Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies.

abstract：:Variations within proteasome β (PSMB) genes, which encode the β subunits of the 20S proteasome, may affect proteasome function, assembly, and/or binding of proteasome inhibitors. To investigate the potential association between PSMB gene variants and treatment-emergent resistance to bortezomib and/or long-term outcome...

journal_title：Blood

authors： Lichter DI,Danaee H,Pickard MD,Tayber O,Sintchak M,Shi H,Richardson PG,Cavenagh J,Bladé J,Façon T,Niesvizky R,Alsina M,Dalton W,Sonneveld P,Lonial S,van de Velde H,Ricci D,Esseltine DL,Trepicchio WL,Mulligan G,And

更新日期：2012-11-29 00:00:00

abstract：:Donor lymphocyte infusion (DLI) can restore durable molecular remission in a high percentage of patients with chronic myeloid leukemia (CML) who have relapses after allogeneic stem cell transplantation, but for patients who do not respond survival is poor. Imatinib mesylate (STI571) is a specific inhibitor of BCR-ABL ...

journal_title：Blood

authors： Olavarria E,Craddock C,Dazzi F,Marin D,Marktel S,Apperley JF,Goldman JM

更新日期：2002-05-15 00:00:00

abstract：:Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-t...

journal_title：Blood

authors： Pendino F,Nguyen E,Jonassen I,Dysvik B,Azouz A,Lanotte M,Ségal-Bendirdjian E,Lillehaug JR

更新日期：2009-04-02 00:00:00

abstract：:Epinephrine causes platelet aggregation and secretion by interacting with alpha 2-adrenergic receptors on the platelet surface. Platelet aggregation requires the binding of fibrinogen to a specific receptor on the membrane glycoprotein IIb-IIIa complex. Although the IIb-IIIa complex is identifiable on the surface of r...

journal_title：Blood

authors： Shattil SJ,Motulsky HJ,Insel PA,Flaherty L,Brass LF

更新日期：1986-12-01 00:00:00

abstract：:The majority of patients with Hodgkin lymphoma (HL) are cured with initial therapy. However, high-dose therapy with autologous hematopoietic cell transplant (AHCT) allows for the cure of an additional portion of patients with relapsed or primary refractory disease. Positron emission tomography-negative complete remiss...

journal_title：Blood

authors： Shah GL,Moskowitz CH

更新日期：2018-04-12 00:00:00

abstract：:The long form of B-cell lymphoma-x (Bcl-x(L)), an outer mitochondrial membrane protein, has been proposed to mediate the antiapoptotic action of erythropoietin on erythroid progenitor cells and to be necessary for heme synthesis in erythroblasts. Mice with conditional knockout of Bcl-x(L) (conditional bcl-x(-/-) mice)...

journal_title：Blood

authors： Rhodes MM,Kopsombut P,Bondurant MC,Price JO,Koury MJ

更新日期：2005-09-01 00:00:00

abstract：:Human fibrinogen 1 is homodimeric with respect to its gamma chains (gammaA-gammaA'), whereas fibrinogen 2 molecules each contain one gammaA (gammaA1-411V) and one gamma' chain, which differ by containing a unique C-terminal sequence from gamma'408 to 427L that binds thrombin and factor XIII. We investigated the struct...

journal_title：Blood

authors： Siebenlist KR,Mosesson MW,Hernandez I,Bush LA,Di Cera E,Shainoff JR,Di Orio JP,Stojanovic L

更新日期：2005-10-15 00:00:00

abstract：:Functionally inhibitory antibody to the plasma membrane complement inhibitor CD59 has been used to investigate control of the terminal complement proteins at the endothelial cell surface. Antibodies against purified human erythrocyte CD59 (polyclonal anti-CD59 and monoclonal antibodies [MoAbs] 1F1 and 1F5) were found ...

journal_title：Blood

authors： Hamilton KK,Ji Z,Rollins S,Stewart BH,Sims PJ

更新日期：1990-12-15 00:00:00

abstract：:Rauscher murine erythroleukemia cells, grown continuously in vitro, undergo erythroid differentiation in response to the hormone erythropoietin. Therefore, they serve as an important model system with which to examine critical biochemical aspects of this developmental process. Intact, uninduced Rauscher cells possess ...

journal_title：Blood

authors： Sytkowski AJ,Kessler CJ

更新日期：1984-07-01 00:00:00

abstract：:We have previously shown that coculture of human embryonic stem cells (hESCs) for 14 days with immortalized fetal hepatocytes yields CD34(+) cells that can be expanded in serum-free liquid culture into large numbers of megaloblastic nucleated erythroblasts resembling yolk sac-derived cells. We show here that these pri...

journal_title：Blood

authors： Qiu C,Olivier EN,Velho M,Bouhassira EE

更新日期：2008-02-15 00:00:00

abstract：:The extended use of brentuximab-vedotin was reported for CD30(+) nonanaplastic peripheral T-cell lymphomas (PTCLs) with promising efficacy. CD30 status assessment is thus a critical factor for therapeutic decision, but the reliability of immunohistochemistry (IHC) in evaluating its expression remains to be defined. Th...

