A novel deletion mutation is recurrent in von Willebrand disease types 1 and 3.

abstract：:Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) was performed in non-Hodgkin's lymphoma (NHL), which is known to be highly responsive to chemotherapy, but also yields variable treatment results to answer the following questions: (1) What is the extent and time course of changes in FDG utilizatio...

journal_title：Blood

authors： Römer W,Hanauske AR,Ziegler S,Thödtmann R,Weber W,Fuchs C,Enne W,Herz M,Nerl C,Garbrecht M,Schwaiger M

更新日期：1998-06-15 00:00:00

abstract：:Dendritic cells (DCs) are considered critical for the induction of graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In addition to their priming function, dendritic cells have been shown to induce organ-tropism through induction of specific homing molecules on T cells. Using adoptive transfer ...

journal_title：Blood

authors： Kim TD,Terwey TH,Zakrzewski JL,Suh D,Kochman AA,Chen ME,King CG,Borsotti C,Grubin J,Smith OM,Heller G,Liu C,Murphy GF,Alpdogan O,van den Brink MR

更新日期：2008-03-01 00:00:00

abstract：:Additional sex combs-like 1 (ASXL1), an epigenetic modulator, is frequently mutated in myeloid neoplasms. Recent analyses of mutant ASXL1 conditional knockin (ASXL1-MT-KI) mice suggested that ASXL1-MT alone is insufficient for myeloid transformation. In our previous study, we used retrovirus-mediated insertional mutag...

journal_title：Blood

authors： Takeda R,Asada S,Park SJ,Yokoyama A,Becker HJ,Kanai A,Visconte V,Hershberger C,Hayashi Y,Yonezawa T,Tamura M,Fukushima T,Tanaka Y,Fukuyama T,Matsumoto A,Yamasaki S,Nakai K,Yamazaki S,Inaba T,Shibata T,Inoue D,Ho

更新日期：2020-10-01 00:00:00

abstract：:Aggregation of blood platelets contributes to the arrest of bleeding at sites of vascular injury, but it can occlude atherosclerotic arteries and precipitate diseases such as myocardial infarction. The bonds that link platelets under flow conditions were identified using confocal videomicroscopy in real time. Glycopro...

journal_title：Blood

authors： Ruggeri ZM,Dent JA,Saldívar E

更新日期：1999-07-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a common type of non-Hodgkin's lymphoma (NHL) that is highly heterogeneous from both clinical and histopathologic viewpoints. The immunoglobulin (Ig) heavy (H) chain variable region genes were examined in 71 patients with untreated primary DLBCL. Fifty-eight potentially functio...

journal_title：Blood

authors： Lossos IS,Okada CY,Tibshirani R,Warnke R,Vose JM,Greiner TC,Levy R

更新日期：2000-03-01 00:00:00

abstract：:To evaluate the association between fetal hemoglobin (HbF) levels and morbidity in β-thalassemia intermedia (TI), we analyzed data from 63 untransfused patients who had also never received HbF induction therapy. Patient records were reviewed for any history of 10 predefined morbidities. Laboratory measurements for mar...

journal_title：Blood

authors： Musallam KM,Sankaran VG,Cappellini MD,Duca L,Nathan DG,Taher AT

更新日期：2012-01-12 00:00:00

abstract：:Overexpression of BAALC is an adverse prognostic factor in adults with cytogenetically normal acute myeloid leukemia and T-cell acute lymphoblastic leukemia (ALL). Here, we analyzed the prognostic significance of BAALC in B-precursor ALL. BAALC MRNA expression was determined in 368 primary adult B-precursor ALL patien...

journal_title：Blood

authors： Kühnl A,Gökbuget N,Stroux A,Burmeister T,Neumann M,Heesch S,Haferlach T,Hoelzer D,Hofmann WK,Thiel E,Baldus CD

