IFN-gamma gene polymorphisms associate with development of EBV+ lymphoproliferative disease in hu PBL-SCID mice.

abstract：:Fluid shear stress generated by steady laminar blood flow protects vessels from atherosclerosis. Krüppel-like factor 2 (KLF2) and endothelial nitric oxide synthase (eNOS) are fluid shear stress-responsive genes and key mediators in flow anti-inflammatory and antiatherosclerotic actions. However, the molecular mechanis...

journal_title：Blood

authors： Wang W,Ha CH,Jhun BS,Wong C,Jain MK,Jin ZG

更新日期：2010-04-08 00:00:00

abstract：:Ecotropic viral integration site 1 (Evi1) is one of the master regulators in the development of acute myeloid leukemia (AML) and myelodysplastic syndrome. High expression of Evi1 is found in 10% of patients with AML and indicates a poor outcome. Several recent studies have indicated that Evi1 requires collaborative fa...

journal_title：Blood

authors： Watanabe-Okochi N,Yoshimi A,Sato T,Ikeda T,Kumano K,Taoka K,Satoh Y,Shinohara A,Tsuruta T,Masuda A,Yokota H,Yatomi Y,Takahashi K,Kitaura J,Kitamura T,Kurokawa M

更新日期：2013-05-16 00:00:00

abstract：:Digital protein assays have great potential to advance immunodiagnostics because of their single-molecule sensitivity, high precision, and robust measurements. However, translating digital protein assays to acute clinical care has been challenging because it requires their deployment with a rapid turnaround. Herein, w...

journal_title：Blood

authors： Song Y,Sandford E,Tian Y,Yin Q,Kozminski AG,Su SH,Cai T,Ye Y,Chung MT,Lindstrom R,Goicochea A,Barabas J,Olesnavich M,Rozwadowski M,Li Y,Alam HB,Singer BH,Ghosh M,Choi SW,Tewari M,Kurabayashi K

更新日期：2020-12-04 00:00:00

abstract：:Chemokines regulate hematopoiesis in part by influencing the proliferative status of myeloid progenitor cells (MPC). Human MCP-1/murine JE, a myelosuppressive chemokine, specifically binds C-C chemokine receptor 2 (CCR2). Transgenic mice containing a targeted disruption in CCR2 that prevents expression of CCR2 mRNA an...

journal_title：Blood

authors： Reid S,Ritchie A,Boring L,Gosling J,Cooper S,Hangoc G,Charo IF,Broxmeyer HE

更新日期：1999-03-01 00:00:00

abstract：:There is emerging evidence that neutrophil extracellular traps (NETs) play important roles in inflammatory processes. Here we report that neutrophils have to be simultaneously activated by integrin-mediated outside-in- and G-protein-coupled receptor (GPCR) signaling to induce NET formation in acute lung injury (ALI), ...

journal_title：Blood

authors： Rossaint J,Herter JM,Van Aken H,Napirei M,Döring Y,Weber C,Soehnlein O,Zarbock A

更新日期：2014-04-17 00:00:00

abstract：:The International Prognostic Scoring System (IPSS) has been widely used to predict the prognosis of patients with myelodysplastic syndrome (MDS). However, IPSS does not always provide a sufficiently precise evaluation of patients to allow the appropriate choice of clinical interventions. Here, we analyzed the expressi...

journal_title：Blood

authors： Mihara K,Chowdhury M,Nakaju N,Hidani S,Ihara A,Hyodo H,Yasunaga S,Takihara Y,Kimura A

更新日期：2006-01-01 00:00:00

abstract：:Donor alloreactive CD4(+) T cells are important to the pathogenesis of chronic graft-versus-host disease (cGVHD), but specific subsets of CD4(+) T cells responsible for GVHD have not been defined. We hypothesized that cGVHD might be associated with a preponderance of CD4(+) effector memory cells (CCR7(-)/CD62L(low), C...

