Characterization of human marrow stromal cells: role in progenitor cell binding and granulopoiesis.

abstract：:Epithelial mesenchymal transitions are a remarkable example of cellular plasticity. These transitions are the hallmark of embryo development, are pivotal in cancer progression, and seem to occur infrequently in adult organisms. The reduced incidence of transitions in the adult could result from restrictive functions o...

journal_title：Blood

authors： Prindull G,Zipori D

更新日期：2004-04-15 00:00:00

abstract：:Typical acute promyelocytic leukemia (APL) is associated with expression of the PML-RARalpha fusion protein and responsiveness to treatment with all-trans retinoic acid (ATRA). A rare, but recurrent, APL has been described that does not respond to ATRA treatment and is associated with a variant chromosomal translocati...

journal_title：Blood

authors： Guidez F,Ivins S,Zhu J,Söderström M,Waxman S,Zelent A

更新日期：1998-04-15 00:00:00

abstract：:To address the mechanism by which the human globin genes are activated during erythropoiesis, we have used a tiled microarray to analyze the pattern of transcription factor binding and associated histone modifications across the telomeric region of human chromosome 16 in primary erythroid and nonerythroid cells. This ...

journal_title：Blood

authors： De Gobbi M,Anguita E,Hughes J,Sloane-Stanley JA,Sharpe JA,Koch CM,Dunham I,Gibbons RJ,Wood WG,Higgs DR

更新日期：2007-12-15 00:00:00

abstract：:The expression of Rhesus antigens on hematopoietic progenitor cells was studied using monoclonal antibodies. Because these antibodies are not capable of lysing mature red blood cells in a complement-dependent cytotoxicity assay, fluorescence-activated cell sorting was performed. Using the monoclonal anti-Rh 29 antibod...

journal_title：Blood

authors： Falkenburg JH,Fibbe WE,van der Vaart-Duinkerken N,Nichols ME,Rubinstein P,Jansen J

更新日期：1985-09-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) is the most important cytokine involved in the promotion of myelofibrosis. Mechanisms leading to its local activation in the bone marrow environment remain unclear. As a recent study has highlighted the role of thrombospondin-1 (TSP-1) in platelet-derived TGF-β1 activation, we in...

journal_title：Blood

authors： Evrard S,Bluteau O,Tulliez M,Rameau P,Gonin P,Zetterberg E,Palmblad J,Bonnefoy A,Villeval JL,Vainchenker W,Giraudier S,Wagner-Ballon O

更新日期：2011-01-06 00:00:00

abstract：:An acquired gain-of-function mutation in the Janus kinase 2 (JAK2-V617F) is frequently found in patients with myeloproliferative disorders (MPDs). To test the hypothesis that JAK2-V617F is the disease-initiating mutation, we examined whether all cells of clonal origin carry the JAK2-V617F mutation. Using allele-specif...

journal_title：Blood

authors： Kralovics R,Teo SS,Li S,Theocharides A,Buser AS,Tichelli A,Skoda RC

更新日期：2006-08-15 00:00:00

abstract：:Glycoprotein (GP) Ibalpha, a member of the leucine-rich repeat (LRR) protein family, mediates platelet adhesion to immobilized von Willebrand factor (VWF). We investigated the role in VWF binding of charged residues in the LRR region of GP Ibalpha that are conserved in human, canine, and murine proteins. Substitution ...

journal_title：Blood

authors： Peng Y,Shrimpton CN,Dong JF,López JA

更新日期：2005-09-15 00:00:00

abstract：:This study was designed to assess the presence of endogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) within adherent layers of human Dexter-type cultures and to investigate the effect on granulomonopoiesis of adding exogenous GM-CSF to the culture medium. The presence of GM-CSF was demonstrated using...

journal_title：Blood

authors： Charbord P,Tamayo E,Saeland S,Duvert V,Poulet J,Gown AM,Herve P

更新日期：1991-09-01 00:00:00

abstract：:Merkel cell polyomavirus (MCPyV), a DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukemia. MCPyV sequences have also been detected in various normal tissues in tumor-affected patients. Immunologic studies have detected MCPyV antibodies in as many as 80% of healthy...

journal_title：Blood

authors： Pancaldi C,Corazzari V,Maniero S,Mazzoni E,Comar M,Martini F,Tognon M

更新日期：2011-06-30 00:00:00

abstract：:Plasmacytoid dendritic cells (PDCs) are crucial effectors in innate immunity. In this study, we show that imatinib, a potent inhibitor of BCR/ABL tyrosine kinase activity, in the presence of Flt3-Ligand, could induce CD34+ progenitors from chronic myeloid leukemia (CML) to give rise in vitro to typical BDCA-2+ type I ...

journal_title：Blood

authors： Mohty M,Jourdan E,Mami NB,Vey N,Damaj G,Blaise D,Isnardon D,Olive D,Gaugler B