更新日期：2010-05-06 00:00:00

abstract：:The anemia of chronic disease (ACD) results from 3 major processes: slightly shortened red cell survival, impaired reticuloendothelial system iron mobilization, and impaired erythropoiesis. Hepcidin is an acute-phase protein with specific iron regulatory properties, which, along with the anemia seen with increased hep...

journal_title：Blood

authors： Dallalio G,Law E,Means RT Jr

更新日期：2006-04-01 00:00:00

abstract：:Dickkopf-1 (DKK1), a soluble inhibitor of Wnt signaling secreted by multiple myeloma (MM) cells contributes to osteolytic bone disease by inhibiting the differentiation of osteoblasts. In this study, we tested the effect of anti-DKK1 therapy on bone metabolism and tumor growth in a SCID-rab system. SCID-rab mice were ...

journal_title：Blood

authors： Yaccoby S,Ling W,Zhan F,Walker R,Barlogie B,Shaughnessy JD Jr

更新日期：2007-03-01 00:00:00

abstract：:Peripheral blood from patients with acute myeloblastic leukemia (AML) contains cells capable of giving rise to colonies in culture when stimulated by media conditioned by leukocytes (LCM) in the presence of phytohemagglutinin (PHA). Two types of colonies are recognized with high frequency: The first grows in the prese...

journal_title：Blood

authors： Minden MD,Till JE,McCulloch EA

更新日期：1978-09-01 00:00:00

abstract：:Human bone marrow (BM) cells contain low levels of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, which may explain their susceptibility to nitrosourea-induced cytotoxicity and the development of secondary leukemia after nitrosourea treatment. Isolated CD34+ myeloid progenitors were also found to have l...

journal_title：Blood

authors： Gerson SL,Phillips W,Kastan M,Dumenco LL,Donovan C

更新日期：1996-09-01 00:00:00

abstract：:Currently, there are no reliable RBC invasion assays to guide the discovery of vaccines against Plasmodium vivax, the most prevalent malaria parasite in Asia and South America. Here we describe a protocol for an ex vivo P vivax invasion assay that can be easily deployed in laboratories located in endemic countries. Th...

journal_title：Blood

authors： Russell B,Suwanarusk R,Borlon C,Costa FT,Chu CS,Rijken MJ,Sriprawat K,Warter L,Koh EG,Malleret B,Colin Y,Bertrand O,Adams JH,D'Alessandro U,Snounou G,Nosten F,Rénia L

更新日期：2011-09-29 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic stem cell transplant (alloHSCT), underscoring the need to further elucidate its mechanisms and develop novel treatments. Based on recent observations that microRNA-155 (miR-155) is up-regulated during T-cell activation, we...

journal_title：Blood

authors： Ranganathan P,Heaphy CE,Costinean S,Stauffer N,Na C,Hamadani M,Santhanam R,Mao C,Taylor PA,Sandhu S,He G,Shana'ah A,Nuovo GJ,Lagana A,Cascione L,Obad S,Broom O,Kauppinen S,Byrd JC,Caligiuri M,Perrotti D,Hadley G

更新日期：2012-05-17 00:00:00

abstract：:The association of thrombosis and gestational morbidity with antiphospholipid antibodies is termed antiphospholipid syndrome (APS). Annexin 2 (A2) is a profibrinolytic endothelial cell surface receptor that binds plasminogen, its tissue activator (tPA), and beta(2)-glycoprotein I (beta2GPI), the main antigen for antip...

journal_title：Blood

authors： Cesarman-Maus G,Ríos-Luna NP,Deora AB,Huang B,Villa R,Cravioto Mdel C,Alarcón-Segovia D,Sánchez-Guerrero J,Hajjar KA

更新日期：2006-06-01 00:00:00

abstract：:Escherichia coli were labeled with 59Fe and then either treated with myeloperoxidase, H2O2, and chloride or opsonized and mixed with human neutrophils. The myeloperoxidase system at pH 7.4 caused release of most of the bacterial 59Fe. A similar result has been obtained by Rosen and Klebanoff (J Biol Chem 257:13731, 19...

