The Hermansky-Pudlak syndrome 1 (HPS1) and HPS2 genes independently contribute to the production and function of platelet dense granules, melanosomes, and lysosomes.

abstract：:A decrease in inhibitor titer has been reported in some patients with acquired factor VIII inhibitors treated with intravenous gammaglobulin (IGIV). We have conducted a prospective, multicenter study of high-dose IGIV in treatment of this disorder to determine efficacy. Nineteen patients received induction therapy wit...

journal_title：Blood

authors： Schwartz RS,Gabriel DA,Aledort LM,Green D,Kessler CM

更新日期：1995-07-15 00:00:00

abstract：:In this issue of Blood, Palomo et al provide new insight into the mechanism of action of defibrotide as an endothelial protective agent, while Richardson et al present the encouraging final results of the phase 3 clinical study of defibrotide for the treatment of severe hepatic veno-occlusive disease (VOD), showing a ...

journal_title：Blood

authors： Arai S

更新日期：2016-03-31 00:00:00

abstract：:The t(15;17) translocation is specifically observed in patients with promyelocytic leukemia (AML3). The chromosomal rearrangement juxtaposes the retinoic acid receptor alpha (RAR alpha) and PML genes, resulting in PML/RAR alpha fusion transcripts. Our previous studies have shown that a polymerase chain reaction (PCR) ...

journal_title：Blood

authors： Castaigne S,Balitrand N,de Thé H,Dejean A,Degos L,Chomienne C

更新日期：1992-06-15 00:00:00

abstract：:We have studied the antileukemic effects of cyclosporin-A (CyA) on the cells of a number of human hematopoietic biopsies and established cell lines in vitro. Cya killed the tumor cells but not the nonmalignant control cells from three of four patients with T-lymphocytic leukemia/lymphoma at concentrations comparable t...

journal_title：Blood

authors： Tötterman TH,Danersund A,Nilsson K,Killander A

更新日期：1982-05-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) is a potentially immunosuppressive agent that has been suggested to act as a cofactor in the progression of HIV disease. Exposure of human macrophages to HHV-6A or HHV-6B profoundly impaired their ability to produce interleukin 12 (IL-12) upon stimulation with interferon-gamma (IFN-gamma) a...

journal_title：Blood

authors： Smith A,Santoro F,Di Lullo G,Dagna L,Verani A,Lusso P

更新日期：2003-10-15 00:00:00

abstract：:The human burst-forming unit-megakaryocyte (BFU-MK) is a primitive megakaryocytic progenitor cell. A marrow cell population enriched for BFU-MK (CD34+ DR-) was obtained by monoclonal antibody labeling and fluorescence-activated cell sorting. CD34+DR- cells were assayed in a serum-depleted, fibrin clot culture system. ...

journal_title：Blood

authors： Briddell RA,Hoffman R

更新日期：1990-08-01 00:00:00

abstract：:Human subjects maintain long-term immunologic memory against infective organisms but the mechanism is unclear. CD4+ T-helper memory (Thmem) cells are pivotal in controlling humoral and cellular responses, therefore their longevity and response to vaccination are critical for maintenance of protective immunity. To prob...

journal_title：Blood

authors： Di Genova G,Roddick J,McNicholl F,Stevenson FK

更新日期：2006-04-01 00:00:00

abstract：:To clarify the nature of null cell acute lymphoblastic leukemia (ALL) we tested null lymphoblasts and other leukemic cells for human T and B lymphocyte antigens detected by reciprocally absorbed rabbit antisera prepared against autologous T and B lymphoblast cell lines HSB-2 and SB. Blasts from 4 of 4 patients with T ...

journal_title：Blood

authors： Kaplan J,Ravindranath Y,Peterson WD Jr

更新日期：1977-03-01 00:00:00

abstract：:Peripheral T-cell lymphomas (PTCLs) are aggressive tumors in which the current therapy based on multiagent chemotherapy is not successful. Since cytochrome P450 3A subfamily (CYP3A) enzymes are involved in the inactivation of chemotherapy drugs, we hypothesized that CYP3A and P-glycoprotein (MDR1) expression in these ...

journal_title：Blood

authors： Rodríguez-Antona C,Leskelä S,Zajac M,Cuadros M,Alvés J,Moneo MV,Martín C,Cigudosa JC,Carnero A,Robledo M,Benitez J,Martínez-Delgado B

更新日期：2007-11-01 00:00:00

abstract：:Although hairy cell leukemia is uniquely sensitive to interferon-alpha (IFN-alpha), the biologic basis for this phenomenon remains unclear. Here we examine the effects of IFN-alpha on cultured hairy cells (HCs), taking into account the possible modifying influence of cell adhesion. We make the novel observation that t...

journal_title：Blood

authors： Baker PK,Pettitt AR,Slupsky JR,Chen HJ,Glenn MA,Zuzel M,Cawley JC

更新日期：2002-07-15 00:00:00

abstract：:The onset of hematopoiesis in the mouse embryo and in the embryonic stem (ES) cell differentiation model is defined by the emergence of the hemangioblast, a progenitor with both hematopoietic and vascular potential. While there is evidence for the existence of a hemangioblast in the mouse, it is unclear if this progen...