更新日期：2004-06-15 00:00:00

abstract：:Casein kinase 2 (CK2) is a ubiquitous cellular serine-threonine kinase that regulates relevant biologic processes, many of which are dysregulated in malignant plasma cells. Here we investigated its role in multiple myeloma (MM). Analysis of MM cell lines and highly purified malignant plasma cells in patients with MM r...

journal_title：Blood

authors： Piazza FA,Ruzzene M,Gurrieri C,Montini B,Bonanni L,Chioetto G,Di Maira G,Barbon F,Cabrelle A,Zambello R,Adami F,Trentin L,Pinna LA,Semenzato G

更新日期：2006-09-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs), members of the transforming growth factor (TGF)-beta superfamily, are a group of related proteins that are capable of inducing the formation of cartilage and bone but are now regarded as multifunctional cytokines. We show in this report a novel function of BMPs in hematopoietic cell...

journal_title：Blood

authors： Kawamura C,Kizaki M,Yamato K,Uchida H,Fukuchi Y,Hattori Y,Koseki T,Nishihara T,Ikeda Y

更新日期：2000-09-15 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplant reflects a complex immune response resulting in chronic damage to multiple tissues. Previous studies indicated that donor B cells and the antibodies they produce play an important role in the development of cGVHD. To understa...

journal_title：Blood

authors： Wang KS,Kim HT,Nikiforow S,Heubeck AT,Ho VT,Koreth J,Alyea EP,Armand P,Blazar BR,Soiffer RJ,Antin JH,Cutler CS,Ritz J

更新日期：2017-12-28 00:00:00

abstract：:Stroke is a leading cause of death and disability. The only therapy available is recombinant tissue plasminogen activator, but side effects limit its use. Platelets play a crucial role during stroke, and the inflammatory reaction promotes neurodegeneration. von Willebrand factor (VWF), an adhesion molecule for platele...

journal_title：Blood

authors： Zhao BQ,Chauhan AK,Canault M,Patten IS,Yang JJ,Dockal M,Scheiflinger F,Wagner DD

更新日期：2009-10-08 00:00:00

abstract：:The relationship between platelet density and platelet age appears to vary between species with relatively few labeling studies in humans reported. In this study, irreversible monoamine oxidase (MAO) inhibitors were used to biochemically label the circulating platelet population in 15 humans. Platelet samples were the...

journal_title：Blood

authors： Chamberlain KG,Tong M,Chiu E,Penington DG

更新日期：1989-04-01 00:00:00

abstract：:Adoptive transfer of patient-derived T cells modified to express chimeric antigen receptors (CARTs) has demonstrated dramatic success in relapsed/refractory pre-B-cell acute lymphoblastic leukemia (ALL), but response and durability of remission requires exponential CART expansion and persistence. Tumors are known to a...

journal_title：Blood

authors： Qin H,Ishii K,Nguyen S,Su PP,Burk CR,Kim BH,Duncan BB,Tarun S,Shah NN,Kohler ME,Fry TJ

更新日期：2018-11-01 00:00:00

abstract：:L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion by myeloid-derived suppressor cells producing arginase I is seen in patients with cancer inducing T-cell anergy. We studied how L-Arg starvation could regulate T-cell-cycle progression. Stim...

journal_title：Blood

authors： Rodriguez PC,Quiceno DG,Ochoa AC

更新日期：2007-02-15 00:00:00

abstract：:Heavy chain ferritin (H-ferritin) is a component of the iron-binding protein, ferritin. We have previously shown that H-ferritin inhibits anti-CD3-stimulated lymphocyte proliferation and that this was due to increased production of interleukin-10 (IL-10). In the present study we have shown that induction of IL-10 prod...

journal_title：Blood

authors： Gray CP,Arosio P,Hersey P

更新日期：2002-05-01 00:00:00

abstract：:The existence of spontaneous heparin-induced thrombocytopenia (HIT) syndrome (or autoimmune HIT), defined as a transient prothrombotic thrombocytopenic disorder without proximate heparin exposure serologically indistinguishable from HIT, is controversial. We describe 2 new cases presenting with thrombotic stroke/throm...

journal_title：Blood

authors： Warkentin TE,Basciano PA,Knopman J,Bernstein RA

更新日期：2014-06-05 00:00:00

abstract：:Dosing of enzyme replacement therapy (ERT) for Gaucher disease type 1 is still a subject of debate and varies from 15 to 130 U/kg/mo, making a huge economic difference of 70,000 US dollars to 380,000 US dollars(euro55,000-300,000) per patient per year. To investigate whether this difference in dosing ultimately transl...

journal_title：Blood

authors： de Fost M,Hollak CE,Groener JE,Aerts JM,Maas M,Poll LW,Wiersma MG,Häussinger D,Brett S,Brill N,vom Dahl S