journal_title：Blood

authors： Bossard C,Dobay MP,Parrens M,Lamant L,Missiaglia E,Haioun C,Martin A,Fabiani B,Delarue R,Tournilhac O,Delorenzi M,Gaulard P,de Leval L

更新日期：2014-11-06 00:00:00

abstract：:Antibodies play a fundamental role in diagnostic immunophenotyping of leukemias and in cell-targeting therapy. However, this versatility is not reflected in imaging diagnostics. In the present study, we labeled anti–human mAbs monochromatically against selected human myeloid markers expressed on acute myeloid leukemia...

journal_title：Blood

authors： McCormack E,Mujić M,Osdal T,Bruserud Ø,Gjertsen BT

更新日期：2013-02-14 00:00:00

abstract：:Endothelial progenitor cell (EPC) mobilization has been reported following tissue damage, whereas no data are available regarding the mobilization of hematopoietic progenitor cells (HPCs). We performed the phenotypic and functional analysis of circulating CD34+ progenitor cells in patients with acute myocardial infarc...

journal_title：Blood

authors： Massa M,Rosti V,Ferrario M,Campanelli R,Ramajoli I,Rosso R,De Ferrari GM,Ferlini M,Goffredo L,Bertoletti A,Klersy C,Pecci A,Moratti R,Tavazzi L

更新日期：2005-01-01 00:00:00

abstract：:We studied T-cell reconstitution in 31 primary T-cell-immunodeficient patients who had undergone hematopoietic stem-cell transplantation (HSCT) over 10 years previously. In 19 patients, there was no evidence of myeloid chimerism because little or no myeloablation had been performed. Given this context, we sought facto...

journal_title：Blood

authors： Cavazzana-Calvo M,Carlier F,Le Deist F,Morillon E,Taupin P,Gautier D,Radford-Weiss I,Caillat-Zucman S,Neven B,Blanche S,Cheynier R,Fischer A,Hacein-Bey-Abina S

更新日期：2007-05-15 00:00:00

abstract：:Mutations within exon 3 of the beta-globin gene are relatively uncommon, and many of these mutations produce a dominant thalassemia-like phenotype. We describe a novel thalassemic hemoglobinopathy caused by a single nucleotide substitution (CTG-->CCG) at codon 114 resulting in a leucine to proline substitution and des...

journal_title：Blood

authors： de Castro CM,Devlin B,Fleenor DE,Lee ME,Kaufman RE

更新日期：1994-02-15 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATLL) is an incurable disease where most patients succumb within the first year of diagnosis. Both standard chemotherapy regimens and mAbs directed against ATLL tumor markers do not alter this aggressive clinical course. Therapeutic development would be facilitated by the discovery of g...

journal_title：Blood

authors： Elliott NE,Cleveland SM,Grann V,Janik J,Waldmann TA,Davé UP

更新日期：2011-10-06 00:00:00

abstract：:Treatment with warfarin using a target International Normalized Ratio (INR) range of 1.7 to 2.5 is efficacious for many clinical indications, but the minimal intensity of anticoagulation required for antithrombotic protection has yet to be determined. To evaluate whether patients could be reliably monitored with a les...

journal_title：Blood

authors： Millenson MM,Bauer KA,Kistler JP,Barzegar S,Tulin L,Rosenberg RD

更新日期：1992-04-15 00:00:00

abstract：:A global phase 3 study evaluated the pharmacokinetics, efficacy, and safety of recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in 63 previously treated male patients (12-61 years) with severe hemophilia B (factor IX [FIX] activity ≤2%). The study included 2 groups: group 1 patients recei...

journal_title：Blood

authors： Santagostino E,Martinowitz U,Lissitchkov T,Pan-Petesch B,Hanabusa H,Oldenburg J,Boggio L,Negrier C,Pabinger I,von Depka Prondzinski M,Altisent C,Castaman G,Yamamoto K,Álvarez-Roman MT,Voigt C,Blackman N,Jacobs I,PROLONG

更新日期：2016-04-07 00:00:00

abstract：:Transcriptional profiles of cultured primary human erythroid cells were examined to identify those genes involved in the control of erythroid growth during the terminal phase of maturation. Our in silico screening strategy indicated that a hypoxia-inducible proapoptotic member of the Bcl-2 gene family called Nix is ex...

journal_title：Blood

authors： Aerbajinai W,Giattina M,Lee YT,Raffeld M,Miller JL

更新日期：2003-07-15 00:00:00

abstract：:The duration of immunodeficiency following marrow transplantation is not known. Questionnaires were used to study the infection rates in 72 patients surviving 20 to 30 years after marrow grafting. Furthermore, in 33 of the 72 patients and in 16 donors (siblings who originally donated the marrow) leukocyte subsets were...