journal_title：Blood

authors： Yamashita K,Choi U,Woltz PC,Foster SF,Sneller MC,Hakim FT,Fowler DH,Bishop MR,Pavletic SZ,Tamari M,Castro K,Barrett AJ,Childs RW,Illei GG,Leitman SF,Malech HL,Horwitz ME

更新日期：2004-05-15 00:00:00

abstract：:In this study, we randomly compared high doses of the tyrosine kinase inhibitor imatinib combined with reduced-intensity chemotherapy (arm A) to standard imatinib/hyperCVAD (cyclophosphamide/vincristine/doxorubicin/dexamethasone) therapy (arm B) in 268 adults (median age, 47 years) with Philadelphia chromosome-positiv...

journal_title：Blood

authors： Chalandon Y,Thomas X,Hayette S,Cayuela JM,Abbal C,Huguet F,Raffoux E,Leguay T,Rousselot P,Lepretre S,Escoffre-Barbe M,Maury S,Berthon C,Tavernier E,Lambert JF,Lafage-Pochitaloff M,Lhéritier V,Chevret S,Ifrah N,Dombr

更新日期：2015-06-11 00:00:00

abstract：:To identify molecular targets that modify sensitivity to lenalidomide, we measured proliferation in multiple myeloma (MM) cells transfected with 27 968 small interfering RNAs in the presence of increasing concentrations of drug and identified 63 genes that enhance activity of lenalidomide upon silencing. Ribosomal pro...

journal_title：Blood

authors： Zhu YX,Yin H,Bruins LA,Shi CX,Jedlowski P,Aziz M,Sereduk C,Kortuem KM,Schmidt JE,Champion M,Braggio E,Keith Stewart A

更新日期：2015-01-15 00:00:00

abstract：:Interleukin 2 (IL-2) rescued human natural killer (NK) KHYG-1 cells from apoptosis along with a reduction of ceramide. Conversely, an increase of ceramide inhibited IL-2-rescued survival. IL-2 deprivation-induced activation of acid sphingomyelinase (SMase) and inhibition of glucosylceramide synthase (GCS) and sphingom...

journal_title：Blood

authors： Taguchi Y,Kondo T,Watanabe M,Miyaji M,Umehara H,Kozutsumi Y,Okazaki T

更新日期：2004-11-15 00:00:00

abstract：:Eighty-three patients with circulating anticoagulants were studied at The New York Hospital. The lupus-type anticoagulant, an inhibitor of the prothrombin activator complex, was demonstrated in 58 patients. The inhibitor was identified using the blood and tissue thromboplastin inhibition tests. Inhibition by the lupus...

journal_title：Blood

authors： Schleider MA,Nachman RL,Jaffe EA,Coleman M

更新日期：1976-10-01 00:00:00

abstract：:We here investigate the occurrence of fluoride intake-associated alterations in patients with hematologic disease on triazol antifungal medication. Clinical, laboratory, and radiology data of overall 43 patients with hematologic malignancies taking voriconazole (n = 20), posaconazole (n = 8), and itraconazole (n = 4),...

journal_title：Blood

authors： Gerber B,Guggenberger R,Fasler D,Nair G,Manz MG,Stussi G,Schanz U

更新日期：2012-09-20 00:00:00

abstract：:Sera from patients with bone marrow megakaryocyte aplasia are a rich source of megakaryocyte colony-stimulating activity (Meg-CSA). Other biologic materials exhibiting Meg-CSA include phytohemagglutinin-stimulated human lymphocyte-conditioned medium (PHA-LCM), recombinant interleukin-3 (IL-3), and recombinant granuloc...

journal_title：Blood

authors： Mazur EM,Cohen JL,Newton J,Sohl P,Narendran A,Gesner TG,Mufson RA

更新日期：1990-07-15 00:00:00

abstract：:Somatic mutation in immunoglobulin variable (V) region genes occurs largely in the germinal center and, after neoplastic transformation, imprints V genes of B-cell tumors with the mutational history of the cell of origin. Recently, it has been found that chronic lymphocytic leukemia (CLL) consists of 2 subsets, each w...

