07-15 00:00:00

abstract：:The effects of human recombinant erythropoietin (rEpo) in the presence of other stimulators on the growth of clonogenic leukemic blast cells from ten Japanese patients with acute myeloblastic leukemia were studied with an in vitro leukemic blast colony assay in methylcellulose culture. With the addition of rEpo alone,...

journal_title：Blood

authors： Asano Y,Okamura S,Shibuya T,Harada M,Niho Y

更新日期：1988-11-01 00:00:00

abstract：:Childhood acute myeloid leukemia (AML) has a poor prognosis with standard chemotherapy. Allogeneic bone marrow transplantation (BMT) in remission improves the outlook only for the one third of patients with sibling donors. Autologous BMT with a lower morbidity and mortality is available to all. In this study, maximum ...

journal_title：Blood

authors： Tiedemann K,Waters KD,Tauro GP,Tucker D,Ekert H

更新日期：1993-12-15 00:00:00

abstract：:In this issue of Blood, Palomo et al provide new insight into the mechanism of action of defibrotide as an endothelial protective agent, while Richardson et al present the encouraging final results of the phase 3 clinical study of defibrotide for the treatment of severe hepatic veno-occlusive disease (VOD), showing a ...

journal_title：Blood

authors： Arai S

更新日期：2016-03-31 00:00:00

abstract：:Human plasma fibrinogen is produced by liver parenchymal cells. Such molecules contain two classes of gamma-chains (gamma A, gamma'), which differ with respect to their COOH-terminal sequences. When fibrin is crosslinked in the presence of factor XIIIa and Ca2+, three types of gamma-dimer are formed (gamma A-gamma A; ...

journal_title：Blood

authors： Mosesson MW,Homandberg GA,Amrani DL

更新日期：1984-05-01 00:00:00

abstract：:T cells are known to interact cooperatively with monocytes to produce Colony-Stimulating Factors (CSF), although T cell-mediated signals leading to CSF secretion by monocytes are not completely understood. We have made use of Northern blot hybridization and specific bioassays to study the effects of the T cell product...

journal_title：Blood

authors： Wieser M,Bonifer R,Oster W,Lindemann A,Mertelsmann R,Herrmann F

更新日期：1989-04-01 00:00:00