journal_title：Blood

authors： Storek J,Joseph A,Espino G,Dawson MA,Douek DC,Sullivan KM,Flowers ME,Martin P,Mathioudakis G,Nash RA,Storb R,Appelbaum FR,Maloney DG

更新日期：2001-12-15 00:00:00

abstract：:Liver X receptors (LXRs) are transcription factors involved in the regulation of cholesterol homeostasis. LXR ligands have athero-protective properties independent of their effects on cholesterol metabolism. Platelets are involved in the initiation of atherosclerosis and despite being anucleate express nuclear recepto...

journal_title：Blood

authors： Spyridon M,Moraes LA,Jones CI,Sage T,Sasikumar P,Bucci G,Gibbins JM

更新日期：2011-05-26 00:00:00

abstract：:Heme biosynthesis was examined in erythroid tissue of a 4-yr-old girl with severe sideroblastic anemia since infancy, as documented by the presence of intramitochondrial deposits of iron in erythroblasts. Free red cell protoporphyrin, urinary porphyrins, and activities of erythrocyte porphobilinogen synthase, uroporph...

journal_title：Blood

authors： Buchanan GR,Bottomley SS,Nitschke R

更新日期：1980-01-01 00:00:00

abstract：:The proteolytic cleavage and subsequent inactivation of recombinant human factor VIII (rhFVIII) and human factor VIIIa (rhFVIIIa) by recombinant human activated protein C (rAPC) was analyzed in the presence and absence of human protein S and human factor V (FV). Membrane-bound rhFVIIIa spontaneously looses most of its...

journal_title：Blood

authors： Lu D,Kalafatis M,Mann KG,Long GL

更新日期：1996-06-01 00:00:00

abstract：:The genes for the hemopoietic growth factors, GM colony-stimulating factor (CSF) and G-CSF have been cloned, and recombinant material is available for both. We tested these recombinant factors for their effects on the blast cells of acute myeloblastic leukemia (AML). Culture methods are available that support both col...

journal_title：Blood

authors： Kelleher C,Miyauchi J,Wong G,Clark S,Minden MD,McCulloch EA

更新日期：1987-05-01 00:00:00

abstract：:Murine myeloid cells can be transformed in vitro by infection with recombinant retroviruses carrying activated myb genes. While these myb-transformed hematopoietic cells (MTHCs) can proliferate continuously in culture, they exhibit several characteristics of progenitor cells of the granulocyte-macrophage (GM) lineage,...

journal_title：Blood

authors： Macmillan EM,Gonda TJ

更新日期：1994-01-01 00:00:00

abstract：:Direct sequencing of VWF genomic DNA in 21 patients with type 3 von Willebrand disease (VWD) failed to reveal a causative homozygous or compound heterozygous VWF genotype in 5 cases. Subsequent analysis of VWF mRNA led to the discovery of a deletion (c.221-977_532 + 7059del [p.Asp75_Gly178del]) of VWF in 7 of 12 white...

journal_title：Blood

authors： Sutherland MS,Cumming AM,Bowman M,Bolton-Maggs PH,Bowen DJ,Collins PW,Hay CR,Will AM,Keeney S

更新日期：2009-07-30 00:00:00

abstract：:The murine Ly6-E gene is transcriptionally induced by interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma in a variety of distinct cell types. The mechanism of IFN inducibility in B-cell lines was investigated by deletion analysis of the promoter and by identifying DNA binding proteins in mobility shift assays. A reg...

journal_title：Blood

authors： Khodadoust MM,Khan KD,Park EH,Bothwell AL

更新日期：1998-10-01 00:00:00

abstract：:The use of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) following autologous marrow transplantation for lymphoid malignancies was explored in a phase I/II dose escalation study. rhGM-CSF given as a 2-hour infusion daily for 14 days was well tolerated at doses up to 240 micrograms/m2/da...

journal_title：Blood

authors： Nemunaitis J,Singer JW,Buckner CD,Hill R,Storb R,Thomas ED,Appelbaum FR

更新日期：1988-08-01 00:00:00

abstract：:Human early thymic precursors have the potential to differentiate into multiple cell lineages, including T cells and plasmacytoid dendritic cells (pDCs). This decision is guided by the induction or silencing of lineage-specific transcription factors. The ETS family member Spi-B is a key regulator of pDC development, w...

journal_title：Blood

authors： Dontje W,Schotte R,Cupedo T,Nagasawa M,Scheeren F,Gimeno R,Spits H,Blom B

更新日期：2006-03-15 00:00:00

abstract：:The relationship between the level of retinoblastoma protein (RB) expression and the survival of 113 newly diagnosed acute myelogenous leukemia (AML) patients was studied. Western blotting was used to determine the level of RB protein present in peripheral blood leukemia cells and results were confirmed in 26 patients...

journal_title：Blood

authors： Kornblau SM,Xu HJ,Zhang W,Hu SX,Beran M,Smith TL,Hester J,Estey E,Benedict WF,Deisseroth AB

更新日期：1994-07-01 00:00:00