journal_title：Blood

authors： Sahota SS,Davis Z,Hamblin TJ,Stevenson FK

更新日期：2000-06-01 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (NGAL) is a novel 25-kD protein of human neutrophils, that is in part covalently complexed with neutrophil gelatinase. However, both NGAL and gelatinase exist mainly in forms not associated with each other. An explanation for this phenomenon might be that the unassociated pro...

journal_title：Blood

authors： Kjeldsen L,Bainton DF,Sengeløv H,Borregaard N

更新日期：1994-02-01 00:00:00

abstract：:Cerebral malaria is a severe multifactorial condition associated with the interaction of high numbers of infected erythrocytes to human brain endothelium without invasion into the brain. The result is coma and seizures with death in more than 20% of cases. Because the brain endothelium is at the interface of these pro...

journal_title：Blood

authors： Tripathi AK,Sha W,Shulaev V,Stins MF,Sullivan DJ Jr

更新日期：2009-11-05 00:00:00

abstract：:A hamster antimouse CD3 monoclonal antibody (MoAb) opened the way to experimental studies on the suppression of allograft rejection and cytokine-related morbidity after treatment with antibodies modulating the CD3/T-cell receptor complex (CD3/TCR). Because earlier attempts to suppress graft-versus-host disease (GVHD) ...

journal_title：Blood

authors： Mysliwietz J,Thierfelder S

更新日期：1992-11-15 00:00:00

abstract：:Germline mutations of the CDKN2A (p16(INK4A)) tumor suppressor gene predispose patients to melanoma and pancreatic carcinoma. In contrast, mutations of the murine CDKN2A gene predispose BALB/c mice to pristane-induced plasmacytoma. We describe here a family in which a germline mutation of CDKN2A is present in 4 indivi...

journal_title：Blood

authors： Dilworth D,Liu L,Stewart AK,Berenson JR,Lassam N,Hogg D

更新日期：2000-03-01 00:00:00

abstract：:The purpose of this study was to determine the relative merits of idarubicin and daunorubicin in acute myeloid leukemia (AML) therapy. Thirty-two sites provided 214 previously untreated adults with AML aged 15 years or more who were randomized to receive for induction therapy cytarabine 100 mg/m2/d as a continuous 7-d...

journal_title：Blood

authors： Wiernik PH,Banks PL,Case DC Jr,Arlin ZA,Periman PO,Todd MB,Ritch PS,Enck RE,Weitberg AB

更新日期：1992-01-15 00:00:00

abstract：:It has been hypothesized that some of the irreversible microrheologic abnormalities of sickle red blood cell (RBC) membranes could result from autoxidative perturbation. To model this possibility, we used micromechanical manipulation to examine the static extensional rigidity and inelastic or plastic behavior of norma...

journal_title：Blood

authors： Hebbel RP,Leung A,Mohandas N

更新日期：1990-09-01 00:00:00

abstract：:Previous studies have suggested that, in patients with AL amyloidosis treated with high-dose melphalan and autologous stem-cell transplantation (HDM/SCT), the greatest benefit is seen in those patients achieving a hematologic complete response (CR). We analyzed a series of 421 consecutive patients treated with HDM/SCT...

journal_title：Blood

authors： Cibeira MT,Sanchorawala V,Seldin DC,Quillen K,Berk JL,Dember LM,Segal A,Ruberg F,Meier-Ewert H,Andrea NT,Sloan JM,Finn KT,Doros G,Blade J,Skinner M

更新日期：2011-10-20 00:00:00

abstract：:LMP-1, an Epstein-Barr viral (EBV) latency protein, is considered a viral oncogene because of its ability to transform rodent fibroblasts in vivo and render them tumorigenic in nude mice. In human B cells, EBV LMP-1 induces DNA synthesis and abrogates apoptosis. LMP-1 is expressed in EBV-transformed lymphoblastoid cel...