journal_title：Blood

authors： Molloy AL,Winterbourn CC

更新日期：1990-02-15 00:00:00

abstract：:Severe congenital neutropenia (CN) is a preleukemic bone marrow failure syndrome with a 20% risk of evolving into leukemia or myelodysplastic syndrome (MDS). Patterns of acquisition of leukemia-associated mutations were investigated using next-generation deep-sequencing in 31 CN patients who developed leukemia or MDS....

journal_title：Blood

authors： Skokowa J,Steinemann D,Katsman-Kuipers JE,Zeidler C,Klimenkova O,Klimiankou M,Unalan M,Kandabarau S,Makaryan V,Beekman R,Behrens K,Stocking C,Obenauer J,Schnittger S,Kohlmann A,Valkhof MG,Hoogenboezem R,Göhring G,Rein

更新日期：2014-04-03 00:00:00

abstract：:The interaction between platelet receptor glycoprotein Ibα and the A1 domain of von Willebrand factor (VWF) mediates tethering/translocation of platelets to sites of vascular injury. Unexpectedly, we observed platelets translocating over A1A2A3 domains protein slower than on A1 domain at high shear stress. This observ...

journal_title：Blood

authors： Da Q,Behymer M,Correa JI,Vijayan KV,Cruz MA

更新日期：2014-04-24 00:00:00

abstract：:To test the efficacy of poststorage bedside leucodepletion of blood products in the prevention of primary HLA alloimmunization and its clinical sequelae, 172 patients with hematologic malignancy requiring intensive red blood cell and platelet support were randomized to receive either standard or filtered red blood cel...

journal_title：Blood

authors： Williamson LM,Wimperis JZ,Williamson P,Copplestone JA,Gooi HC,Morgenstern GR,Norfolk DR

更新日期：1994-05-15 00:00:00

abstract：:The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hep...

journal_title：Blood

authors： Pippard MJ,Johnson DK,Finch CA

更新日期：1981-10-01 00:00:00

abstract：:Development of acute graft-versus-host disease (aGVHD) predisposes to chronic GVHD with autoimmune manifestations. A characteristic of experimental aGVHD is the de novo generation of autoreactive T cells. Central tolerance is dependent on the intrathymic expression of tissue-restricted peripheral self-antigens (TRA), ...

journal_title：Blood

authors： Dertschnig S,Nusspaumer G,Ivanek R,Hauri-Hohl MM,Holländer GA,Krenger W

更新日期：2013-08-01 00:00:00

abstract：:Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency. To identify mutations that cooperate with Mll-AF9, we infected neonatal wild-type (WT) or Mll-AF9 ...

journal_title：Blood

authors： Bergerson RJ,Collier LS,Sarver AL,Been RA,Lugthart S,Diers MD,Zuber J,Rappaport AR,Nixon MJ,Silverstein KA,Fan D,Lamblin AF,Wolff L,Kersey JH,Delwel R,Lowe SW,O'Sullivan MG,Kogan SC,Adams DJ,Largaespada DA

更新日期：2012-05-10 00:00:00

abstract：:Production of tumor necrosis factor-alpha (TNFalpha) by the neutrophil (PMN) is a pivotal event in innate immunity, but the signals regulating TNFalpha induction in this primary cell are poorly understood. Herein, we use protein transduction to identify novel, opposing anti- and pro-cytokine-inducing roles for RhoA in...

journal_title：Blood

authors： Fessler MB,Arndt PG,Just I,Nick JA,Malcolm KC,Worthen GS

更新日期：2007-02-01 00:00:00

abstract：:We have established four hybridoma cells that produce monoclonal antibodies (MoAbs) R2, R4, R6, and R12 directed toward recombinant human erythropoietin (rHuEPO). MoAbs R2, R4, and R6 bound to EPO with high affinities (kd = approximately 2, 4, and 1 nmol/L, respectively) but MoAb R12 had a low affinity (240 nmol/L). T...