更新日期：2006-08-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widely used in healthy donors for collection of peripheral blood progenitor cells (PBPCs) for allogeneic transplantation and granulocytes for transfusion. The spectrum of its biologic and molecular activities in healthy individuals is coming into sha...

journal_title：Blood

authors： Anderlini P,Champlin RE

更新日期：2008-02-15 00:00:00

abstract：:To determine if megakaryocytes are targeted by immune thrombocytopenic purpura (ITP) autoantibodies, as are platelets, we have studied the effects of ITP plasma on in vitro megakaryocytopoiesis. Umbilical cord blood mononuclear cells were incubated in the presence of thrombopoietin and 10% plasma from either ITP patie...

journal_title：Blood

authors： Chang M,Nakagawa PA,Williams SA,Schwartz MR,Imfeld KL,Buzby JS,Nugent DJ

更新日期：2003-08-01 00:00:00

abstract：:Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We report the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of mavorixafor from a phase 2 open-label dose-escalatio...

journal_title：Blood

authors： Dale DC,Firkin F,Bolyard AA,Kelley M,Makaryan V,Gorelick KJ,Ebrahim T,Garg V,Tang W,Jiang H,Skerlj R,Beaussant Cohen S

更新日期：2020-12-24 00:00:00

abstract：:In this issue of Blood, Savona and an international consortium of clinical investigators propose uniform response criteria for treatment trials enrolling adult patients with myelodysplastic/myeloproliferative neoplasms (MDS/MPNs). Such a proposal is needed because new drugs are finally being tested in these rare “over...

journal_title：Blood

authors： Steensma DP

更新日期：2015-03-19 00:00:00

abstract：:The interleukin-6 receptor (IL-6R)/signal transducer and activator of transcription 3 (STAT3) pathway contributes to the pathogenesis of multiple myeloma (MM) and protects MM cells from apoptosis. However, MM cells survive the IL-6R blockade if they are cocultured with bone marrow stromal cells (BMSCs), suggesting tha...

journal_title：Blood

authors： Chatterjee M,Stühmer T,Herrmann P,Bommert K,Dörken B,Bargou RC

更新日期：2004-12-01 00:00:00

abstract：:Infections during granulocytopenia are major complications of autologous bone marrow transplantation (ABMT). Since recombinant human granulocyte-macrophage colony-stimulating factor (rhuGM-CSF) has proved to accelerate bone marrow recovery after cytostatic chemotherapy, we studied its effects on hematopoietic regenera...

journal_title：Blood

authors： Link H,Boogaerts MA,Carella AM,Ferrant A,Gadner H,Gorin NC,Harabacz I,Harousseau JL,Hervé P,Holldack J

更新日期：1992-11-01 00:00:00

abstract：:Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quantitative trait that is strongly correlated with thrombosis risk. Polymorphisms within only 1 gene, the ABO blood-group locus, have been unequivocally demonstrated to contribute to the broad population variability observed for this trait. B...

journal_title：Blood

authors： Viel KR,Machiah DK,Warren DM,Khachidze M,Buil A,Fernstrom K,Souto JC,Peralta JM,Smith T,Blangero J,Porter S,Warren ST,Fontcuberta J,Soria JM,Flanders WD,Almasy L,Howard TE

更新日期：2007-05-01 00:00:00

abstract：:Transfusion-related acute lung injury (TRALI) is a hazardous complication of transfusion and has become the leading cause of transfusion-related death in the United States and United Kingdom. Although leukoagglutinating antibodies have been frequently shown to be associated with the syndrome, the mechanism by which th...

journal_title：Blood

authors： Sachs UJ,Hattar K,Weissmann N,Bohle RM,Weiss T,Sibelius U,Bux J

更新日期：2006-02-01 00:00:00

abstract：:For many in vivo gene therapy clinical applications, it is desirable to control the expression of the transferred transgene using pharmacologic agents. To evaluate the feasibility of accomplishing this using corticosteroids, pharmacologic agents widely used in clinical medicine, we constructed replication deficient ad...

journal_title：Blood

authors： Narumi K,Suzuki M,Song W,Moore MA,Crystal RG

更新日期：1998-08-01 00:00:00

abstract：:The extended (E) isoform unique to Fibrinogen420 (Fib420) is distinguished from the conventional chain of Fibrinogen340 by the presence of an additional 236-residue carboxyl terminus globular domain (EC). A recombinant form of EC (rEC), having a predicted mass of 27,653 Daltons, was expressed in yeast (Pichia pastoris...

journal_title：Blood

authors： Applegate D,Haraga L,Hertzberg KM,Steben LS,Zhang JZ,Redman CM,Grieninger G

更新日期：1998-11-15 00:00:00