journal_title：Blood

authors： Kennedy M,D'Souza SL,Lynch-Kattman M,Schwantz S,Keller G

更新日期：2007-04-01 00:00:00

abstract：:Regulatory dendritic cells (DCs) play an important role in maintaining peripheral tolerance or immune homeostasis. Our previous study demonstrated that mature DCs could be driven by splenic stroma to proliferate and differentiate into a novel subset of regulatory DCs (diffDCs) displaying a Th2-biased cytokine profile....

journal_title：Blood

authors： Qian C,Jiang X,An H,Yu Y,Guo Z,Liu S,Xu H,Cao X

更新日期：2006-10-01 00:00:00

abstract：:The first hematopoietic and endothelial progenitors are derived from a common embryonic precursor termed the hemangioblast. The genetic cascades that regulate the differentiation of the hemangioblast to hematopoietic and endothelial cells are largely unknown. In general, much of embryonic development is coordinately r...

journal_title：Blood

authors： Guo Y,Chan R,Ramsey H,Li W,Xie X,Shelley WC,Martinez-Barbera JP,Bort B,Zaret K,Yoder M,Hromas R

更新日期：2003-10-01 00:00:00

abstract：:The purpose of this report was to evaluate scintigraphy analysis of Southern blot hybridization as a method to quantify the breakpoint cluster region (BCR) rearrangement of Philadelphia chromosome (Ph)+ chronic myelogenous leukemia (CML). Cytogenetic and molecular studies performed simultaneously on 474 bone marrow an...

journal_title：Blood

authors： Verschraegen CF,Talpaz M,Hirsch-Ginsberg CF,Pherwani R,Rios MB,Stass SA,Kantarjian HM

更新日期：1995-05-15 00:00:00

abstract：:Acute promyelocytic leukemia (APL) has a specific genetic rearrangement between the retinoic acid receptor (RAR)-alpha gene and the pml nuclear protein gene. All-trans retinoic acid (ATRA) induces granulocytic differentiation of APL-derived cells and is used to treat APL patients. However, ATRA interacts with normal c...

journal_title：Blood

authors： Makishima M,Umesono K,Shudo K,Naoe T,Kishi K,Honma Y

更新日期：1998-06-15 00:00:00

abstract：:We tested baseline positron emission tomography (PET)/computed tomography (CT) as a measure of total tumor burden to better identify high-risk patients with early-stage Hodgkin lymphoma (HL). Patients with stage I-II HL enrolled in the standard arm (combined modality treatment) of the H10 trial (NCT00433433) with avai...

journal_title：Blood

authors： Cottereau AS,Versari A,Loft A,Casasnovas O,Bellei M,Ricci R,Bardet S,Castagnoli A,Brice P,Raemaekers J,Deau B,Fortpied C,Raveloarivahy T,Van Zele E,Chartier L,Vander Borght T,Federico M,Hutchings M,Ricardi U,Andre M

更新日期：2018-03-29 00:00:00

abstract：:In an attempt to decrease the relapse rate after bone marrow transplantation (BMT) for advanced acute leukemia, we initiated studies using 131I-labeled anti-CD45 antibody (BC8) to deliver radiation specifically to hematopoietic tissues, followed by a standard transplant preparative regimen. Biodistribution studies wer...

journal_title：Blood

authors： Matthews DC,Appelbaum FR,Eary JF,Fisher DR,Durack LD,Bush SA,Hui TE,Martin PJ,Mitchell D,Press OW

更新日期：1995-02-15 00:00:00

abstract：:In vitro studies as well as clinical trials indicate that the cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) enhance the ability of neutrophils (polymorphonuclear leukocytes) to eliminate microbial organisms. Toll-like receptor (TLR) proteins, homo...

journal_title：Blood

authors： Kurt-Jones EA,Mandell L,Whitney C,Padgett A,Gosselin K,Newburger PE,Finberg RW

更新日期：2002-09-01 00:00:00

abstract：:During innate immune responses, the inflammatory CC chemokine receptors CCR1, CCR2, and CCR5 mediate the recruitment of blood monocytes to infected tissues by promoting cell migration in response to chemokines CCL2-5. Toll-like receptors also play an essential role, allowing pathogen recognition by the recruited monoc...

journal_title：Blood

authors： Fox JM,Letellier E,Oliphant CJ,Signoret N

更新日期：2011-02-10 00:00:00

abstract：:Noncovalent association between the von Willebrand factor (VWF) propeptide (VWFpp) and mature VWF aids N-terminal multimerization and protein compartmentalization in storage granules. This association is currently thought to dissipate after secretion into blood. In the present study, we examined this proposition by qu...

journal_title：Blood

authors： Madabhushi SR,Shang C,Dayananda KM,Rittenhouse-Olson K,Murphy M,Ryan TE,Montgomery RR,Neelamegham S