journal_title：Blood

authors： Goto M,Murakami A,Akai K,Kawanishi G,Ueda M,Chiba H,Sasaki R

更新日期：1989-09-01 00:00:00

abstract：:Ectopic expression of fibroblast growth factor receptor 3 (FGFR3) associated with t(4;14) has been implicated in the pathogenesis of human multiple myeloma. Some t(4;14) patients have activating mutations of FGFR3, of which a minority are K650E (thanatophoric dysplasia type II [TDII]). To investigate the role of autop...

journal_title：Blood

authors： Chen J,Williams IR,Lee BH,Duclos N,Huntly BJ,Donoghue DJ,Gilliland DG

更新日期：2005-07-01 00:00:00

abstract：:Depletion of guanine nucleotide pools after inhibition of inosine monophosphate dehydrogenase (IMPDH) potently inhibits DNA synthesis by arresting cells in G1 and has been shown to induce the differentiation of cultured myeloid and erythroid cell lines, as well as chronic granulocytic leukemic cells after blast transf...

journal_title：Blood

authors： Laliberté J,Yee A,Xiong Y,Mitchell BS

更新日期：1998-04-15 00:00:00

abstract：:Because the causes of most lymphoid neoplasms remain unknown, comparison of incidence patterns by disease subtype may provide critical clues for future etiologic investigations. We therefore conducted a comprehensive assessment of 114,548 lymphoid neoplasms diagnosed during 1992-2001 in 12 Surveillance, Epidemiology, ...

journal_title：Blood

authors： Morton LM,Wang SS,Devesa SS,Hartge P,Weisenburger DD,Linet MS

更新日期：2006-01-01 00:00:00

abstract：:A qualitative defect of antithrombin III (AT III) has been demonstrated over three generations in eight members of an Italian family by the discrepancy between a normal amount of antigen and decreased antithrombin and anti-Xa activity in the presence or in the absence of heparin. By two-dimensional immunoelectrophores...

journal_title：Blood

authors： Wolf M,Boyer C,Tripodi A,Meyer D,Larrieu MJ,Mannucci PM

更新日期：1985-02-01 00:00:00

abstract：:To assess the relationship between venous thrombosis and plasma glucosylceramide (GlcCer) or phosphatidylethanolamine (PE), plasma levels of GlcCer and PE were determined for 70 venous thrombosis patients referred for evaluation and 70 healthy blood donors. The mean GlcCer level, but not the PE level, was lower in pat...

journal_title：Blood

authors： Deguchi H,Fernández JA,Pabinger I,Heit JA,Griffin JH

更新日期：2001-04-01 00:00:00

abstract：:We tested baseline positron emission tomography (PET)/computed tomography (CT) as a measure of total tumor burden to better identify high-risk patients with early-stage Hodgkin lymphoma (HL). Patients with stage I-II HL enrolled in the standard arm (combined modality treatment) of the H10 trial (NCT00433433) with avai...

journal_title：Blood

authors： Cottereau AS,Versari A,Loft A,Casasnovas O,Bellei M,Ricci R,Bardet S,Castagnoli A,Brice P,Raemaekers J,Deau B,Fortpied C,Raveloarivahy T,Van Zele E,Chartier L,Vander Borght T,Federico M,Hutchings M,Ricardi U,Andre M

更新日期：2018-03-29 00:00:00

abstract：:Dentin matrix protein 1 (DMP1) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family, a group of proteins initially described as mineralized extracellular matrices components. More recently, SIBLINGs have been implicated in several key steps of cancer progression, including angiogenes...

journal_title：Blood

authors： Pirotte S,Lamour V,Lambert V,Alvarez Gonzalez ML,Ormenese S,Noël A,Mottet D,Castronovo V,Bellahcène A

更新日期：2011-02-24 00:00:00