journal_title：Blood

authors： Kingma DW,Weiss WB,Jaffe ES,Kumar S,Frekko K,Raffeld M

更新日期：1996-07-01 00:00:00

abstract：:Activated protein C (APC) is inhibited by two major plasma inhibitors (PCIs). To find evidence for in vivo complexation of APC, immunoblotting studies were performed on plasmas of 85 patients with suspected disseminated intravascular coagulation (DIC). Samples from 62 of these patients contained 5% to 35% of protein C...

journal_title：Blood

authors： Heeb MJ,Mosher D,Griffin JH

更新日期：1989-02-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (alloHSCT) is the only potentially curative treatment available for patients with B-cell chronic lymphocytic leukemia (B-CLL). Here, we show that post-alloHSCT antibody repertoires can be mined for the discovery of fully human monoclonal antibodies to B-CLL cell-surfa...

journal_title：Blood

authors： Baskar S,Suschak JM,Samija I,Srinivasan R,Childs RW,Pavletic SZ,Bishop MR,Rader C

更新日期：2009-11-12 00:00:00

abstract：:Multiple myeloma is characterized by increased osteoclast activity that results in bone destruction and lytic lesions. With the prolonged overall patient survival achieved by new treatment modalities, additional drugs are required to inhibit bone destruction. We focused on a novel and more potent structural analog of ...

journal_title：Blood

authors： Feng R,Anderson G,Xiao G,Elliott G,Leoni L,Mapara MY,Roodman GD,Lentzsch S

更新日期：2007-03-01 00:00:00

abstract：:The three-dimensional tertiary structure of human von Willebrand Factor (vWF) on a hydrophobic surface under aqueous conditions and different shear stress regimes was studied by atomic force microscopy (AFM). vWF was imaged by AFM at molecular level resolution under negligible shear stress, under a local applied shear...

journal_title：Blood

authors： Siedlecki CA,Lestini BJ,Kottke-Marchant KK,Eppell SJ,Wilson DL,Marchant RE

更新日期：1996-10-15 00:00:00

abstract：:Interleukin-8 (IL-8) is a neutrophil chemotactic and activating cytokine that is produced in response to several stimuli. Because monocytic cells are important producers of IL-8, we investigated whether interferon-gamma (IFN-gamma), a potent inducer of activation and differentiation of mononuclear phagocytes, affected...

journal_title：Blood

authors： Bosco MC,Gusella GL,Espinoza-Delgado I,Longo DL,Varesio L

更新日期：1994-01-15 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) has potent physiologic and pathologic effects on a variety of cell types at subnanomolar concentrations. Platelets contain 40 times as much TGF-beta1 as other cells and secrete it as an inactive (latent) form in complex with latency-associated peptide (LAP), which is disulf...

journal_title：Blood

authors： Ahamed J,Burg N,Yoshinaga K,Janczak CA,Rifkin DB,Coller BS

更新日期：2008-11-01 00:00:00

abstract：:We studied the expression of the two tumor necrosis factor (TNF) receptors, p55 and p75, on B cells from patients with chronic lymphocytic leukemia (CLL), and the presence of soluble TNF receptors in serum. Expression of membrane-associated receptors was quantified by double labeling of peripheral blood mononuclear ce...

journal_title：Blood

authors： Waage A,Liabakk N,Lien E,Lamvik J,Espevik T

更新日期：1992-11-15 00:00:00

abstract：:Immune deficiency viruses such as SIV in macaques or HIV-1 in human beings have evolved mechanisms to defeat host immunity that also impact the efficacy of vaccines. A key factor for vaccine protection is whether immune responses elicited by prior immunization remain at levels sufficient to limit disease progression o...

journal_title：Blood

authors： Poonia B,Salvato MS,Yagita H,Maeda T,Okumura K,Pauza CD

更新日期：2009-08-06 00:00:00