更新日期：2012-05-17 00:00:00

abstract：:Macrophages as inflammatory cells are involved in the pathogenesis of atherosclerosis that today is recognized as an inflammatory disease. Activation of coagulation leads to the late complication of atherosclerosis, namely atherothrombosis with its clinical manifestations stroke, unstable angina, myocardial infarction...

journal_title：Blood

authors： Kastl SP,Speidl WS,Katsaros KM,Kaun C,Rega G,Assadian A,Hagmueller GW,Hoeth M,de Martin R,Ma Y,Maurer G,Huber K,Wojta J

更新日期：2009-09-24 00:00:00

abstract：:A cytologic and cytogenetic study of 10 cases of acute myeloblastic leukemia with maturation and t(8;21) translocation is reported. Despite a certain polymorphic appearance, the characteristic cytologic picture, consisting essentially of large myeloblasts with an abundant cytoplasma containing a large Auer rod, allowe...

journal_title：Blood

authors： Berger R,Bernheim A,Daniel MT,Valensi F,Sigaux F,Flandrin G

更新日期：1982-01-01 00:00:00

abstract：:Folylpolyglutamate synthetase (FPGS) is responsible for the metabolism of natural folates and a broad range of folate antagonists to polyglutamate derivatives. Recent studies indicated increased accumulation of methotrexate (MTX) polyglutamates (MTX-PG) in blast cells as a predictor of favorable treatment outcome in c...

journal_title：Blood

authors： Barredo JC,Synold TW,Laver J,Relling MV,Pui CH,Priest DG,Evans WE

更新日期：1994-07-15 00:00:00

abstract：:DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display highly dysregulated DNA methylation profiles, characterized by global hypomethylation in conjunction with hypermethylation of promoter CpG is...

journal_title：Blood

authors： Lio CJ,Yuita H,Rao A

更新日期：2019-10-31 00:00:00

abstract：:The CXC-chemokines interleukin-8 (IL-8), neutrophil-activating peptide-2 (NAP-2), and melanoma growth-stimulatory activity (MGSA) are chemoattractants with high selectivity for neutrophils. Although IL-8 has been shown to act as an extremely potent mediator, reports on NAP-2 and MGSA are still contradictory. Here we s...

journal_title：Blood

authors： Ludwig A,Petersen F,Zahn S,Götze O,Schröder JM,Flad HD,Brandt E

更新日期：1997-12-01 00:00:00

abstract：:The transcription repressor BCL-6 is known to play critical roles in B-cell lymphomagenesis, germinal center formation, and balanced Th1/Th2 differentiation. In macrophages, although BCL-6 has also been shown to regulate the expression of several chemokine genes, its function in other aspects of macrophage biology has...

journal_title：Blood

authors： Yu RY,Wang X,Pixley FJ,Yu JJ,Dent AL,Broxmeyer HE,Stanley ER,Ye BH

更新日期：2005-02-15 00:00:00

abstract：:Incubation of human mononuclear leukocytes (MNL) with human stroma-free hemolysate (SFH), purified adult hemoglobin Ao (HbAo), and oxidized HbAo (METHb) caused MNL to release compounds into the supernate that mediated neutrophil (polymorphonuclear leukocytes, PMN) chemotaxis and PMN adherence to human umbilical vein e...

journal_title：Blood

authors： McFaul SJ,Bowman PD,Villa VM,Gutierrez-Ibanez MJ,Johnson M,Smith D

更新日期：1994-11-01 00:00:00

abstract：:A large English pedigree in which heterocellular hereditary persistence of fetal hemoglobin (HPFH) segregates is described. beta-globin cluster deletions and gamma gene promoter mutations associated with HPFH have been excluded. Of particular importance in this pedigree is the absence of any cosegregating hemoglobinop...

journal_title：Blood

authors： Craig JE,Rochette J,Sampietro M,Wilkie AO,Barnetson R,Hatton CS,Demenais F,Thein SL

更新日期：1997-07-01 00:00:00

abstract：:In cases of T-cell acute lymphoblastic leukemia (T-ALL), the basic helix-loop-helix (bHLH) oncogene SCL/tal undergoes frequent rearrangements activating ectopic expression. Despite the compelling epidemiological association of SCL/tal expression with T-ALL, no specific transforming function has been attributable to th...

journal_title：Blood

authors： Goldfarb AN,Lewandowska K

更新日期：1995-01-15 00:00:00

abstract：:Little is known about the ontogeny of naturally occurring CD4(+)CD25(+) regulatory/suppressor T cells that play a major role in maintaining self-tolerance in mice and humans. In rodents, thymectomy on day 3 of life leads to multiple organ-specific autoimmune diseases that can be prevented by adoptive transfer of regul...

journal_title：Blood

authors： Darrasse-Jèze G,Marodon G,Salomon BL,Catala M,Klatzmann D

更新日期：2005-06-15 00:00:00